Setup

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DIR = 'Y:/DUX4_multiomics/'
RNASEQ_DIR = 'Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/'
RNASEQ_RESULTS_DIR = 'Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/'
RNASEQ_QC_DIR = 'Y:/DUX4_multiomics/DUX4_RNAseq/combine_runs/results/star-salmon-qhqxgg/'
SALMON_DIR = paste0(RNASEQ_RESULTS_DIR,'salmon/')
RNASEQ_ANALYSIS_DIR = 'Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/analysis/'
dir.create(RNASEQ_ANALYSIS_DIR)
## Warning in dir.create(RNASEQ_ANALYSIS_DIR): 'Y:
## \DUX4_multiomics\DUX4_RNAseq\combined_caDUX4\results\analysis' already exists
dir.create(paste(RNASEQ_ANALYSIS_DIR,'log2FC_pval_tables',sep='/'))
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## = "/")): 'Y:\DUX4_multiomics\DUX4_RNAseq\combined_caDUX4\results\analysis\
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dir.create(paste(RNASEQ_ANALYSIS_DIR,'gene_set_analysis',sep='/'))
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## = "/")): 'Y:\DUX4_multiomics\DUX4_RNAseq\combined_caDUX4\results\analysis\
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PROTEOMICS_RESULTS_DIR = 'Y:/DUX4_multiomics/DUX4_MassSpec/Liang_rerun/'
TOTAL_PROTEIN_DIR = 'Y:/DUX4_multiomics/DUX4_MassSpec/Liang_rerun/20210113_Dux4_proteome/outputs/'
PHOSPHOPROTEIN_DIR = 'Y:/DUX4_multiomics/DUX4_MassSpec/Liang_rerun/20210113_DUX4_pSTY/outputs/'
PLOTS_DIR = 'Y:/DUX4_multiomics/Analysis/Plots/'
GSEA_DIR = 'Y:/DUX4_multiomics/Analysis/fGSEA_res/'
MAJIQ_DIR = 'Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/MAJIQ_with_caDUX4/'

updateAnnot = FALSE
run_gsea = FALSE # save time by reading in previously saved results

conditions_to_plot = c('iDUX4dmso','iDUX4t02dox','iDUX4t06dox','iDUX4t14dox')

Load QC and Metadata

Load reads, samples, and gene/transcript annotation.

Some QC results are from the initial STAR-salmon run that did not include the caDUX4 sequence in the reference.

# Alignment Metadata
multiqc_picard_RnaSeqMetrics = read.table(file.path(RNASEQ_QC_DIR,'multiqc-align/multiqc_data/multiqc_picard_RnaSeqMetrics.txt'),header=TRUE,stringsAsFactors=FALSE,sep='\t')
multiqc_star = read.table(file.path(RNASEQ_QC_DIR,'multiqc-align/multiqc_data/multiqc_star.txt'),header=TRUE,stringsAsFactors=FALSE,sep='\t')
alignment_metadata = merge(multiqc_picard_RnaSeqMetrics,multiqc_star)
alignment_metadata = alignment_metadata[grep('RSA',alignment_metadata$Sample),]
n_samples = dim(alignment_metadata)[1]

# Read Metadata
multiqc_fastqc = read.table(file.path(RNASEQ_QC_DIR,'multiqc-reads/multiqc_data/multiqc_general_stats.txt'),header=TRUE,stringsAsFactors=FALSE)
multiqc_fastqc_avg=data.frame(sample_name = alignment_metadata$Sample)
multiqc_fastqc_avg$percent_duplicates = rowMeans(cbind(multiqc_fastqc[2*c(1:n_samples)-1,'FastQC_mqc.generalstats.fastqc.percent_duplicates'],multiqc_fastqc[2*c(1:n_samples),'FastQC_mqc.generalstats.fastqc.percent_duplicates']))
multiqc_fastqc_avg$percent_fails = rowMeans(cbind(multiqc_fastqc[2*c(1:n_samples)-1,'FastQC_mqc.generalstats.fastqc.percent_fails'],multiqc_fastqc[2*c(1:n_samples),'FastQC_mqc.generalstats.fastqc.percent_fails']))
multiqc_fastqc_avg$percent_gc = rowMeans(cbind(multiqc_fastqc[2*c(1:n_samples)-1,'FastQC_mqc.generalstats.fastqc.percent_gc'],multiqc_fastqc[2*c(1:n_samples),'FastQC_mqc.generalstats.fastqc.percent_gc']))

# Salmon metadata
salmon_metadata = read.table(file.path(RNASEQ_RESULTS_DIR,'multiqc-salmon/multiqc_data/multiqc_salmon.txt'),header=TRUE,stringsAsFactors=FALSE,sep='\t')

# combine QC data
mapping_metrics = cbind(alignment_metadata, multiqc_fastqc_avg[,2:4],salmon_metadata[,2:dim(salmon_metadata)[2]])


# Sample metadata
RNA_sample_metadata = read_delim(paste(RNASEQ_DIR,'Sample_Metadata.txt',sep='/'),delim='\t')
## Rows: 24 Columns: 2
## ── Column specification ────────────────────────────────────────────────────────
## Delimiter: "\t"
## chr (2): Name, Biospecimen
## 
## ℹ Use `spec()` to retrieve the full column specification for this data.
## ℹ Specify the column types or set `show_col_types = FALSE` to quiet this message.
RNA_sample_metadata$treatment = gsub('t00','dmso',unlist(strsplit(RNA_sample_metadata$Biospecimen,' '))[c(1:n_samples)*3-1])
RNA_sample_metadata$treatment = gsub('t02','t02dox',RNA_sample_metadata$treatment)
RNA_sample_metadata$treatment = gsub('t06','t06dox',RNA_sample_metadata$treatment)
RNA_sample_metadata$treatment = gsub('t14','t14dox',RNA_sample_metadata$treatment)
RNA_sample_metadata$cells = unlist(strsplit(RNA_sample_metadata$Biospecimen,' '))[c(1:n_samples)*3-2]
RNA_sample_metadata$cells[RNA_sample_metadata$cells == 'WT'] = '0WT'
RNA_sample_metadata$condition = paste(RNA_sample_metadata$cells,RNA_sample_metadata$treatment,sep='')
colnames(RNA_sample_metadata) = gsub(' ','_',tolower(colnames(RNA_sample_metadata)),fixed=TRUE)
RNA_sample_metadata$biospecimen = gsub('WT','0WT',as.character(RNA_sample_metadata$biospecimen))
colnames(RNA_sample_metadata)[1] = 'sample_name'
RNA_sample_metadata$biospecimen = gsub('t00','dmso',RNA_sample_metadata$biospecimen)
RNA_sample_metadata
## # A tibble: 24 × 5
##    sample_name                 biospecimen    treatment cells condition  
##    <chr>                       <chr>          <chr>     <chr> <chr>      
##  1 RSA0000107803_RSA0000107683 iDUX4 t06 rep1 t06dox    iDUX4 iDUX4t06dox
##  2 RSA0000107804_RSA0000107684 iDUX4 t06 rep2 t06dox    iDUX4 iDUX4t06dox
##  3 RSA0000107805_RSA0000107685 iDUX4 t06 rep3 t06dox    iDUX4 iDUX4t06dox
##  4 RSA0000107806_RSA0000107686 iDUX4 t06 rep4 t06dox    iDUX4 iDUX4t06dox
##  5 RSA0000107807_RSA0000107687 iDUX4 t14 rep1 t14dox    iDUX4 iDUX4t14dox
##  6 RSA0000107808_RSA0000107688 iDUX4 t14 rep2 t14dox    iDUX4 iDUX4t14dox
##  7 RSA0000107809_RSA0000107689 iDUX4 t14 rep3 t14dox    iDUX4 iDUX4t14dox
##  8 RSA0000107810_RSA0000107690 iDUX4 t14 rep4 t14dox    iDUX4 iDUX4t14dox
##  9 RSA0000107811_RSA0000107691 0WT dmso rep1  dmso      0WT   0WTdmso    
## 10 RSA0000107812_RSA0000107692 0WT dmso rep2  dmso      0WT   0WTdmso    
## # … with 14 more rows
MS_sample_metadata = read.table(paste0(TOTAL_PROTEIN_DIR,'/annotation_with_channels.csv'),sep=',',header=TRUE)
MS_sample_metadata = unique(MS_sample_metadata[,c('biospecimenName','BioRep','Channel','Exp')])
MS_n_samples = dim(MS_sample_metadata)[1]
MS_sample_metadata$sample = gsub('_','',MS_sample_metadata$biospecimenName)
MS_sample_metadata$sample = gsub('t00','dmso',MS_sample_metadata$sample)
MS_sample_metadata$sample = gsub('t02','t02dox',MS_sample_metadata$sample)
MS_sample_metadata$sample = gsub('t06','t06dox',MS_sample_metadata$sample)
MS_sample_metadata$sample = gsub('t14','t14dox',MS_sample_metadata$sample)
MS_sample_metadata$condition = gsub('_','',MS_sample_metadata$Exp)
MS_sample_metadata$condition = gsub('t00','dmso',MS_sample_metadata$condition)
MS_sample_metadata$condition = gsub('t02','t02dox',MS_sample_metadata$condition)
MS_sample_metadata$condition = gsub('t06','t06dox',MS_sample_metadata$condition)
MS_sample_metadata$condition = gsub('t14','t14dox',MS_sample_metadata$condition)
MS_sample_metadata$cells = unlist(strsplit(MS_sample_metadata$biospecimenName,'_'))[c(1:MS_n_samples)*3-2]
MS_sample_metadata
##    biospecimenName        BioRep Channel       Exp         sample   condition
## 1    iDUX4_t00_BR1 iDUX4_t00_BR1     126 iDUX4_t00   iDUX4dmsoBR1   iDUX4dmso
## 2    iDUX4_t00_BR2 iDUX4_t00_BR2   127_N iDUX4_t00   iDUX4dmsoBR2   iDUX4dmso
## 3    iDUX4_t00_BR3 iDUX4_t00_BR3   127_C iDUX4_t00   iDUX4dmsoBR3   iDUX4dmso
## 4    iDUX4_t02_BR1 iDUX4_t02_BR1   128_N iDUX4_t02 iDUX4t02doxBR1 iDUX4t02dox
## 5    iDUX4_t02_BR2 iDUX4_t02_BR2   128_C iDUX4_t02 iDUX4t02doxBR2 iDUX4t02dox
## 6    iDUX4_t02_BR3 iDUX4_t02_BR3   129_N iDUX4_t02 iDUX4t02doxBR3 iDUX4t02dox
## 7    iDUX4_t06_BR1 iDUX4_t06_BR1   129_C iDUX4_t06 iDUX4t06doxBR1 iDUX4t06dox
## 8    iDUX4_t06_BR2 iDUX4_t06_BR2   130_N iDUX4_t06 iDUX4t06doxBR2 iDUX4t06dox
## 9    iDUX4_t06_BR3 iDUX4_t06_BR3   130_C iDUX4_t06 iDUX4t06doxBR3 iDUX4t06dox
## 10   iDUX4_t14_BR1 iDUX4_t14_BR1   131_N iDUX4_t14 iDUX4t14doxBR1 iDUX4t14dox
## 11   iDUX4_t14_BR2 iDUX4_t14_BR2   131_C iDUX4_t14 iDUX4t14doxBR2 iDUX4t14dox
## 12   iDUX4_t14_BR3 iDUX4_t14_BR3   132_N iDUX4_t14 iDUX4t14doxBR3 iDUX4t14dox
## 13      WT_t00_BR1    WT_t00_BR1   132_C    WT_t00      WTdmsoBR1      WTdmso
## 14      WT_t00_BR2    WT_t00_BR2   133_N    WT_t00      WTdmsoBR2      WTdmso
## 15      WT_t14_BR1    WT_t14_BR1   133_C    WT_t14    WTt14doxBR1    WTt14dox
## 16      WT_t14_BR2    WT_t14_BR2   134_N    WT_t14    WTt14doxBR2    WTt14dox
##    cells
## 1  iDUX4
## 2  iDUX4
## 3  iDUX4
## 4  iDUX4
## 5  iDUX4
## 6  iDUX4
## 7  iDUX4
## 8  iDUX4
## 9  iDUX4
## 10 iDUX4
## 11 iDUX4
## 12 iDUX4
## 13    WT
## 14    WT
## 15    WT
## 16    WT
contrasts = read.table(paste(DIR,'Contrasts.txt',sep='/'),sep='\t',header=TRUE)
all_model_contrasts = contrasts[,2:7]
contrasts_of_interest = contrasts[c(1,2,4:6,16),]
model_contrasts_of_interest = contrasts_of_interest[,2:7]


# Gene/Transcript metadata/annotation
salmon_transcript_ids = read.table(paste(SALMON_DIR,list.files(SALMON_DIR)[1],'quant.sf',sep='/'),stringsAsFactors=FALSE,header=TRUE)[,1]
if(updateAnnot==TRUE){
  ensembl_v98_human <- useMart(host='sep2019.archive.ensembl.org',biomart='ENSEMBL_MART_ENSEMBL', dataset='hsapiens_gene_ensembl')
  biomartTranscriptAnnot = getBM(attributes=c('ensembl_transcript_id','ensembl_transcript_id_version','transcript_length','transcript_biotype','transcript_count','ensembl_gene_id','ensembl_gene_id_version','external_gene_name','gene_biotype'),filters=c('ensembl_transcript_id_version'),values=salmon_transcript_ids,mart=ensembl_v98_human)
write.table(biomartTranscriptAnnot,'Y:/Resources_Abby/Annotation/hsapiens/ensembl_98/biomartTranscriptAnnot.txt',sep='\t')
  
  biomartGeneAnnot = getBM(attributes=c('ensembl_gene_id','ensembl_gene_id_version','external_gene_name','gene_biotype','strand','chromosome_name','start_position','end_position','band','description'),filters=c('ensembl_gene_id'),values=unique(biomartTranscriptAnnot$ensembl_gene_id),mart=ensembl_v98_human)
  write.table(biomartGeneAnnot,'Y:/Resources_Abby/Annotation/hsapiens/ensembl_98/biomartGeneAnnot.txt',sep='\t')
  
 biomartProteinAnnot = getBM(attributes=c('hgnc_symbol','uniprotswissprot','ensembl_gene_id'),filters=c('ensembl_gene_id'),values=unique(biomartTranscriptAnnot$ensembl_gene_id),mart=ensembl_v98_human)
  write.table(biomartProteinAnnot,'Y:/Resources_Abby/Annotation/hsapiens/ensembl_98/biomartProteinAnnot.txt',row.names=FALSE,sep='\t')
  
} else {
  biomartTranscriptAnnot = read.table('Y:/Resources_Abby/Annotation/hsapiens/ensembl_98/biomartTranscriptAnnot.txt',sep='\t',header=TRUE,stringsAsFactors=FALSE)
  biomartGeneAnnot = read.table('Y:/Resources_Abby/Annotation/hsapiens/ensembl_98/biomartGeneAnnot.txt',sep='\t',header=TRUE,stringsAsFactors=FALSE)
  biomartProteinAnnot = read.table('Y:/Resources_Abby/Annotation/hsapiens/ensembl_98/biomartProteinAnnot.txt',sep='\t',header=TRUE,stringsAsFactors=FALSE)
}

biomartProteinAnnot_uniprot_select = biomartProteinAnnot[biomartProteinAnnot$uniprotswissprot != '',]

biomart_tx2gene = unique(biomartTranscriptAnnot[,c('ensembl_transcript_id_version','ensembl_gene_id')])

# Add in the sequence for the dox-inducible caDUX4 gene
biomart_tx2gene_caDUX4 = rbind(biomart_tx2gene,c('caDUX4_sequence','caDUX4_sequence'))
caDUX4_geneAnnot = biomartGeneAnnot[biomartGeneAnnot$external_gene_name=='DUX4',]
caDUX4_geneAnnot[1,] = c('caDUX4_sequence','caDUX4_sequence','caDUX4','inducible_protein_coding','NA','NA','NA','NA','NA','inducible codon altered DUX4')
biomartGeneAnnot = rbind(biomartGeneAnnot,caDUX4_geneAnnot)

Total Proteomics

Read in data

Total protein protein-level analysis (from Liang Xue’s pipeline based on MSstats)

total_protein_quantwide = read.table(paste(TOTAL_PROTEIN_DIR,'q09_quantwide_rbiname_protein_prname.txt',sep='/'),header=TRUE)
total_protein_comparewide = read.table(paste(TOTAL_PROTEIN_DIR,'DUX4_added_columns/q10_comparewide_protein_prname.txt',sep='/'),header=TRUE)
correct_condition_labels <- function(data_colnames){
  data_colnames = gsub('_t','t',data_colnames)
  data_colnames = gsub('_BR','BR',data_colnames)
  data_colnames = gsub('.','_',data_colnames,fixed=TRUE)
  data_colnames = gsub('t00','dmso',data_colnames,fixed=TRUE)
  data_colnames = gsub('t02','t02dox',data_colnames,fixed=TRUE)
  data_colnames = gsub('t06','t06dox',data_colnames,fixed=TRUE)
  data_colnames = gsub('t14','t14dox',data_colnames,fixed=TRUE)
}
colnames(total_protein_quantwide) = correct_condition_labels(colnames(total_protein_quantwide))
colnames(total_protein_comparewide) = correct_condition_labels(colnames(total_protein_comparewide))
total_protein_merged = merge(total_protein_quantwide,total_protein_comparewide,by.x='ProteinGroup',by.y='ProteinGroup',all.x=TRUE,all.y=TRUE)
duplicated_proteins = names(table(total_protein_merged$Protein)[table(total_protein_merged$Protein)>1])

ms_comparisons = gsub('log2FC_','',colnames(total_protein_comparewide)[grep('log2FC',colnames(total_protein_comparewide))])

total_protein_comparisons = list()
for(curr_contrast_idx in 1:length(ms_comparisons)){
  curr_contrast = ms_comparisons[curr_contrast_idx]
  curr_reference = strsplit(curr_contrast,'_')[[1]][2]
  curr_numerator = strsplit(curr_contrast,'_')[[1]][1]
  total_protein_comparisons[[curr_contrast]] = total_protein_comparewide[,c(1:4,grep(curr_contrast,colnames(total_protein_comparewide)))]
  colnames(total_protein_comparisons[[curr_contrast]]) = gsub(paste0('_',curr_contrast),'',colnames(total_protein_comparisons[[curr_contrast]]))
  # total_protein_comparisons[[curr_contrast]]$reference_mean = rowMeans(total_protein_quantwide[,grep(curr_reference,colnames(total_protein_quantwide))])
}

Exploratory data analysis: PCA on total proteomics data

total_protein_quantwide_for_PCA = total_protein_quantwide[,grep('BR',colnames(total_protein_quantwide))]
total_protein_quantwide_for_PCA = total_protein_quantwide_for_PCA[rowSums(is.na(total_protein_quantwide_for_PCA))==0,]
  
PCAres_total_protein_0 = prcomp(t(total_protein_quantwide_for_PCA),center=TRUE,scale=TRUE)
PCAres_total_protein = merge(as.data.frame(PCAres_total_protein_0$x), as.data.frame(MS_sample_metadata),by.x=0,by.y='sample')
percentVar_total_protein = round(100 * summary(PCAres_total_protein_0)$importance[2,])
ggplot(PCAres_total_protein,aes(PC1,PC2,color=condition)) + geom_point() + 
  ggtitle('total proteomics data, centered and scaled') +
  xlab(paste0("PC1: ",percentVar_total_protein[1],"% variance")) +
  ylab(paste0("PC2: ",percentVar_total_protein[2],"% variance"))

PCAres_total_protein_0 = prcomp(t(total_protein_quantwide_for_PCA),center=TRUE,scale=FALSE)
PCAres_total_protein = merge(as.data.frame(PCAres_total_protein_0$x), as.data.frame(MS_sample_metadata),by.x=0,by.y='sample')
percentVar_total_protein = round(100 * summary(PCAres_total_protein_0)$importance[2,])
ggplot(PCAres_total_protein,aes(PC1,PC2,color=condition)) + geom_point() + 
  ggtitle('total proteomics data, centered NOT scaled') +
  xlab(paste0("PC1: ",percentVar_total_protein[1],"% variance")) +
  ylab(paste0("PC2: ",percentVar_total_protein[2],"% variance"))

Total protein volcano plots

ms_total_protein_condition_means = as.data.frame(matrix(0,nrow=dim(total_protein_quantwide)[1],ncol=length(unique(MS_sample_metadata$condition))))
colnames(ms_total_protein_condition_means) = gsub('0WT','WT',unique(MS_sample_metadata$condition))
for(curr_condition in gsub('0WT','WT',unique(MS_sample_metadata$condition))){
  ms_total_protein_condition_means[,curr_condition] = log2(rowMeans(2^total_protein_quantwide[,grep(curr_condition,colnames(total_protein_quantwide))]))
}
colnames(ms_total_protein_condition_means) = gsub('0WT','WT',colnames(ms_total_protein_condition_means))

ms_total_protein_conditions_contrasts = list()
for(contrast_idx in 1:length(ms_comparisons)){
  curr_contrast = ms_comparisons[contrast_idx]
  curr_reference = strsplit(curr_contrast,'_')[[1]][2]
  curr_numerator = strsplit(curr_contrast,'_')[[1]][1]
  curr_condition_means = ms_total_protein_condition_means[,c(curr_numerator,curr_reference)]
  colnames(curr_condition_means) = c('numerator_mean','reference_mean')
  ms_total_protein_conditions_contrasts[[contrast_idx]] = merge(total_protein_comparewide[,c(1:4,grep(curr_contrast,colnames(total_protein_comparewide)))],curr_condition_means,by.x=0,by.y=0,all.x=TRUE,all.y=FALSE)
  ms_total_protein_conditions_contrasts[[contrast_idx]] = merge(ms_total_protein_conditions_contrasts[[contrast_idx]],biomartProteinAnnot,by.x='Protein',by.y='uniprotswissprot',all.x=TRUE,all.y=FALSE)
  colnames(ms_total_protein_conditions_contrasts[[contrast_idx]])[grep('log2FC',colnames(ms_total_protein_conditions_contrasts[[contrast_idx]]))] = 'log2FC'
  colnames(ms_total_protein_conditions_contrasts[[contrast_idx]])[grep('adj_p',colnames(ms_total_protein_conditions_contrasts[[contrast_idx]]))] = 'adj_pvalue'
}
names(ms_total_protein_conditions_contrasts) = ms_comparisons

make_save_contrast_volcano_plots <- function(contrasts_data,dir,color_by='reference_mean',color_trans='identity',legend_title='reference level CPM'){
  dir.create(dir,recursive=TRUE,showWarnings=FALSE)
  log2FC_lim = max(max(unlist(lapply(contrasts_data,function(x) max(x$log2FC,na.rm=TRUE)))),-1*min(unlist(lapply(contrasts_data,function(x) min(x$log2FC,na.rm=TRUE)))))
  max_neg_log_adj_p = max(unlist(lapply(contrasts_data,function(x) max(-log10(x$adj_pvalue),na.rm=TRUE))))
  for(curr_contrast_idx in 1:length(contrasts_data)){
    curr_contrast = names(contrasts_data)[curr_contrast_idx]
    print(ggplot(contrasts_data[[curr_contrast]],aes(x=log2FC,y=-log10(adj_pvalue),color=get(color_by))) + geom_point(alpha=1,shape=16,size=2) + ggtitle(paste('condition contrasts model:',curr_contrast)) + coord_cartesian(xlim=log2FC_lim*c(-1.05,1.05),ylim=c(0,1.05*max_neg_log_adj_p)) + scale_color_gradient(trans=color_trans,low="#a1dab4",high="#253494",space="Lab",na.value="grey50",guide="colourbar",aesthetics="color",name=legend_title) + xlab('log2(fold change)') + ylab('-log10(adjusted p-value)') + theme_bw())
    ggsave(paste(dir,'/',curr_contrast,'.pdf',sep=''),device='pdf',width=10,height=8)
  }
}

make_save_contrast_volcano_plots(ms_total_protein_conditions_contrasts,dir=paste0(PLOTS_DIR,'MS_total_protein/'),legend_title='reference level abundance')
## Warning: Removed 2 rows containing missing values (geom_point).
## Removed 2 rows containing missing values (geom_point).

## Warning: Removed 4 rows containing missing values (geom_point).
## Warning: Removed 4 rows containing missing values (geom_point).

## Warning: Removed 5 rows containing missing values (geom_point).
## Warning: Removed 5 rows containing missing values (geom_point).

## Plot selected proteins

total_protein_to_plot = as.data.frame(t(total_protein_quantwide[,grep('BR',colnames(total_protein_quantwide))]))
colnames(total_protein_to_plot) = total_protein_quantwide$ProteinGroup
row.names(total_protein_to_plot) == MS_sample_metadata$sample
##  [1] TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE
## [16] TRUE
total_protein_to_plot$Sample = MS_sample_metadata$sample
total_protein_to_plot$Condition = MS_sample_metadata$condition
total_protein_to_plot$Cells = MS_sample_metadata$cells

plot_protein_normalized_abundance <- function(curr_gene_symbol){
  curr_protein_id = biomartProteinAnnot$uniprotswissprot[biomartProteinAnnot$hgnc_symbol==curr_gene_symbol]
  if(is.na(curr_protein_id)){
    message('protein id not found')
  } else { 
    ggplot(total_protein_to_plot,aes_string(x='Condition', y=curr_protein_id, color='Condition')) + 
      geom_jitter(width=0.1,height=0,size=2.5) + 
      theme(axis.text.x = element_text(angle = 90),legend.title=element_text('Condition')) +   
      stat_summary( fun.data = 'mean_se', geom = 'crossbar' ) +
      labs( title = paste(curr_gene_symbol,' (',curr_protein_id,')',sep='')) + 
      ylab(paste(curr_protein_id,' normalized abundance'))
  }
}

plot_protein_normalized_abundance('ZSCAN4')
## Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)): font family not
## found in Windows font database
## Warning in grid.Call(C_textBounds, as.graphicsAnnot(x$label), x$x, x$y, : font
## family not found in Windows font database

plot_protein_normalized_abundance('DUXA')
## Warning in grid.Call(C_textBounds, as.graphicsAnnot(x$label), x$x, x$y, : font
## family not found in Windows font database

## Warning in grid.Call(C_textBounds, as.graphicsAnnot(x$label), x$x, x$y, : font
## family not found in Windows font database

plot_protein_normalized_abundance('PRAMEF12')
## Warning in grid.Call(C_textBounds, as.graphicsAnnot(x$label), x$x, x$y, : font
## family not found in Windows font database

## Warning in grid.Call(C_textBounds, as.graphicsAnnot(x$label), x$x, x$y, : font
## family not found in Windows font database

Peptide-level data

read in and format total proteomics peptide-level data, make and save volcano plots for all available comparisons

total_protein_quantwide_peptides = read.table(paste(TOTAL_PROTEIN_DIR,'q09_quantwide_rbiname_peptide_prname.txt',sep='/'),header=TRUE)
total_protein_comparewide_peptides = read.table(paste(TOTAL_PROTEIN_DIR,'q10_comparewide_peptide_prname.txt',sep='/'),header=TRUE)
colnames(total_protein_comparewide_peptides) = correct_condition_labels(colnames(total_protein_comparewide_peptides))
colnames(total_protein_quantwide_peptides) = correct_condition_labels(colnames(total_protein_quantwide_peptides))

total_protein_peptide_comparisons = list()
for(curr_contrast_idx in 1:length(ms_comparisons)){
  curr_contrast = ms_comparisons[curr_contrast_idx]
  total_protein_peptide_comparisons[[curr_contrast]] = total_protein_comparewide_peptides[,c(1:3,grep(curr_contrast,colnames(total_protein_comparewide_peptides)))]
  colnames(total_protein_peptide_comparisons[[curr_contrast]]) = gsub(paste0('_',curr_contrast),'',colnames(total_protein_peptide_comparisons[[curr_contrast]]))
}

ms_total_protein_peptide_condition_means = as.data.frame(matrix(0,nrow=dim(total_protein_quantwide_peptides)[1],ncol=length(unique(MS_sample_metadata$condition))))
colnames(ms_total_protein_peptide_condition_means) = gsub('0WT','WT',unique(MS_sample_metadata$condition))
for(curr_condition in gsub('0WT','WT',unique(MS_sample_metadata$condition))){
  ms_total_protein_peptide_condition_means[,curr_condition] = log2(rowMeans(2^total_protein_quantwide_peptides[,grep(curr_condition,colnames(total_protein_quantwide_peptides))]))
}
colnames(ms_total_protein_peptide_condition_means) = gsub('0WT','WT',colnames(ms_total_protein_peptide_condition_means))


ms_total_protein_peptide_conditions_contrasts = list()
for(contrast_idx in 1:length(ms_comparisons)){
  curr_contrast = ms_comparisons[contrast_idx]
  curr_reference = strsplit(curr_contrast,'_')[[1]][2]
  curr_numerator = strsplit(curr_contrast,'_')[[1]][1]
  curr_condition_means = ms_total_protein_peptide_condition_means[,c(curr_numerator,curr_reference)]
  colnames(curr_condition_means) = c('numerator_mean','reference_mean')
  ms_total_protein_peptide_conditions_contrasts[[contrast_idx]] = merge(total_protein_comparewide_peptides[,c(1:4,grep(curr_contrast,colnames(total_protein_comparewide_peptides)))],curr_condition_means,by.x=0,by.y=0,all.x=TRUE,all.y=FALSE)
  ms_total_protein_peptide_conditions_contrasts[[contrast_idx]] = merge(ms_total_protein_peptide_conditions_contrasts[[contrast_idx]],biomartProteinAnnot,by.x='Protein',by.y='uniprotswissprot',all.x=TRUE,all.y=FALSE)
  colnames(ms_total_protein_peptide_conditions_contrasts[[contrast_idx]])[grep('log2FC',colnames(ms_total_protein_peptide_conditions_contrasts[[contrast_idx]]))] = 'log2FC'
  colnames(ms_total_protein_peptide_conditions_contrasts[[contrast_idx]])[grep('adj_p',colnames(ms_total_protein_peptide_conditions_contrasts[[contrast_idx]]))] = 'adj_pvalue'
}

names(ms_total_protein_peptide_conditions_contrasts) = ms_comparisons

make_save_contrast_volcano_plots(ms_total_protein_peptide_conditions_contrasts,dir=paste0(PLOTS_DIR,'MS_total_protein_peptides/'),legend_title='reference level abundance')
## Warning: Removed 7 rows containing missing values (geom_point).
## Removed 7 rows containing missing values (geom_point).

## Warning: Removed 16 rows containing missing values (geom_point).
## Warning: Removed 16 rows containing missing values (geom_point).

## Warning: Removed 19 rows containing missing values (geom_point).
## Warning: Removed 19 rows containing missing values (geom_point).

Phospho-proteomics

Read in data

Read in and format phospho-peptide data, make and save volcano plots

phospho_quantwide_peptides = read.table(paste(PHOSPHOPROTEIN_DIR,'q09_quantwide_rbiname_peptide_prname.txt',sep='/'),header=TRUE)
phospho_comparewide_peptides = read.table(paste(PHOSPHOPROTEIN_DIR,'q10_comparewide_peptide_prname.txt',sep='/'),header=TRUE)
colnames(phospho_comparewide_peptides) = correct_condition_labels(colnames(phospho_comparewide_peptides))
colnames(phospho_quantwide_peptides) = correct_condition_labels(colnames(phospho_quantwide_peptides))

phospho_comparewide_peptides$Peptide = unlist(lapply(phospho_comparewide_peptides$PeptideSequence,function(x) toupper(strsplit(x,'|',fixed=TRUE)[[1]][1])))
phospho_comparewide_peptides$Residue.Both = unlist(lapply(phospho_comparewide_peptides$PeptideSequence,function(x) gsub('(Phospho)','',(strsplit(x,'|',fixed=TRUE)[[1]][2]),fixed=TRUE)))

phospho_peptide_comparisons = list()
for(curr_contrast_idx in 1:length(ms_comparisons)){
  curr_contrast = ms_comparisons[curr_contrast_idx]
  phospho_peptide_comparisons[[curr_contrast]] = phospho_comparewide_peptides[,c(1:3,grep(curr_contrast,colnames(phospho_comparewide_peptides)))]
  colnames(phospho_peptide_comparisons[[curr_contrast]]) = gsub(paste0('_',curr_contrast),'',colnames(phospho_peptide_comparisons[[curr_contrast]]))
}


ms_phospho_peptide_condition_means = as.data.frame(matrix(0,nrow=dim(phospho_quantwide_peptides)[1],ncol=length(unique(MS_sample_metadata$condition))))
colnames(ms_phospho_peptide_condition_means) = gsub('0WT','WT',unique(MS_sample_metadata$condition))
for(curr_condition in gsub('0WT','WT',unique(MS_sample_metadata$condition))){
  ms_phospho_peptide_condition_means[,curr_condition] = log2(rowMeans(2^phospho_quantwide_peptides[,grep(curr_condition,colnames(phospho_quantwide_peptides))]))
}
colnames(ms_phospho_peptide_condition_means) = gsub('0WT','WT',colnames(ms_phospho_peptide_condition_means))


ms_phospho_peptide_conditions_contrasts = list()
for(contrast_idx in 1:length(ms_comparisons)){
  curr_contrast = ms_comparisons[contrast_idx]
  curr_reference = strsplit(curr_contrast,'_')[[1]][2]
  curr_numerator = strsplit(curr_contrast,'_')[[1]][1]
  curr_condition_means = ms_phospho_peptide_condition_means[,c(curr_numerator,curr_reference)]
  colnames(curr_condition_means) = c('numerator_mean','reference_mean')
  ms_phospho_peptide_conditions_contrasts[[contrast_idx]] = merge(phospho_comparewide_peptides[,c(1:4,grep(curr_contrast,colnames(phospho_comparewide_peptides)),dim(phospho_comparewide_peptides)[2]-1,dim(phospho_comparewide_peptides)[2])],curr_condition_means,by.x=0,by.y=0,all.x=TRUE,all.y=FALSE)
  ms_phospho_peptide_conditions_contrasts[[contrast_idx]]$Row.names=NULL
  ms_phospho_peptide_conditions_contrasts[[contrast_idx]] = merge(ms_phospho_peptide_conditions_contrasts[[contrast_idx]],biomartProteinAnnot,by.x='Protein',by.y='uniprotswissprot',all.x=TRUE,all.y=FALSE)
  colnames(ms_phospho_peptide_conditions_contrasts[[contrast_idx]])[grep('log2FC',colnames(ms_phospho_peptide_conditions_contrasts[[contrast_idx]]))] = 'log2FC'
  colnames(ms_phospho_peptide_conditions_contrasts[[contrast_idx]])[grep('adj_p',colnames(ms_phospho_peptide_conditions_contrasts[[contrast_idx]]))] = 'adj_pvalue'
}

names(ms_phospho_peptide_conditions_contrasts) = ms_comparisons

make_save_contrast_volcano_plots(ms_phospho_peptide_conditions_contrasts,dir=paste0(PLOTS_DIR,'MS_phospho_peptides/'),legend_title='reference level abundance')
## Warning: Removed 27 rows containing missing values (geom_point).
## Removed 27 rows containing missing values (geom_point).

## Warning: Removed 5 rows containing missing values (geom_point).
## Warning: Removed 5 rows containing missing values (geom_point).

## Warning: Removed 2 rows containing missing values (geom_point).
## Warning: Removed 2 rows containing missing values (geom_point).

## Warning: Removed 6 rows containing missing values (geom_point).
## Warning: Removed 6 rows containing missing values (geom_point).

## Warning: Removed 42 rows containing missing values (geom_point).
## Warning: Removed 42 rows containing missing values (geom_point).

## Warning: Removed 56 rows containing missing values (geom_point).
## Warning: Removed 56 rows containing missing values (geom_point).

Normalize phospho data

Normalize phospho-peptide comparison data Following Liang’s advice, normalize (subtract log2FC) phospho-peptide log2FC comparison data minus corresponding total protein protein-level comparison log2FC

ms_total_protein_conditions_contrasts_filtered = list()
for(i in 1:length(ms_total_protein_conditions_contrasts)){
  ms_total_protein_conditions_contrasts_filtered[[i]] = ms_total_protein_conditions_contrasts[[i]][ms_total_protein_conditions_contrasts[[i]]$Protein == ms_total_protein_conditions_contrasts[[i]]$ProteinGroup,]
}
names(ms_total_protein_conditions_contrasts_filtered) = ms_comparisons

ms_phospho_peptide_norm_conditions_contrasts = ms_phospho_peptide_conditions_contrasts
merged_total_and_phospho_conditions_contrasts = ms_phospho_peptide_conditions_contrasts

for(contrast_idx in 1:length(ms_comparisons)){
 curr_contrast = names(ms_phospho_peptide_norm_conditions_contrasts[contrast_idx])
 merged_total_and_phospho_conditions_contrasts[[curr_contrast]] = merge(ms_phospho_peptide_conditions_contrasts[[curr_contrast]],ms_total_protein_conditions_contrasts_filtered[[curr_contrast]][,c('Protein','log2FC','adj_pvalue','numerator_mean','reference_mean')],by='Protein',all=FALSE,suffixes=c('_phospho','_total'))
 merged_total_and_phospho_conditions_contrasts[[curr_contrast]]$log2FC_norm = merged_total_and_phospho_conditions_contrasts[[curr_contrast]]$log2FC_phospho - merged_total_and_phospho_conditions_contrasts[[curr_contrast]]$log2FC_total
}

Gene-level RNA-seq

Read in count data

Using tximport (length scaled)

salmonAln_files = paste0(list.files(file.path (SALMON_DIR),pattern='RSA',full.names = TRUE),'/quant.sf')
names = list.files(file.path (SALMON_DIR),pattern='RSA',full.names = FALSE) 
names(salmonAln_files) = names
salmonAln_files
##                                                                                             RSA0000107803_RSA0000107683 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107803_RSA0000107683/quant.sf" 
##                                                                                             RSA0000107804_RSA0000107684 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107804_RSA0000107684/quant.sf" 
##                                                                                             RSA0000107805_RSA0000107685 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107805_RSA0000107685/quant.sf" 
##                                                                                             RSA0000107806_RSA0000107686 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107806_RSA0000107686/quant.sf" 
##                                                                                             RSA0000107807_RSA0000107687 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107807_RSA0000107687/quant.sf" 
##                                                                                             RSA0000107808_RSA0000107688 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107808_RSA0000107688/quant.sf" 
##                                                                                             RSA0000107809_RSA0000107689 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107809_RSA0000107689/quant.sf" 
##                                                                                             RSA0000107810_RSA0000107690 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107810_RSA0000107690/quant.sf" 
##                                                                                             RSA0000107811_RSA0000107691 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107811_RSA0000107691/quant.sf" 
##                                                                                             RSA0000107812_RSA0000107692 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107812_RSA0000107692/quant.sf" 
##                                                                                             RSA0000107813_RSA0000107693 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107813_RSA0000107693/quant.sf" 
##                                                                                             RSA0000107814_RSA0000107694 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107814_RSA0000107694/quant.sf" 
##                                                                                             RSA0000107815_RSA0000107695 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107815_RSA0000107695/quant.sf" 
##                                                                                             RSA0000107816_RSA0000107696 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107816_RSA0000107696/quant.sf" 
##                                                                                             RSA0000107817_RSA0000107697 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107817_RSA0000107697/quant.sf" 
##                                                                                             RSA0000107818_RSA0000107698 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107818_RSA0000107698/quant.sf" 
##                                                                                             RSA0000107819_RSA0000107699 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107819_RSA0000107699/quant.sf" 
##                                                                                             RSA0000107820_RSA0000107700 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107820_RSA0000107700/quant.sf" 
##                                                                                             RSA0000107821_RSA0000107701 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107821_RSA0000107701/quant.sf" 
##                                                                                             RSA0000107822_RSA0000107702 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107822_RSA0000107702/quant.sf" 
##                                                                                             RSA0000107823_RSA0000107703 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107823_RSA0000107703/quant.sf" 
##                                                                                             RSA0000107824_RSA0000107704 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107824_RSA0000107704/quant.sf" 
##                                                                                             RSA0000107825_RSA0000107705 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107825_RSA0000107705/quant.sf" 
##                                                                                             RSA0000107826_RSA0000107706 
## "Y:/DUX4_multiomics/DUX4_RNAseq/combined_caDUX4/results/star-salmon-t1xczk/salmon/RSA0000107826_RSA0000107706/quant.sf"
salmon_gene_counts_lengthScaled <- tximport::tximport(salmonAln_files,type='salmon',tx2gene=biomart_tx2gene_caDUX4,countsFromAbundance='lengthScaledTPM')
## reading in files with read_tsv
## 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 
## transcripts missing from tx2gene: 96
## summarizing abundance
## summarizing counts
## summarizing length
salmon_gene_counts_lengthScaled$counts %>%
  round() %>%
  as.data.frame() %>%
  tibble::rownames_to_column('ensembl_id') %>%
  tibble::as_tibble() %>%
  dplyr::mutate_if(is.double, as.integer) %>%
  readr::write_csv(file.path(RNASEQ_RESULTS_DIR,'salmon_gene_counts_lengthScaled.csv'))
#row.names(salmon_counts$counts) = lapply(row.names(salmon_counts$counts),truncate_gene_version)

Filter and normalize

For limma

counts_lengthScaled = salmon_gene_counts_lengthScaled$counts
dge_lengthScaled = DGEList(counts=counts_lengthScaled)

dge_lengthScaled$samples$group = RNA_sample_metadata$condition
dim(dge_lengthScaled)
## [1] 60624    24
as.data.frame(apply(dge_lengthScaled$counts,2,median))
##                             apply(dge_lengthScaled$counts, 2, median)
## RSA0000107803_RSA0000107683                                         0
## RSA0000107804_RSA0000107684                                         0
## RSA0000107805_RSA0000107685                                         0
## RSA0000107806_RSA0000107686                                         0
## RSA0000107807_RSA0000107687                                         0
## RSA0000107808_RSA0000107688                                         0
## RSA0000107809_RSA0000107689                                         0
## RSA0000107810_RSA0000107690                                         0
## RSA0000107811_RSA0000107691                                         0
## RSA0000107812_RSA0000107692                                         0
## RSA0000107813_RSA0000107693                                         0
## RSA0000107814_RSA0000107694                                         0
## RSA0000107815_RSA0000107695                                         0
## RSA0000107816_RSA0000107696                                         0
## RSA0000107817_RSA0000107697                                         0
## RSA0000107818_RSA0000107698                                         0
## RSA0000107819_RSA0000107699                                         0
## RSA0000107820_RSA0000107700                                         0
## RSA0000107821_RSA0000107701                                         0
## RSA0000107822_RSA0000107702                                         0
## RSA0000107823_RSA0000107703                                         0
## RSA0000107824_RSA0000107704                                         0
## RSA0000107825_RSA0000107705                                         0
## RSA0000107826_RSA0000107706                                         0
# Filter low counts 
min_counts = 2
min_samples = 4
idx_keep_genes = apply(counts_lengthScaled,1,function(x) sum(x>=min_counts)) >= min_samples

dge_lengthScaled_prefiltered = dge_lengthScaled[idx_keep_genes,]
dim(dge_lengthScaled_prefiltered)
## [1] 22537    24
as.data.frame(apply(dge_lengthScaled_prefiltered$counts,2,median))
##                             apply(dge_lengthScaled_prefiltered$counts, 2, median)
## RSA0000107803_RSA0000107683                                             101.32017
## RSA0000107804_RSA0000107684                                             125.09342
## RSA0000107805_RSA0000107685                                             108.22994
## RSA0000107806_RSA0000107686                                              95.86566
## RSA0000107807_RSA0000107687                                              53.51786
## RSA0000107808_RSA0000107688                                              77.68297
## RSA0000107809_RSA0000107689                                             102.44394
## RSA0000107810_RSA0000107690                                             103.45741
## RSA0000107811_RSA0000107691                                             120.18044
## RSA0000107812_RSA0000107692                                             116.55706
## RSA0000107813_RSA0000107693                                             120.51982
## RSA0000107814_RSA0000107694                                             110.12530
## RSA0000107815_RSA0000107695                                             105.46270
## RSA0000107816_RSA0000107696                                              89.72790
## RSA0000107817_RSA0000107697                                             127.02133
## RSA0000107818_RSA0000107698                                              71.04003
## RSA0000107819_RSA0000107699                                             105.76433
## RSA0000107820_RSA0000107700                                              91.09496
## RSA0000107821_RSA0000107701                                             121.67501
## RSA0000107822_RSA0000107702                                             126.23000
## RSA0000107823_RSA0000107703                                             125.51527
## RSA0000107824_RSA0000107704                                             111.67002
## RSA0000107825_RSA0000107705                                             109.32710
## RSA0000107826_RSA0000107706                                              89.92093
dge_lengthScaled_prefiltered_RLE = calcNormFactors(dge_lengthScaled_prefiltered,method='RLE')

cpm_lengthScaled_prefiltered_RLE = cpm(dge_lengthScaled_prefiltered_RLE)

cpm_condition_means = 0*cpm_lengthScaled_prefiltered_RLE[,1:length(unique(RNA_sample_metadata$condition))]
colnames(cpm_condition_means) = unique(RNA_sample_metadata$condition)
for(curr_condition in unique(RNA_sample_metadata$condition)){
  cpm_condition_means[,curr_condition] = rowMeans(cpm_lengthScaled_prefiltered_RLE[,RNA_sample_metadata$sample_name[RNA_sample_metadata$condition==curr_condition]])
}
colnames(cpm_condition_means) = gsub('0WT','WT',colnames(cpm_condition_means))

PCA

PCAres_edgeR_RLE_0 = prcomp(t(cpm_lengthScaled_prefiltered_RLE),center=TRUE,scale=TRUE)
PCAres_edgeR_RLE = merge(as.data.frame(PCAres_edgeR_RLE_0$x), RNA_sample_metadata,by.x=0,by.y=1)
percentVar_edgeR_RLE = round(100 * summary(PCAres_edgeR_RLE_0)$importance[2,])
ggplot(PCAres_edgeR_RLE,aes(PC1,PC2,color=condition)) + geom_point() + 
  ggtitle('edgeR RLE norm CPM, centered and scaled') +
  xlab(paste0("PC1: ",percentVar_edgeR_RLE[1],"% variance")) +
  ylab(paste0("PC2: ",percentVar_edgeR_RLE[2],"% variance"))

PCAres_edgeR_RLE_0 = prcomp(t(cpm_lengthScaled_prefiltered_RLE),center=TRUE,scale=FALSE)
PCAres_edgeR_RLE = merge(as.data.frame(PCAres_edgeR_RLE_0$x), RNA_sample_metadata,by.x=0,by.y=1)
percentVar_edgeR_RLE = round(100 * summary(PCAres_edgeR_RLE_0)$importance[2,])
ggplot(PCAres_edgeR_RLE,aes(PC1,PC2,color=condition)) + geom_point() + 
  ggtitle('edgeR RLE norm CPM, centered, NOT scaled') +
  xlab(paste0("PC1: ",percentVar_edgeR_RLE[1],"% variance")) +
  ylab(paste0("PC2: ",percentVar_edgeR_RLE[2],"% variance"))

prince_covars = mapping_metrics
prince_covars = prince_covars[, c('total_reads','multimapped_percent','PCT_CODING_BASES','PCT_MRNA_BASES','PCT_RIBOSOMAL_BASES','PCT_UTR_BASES','PCT_INTRONIC_BASES','PCT_INTERGENIC_BASES','percent_fails','percent_duplicates')]
row.names(prince_covars) = mapping_metrics$Sample

pca_corr = swamp::prince(cpm_lengthScaled_prefiltered_RLE, prince_covars, top=min(25,dim(cpm_lengthScaled_prefiltered_RLE)[2]))
# visualize significance of correlations
prince.plot(pca_corr)

prince.plot(pca_corr, Rsquared=TRUE)

mapping_metrics_labeled = merge(mapping_metrics, RNA_sample_metadata, by.x='Sample',by.y='sample_name')
ggplot(mapping_metrics_labeled[mapping_metrics_labeled$condition %in% conditions_to_plot,],aes_string(x='condition', y='PCT_INTRONIC_BASES', color='condition')) + 
      geom_jitter(width=0.1,height=0,size=2.5) + 
      theme(axis.text.x = element_text(angle = 90)) +   
      # stat_summary( fun.data = 'mean_se', geom = 'crossbar' ) +
      ylab('Percent intronic bases') + 
      ggtitle('Intronic Bases')

ggsave('Y:/DUX4_multiomics/Analysis/splicing_plots/intronic_bases.pdf',device='pdf',width=10,height=8)
ggplot(mapping_metrics_labeled[mapping_metrics_labeled$condition %in% conditions_to_plot,],aes_string(x='condition', y='PCT_INTRONIC_BASES', color='condition')) + 
      geom_jitter(width=0.1,height=0,size=2.5) + 
      theme(axis.text.x = element_text(angle = 90)) +   
      stat_summary( fun.data = 'mean_se', geom = 'crossbar' ) +
      ylab('Percent intronic bases') + 
      ggtitle('Intronic Bases')

ggsave('Y:/DUX4_multiomics/Analysis/splicing_plots/intronic_bases_summary.pdf',device='pdf',width=10,height=8)

ggplot(mapping_metrics_labeled[mapping_metrics_labeled$condition %in% conditions_to_plot,],aes_string(x='condition', y='PCT_INTERGENIC_BASES', color='condition')) + 
      geom_jitter(width=0.1,height=0,size=2.5) + 
      theme(axis.text.x = element_text(angle = 90)) + 
      # stat_summary( fun.data = 'mean_se', geom = 'crossbar' ) +
      ylab('Percent intergenic bases') + 
      ggtitle('Intergenic Bases')

ggsave('Y:/DUX4_multiomics/Analysis/splicing_plots/intergenic_bases.pdf',device='pdf',width=10,height=8)
ggplot(mapping_metrics_labeled[mapping_metrics_labeled$condition %in% conditions_to_plot,],aes_string(x='condition', y='PCT_INTERGENIC_BASES', color='condition')) + 
      geom_jitter(width=0.1,height=0,size=2.5) + 
      theme(axis.text.x = element_text(angle = 90)) + 
      stat_summary( fun.data = 'mean_se', geom = 'crossbar' ) +
      ylab('Percent intergenic bases') + 
      ggtitle('Intergenic Bases')

ggsave('Y:/DUX4_multiomics/Analysis/splicing_plots/intergenic_bases_summary.pdf',device='pdf',width=10,height=8)
#dev.off()

write.table(mapping_metrics_labeled[,c('condition','PCT_INTRONIC_BASES','PCT_INTERGENIC_BASES')],'Y:/DUX4_multiomics/DUX4_RNAseq/intronic_intergenic_pcts.txt',row.names=FALSE,sep='\t')

test_mapping_metric_statistics <- function(mapping_metrics_labeled,metric){
  message(paste(metric))
  anova_res = aov(get(metric) ~ condition,mapping_metrics_labeled[,c(metric,'condition')])
  print(summary(anova_res))
  write_lines(summary(anova_res),paste0('Y:/DUX4_multiomics/DUX4_RNAseq/',metric,'_anova.txt'))
  print(TukeyHSD(anova_res))
  write.table(TukeyHSD(anova_res)$condition,paste0('Y:/DUX4_multiomics/DUX4_RNAseq/',metric,'_TukeyHSD.txt'))
  print(pairwise.t.test(mapping_metrics_labeled[,metric],mapping_metrics_labeled$condition,p.adjust.method='BH'))
  write.table(pairwise.t.test(mapping_metrics_labeled[,metric],mapping_metrics_labeled$condition,p.adjust.method='BH')$p.value,paste0('Y:/DUX4_multiomics/DUX4_RNAseq/',metric,'_ttest_BHFDR.txt'))
}

test_mapping_metric_statistics(mapping_metrics_labeled[mapping_metrics_labeled$condition %in% conditions_to_plot,],'PCT_INTRONIC_BASES')
## PCT_INTRONIC_BASES
##             Df Sum Sq Mean Sq F value   Pr(>F)    
## condition    3 20.660   6.887   35.09 3.21e-06 ***
## Residuals   12  2.355   0.196                     
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##   Tukey multiple comparisons of means
##     95% family-wise confidence level
## 
## Fit: aov(formula = get(metric) ~ condition, data = mapping_metrics_labeled[, c(metric, "condition")])
## 
## $condition
##                              diff        lwr       upr     p adj
## iDUX4t02dox-iDUX4dmso   -0.042800 -0.9727778 0.8871778 0.9990363
## iDUX4t06dox-iDUX4dmso    1.306500  0.3765222 2.2364778 0.0061458
## iDUX4t14dox-iDUX4dmso    2.727325  1.7973472 3.6573028 0.0000081
## iDUX4t06dox-iDUX4t02dox  1.349300  0.4193222 2.2792778 0.0048592
## iDUX4t14dox-iDUX4t02dox  2.770125  1.8401472 3.7001028 0.0000069
## iDUX4t14dox-iDUX4t06dox  1.420825  0.4908472 2.3508028 0.0032938
## 
## 
##  Pairwise comparisons using t tests with pooled SD 
## 
## data:  mapping_metrics_labeled[, metric] and mapping_metrics_labeled$condition 
## 
##             iDUX4dmso iDUX4t02dox iDUX4t06dox
## iDUX4t02dox 0.8936    -           -          
## iDUX4t06dox 0.0016    0.0015      -          
## iDUX4t14dox 4.7e-06   4.7e-06     0.0014     
## 
## P value adjustment method: BH
test_mapping_metric_statistics(mapping_metrics_labeled[mapping_metrics_labeled$condition %in% conditions_to_plot,],'PCT_INTERGENIC_BASES')
## PCT_INTERGENIC_BASES
##             Df Sum Sq Mean Sq F value   Pr(>F)    
## condition    3  9.561   3.187   215.7 1.06e-10 ***
## Residuals   12  0.177   0.015                     
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##   Tukey multiple comparisons of means
##     95% family-wise confidence level
## 
## Fit: aov(formula = get(metric) ~ condition, data = mapping_metrics_labeled[, c(metric, "condition")])
## 
## $condition
##                            diff         lwr       upr     p adj
## iDUX4t02dox-iDUX4dmso   0.12305 -0.13213361 0.3782336 0.5048435
## iDUX4t06dox-iDUX4dmso   0.44060  0.18541639 0.6957836 0.0012368
## iDUX4t14dox-iDUX4dmso   1.93405  1.67886639 2.1892336 0.0000000
## iDUX4t06dox-iDUX4t02dox 0.31755  0.06236639 0.5727336 0.0140775
## iDUX4t14dox-iDUX4t02dox 1.81100  1.55581639 2.0661836 0.0000000
## iDUX4t14dox-iDUX4t06dox 1.49345  1.23826639 1.7486336 0.0000000
## 
## 
##  Pairwise comparisons using t tests with pooled SD 
## 
## data:  mapping_metrics_labeled[, metric] and mapping_metrics_labeled$condition 
## 
##             iDUX4dmso iDUX4t02dox iDUX4t06dox
## iDUX4t02dox 0.17778   -           -          
## iDUX4t06dox 0.00038   0.00368     -          
## iDUX4t14dox 2.1e-10   2.3e-10     1.4e-09    
## 
## P value adjustment method: BH
intronic_anova_res = aov(PCT_INTRONIC_BASES ~ condition,mapping_metrics_labeled[,c('PCT_INTRONIC_BASES','condition')])
summary(intronic_anova_res)
##             Df Sum Sq Mean Sq F value   Pr(>F)    
## condition    5 21.309   4.262   26.61 1.01e-07 ***
## Residuals   18  2.883   0.160                     
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
write_lines(summary(intronic_anova_res),'Y:/DUX4_multiomics/DUX4_RNAseq/intronic_anova.txt')
TukeyHSD(intronic_anova_res)
##   Tukey multiple comparisons of means
##     95% family-wise confidence level
## 
## Fit: aov(formula = PCT_INTRONIC_BASES ~ condition, data = mapping_metrics_labeled[, c("PCT_INTRONIC_BASES", "condition")])
## 
## $condition
##                              diff        lwr        upr     p adj
## 0WTt14dox-0WTdmso        0.180150 -0.7192491 1.07954905 0.9865495
## iDUX4dmso-0WTdmso       -0.576725 -1.4761241 0.32267405 0.3605610
## iDUX4t02dox-0WTdmso     -0.619525 -1.5189241 0.27987405 0.2896929
## iDUX4t06dox-0WTdmso      0.729775 -0.1696241 1.62917405 0.1535306
## iDUX4t14dox-0WTdmso      2.150600  1.2512009 3.04999905 0.0000066
## iDUX4dmso-0WTt14dox     -0.756875 -1.6562741 0.14252405 0.1296290
## iDUX4t02dox-0WTt14dox   -0.799675 -1.6990741 0.09972405 0.0983701
## iDUX4t06dox-0WTt14dox    0.549625 -0.3497741 1.44902405 0.4102945
## iDUX4t14dox-0WTt14dox    1.970450  1.0710509 2.86984905 0.0000216
## iDUX4t02dox-iDUX4dmso   -0.042800 -0.9421991 0.85659905 0.9999868
## iDUX4t06dox-iDUX4dmso    1.306500  0.4071009 2.20589905 0.0025009
## iDUX4t14dox-iDUX4dmso    2.727325  1.8279259 3.62672405 0.0000002
## iDUX4t06dox-iDUX4t02dox  1.349300  0.4499009 2.24869905 0.0018160
## iDUX4t14dox-iDUX4t02dox  2.770125  1.8707259 3.66952405 0.0000002
## iDUX4t14dox-iDUX4t06dox  1.420825  0.5214259 2.32022405 0.0010661
write.table(TukeyHSD(intronic_anova_res)$condition,'Y:/DUX4_multiomics/DUX4_RNAseq/intronic_TukeyHSD.txt')
pairwise.t.test(mapping_metrics_labeled$PCT_INTRONIC_BASES,mapping_metrics_labeled$condition,p.adjust.method='BH')
## 
##  Pairwise comparisons using t tests with pooled SD 
## 
## data:  mapping_metrics_labeled$PCT_INTRONIC_BASES and mapping_metrics_labeled$condition 
## 
##             0WTdmso 0WTt14dox iDUX4dmso iDUX4t02dox iDUX4t06dox
## 0WTt14dox   0.57045 -         -         -           -          
## iDUX4dmso   0.07067 0.02578   -         -           -          
## iDUX4t02dox 0.05729 0.02101   0.88147   -           -          
## iDUX4t06dox 0.02839 0.07839   0.00046   0.00038     -          
## iDUX4t14dox 2.5e-06 6.3e-06   1.2e-07   1.2e-07     0.00027    
## 
## P value adjustment method: BH
write.table(pairwise.t.test(mapping_metrics_labeled$PCT_INTRONIC_BASES,mapping_metrics_labeled$condition,p.adjust.method='BH')$p.value,'Y:/DUX4_multiomics/DUX4_RNAseq/intronic_ttest_BHFDR.txt')

Contrasts

design_condition = model.matrix(~0+condition,RNA_sample_metadata)
design_condition
##    condition0WTdmso condition0WTt14dox conditioniDUX4dmso conditioniDUX4t02dox
## 1                 0                  0                  0                    0
## 2                 0                  0                  0                    0
## 3                 0                  0                  0                    0
## 4                 0                  0                  0                    0
## 5                 0                  0                  0                    0
## 6                 0                  0                  0                    0
## 7                 0                  0                  0                    0
## 8                 0                  0                  0                    0
## 9                 1                  0                  0                    0
## 10                1                  0                  0                    0
## 11                1                  0                  0                    0
## 12                1                  0                  0                    0
## 13                0                  0                  0                    1
## 14                0                  0                  0                    1
## 15                0                  0                  0                    1
## 16                0                  0                  0                    1
## 17                0                  1                  0                    0
## 18                0                  1                  0                    0
## 19                0                  1                  0                    0
## 20                0                  1                  0                    0
## 21                0                  0                  1                    0
## 22                0                  0                  1                    0
## 23                0                  0                  1                    0
## 24                0                  0                  1                    0
##    conditioniDUX4t06dox conditioniDUX4t14dox
## 1                     1                    0
## 2                     1                    0
## 3                     1                    0
## 4                     1                    0
## 5                     0                    1
## 6                     0                    1
## 7                     0                    1
## 8                     0                    1
## 9                     0                    0
## 10                    0                    0
## 11                    0                    0
## 12                    0                    0
## 13                    0                    0
## 14                    0                    0
## 15                    0                    0
## 16                    0                    0
## 17                    0                    0
## 18                    0                    0
## 19                    0                    0
## 20                    0                    0
## 21                    0                    0
## 22                    0                    0
## 23                    0                    0
## 24                    0                    0
## attr(,"assign")
## [1] 1 1 1 1 1 1
## attr(,"contrasts")
## attr(,"contrasts")$condition
## [1] "contr.treatment"
v_lengthScaled_prefiltered_all = voom(dge_lengthScaled_prefiltered_RLE,design_condition,plot=TRUE)

PCAres_voom_0 = prcomp(t(cpm_lengthScaled_prefiltered_RLE),center=TRUE,scale=TRUE)
PCAres_voom = merge(as.data.frame(PCAres_voom_0$x), RNA_sample_metadata,by.x=0,by.y=1)
percentVar_PCAres_voom = round(100 * summary(PCAres_voom_0)$importance[2,])
ggplot(PCAres_voom,aes(PC1,PC2,color=condition)) + geom_point() + 
  ggtitle('voom transformed, centered and scaled') +
  xlab(paste0("PC1: ",percentVar_PCAres_voom[1],"% variance")) +
  ylab(paste0("PC2: ",percentVar_PCAres_voom[2],"% variance"))

#colnames(model_contrasts_of_interest) = colnames(design_condition)
rownames(model_contrasts_of_interest) = contrasts_of_interest$Contrast

fit_lengthScaled_prefiltered_all = lmFit(v_lengthScaled_prefiltered_all,design_condition)
fit_lengthScaled_prefiltered_all_contrasts = contrasts.fit(fit_lengthScaled_prefiltered_all,t(model_contrasts_of_interest))
fit_lengthScaled_prefiltered_all_eBayes = eBayes(fit_lengthScaled_prefiltered_all_contrasts,proportion=0.5)

Contrast volcano plots

limma_res_lengthScaled_conditions_contrasts = list()
for(contrast_idx in 1:length(rownames(model_contrasts_of_interest))){
  curr_contrast = rownames(model_contrasts_of_interest)[contrast_idx]
  curr_reference = strsplit(curr_contrast,'_')[[1]][2]
  curr_numerator = strsplit(curr_contrast,'_')[[1]][1]
  curr_condition_means = cpm_condition_means[,c(curr_numerator,curr_reference)]
  colnames(curr_condition_means) = c('numerator_mean','reference_mean')
  limma_res_lengthScaled_conditions_contrasts[[contrast_idx]] = merge(topTable(fit_lengthScaled_prefiltered_all_eBayes,coef=rownames(model_contrasts_of_interest)[contrast_idx],number=1e7),curr_condition_means,by.x=0,by.y=0,all.x=TRUE,all.y=FALSE)
  limma_res_lengthScaled_conditions_contrasts[[contrast_idx]] = merge(limma_res_lengthScaled_conditions_contrasts[[contrast_idx]],biomartGeneAnnot,by.x='Row.names',by.y=1,all.x=TRUE,all.y=FALSE)
  colnames(limma_res_lengthScaled_conditions_contrasts[[contrast_idx]])[grep('logFC',colnames(limma_res_lengthScaled_conditions_contrasts[[contrast_idx]]))] = 'log2FC'
  colnames(limma_res_lengthScaled_conditions_contrasts[[contrast_idx]])[grep('adj',colnames(limma_res_lengthScaled_conditions_contrasts[[contrast_idx]]))] = 'adj_pvalue'
}
names(limma_res_lengthScaled_conditions_contrasts) = rownames(model_contrasts_of_interest)

for(contrast_idx in 1:length(rownames(model_contrasts_of_interest))){
  curr_contrast = rownames(model_contrasts_of_interest)[contrast_idx]
  write.table(limma_res_lengthScaled_conditions_contrasts,paste0(RNASEQ_ANALYSIS_DIR,'/',curr_contrast,'_limma_res_lengthScaled.txt'),sep='\t',row.names=FALSE)
}

for(contrast_idx in 1:length(rownames(model_contrasts_of_interest))){
  curr_contrast = rownames(model_contrasts_of_interest)[contrast_idx]
  curr_reference = strsplit(curr_contrast,'_')[[1]][2]
  log2FC_lim = max(max(unlist(lapply(limma_res_lengthScaled_conditions_contrasts,function(x) max(x$log2FC,na.rm=TRUE)))),-1*min(unlist(lapply(limma_res_lengthScaled_conditions_contrasts,function(x) min(x$log2FC,na.rm=TRUE)))))
  max_neg_log_adj_p = max(unlist(lapply(limma_res_lengthScaled_conditions_contrasts,function(x) max(-log10(x$adj_pvalue),na.rm=TRUE))))
  print(ggplot(limma_res_lengthScaled_conditions_contrasts[[curr_contrast]],aes(x=log2FC,y=-log10(adj_pvalue),color=(reference_mean>1))) + geom_point(alpha=0.5,shape=16) + ggtitle(paste('condition contrasts model:',curr_contrast)) + xlab('log2(fold change)') + ylab('-log10(adjusted p-value)') + scale_color_manual(values = c("#008837","#7b3294"),name='reference mean CPM > 1') + theme_bw()  + coord_cartesian(xlim=log2FC_lim*c(-1.05,1.05),ylim=c(0,1.05*max_neg_log_adj_p)))
  ggsave(paste('Y:/DUX4_multiomics/Analysis/volcano_plots_lessthan1/',curr_contrast,'.pdf',sep=''),device='pdf',width=10,height=8)
}

make_save_contrast_volcano_plots(limma_res_lengthScaled_conditions_contrasts,dir=paste0(PLOTS_DIR,'RNAseq_gene_level/'),color_by='reference_mean',color_trans='log10')
## Warning: Transformation introduced infinite values in discrete y-axis
## Transformation introduced infinite values in discrete y-axis

## Warning: Transformation introduced infinite values in discrete y-axis
## Transformation introduced infinite values in discrete y-axis

## Warning: Transformation introduced infinite values in discrete y-axis
## Transformation introduced infinite values in discrete y-axis

## Warning: Transformation introduced infinite values in discrete y-axis
## Transformation introduced infinite values in discrete y-axis

## Warning: Transformation introduced infinite values in discrete y-axis
## Transformation introduced infinite values in discrete y-axis

## Warning: Transformation introduced infinite values in discrete y-axis
## Transformation introduced infinite values in discrete y-axis

Plot selected genes

cpm_lengthScaled_prefiltered_RLE_to_plot = as.data.frame(t(cpm_lengthScaled_prefiltered_RLE))
all(row.names(cpm_lengthScaled_prefiltered_RLE_to_plot)==RNA_sample_metadata$sample_name)
## [1] TRUE
cpm_lengthScaled_prefiltered_RLE_to_plot$Sample = RNA_sample_metadata$sample_name
cpm_lengthScaled_prefiltered_RLE_to_plot$Condition = RNA_sample_metadata$condition
cpm_lengthScaled_prefiltered_RLE_to_plot$Cells = RNA_sample_metadata$cells
cpm_lengthScaled_prefiltered_RLE_to_plot$Timepoint = RNA_sample_metadata$treatment

ggplot(cpm_lengthScaled_prefiltered_RLE_to_plot,aes_string(x='Condition',y='caDUX4_sequence',color='Condition')) + geom_jitter(width=0.1,height=0,size=2.5) + 
      theme(axis.text.x = element_text(angle = 90)) +   
      stat_summary( fun.data = 'mean_se', geom = 'crossbar' ) +
      labs( title = 'caDUX4' ) + 
      ylab('caDUX4 length scaled normalized CPM')

plot_gene_normalized_counts <- function(curr_gene_symbol, cpm_to_plot){
  curr_gene_id = biomartGeneAnnot$ensembl_gene_id[biomartGeneAnnot$external_gene_name==curr_gene_symbol]
  if(is.na(curr_gene_id)){
    message('gene id not found')
  } else { 
    ggplot(cpm_to_plot,aes_string(x='Condition', y=curr_gene_id, color='Condition')) + 
      geom_jitter(width=0.1,height=0,size=2.5) + 
      theme(axis.text.x = element_text(angle = 90)) +   
      stat_summary( fun.data = 'mean_se', geom = 'crossbar' ) +
      labs( title = paste(curr_gene_symbol,' (',curr_gene_id,')',sep='')) + 
      ylab(paste(curr_gene_id,' length scaled normalized CPM'))
  }
}

plot_gene_normalized_counts('MBD3L2',cpm_lengthScaled_prefiltered_RLE_to_plot)

plot_gene_normalized_counts('ZSCAN4',cpm_lengthScaled_prefiltered_RLE_to_plot)

plot_gene_normalized_counts('LEUTX',cpm_lengthScaled_prefiltered_RLE_to_plot)

plot_gene_normalized_counts('DUXA',cpm_lengthScaled_prefiltered_RLE_to_plot)

plot_gene_normalized_counts('TRIM43',cpm_lengthScaled_prefiltered_RLE_to_plot)

plot_gene_normalized_counts('PRAMEF12',cpm_lengthScaled_prefiltered_RLE_to_plot)

plot_gene_normalized_counts('MYOD1',cpm_lengthScaled_prefiltered_RLE_to_plot)

plot_gene_normalized_counts('PAX7',cpm_lengthScaled_prefiltered_RLE_to_plot)

plot_gene_normalized_counts('SMCHD1',cpm_lengthScaled_prefiltered_RLE_to_plot)

# Plot selected conditions only

cpm_lengthScaled_prefiltered_RLE_to_plot_selected_conditions = cpm_lengthScaled_prefiltered_RLE_to_plot[cpm_lengthScaled_prefiltered_RLE_to_plot$Condition %in% c('iDUX4dmso','iDUX4t02dox','iDUX4t06dox','iDUX4t14dox'),]
plot_gene_normalized_counts('ZSCAN4',cpm_lengthScaled_prefiltered_RLE_to_plot_selected_conditions)

ggsave(paste('Y:/DUX4_multiomics/Analysis/RNAseq_gene_plots/ZSCAN4.pdf',sep=''),device='pdf',width=10,height=8)
plot_gene_normalized_counts('MBD3L2',cpm_lengthScaled_prefiltered_RLE_to_plot_selected_conditions)

ggsave(paste('Y:/DUX4_multiomics/Analysis/RNAseq_gene_plots/MBD3L2.pdf',sep=''),device='pdf',width=10,height=8)
plot_gene_normalized_counts('LEUTX',cpm_lengthScaled_prefiltered_RLE_to_plot_selected_conditions)

ggsave(paste('Y:/DUX4_multiomics/Analysis/RNAseq_gene_plots/LEUTX.pdf',sep=''),device='pdf',width=10,height=8)

write.table(cpm_lengthScaled_prefiltered_RLE_to_plot[,c(colnames(cpm_lengthScaled_prefiltered_RLE_to_plot)[which(colnames(cpm_lengthScaled_prefiltered_RLE_to_plot) %in% biomartGeneAnnot[biomartGeneAnnot$external_gene_name %in% c('ZSCAN4','MBD3L2','LEUTX','caDUX4'),'ensembl_gene_id'])],'Condition')],'Y:/DUX4_multiomics/Analysis/RNAseq_gene_plots/lengthScaled_normalized_CPM_selected.txt',sep='\t',row.names=TRUE)

Transcript-level analysis

Read depth is low for transcriptome-level assignment of transcripts. Results will be low-confidence but it may be possible to gain some information (in combination with LSV from MAJIQ) on the functionality of differentially expressed isoforms. I will try it, but all results should be viewed with caution and we should evaluate whether (inferred) differentially expressed isoforms identified here are consistent with MAJIQ results and actual reads before experimental follow-up.

Read in data

Transcript-level count data with tx import (length scaled)

Filter and normalize

transcript_counts_lengthScaled = salmon_transcript_counts_lengthScaled$counts
transcript_dge_lengthScaled = DGEList(counts=transcript_counts_lengthScaled)

transcript_dge_lengthScaled$samples$group = RNA_sample_metadata$condition
dim(transcript_dge_lengthScaled)
## [1] 227465     24
as.data.frame(apply(transcript_dge_lengthScaled$counts,2,median))
##                             apply(transcript_dge_lengthScaled$counts, 2, median)
## RSA0000107803_RSA0000107683                                                    0
## RSA0000107804_RSA0000107684                                                    0
## RSA0000107805_RSA0000107685                                                    0
## RSA0000107806_RSA0000107686                                                    0
## RSA0000107807_RSA0000107687                                                    0
## RSA0000107808_RSA0000107688                                                    0
## RSA0000107809_RSA0000107689                                                    0
## RSA0000107810_RSA0000107690                                                    0
## RSA0000107811_RSA0000107691                                                    0
## RSA0000107812_RSA0000107692                                                    0
## RSA0000107813_RSA0000107693                                                    0
## RSA0000107814_RSA0000107694                                                    0
## RSA0000107815_RSA0000107695                                                    0
## RSA0000107816_RSA0000107696                                                    0
## RSA0000107817_RSA0000107697                                                    0
## RSA0000107818_RSA0000107698                                                    0
## RSA0000107819_RSA0000107699                                                    0
## RSA0000107820_RSA0000107700                                                    0
## RSA0000107821_RSA0000107701                                                    0
## RSA0000107822_RSA0000107702                                                    0
## RSA0000107823_RSA0000107703                                                    0
## RSA0000107824_RSA0000107704                                                    0
## RSA0000107825_RSA0000107705                                                    0
## RSA0000107826_RSA0000107706                                                    0
# Filter low counts 
transcript_idx_keep_genes = apply(transcript_counts_lengthScaled,1,function(x) sum(x>=min_counts)) >= min_samples

transcript_dge_lengthScaled_prefiltered = transcript_dge_lengthScaled[transcript_idx_keep_genes,]
dim(transcript_dge_lengthScaled_prefiltered)
## [1] 98583    24
as.data.frame(apply(transcript_dge_lengthScaled_prefiltered$counts,2,median))
##                             apply(transcript_dge_lengthScaled_prefiltered$counts, 2, median)
## RSA0000107803_RSA0000107683                                                         9.186366
## RSA0000107804_RSA0000107684                                                        11.492367
## RSA0000107805_RSA0000107685                                                        10.083535
## RSA0000107806_RSA0000107686                                                         8.192418
## RSA0000107807_RSA0000107687                                                         5.536859
## RSA0000107808_RSA0000107688                                                         8.260102
## RSA0000107809_RSA0000107689                                                        11.399260
## RSA0000107810_RSA0000107690                                                        11.214004
## RSA0000107811_RSA0000107691                                                        11.195994
## RSA0000107812_RSA0000107692                                                        11.188850
## RSA0000107813_RSA0000107693                                                        11.402396
## RSA0000107814_RSA0000107694                                                        10.070158
## RSA0000107815_RSA0000107695                                                         9.308705
## RSA0000107816_RSA0000107696                                                         6.856725
## RSA0000107817_RSA0000107697                                                        10.970384
## RSA0000107818_RSA0000107698                                                         5.362795
## RSA0000107819_RSA0000107699                                                         9.821525
## RSA0000107820_RSA0000107700                                                         7.860204
## RSA0000107821_RSA0000107701                                                        11.530450
## RSA0000107822_RSA0000107702                                                        11.803650
## RSA0000107823_RSA0000107703                                                        11.344548
## RSA0000107824_RSA0000107704                                                         9.120544
## RSA0000107825_RSA0000107705                                                        10.312965
## RSA0000107826_RSA0000107706                                                         8.100109
transcript_dge_lengthScaled_prefiltered_RLE = calcNormFactors(transcript_dge_lengthScaled_prefiltered,method='RLE')

transcript_cpm_lengthScaled_prefiltered_RLE = cpm(transcript_dge_lengthScaled_prefiltered_RLE)

transcript_cpm_condition_means = 0*transcript_cpm_lengthScaled_prefiltered_RLE[,1:length(unique(RNA_sample_metadata$condition))]
colnames(transcript_cpm_condition_means) = unique(RNA_sample_metadata$condition)
for(curr_condition in unique(RNA_sample_metadata$condition)){
  transcript_cpm_condition_means[,curr_condition] = rowMeans(transcript_cpm_lengthScaled_prefiltered_RLE[,RNA_sample_metadata$sample_name[RNA_sample_metadata$condition==curr_condition]])
}
colnames(transcript_cpm_condition_means) = gsub('0WT','WT',colnames(transcript_cpm_condition_means))
transcript_cpm_condition_means_ann = merge(transcript_cpm_condition_means, biomartTranscriptAnnot,by.x=0,by.y='ensembl_transcript_id_version',all.x=TRUE,all.y=FALSE)

PCA

Exploratory data analysis: PCA on transcript-level data

PCAres_edgeR_RLE_transcript_0 = prcomp(t(transcript_cpm_lengthScaled_prefiltered_RLE),center=TRUE,scale=TRUE)
PCAres_edgeR_RLE_transcript = merge(as.data.frame(PCAres_edgeR_RLE_transcript_0$x), RNA_sample_metadata,by.x=0,by.y=1)
percentVar_edgeR_RLE_transcript = round(100 * summary(PCAres_edgeR_RLE_transcript_0)$importance[2,])
ggplot(PCAres_edgeR_RLE_transcript,aes(PC1,PC2,color=condition)) + geom_point() + 
  ggtitle('edgeR RLE norm transcript CPM, centered and scaled') +
  xlab(paste0("PC1: ",percentVar_edgeR_RLE[1],"% variance")) +
  ylab(paste0("PC2: ",percentVar_edgeR_RLE[2],"% variance"))

PCAres_edgeR_RLE_transcript_0 = prcomp(t(transcript_cpm_lengthScaled_prefiltered_RLE),center=TRUE,scale=FALSE)
PCAres_edgeR_RLE_transcript = merge(as.data.frame(PCAres_edgeR_RLE_transcript_0$x), RNA_sample_metadata,by.x=0,by.y=1)
percentVar_edgeR_RLE_transcript = round(100 * summary(PCAres_edgeR_RLE_transcript_0)$importance[2,])
ggplot(PCAres_edgeR_RLE_transcript,aes(PC1,PC2,color=condition)) + geom_point() + 
  ggtitle('edgeR RLE norm transcript CPM, centered, NOT scaled') +
  xlab(paste0("PC1: ",percentVar_edgeR_RLE[1],"% variance")) +
  ylab(paste0("PC2: ",percentVar_edgeR_RLE[2],"% variance"))

prince_covars = mapping_metrics
prince_covars = prince_covars[, c('total_reads','multimapped_percent','PCT_CODING_BASES','PCT_MRNA_BASES','PCT_RIBOSOMAL_BASES','PCT_UTR_BASES','PCT_INTRONIC_BASES','PCT_INTERGENIC_BASES','percent_fails','percent_duplicates')]
row.names(prince_covars) = mapping_metrics$Sample

pca_corr = swamp::prince(transcript_cpm_lengthScaled_prefiltered_RLE, prince_covars, top=min(25,dim(transcript_cpm_lengthScaled_prefiltered_RLE)[2]))
# visualize significance of correlations
prince.plot(pca_corr)

prince.plot(pca_corr, Rsquared=TRUE)

Voom all transcript-level data

v_lengthScaled_prefiltered_transcript_all = voom(transcript_dge_lengthScaled_prefiltered_RLE,design_condition,plot=TRUE)

fit_lengthScaled_prefiltered_transcript_all = lmFit(v_lengthScaled_prefiltered_transcript_all,design_condition)
fit_lengthScaled_prefiltered_transcript_all_contrasts = contrasts.fit(fit_lengthScaled_prefiltered_transcript_all,t(model_contrasts_of_interest))
fit_lengthScaled_prefiltered_transcript_all_eBayes = eBayes(fit_lengthScaled_prefiltered_transcript_all_contrasts,proportion=0.5)

Transcript-level contrasts

transcript_limma_res_lengthScaled_conditions_contrasts = list()
for(contrast_idx in 1:length(rownames(model_contrasts_of_interest))){
  message(paste(rownames(model_contrasts_of_interest)[[contrast_idx]]))
  curr_contrast = rownames(model_contrasts_of_interest)[contrast_idx]
  curr_reference = strsplit(curr_contrast,'_')[[1]][2]
  curr_numerator = strsplit(curr_contrast,'_')[[1]][1]
  curr_condition_means = transcript_cpm_condition_means[,c(curr_numerator,curr_reference)]
  colnames(curr_condition_means) = c('numerator_mean','reference_mean')
  transcript_limma_res_lengthScaled_conditions_contrasts[[contrast_idx]] = merge(topTable(fit_lengthScaled_prefiltered_transcript_all_eBayes,coef=rownames(model_contrasts_of_interest)[contrast_idx],number=1e7),curr_condition_means,by.x=0,by.y=0,all.x=TRUE,all.y=FALSE)
  transcript_limma_res_lengthScaled_conditions_contrasts[[contrast_idx]] = merge(transcript_limma_res_lengthScaled_conditions_contrasts[[contrast_idx]],biomartTranscriptAnnot,by.x='Row.names',by.y='ensembl_transcript_id_version',all.x=TRUE,all.y=FALSE)
  colnames(transcript_limma_res_lengthScaled_conditions_contrasts[[contrast_idx]])[grep('logFC',colnames(transcript_limma_res_lengthScaled_conditions_contrasts[[contrast_idx]]))] = 'log2FC'
  colnames(transcript_limma_res_lengthScaled_conditions_contrasts[[contrast_idx]])[grep('adj',colnames(transcript_limma_res_lengthScaled_conditions_contrasts[[contrast_idx]]))] = 'adj_pvalue'

}
## iDUX4dmso_WTdmso
## iDUX4t14dox_WTt14dox
## iDUX4t02dox_iDUX4dmso
## iDUX4t06dox_iDUX4dmso
## iDUX4t14dox_iDUX4dmso
## WTt14dox_WTdmso
names(transcript_limma_res_lengthScaled_conditions_contrasts) = rownames(model_contrasts_of_interest)

Transcript volcano plots

for(contrast_idx in 1:length(rownames(model_contrasts_of_interest))){
  curr_contrast = rownames(model_contrasts_of_interest)[contrast_idx]
  curr_reference = strsplit(curr_contrast,'_')[[1]][2]
  print(ggplot(transcript_limma_res_lengthScaled_conditions_contrasts[[curr_contrast]],aes(x=log2FC,y=-log10(adj_pvalue),color=(reference_mean>1))) + geom_point(alpha=0.5,shape=16) + ggtitle(paste('condition contrasts model:',curr_contrast)) + xlab('log2(fold change)') + ylab('-log10(adjusted p-value)') + scale_color_manual(values = c("#008837","#7b3294"),name='reference mean CPM > 1') + theme_bw())
  ggsave(paste('Y:/DUX4_multiomics/Analysis/volcano_plots_lessthan1/transcripts_',curr_contrast,'.pdf',sep=''),device='pdf',width=10,height=8)
}

make_save_contrast_volcano_plots(transcript_limma_res_lengthScaled_conditions_contrasts,dir=paste0(PLOTS_DIR,'RNAseq_transcript_level/'),color_by='reference_mean',color_trans='log10')
## Warning: Transformation introduced infinite values in discrete y-axis
## Transformation introduced infinite values in discrete y-axis

## Warning: Transformation introduced infinite values in discrete y-axis
## Transformation introduced infinite values in discrete y-axis

## Warning: Transformation introduced infinite values in discrete y-axis
## Transformation introduced infinite values in discrete y-axis

## Warning: Transformation introduced infinite values in discrete y-axis
## Transformation introduced infinite values in discrete y-axis

## Warning: Transformation introduced infinite values in discrete y-axis
## Transformation introduced infinite values in discrete y-axis

## Warning: Transformation introduced infinite values in discrete y-axis
## Transformation introduced infinite values in discrete y-axis

hist(transcript_limma_res_lengthScaled_conditions_contrasts$iDUX4t14dox_WTt14dox$log2FC[transcript_limma_res_lengthScaled_conditions_contrasts$iDUX4t14dox_WTt14dox$transcript_biotype=='protein_coding'],c(-180:180)/10,main='protein coding transcripts')

hist(transcript_limma_res_lengthScaled_conditions_contrasts$iDUX4t14dox_WTt14dox$log2FC[transcript_limma_res_lengthScaled_conditions_contrasts$iDUX4t14dox_WTt14dox$transcript_biotype=='nonsense_mediated_decay'],c(-180:180)/10,main='nonsense mediated decay transcripts')

fGSEA

Gene level

Run fGSEA on RNA-seq gene-level data, using REACTOME gene sets

# run_gsea from setup section
gsea_nreps = 1e7
reactome_res <- httr::GET('http://csei.pfizer.com:8132/v4/dataset/GDMJT/export/ensembl/tsv?label=C2:CP:REACTOME')
gsi_pathways_reactome = readr::read_delim(content(reactome_res, as='text'), delim='\t', comment='#')
## Rows: 1453 Columns: 4
## ── Column specification ────────────────────────────────────────────────────────
## Delimiter: "\t"
## chr (4): accession, name, systematic_name, items
## 
## ℹ Use `spec()` to retrieve the full column specification for this data.
## ℹ Specify the column types or set `show_col_types = FALSE` to quiet this message.
reactome_pathways = lapply(gsi_pathways_reactome$items,function(x) strsplit(x,',')[[1]])
names(reactome_pathways) = gsi_pathways_reactome$name

hallmark_sets <- httr::GET('http://csei.pfizer.com:8132/v4/dataset/GDMJT/export/ensembl/tsv?label=H')
gsi_pathways_hallmark = readr::read_delim(content(hallmark_sets, as='text'), delim='\t', comment='#')
## Rows: 50 Columns: 4
## ── Column specification ────────────────────────────────────────────────────────
## Delimiter: "\t"
## chr (4): accession, name, systematic_name, items
## 
## ℹ Use `spec()` to retrieve the full column specification for this data.
## ℹ Specify the column types or set `show_col_types = FALSE` to quiet this message.
hallmark_pathways = lapply(gsi_pathways_hallmark$items,function(x) strsplit(x,',')[[1]])
names(hallmark_pathways) = gsi_pathways_hallmark$name

limma_res_lengthScaled_conditions_contrasts_forGsea = list()
fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome = list()
fgsea_RNAseq_lengthScaled_conditions_contrasts_hallmark = list()

for(contrast_idx in 1:length(limma_res_lengthScaled_conditions_contrasts)){
  curr_contrast = names(limma_res_lengthScaled_conditions_contrasts)[contrast_idx]
  limma_res_lengthScaled_conditions_contrasts_forGsea[[curr_contrast]] = limma_res_lengthScaled_conditions_contrasts[[curr_contrast]]$log2FC  
  names(limma_res_lengthScaled_conditions_contrasts_forGsea[[curr_contrast]]) = limma_res_lengthScaled_conditions_contrasts[[curr_contrast]]$Row.names
  if(run_gsea){
    fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[curr_contrast]] = fgsea(reactome_pathways, limma_res_lengthScaled_conditions_contrasts_forGsea[[curr_contrast]],nperm = gsea_nreps, minSize = 1, maxSize = 2000,gseaParam = 1,nproc=1)
    fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[curr_contrast]] = fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[curr_contrast]][order(fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[curr_contrast]]$pval),]
    fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[curr_contrast]][1:20,1:7]
    Write.table(fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[curr_contrast]][,1:7],paste(GSEA_DIR,'/RNAseq_geneLevel/RNA_',curr_contrast,'_reactome.txt',sep=''),sep='\t',row.names=FALSE)

    fgsea_RNAseq_lengthScaled_conditions_contrasts_hallmark[[curr_contrast]] = fgsea(hallmark_pathways, limma_res_lengthScaled_conditions_contrasts_forGsea[[curr_contrast]],nperm = gsea_nreps, minSize = 1, maxSize = 2000,gseaParam = 1,nproc=1)
    fgsea_RNAseq_lengthScaled_conditions_contrasts_hallmark[[curr_contrast]] = fgsea_RNAseq_lengthScaled_conditions_contrasts_hallmark[[curr_contrast]][order(fgsea_RNAseq_lengthScaled_conditions_contrasts_hallmark[[curr_contrast]]$pval),]
    fgsea_RNAseq_lengthScaled_conditions_contrasts_hallmark[[curr_contrast]][1:20,1:7]
    write.table(fgsea_RNAseq_lengthScaled_conditions_contrasts_hallmark[[curr_contrast]][,1:7],paste(GSEA_DIR,'/RNAseq_geneLevel/RNA_',curr_contrast,'_hallmark.txt',sep=''),sep='\t',row.names=FALSE)
  } else {
    curr_contrast = names(limma_res_lengthScaled_conditions_contrasts)[contrast_idx]
    fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[curr_contrast]] = read.table(paste(GSEA_DIR,'/RNAseq_geneLevel/RNA_',curr_contrast,'_reactome.txt',sep=''),sep='\t',header=TRUE)
    fgsea_RNAseq_lengthScaled_conditions_contrasts_hallmark[[curr_contrast]] = read.table(paste(GSEA_DIR,'/RNAseq_geneLevel/RNA_',curr_contrast,'_hallmark.txt',sep=''),sep='\t',header=TRUE)
  message(paste('warning: fgsea was not run, results read from file'))
  }
}
## warning: fgsea was not run, results read from file
## warning: fgsea was not run, results read from file
## warning: fgsea was not run, results read from file
## warning: fgsea was not run, results read from file
## warning: fgsea was not run, results read from file
## warning: fgsea was not run, results read from file
fgsea_RNAseq_lengthScaled_reactome_table_1 = merge(fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[1]][,c('pathway','pval','padj','ES','NES','nMoreExtreme')],fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[2]][,c('pathway','pval','padj','ES','NES','nMoreExtreme')],by='pathway',all=TRUE,suffixes=paste('_',names(fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome)[1:2],collapse=NULL,sep=''))
fgsea_RNAseq_lengthScaled_reactome_table_2 = merge(fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[3]][,c('pathway','pval','padj','ES','NES','nMoreExtreme')],fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[4]][,c('pathway','pval','padj','ES','NES','nMoreExtreme')],by='pathway',all=TRUE,suffixes=paste('_',names(fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome)[3:4],collapse=NULL,sep=''))
fgsea_RNAseq_lengthScaled_reactome_table_3 = merge(fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[5]][,c('pathway','pval','padj','ES','NES','nMoreExtreme')],fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[6]][,c('pathway','pval','padj','ES','NES','nMoreExtreme')],by='pathway',all=TRUE,suffixes=paste('_',names(fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome)[5:6],collapse=NULL,sep=''))
fgsea_RNAseq_lengthScaled_reactome_table = merge(fgsea_RNAseq_lengthScaled_reactome_table_1,fgsea_RNAseq_lengthScaled_reactome_table_2,by='pathway',all=TRUE)
fgsea_RNAseq_lengthScaled_reactome_table = merge(fgsea_RNAseq_lengthScaled_reactome_table,fgsea_RNAseq_lengthScaled_reactome_table_3,by='pathway',all=TRUE)
fgsea_RNAseq_lengthScaled_reactome_table_1 = NULL
fgsea_RNAseq_lengthScaled_reactome_table_2 = NULL
fgsea_RNAseq_lengthScaled_reactome_table_3 = NULL
fgsea_RNAseq_lengthScaled_reactome_table = fgsea_RNAseq_lengthScaled_reactome_table[order(apply(fgsea_RNAseq_lengthScaled_reactome_table[,grep('padj',colnames(fgsea_RNAseq_lengthScaled_reactome_table))],1,min)),]

Enrichment plots

aheatmap(as.matrix(fgsea_RNAseq_lengthScaled_reactome_table[,grep('NES',colnames(fgsea_RNAseq_lengthScaled_reactome_table))]))

cpm_lengthScaled_prefiltered_RLE_to_plot = cpm_lengthScaled_prefiltered_RLE_to_plot[order(cpm_lengthScaled_prefiltered_RLE_to_plot$Condition),]

# compare pseudo-volcano plots in "real" vs "WT only" comparisons
plot(fgsea_RNAseq_lengthScaled_reactome_table$NES_iDUX4t14dox_WTt14dox,-log10(fgsea_RNAseq_lengthScaled_reactome_table$padj_iDUX4t14dox_WTt14dox),col='red',pch=19)
points(fgsea_RNAseq_lengthScaled_reactome_table$NES_iDUX4dmso_WTdmso,-log10(fgsea_RNAseq_lengthScaled_reactome_table$padj_iDUX4dmso_WTdmso),col='blue',pch=19)
points(fgsea_RNAseq_lengthScaled_reactome_table$NES_WTt14dox_WTdmso,-log10(fgsea_RNAseq_lengthScaled_reactome_table$padj_WTt14dox_WTdmso),col='black',pch=19)

make_pathway_plots <- function(curr_pathway,category){
  dir.create(paste0(GSEA_DIR,'/RNAseq_geneLevel/',category,'/'))
  dir.create(paste0(GSEA_DIR,'/RNAseq_geneLevel/',category,'/',curr_pathway))
# curr_pathway = 'REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE'
  curr_pathway_ESmax = max(abs(fgsea_RNAseq_lengthScaled_reactome_table[fgsea_RNAseq_lengthScaled_reactome_table$pathway==curr_pathway,grep('ES',colnames(fgsea_RNAseq_lengthScaled_reactome_table))[c(1:6)*2-1]]))
  barplot(t(fgsea_RNAseq_lengthScaled_reactome_table[fgsea_RNAseq_lengthScaled_reactome_table$pathway==curr_pathway,grep('NES',colnames(fgsea_RNAseq_lengthScaled_reactome_table))]),beside=TRUE,names.arg=names(fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome),las=3,main=curr_pathway)
  curr_pathway_barplot_data = as.data.frame(t(fgsea_RNAseq_lengthScaled_reactome_table[fgsea_RNAseq_lengthScaled_reactome_table$pathway==curr_pathway,grep('NES',colnames(fgsea_RNAseq_lengthScaled_reactome_table))]))
  colnames(curr_pathway_barplot_data) = paste(curr_pathway)
  curr_pathway_barplot_data$comparison = row.names(curr_pathway_barplot_data)
  curr_pathway_barplot_data$comparison = gsub('NES_','',curr_pathway_barplot_data$comparison)
  curr_pathway_barplot_data$NES = curr_pathway_barplot_data[,curr_pathway]
  ggplot(curr_pathway_barplot_data,aes(comparison,NES)) + geom_col()
  ggsave(paste(GSEA_DIR,'/RNAseq_geneLevel/',category,'/',curr_pathway,'/NES_barplot.pdf',sep=''),device='pdf',width=10,height=14)

  ep1 = plotEnrichment(reactome_pathways[[curr_pathway]],limma_res_lengthScaled_conditions_contrasts_forGsea[[1]]) + ggtitle(paste(names(limma_res_lengthScaled_conditions_contrasts_forGsea)[[1]],'p_adj',format(fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[1]]$padj[fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[1]]$pathway==curr_pathway],digits=3))) + coord_cartesian(ylim=curr_pathway_ESmax*c(-1.1,1.1))
  ep2 = plotEnrichment(reactome_pathways[[curr_pathway]],limma_res_lengthScaled_conditions_contrasts_forGsea[[2]]) + ggtitle(paste(names(limma_res_lengthScaled_conditions_contrasts_forGsea)[[2]],'p_adj',format(fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[2]]$padj[fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[2]]$pathway==curr_pathway],digits=3))) + coord_cartesian(ylim=curr_pathway_ESmax*c(-1.1,1.1))
  ep3 = plotEnrichment(reactome_pathways[[curr_pathway]],limma_res_lengthScaled_conditions_contrasts_forGsea[[3]]) + ggtitle(paste(names(limma_res_lengthScaled_conditions_contrasts_forGsea)[[3]],'p_adj',format(fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[3]]$padj[fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[3]]$pathway==curr_pathway],digits=3))) + coord_cartesian(ylim=curr_pathway_ESmax*c(-1.1,1.1))
  ep4 = plotEnrichment(reactome_pathways[[curr_pathway]],limma_res_lengthScaled_conditions_contrasts_forGsea[[4]]) + ggtitle(paste(names(limma_res_lengthScaled_conditions_contrasts_forGsea)[[4]],'p_adj',format(fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[4]]$padj[fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[4]]$pathway==curr_pathway],digits=3))) + coord_cartesian(ylim=curr_pathway_ESmax*c(-1.1,1.1))
  ep5 = plotEnrichment(reactome_pathways[[curr_pathway]],limma_res_lengthScaled_conditions_contrasts_forGsea[[5]]) + ggtitle(paste(names(limma_res_lengthScaled_conditions_contrasts_forGsea)[[5]],'p_adj',format(fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[5]]$padj[fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[5]]$pathway==curr_pathway],digits=3))) + coord_cartesian(ylim=curr_pathway_ESmax*c(-1.1,1.1))
  ep6 = plotEnrichment(reactome_pathways[[curr_pathway]],limma_res_lengthScaled_conditions_contrasts_forGsea[[6]]) + ggtitle(paste(names(limma_res_lengthScaled_conditions_contrasts_forGsea)[[6]],'p_adj',format(fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[6]]$padj[fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome[[6]]$pathway==curr_pathway],digits=3))) + coord_cartesian(ylim=curr_pathway_ESmax*c(-1.1,1.1))
  #grid.arrange(ep1,ep3,ep2,ep4,ep6,ep5,ncol=2)
  ep_all_curr_pathway = grid.arrange(ep1,ep3,ep2,ep4,ep6,ep5,ncol=2)
  ggsave(paste(GSEA_DIR,'/RNAseq_geneLevel/',category,'/',curr_pathway,'/enrichment_plot.pdf',sep=''),plot=ep_all_curr_pathway,device='pdf',width=10,height=14)

  curr_pathway_genes = reactome_pathways[[curr_pathway]]
  ph=pheatmap(t(log10(cpm_lengthScaled_prefiltered_RLE_to_plot[,colnames(cpm_lengthScaled_prefiltered_RLE_to_plot) %in% curr_pathway_genes]+1)),labels_col=cpm_lengthScaled_prefiltered_RLE_to_plot$Condition,labels_row=biomartGeneAnnot$external_gene_name[match(as.character(colnames(cpm_lengthScaled_prefiltered_RLE_to_plot)[colnames(cpm_lengthScaled_prefiltered_RLE_to_plot) %in% curr_pathway_genes]),as.character(biomartGeneAnnot$ensembl_gene_id))],cluster_cols=FALSE)
  ggsave(paste(GSEA_DIR,'/RNAseq_geneLevel/',category,'/',curr_pathway,'/genes_heatmap.pdf',sep=''),plot=ph,device='pdf',width=10,height=14)
  ph_scaled=pheatmap(t(log10(cpm_lengthScaled_prefiltered_RLE_to_plot[,colnames(cpm_lengthScaled_prefiltered_RLE_to_plot) %in% curr_pathway_genes]+1)),labels_col=cpm_lengthScaled_prefiltered_RLE_to_plot$Condition,labels_row=biomartGeneAnnot$external_gene_name[match(as.character(colnames(cpm_lengthScaled_prefiltered_RLE_to_plot)[colnames(cpm_lengthScaled_prefiltered_RLE_to_plot) %in% curr_pathway_genes]),as.character(biomartGeneAnnot$ensembl_gene_id))],cluster_cols=FALSE,scale='row')
  ggsave(paste(GSEA_DIR,'/RNAseq_geneLevel/',category,'/',curr_pathway,'/genes_heatmap_scaled.pdf',sep=''),plot=ph_scaled,device='pdf',width=10,height=14)
  
}

for(curr_pathway in fgsea_RNAseq_lengthScaled_reactome_table$pathway[1:6]){make_pathway_plots(curr_pathway,category='significant')}
## Warning in dir.create(paste0(GSEA_DIR, "/RNAseq_geneLevel/", category, "/")):
## 'Y:\DUX4_multiomics\Analysis\fGSEA_res\\RNAseq_geneLevel\significant' already
## exists
## Warning in dir.create(paste0(GSEA_DIR, "/RNAseq_geneLevel/",
## category, "/", : 'Y:\DUX4_multiomics\Analysis\fGSEA_res\
## \RNAseq_geneLevel\significant\REACTOME_CONDENSATION_OF_PROPHASE_CHROMOSOMES'
## already exists

## Warning in dir.create(paste0(GSEA_DIR, "/RNAseq_geneLevel/", category, "/")):
## 'Y:\DUX4_multiomics\Analysis\fGSEA_res\\RNAseq_geneLevel\significant' already
## exists
## Warning in dir.create(paste0(GSEA_DIR, "/RNAseq_geneLevel/",
## category, "/", : 'Y:\DUX4_multiomics\Analysis\fGSEA_res\
## \RNAseq_geneLevel\significant\REACTOME_DNA_METHYLATION' already exists

## Warning in dir.create(paste0(GSEA_DIR, "/RNAseq_geneLevel/", category, "/")):
## 'Y:\DUX4_multiomics\Analysis\fGSEA_res\\RNAseq_geneLevel\significant' already
## exists
## Warning in dir.create(paste0(GSEA_DIR, "/RNAseq_geneLevel/",
## category, "/", : 'Y:\DUX4_multiomics\Analysis\fGSEA_res\
## \RNAseq_geneLevel\significant\REACTOME_ESTROGEN_DEPENDENT_GENE_EXPRESSION'
## already exists

## Warning in dir.create(paste0(GSEA_DIR, "/RNAseq_geneLevel/", category, "/")):
## 'Y:\DUX4_multiomics\Analysis\fGSEA_res\\RNAseq_geneLevel\significant' already
## exists
## Warning in dir.create(paste0(GSEA_DIR, "/RNAseq_geneLevel/",
## category, "/", : 'Y:\DUX4_multiomics\Analysis\fGSEA_res\
## \RNAseq_geneLevel\significant\REACTOME_HDACS_DEACETYLATE_HISTONES' already
## exists

## Warning in dir.create(paste0(GSEA_DIR, "/RNAseq_geneLevel/", category, "/")):
## 'Y:\DUX4_multiomics\Analysis\fGSEA_res\\RNAseq_geneLevel\significant' already
## exists
## Warning in dir.create(paste0(GSEA_DIR, "/RNAseq_geneLevel/",
## category, "/", : 'Y:\DUX4_multiomics\Analysis\fGSEA_res\
## \RNAseq_geneLevel\significant\REACTOME_PRC2_METHYLATES_HISTONES_AND_DNA' already
## exists

## Warning in dir.create(paste0(GSEA_DIR, "/RNAseq_geneLevel/", category, "/")):
## 'Y:\DUX4_multiomics\Analysis\fGSEA_res\\RNAseq_geneLevel\significant' already
## exists
## Warning in dir.create(paste0(GSEA_DIR, "/RNAseq_geneLevel/",
## category, "/", : 'Y:\DUX4_multiomics\Analysis\fGSEA_res\
## \RNAseq_geneLevel\significant\REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION'
## already exists

#for(curr_pathway in fgsea_RNAseq_lengthScaled_reactome_table$pathway[grep('DAMAGE',fgsea_RNAseq_lengthScaled_reactome_table$pathway)]){make_pathway_plots(curr_pathway,category='other')}
#for(curr_pathway in fgsea_RNAseq_lengthScaled_reactome_table$pathway[grep('SPLIC',fgsea_RNAseq_lengthScaled_reactome_table$pathway)]){make_pathway_plots(curr_pathway,category='other')}
#for(curr_pathway in fgsea_RNAseq_lengthScaled_reactome_table$pathway[grep('SENESC',fgsea_RNAseq_lengthScaled_reactome_table$pathway)]){make_pathway_plots(curr_pathway,category='other')}

total proteomics

ms_total_protein_conditions_contrasts_forGsea = list()
fgsea_ms_total_protein_conditions_contrasts_reactome = list()
fgsea_ms_total_protein_conditions_contrasts_hallmark = list()
for(contrast_idx in 1:length(ms_total_protein_conditions_contrasts)){
  curr_contrast = names(ms_total_protein_conditions_contrasts)[contrast_idx]
  ms_total_protein_conditions_contrasts_forGsea[[curr_contrast]] = ms_total_protein_conditions_contrasts[[curr_contrast]]$log2FC  
  names(ms_total_protein_conditions_contrasts_forGsea[[curr_contrast]]) = ms_total_protein_conditions_contrasts[[curr_contrast]]$ensembl_gene_id
    
    if(run_gsea){
  
    fgsea_ms_total_protein_conditions_contrasts_reactome[[curr_contrast]] = fgsea(reactome_pathways, ms_total_protein_conditions_contrasts_forGsea[[curr_contrast]],nperm = gsea_nreps, minSize = 1, maxSize = 2000,gseaParam = 1,nproc=1)
    fgsea_ms_total_protein_conditions_contrasts_reactome[[curr_contrast]] = fgsea_ms_total_protein_conditions_contrasts_reactome[[curr_contrast]][order(fgsea_ms_total_protein_conditions_contrasts_reactome[[curr_contrast]]$pval),]
    fgsea_ms_total_protein_conditions_contrasts_reactome[[curr_contrast]][1:20,1:7]
    write.table(fgsea_ms_total_protein_conditions_contrasts_reactome[[curr_contrast]][,1:7],paste(GSEA_DIR,'/MS_total_protein/protein_',curr_contrast,'_reactome.txt',sep=''),sep='\t',row.names=FALSE)
    
    fgsea_ms_total_protein_conditions_contrasts_hallmark[[curr_contrast]] = fgsea(hallmark_pathways, ms_total_protein_conditions_contrasts_forGsea[[curr_contrast]],nperm = gsea_nreps, minSize = 1, maxSize = 2000,gseaParam = 1,nproc=1)
    fgsea_ms_total_protein_conditions_contrasts_hallmark[[curr_contrast]] = fgsea_ms_total_protein_conditions_contrasts_hallmark[[curr_contrast]][order(fgsea_ms_total_protein_conditions_contrasts_hallmark[[curr_contrast]]$pval),]
    fgsea_ms_total_protein_conditions_contrasts_hallmark[[curr_contrast]][1:20,1:7]
    write.table(fgsea_ms_total_protein_conditions_contrasts_hallmark[[curr_contrast]][,1:7],paste(GSEA_DIR,'/MS_total_protein/protein_',curr_contrast,'_hallmark.txt',sep=''),sep='\t',row.names=FALSE)
    
  } else {
    curr_contrast = names(ms_total_protein_conditions_contrasts)[contrast_idx]
    fgsea_ms_total_protein_conditions_contrasts_reactome[[curr_contrast]] = read.table(paste(GSEA_DIR,'/MS_total_protein/protein_',curr_contrast,'_reactome.txt',sep=''),sep='\t',header=TRUE)
    fgsea_ms_total_protein_conditions_contrasts_hallmark[[curr_contrast]] = read.table(paste(GSEA_DIR,'/MS_total_protein/protein_',curr_contrast,'_hallmark.txt',sep=''),sep='\t',header=TRUE)
    message(paste('warning: fgsea was not run, results read from file'))
  }
}
## warning: fgsea was not run, results read from file
## warning: fgsea was not run, results read from file
## warning: fgsea was not run, results read from file
## warning: fgsea was not run, results read from file
## warning: fgsea was not run, results read from file
## warning: fgsea was not run, results read from file
fgsea_ms_total_protein_reactome_table_1 = merge(fgsea_ms_total_protein_conditions_contrasts_reactome[[1]][,c('pathway','pval','padj','ES','NES','nMoreExtreme')],fgsea_ms_total_protein_conditions_contrasts_reactome[[2]][,c('pathway','pval','padj','ES','NES','nMoreExtreme')],by='pathway',all=TRUE,suffixes=paste('_',names(fgsea_ms_total_protein_conditions_contrasts_reactome)[1:2],collapse=NULL,sep=''))
fgsea_ms_total_protein_reactome_table_2 = merge(fgsea_ms_total_protein_conditions_contrasts_reactome[[3]][,c('pathway','pval','padj','ES','NES','nMoreExtreme')],fgsea_ms_total_protein_conditions_contrasts_reactome[[4]][,c('pathway','pval','padj','ES','NES','nMoreExtreme')],by='pathway',all=TRUE,suffixes=paste('_',names(fgsea_ms_total_protein_conditions_contrasts_reactome)[3:4],collapse=NULL,sep=''))
fgsea_ms_total_protein_reactome_table_3 = merge(fgsea_ms_total_protein_conditions_contrasts_reactome[[5]][,c('pathway','pval','padj','ES','NES','nMoreExtreme')],fgsea_ms_total_protein_conditions_contrasts_reactome[[6]][,c('pathway','pval','padj','ES','NES','nMoreExtreme')],by='pathway',all=TRUE,suffixes=paste('_',names(fgsea_ms_total_protein_conditions_contrasts_reactome)[5:6],collapse=NULL,sep=''))
fgsea_ms_total_protein_reactome_table = merge(fgsea_ms_total_protein_reactome_table_1,fgsea_ms_total_protein_reactome_table_2,by='pathway',all=TRUE)
fgsea_ms_total_protein_reactome_table = merge(fgsea_ms_total_protein_reactome_table,fgsea_ms_total_protein_reactome_table_3,by='pathway',all=TRUE)
fgsea_ms_total_protein_reactome_table_1 = NULL
fgsea_ms_total_protein_reactome_table_2 = NULL
fgsea_ms_total_protein_reactome_table_3 = NULL
fgsea_ms_total_protein_reactome_table = as.data.frame(fgsea_ms_total_protein_reactome_table)
fgsea_ms_total_protein_reactome_table = fgsea_ms_total_protein_reactome_table[order(apply(fgsea_ms_total_protein_reactome_table[,grep('padj',colnames(fgsea_ms_total_protein_reactome_table))],1,min)),]

Protein-level enrichment plots

aheatmap(as.matrix(fgsea_ms_total_protein_reactome_table[,grep('NES',colnames(fgsea_ms_total_protein_reactome_table))]))

total_protein_to_plot = total_protein_to_plot[order(total_protein_to_plot$Condition),]

# compare pseudo-volcano plots in "real" vs "WT only" comparisons
plot(fgsea_ms_total_protein_reactome_table$NES_iDUX4t14dox_WTt14dox,-log10(fgsea_ms_total_protein_reactome_table$padj_iDUX4t14dox_WTt14dox),col='red',pch=19)
points(fgsea_ms_total_protein_reactome_table$NES_iDUX4dmso_WTdmso,-log10(fgsea_ms_total_protein_reactome_table$padj_iDUX4dmso_WTdmso),col='blue',pch=19)
points(fgsea_ms_total_protein_reactome_table$NES_WTt14dox_WTdmso,-log10(fgsea_ms_total_protein_reactome_table$padj_WTt14dox_WTdmso),col='black',pch=19)

make_protein_pathway_plots <- function(curr_pathway,category){
  dir.create(paste0(GSEA_DIR,'/MS_total_protein/',category,'/'))
  dir.create(paste0(GSEA_DIR,'/MS_total_protein/',category,'/',curr_pathway))
# curr_pathway = 'REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE'
  curr_pathway_ESmax = max(abs(fgsea_ms_total_protein_reactome_table[fgsea_ms_total_protein_reactome_table$pathway==curr_pathway,grep('ES',colnames(fgsea_ms_total_protein_reactome_table))[c(1:6)*2-1]]))
  barplot(t(fgsea_ms_total_protein_reactome_table[fgsea_ms_total_protein_reactome_table$pathway==curr_pathway,grep('NES',colnames(fgsea_ms_total_protein_reactome_table))]),beside=TRUE,names.arg=names(fgsea_RNAseq_lengthScaled_conditions_contrasts_reactome),las=3,main=curr_pathway)
  curr_pathway_barplot_data = as.data.frame(t(fgsea_ms_total_protein_reactome_table[fgsea_ms_total_protein_reactome_table$pathway==curr_pathway,grep('NES',colnames(fgsea_ms_total_protein_reactome_table))]))
  colnames(curr_pathway_barplot_data) = paste(curr_pathway)
  curr_pathway_barplot_data$comparison = row.names(curr_pathway_barplot_data)
  curr_pathway_barplot_data$comparison = gsub('NES_','',curr_pathway_barplot_data$comparison)
  curr_pathway_barplot_data$NES = curr_pathway_barplot_data[,curr_pathway]
  ggplot(curr_pathway_barplot_data,aes(comparison,NES)) + geom_col()
  ggsave(paste(GSEA_DIR,'/MS_total_protein/',category,'/',curr_pathway,'/NES_barplot.pdf',sep=''),device='pdf',width=10,height=14)

  ep1 = plotEnrichment(reactome_pathways[[curr_pathway]],na.omit(ms_total_protein_conditions_contrasts_forGsea[[1]])) + ggtitle(paste(names(ms_total_protein_conditions_contrasts_forGsea)[[1]],'p_adj',format(fgsea_ms_total_protein_conditions_contrasts_reactome[[1]]$padj[fgsea_ms_total_protein_conditions_contrasts_reactome[[1]]$pathway==curr_pathway],digits=3))) + coord_cartesian(ylim=curr_pathway_ESmax*c(-1.1,1.1))
  ep2 = plotEnrichment(reactome_pathways[[curr_pathway]],na.omit(ms_total_protein_conditions_contrasts_forGsea[[2]])) + ggtitle(paste(names(ms_total_protein_conditions_contrasts_forGsea)[[2]],'p_adj',format(fgsea_ms_total_protein_conditions_contrasts_reactome[[2]]$padj[fgsea_ms_total_protein_conditions_contrasts_reactome[[2]]$pathway==curr_pathway],digits=3))) + coord_cartesian(ylim=curr_pathway_ESmax*c(-1.1,1.1))
  ep3 = plotEnrichment(reactome_pathways[[curr_pathway]],na.omit(ms_total_protein_conditions_contrasts_forGsea[[3]])) + ggtitle(paste(names(ms_total_protein_conditions_contrasts_forGsea)[[3]],'p_adj',format(fgsea_ms_total_protein_conditions_contrasts_reactome[[3]]$padj[fgsea_ms_total_protein_conditions_contrasts_reactome[[3]]$pathway==curr_pathway],digits=3))) + coord_cartesian(ylim=curr_pathway_ESmax*c(-1.1,1.1))
  ep4 = plotEnrichment(reactome_pathways[[curr_pathway]],na.omit(ms_total_protein_conditions_contrasts_forGsea[[4]])) + ggtitle(paste(names(ms_total_protein_conditions_contrasts_forGsea)[[4]],'p_adj',format(fgsea_ms_total_protein_conditions_contrasts_reactome[[4]]$padj[fgsea_ms_total_protein_conditions_contrasts_reactome[[4]]$pathway==curr_pathway],digits=3))) + coord_cartesian(ylim=curr_pathway_ESmax*c(-1.1,1.1))
  ep5 = plotEnrichment(reactome_pathways[[curr_pathway]],na.omit(ms_total_protein_conditions_contrasts_forGsea[[5]])) + ggtitle(paste(names(ms_total_protein_conditions_contrasts_forGsea)[[5]],'p_adj',format(fgsea_ms_total_protein_conditions_contrasts_reactome[[5]]$padj[fgsea_ms_total_protein_conditions_contrasts_reactome[[5]]$pathway==curr_pathway],digits=3))) + coord_cartesian(ylim=curr_pathway_ESmax*c(-1.1,1.1))
  ep6 = plotEnrichment(reactome_pathways[[curr_pathway]],na.omit(ms_total_protein_conditions_contrasts_forGsea[[6]])) + ggtitle(paste(names(ms_total_protein_conditions_contrasts_forGsea)[[6]],'p_adj',format(fgsea_ms_total_protein_conditions_contrasts_reactome[[6]]$padj[fgsea_ms_total_protein_conditions_contrasts_reactome[[6]]$pathway==curr_pathway],digits=3))) + coord_cartesian(ylim=curr_pathway_ESmax*c(-1.1,1.1))
  #grid.arrange(ep1,ep3,ep2,ep4,ep6,ep5,ncol=2)
  ep_all_curr_pathway = grid.arrange(ep1,ep3,ep2,ep4,ep6,ep5,ncol=2)
  ggsave(paste(GSEA_DIR,'/MS_total_protein/',category,'/',curr_pathway,'/enrichment_plot.pdf',sep=''),plot=ep_all_curr_pathway,device='pdf',width=10,height=14)

  curr_pathway_proteins = biomartProteinAnnot_uniprot_select$uniprotswissprot[biomartProteinAnnot_uniprot_select$ensembl_gene_id %in% reactome_pathways[[curr_pathway]]]
  if( sum(colnames(total_protein_to_plot) %in% curr_pathway_proteins)>2){
    ph=pheatmap(t(log10(total_protein_to_plot[,colnames(total_protein_to_plot) %in% curr_pathway_proteins]+1)),labels_col=total_protein_to_plot$Condition,labels_row=biomartProteinAnnot_uniprot_select$hgnc_symbol[match(as.character(colnames(total_protein_to_plot)[colnames(total_protein_to_plot) %in% curr_pathway_proteins]),as.character(biomartProteinAnnot_uniprot_select$uniprotswissprot))],cluster_cols=FALSE)
    ggsave(paste(GSEA_DIR,'/MS_total_protein/',category,'/',curr_pathway,'/proteins_heatmap.pdf',sep=''),plot=ph,device='pdf',width=10,height=14)
    ph_scaled=pheatmap(t(log10(total_protein_to_plot[,colnames(total_protein_to_plot) %in% curr_pathway_proteins]+1)),labels_col=total_protein_to_plot$Condition,labels_row=biomartProteinAnnot_uniprot_select$hgnc_symbol[match(as.character(colnames(total_protein_to_plot)[colnames(total_protein_to_plot) %in% curr_pathway_proteins]),as.character(biomartProteinAnnot_uniprot_select$uniprotswissprot))],cluster_cols=FALSE,scale='row')
    ggsave(paste(GSEA_DIR,'/MS_total_protein/',category,'/',curr_pathway,'/proteins_heatmap_scaled.pdf',sep=''),plot=ph_scaled,device='pdf',width=10,height=14)
  }
  
}


fgsea_ms_total_protein_reactome_table[order(apply(fgsea_ms_total_protein_reactome_table[,grep('padj',colnames(fgsea_ms_total_protein_reactome_table))],1,min)),]
##                                                                                                                                            pathway
## 21                                          REACTOME_ACTIVATED_PKN1_STIMULATES_TRANSCRIPTION_OF_AR_ANDROGEN_RECEPTOR_REGULATED_GENES_KLK2_AND_KLK3
## 24                                                   REACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS
## 108                                                                                   REACTOME_B_WICH_COMPLEX_POSITIVELY_REGULATES_RRNA_EXPRESSION
## 109                                                                                                                  REACTOME_BASE_EXCISION_REPAIR
## 110                                                                                                REACTOME_BASE_EXCISION_REPAIR_AP_SITE_FORMATION
## 170                                                                                                                   REACTOME_CELLULAR_SENESCENCE
## 181                                                                                                                REACTOME_CHROMOSOME_MAINTENANCE
## 205                                                                                                  REACTOME_CONDENSATION_OF_PROPHASE_CHROMOSOMES
## 275                                                                      REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE
## 299                                                                                         REACTOME_DNA_DAMAGE_TELOMERE_STRESS_INDUCED_SENESCENCE
## 300                                                                                                                       REACTOME_DNA_METHYLATION
## 341                                                                                              REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION
## 346                                                                           REACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION
## 404                                                                             REACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX
## 483                                                                                                            REACTOME_HDACS_DEACETYLATE_HISTONES
## 487                                                                                                             REACTOME_HDMS_DEMETHYLATE_HISTONES
## 504                                                                                                              REACTOME_HOMOLOGY_DIRECTED_REPAIR
## 521                                                                                           REACTOME_INHIBITION_OF_DNA_RECOMBINATION_AT_TELOMERE
## 624                                                                                                                               REACTOME_MEIOSIS
## 625                                                                                                                 REACTOME_MEIOTIC_RECOMBINATION
## 709                                                                                     REACTOME_NEGATIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION
## 788                                                                                                   REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE
## 847                                                                                     REACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION
## 855                                                                                                      REACTOME_PRC2_METHYLATES_HISTONES_AND_DNA
## 856                                                                                                   REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING
## 865                                                                                            REACTOME_PROCESSING_OF_DNA_DOUBLE_STRAND_BREAK_ENDS
## 906                                                REACTOME_RECOGNITION_AND_ASSOCIATION_OF_DNA_GLYCOSYLASE_WITH_SITE_CONTAINING_AN_AFFECTED_PURINE
## 958                                                                                                                          REACTOME_REPRODUCTION
## 980                                                                                                             REACTOME_RHO_GTPASES_ACTIVATE_PKNS
## 986                                                                                                      REACTOME_RNA_POLYMERASE_I_PROMOTER_ESCAPE
## 987                                                                                                        REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION
## 1013                                                REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION
## 1131                                                                                           REACTOME_SIRT1_NEGATIVELY_REGULATES_RRNA_EXPRESSION
## 1213                                                                                                                 REACTOME_TELOMERE_MAINTENANCE
## 1272                                                                                             REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS
## 1275                                                                                         REACTOME_TRANSCRIPTIONAL_REGULATION_OF_GRANULOPOIESIS
## 355                                                                                                                REACTOME_ESR_MEDIATED_SIGNALING
## 626                                                                                                                      REACTOME_MEIOTIC_SYNAPSIS
## 744                                                                                                        REACTOME_NONHOMOLOGOUS_END_JOINING_NHEJ
## 431                                                                                                            REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT
## 985                                                                                                      REACTOME_RMTS_METHYLATE_HISTONE_ARGININES
## 405                                                                                                   REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE
## 479                                                                                                               REACTOME_HATS_ACETYLATE_HISTONES
## 520                                                                                                                   REACTOME_INFLUENZA_INFECTION
## 587                                                                                                                        REACTOME_KERATINIZATION
## 832                                                                                                       REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES
## 162                                                                                                                    REACTOME_CELL_CYCLE_MITOTIC
## 161                                                                                                                REACTOME_CELL_CYCLE_CHECKPOINTS
## 430                                                                                                                      REACTOME_G2_M_CHECKPOINTS
## 160                                                                                                                            REACTOME_CELL_CYCLE
## 482                                                                                                                      REACTOME_HCMV_LATE_EVENTS
## 647                                                                                                                     REACTOME_METABOLISM_OF_RNA
## 1031                                                                                                                              REACTOME_S_PHASE
## 357                                                                                                    REACTOME_ESTROGEN_DEPENDENT_GENE_EXPRESSION
## 1048                                                                                       REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP
## 366                                                                                                     REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION
## 1144                                                                          REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE
## 180                                                                                                           REACTOME_CHROMATIN_MODIFYING_ENZYMES
## 677                                                                                                                      REACTOME_MITOTIC_PROPHASE
## 362                                                                                                     REACTOME_EUKARYOTIC_TRANSLATION_INITIATION
## 932               REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS
## 1155                                                                                       REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS
## 1111                                                                                                       REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS
## 1154                                                                                                                          REACTOME_SUMOYLATION
## 973                                                                                                                  REACTOME_RHO_GTPASE_EFFECTORS
## 967                                                                                           REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2
## 1037                                                                                                       REACTOME_SCAVENGING_OF_HEME_FROM_PLASMA
## 745                                                                                                           REACTOME_NONSENSE_MEDIATED_DECAY_NMD
## 863                                                                                       REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA
## 44                                                                                              REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX
## 673                                                                                                  REACTOME_MITOTIC_G1_PHASE_AND_G1_S_TRANSITION
## 200                                                                                                                    REACTOME_COLLAGEN_FORMATION
## 1006                                                                                                                      REACTOME_RRNA_PROCESSING
## 480                                                                                                                     REACTOME_HCMV_EARLY_EVENTS
## 688                                                                                                                         REACTOME_MRNA_SPLICING
## 965                                                                                     REACTOME_RESPONSE_OF_EIF2AK4_GCN2_TO_AMINO_ACID_DEFICIENCY
## 25                                                                                    REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS
## 1015                                                           REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_HSCS
## 361                                                                                                     REACTOME_EUKARYOTIC_TRANSLATION_ELONGATION
## 836                                                                                                         REACTOME_PLASMA_LIPOPROTEIN_REMODELING
## 1041                                                                                                          REACTOME_SELENOAMINO_ACID_METABOLISM
## 304                                                                                                                 REACTOME_DNA_STRAND_ELONGATION
## 1319                                                                                                                     REACTOME_UNWINDING_OF_DNA
## 204                                                                                              REACTOME_CONDENSATION_OF_PROMETAPHASE_CHROMOSOMES
## 734                                                                                                              REACTOME_NEUTROPHIL_DEGRANULATION
## 301                                                                                                                       REACTOME_DNA_REPLICATION
## 609                                                                                                                               REACTOME_M_PHASE
## 895                                                                                                               REACTOME_RAB_GERANYLGERANYLATION
## 197                                                                                           REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES
## 535                                                                                                    REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS
## 1208                                                                                           REACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT
## 1127                                                                                                                     REACTOME_SIGNALING_BY_WNT
## 124                                                                                  REACTOME_BINDING_AND_UPTAKE_OF_LIGANDS_BY_SCAVENGER_RECEPTORS
## 481                                                                                                                        REACTOME_HCMV_INFECTION
## 184                                                                                                                REACTOME_CHYLOMICRON_REMODELING
## 1100                                                                                                                   REACTOME_SIGNALING_BY_NOTCH
## 495                                                                                                                            REACTOME_HEMOSTASIS
## 1291                                                                  REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES
## 324                                                                                                                     REACTOME_ECM_PROTEOGLYCANS
## 837                                                                                         REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION
## 182                                                                                                                  REACTOME_CHYLOMICRON_ASSEMBLY
## 1269                                                                                                  REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1
## 921                                                                                           REACTOME_REGULATION_OF_EXPRESSION_OF_SLITS_AND_ROBOS
## 1035                                                                                                      REACTOME_SCAVENGING_BY_CLASS_B_RECEPTORS
## 689                                                                                                           REACTOME_MRNA_SPLICING_MINOR_PATHWAY
## 568                                                                                                              REACTOME_INTRAFLAGELLAR_TRANSPORT
## 563                                                                                                               REACTOME_INTERLEUKIN_7_SIGNALING
## 669                                                                                                          REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT
## 95                                                                           REACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES
## 273                                                                                               REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX
## 1279                                                                                                                          REACTOME_TRANSLATION
## 203                                                                                                                    REACTOME_COMPLEMENT_CASCADE
## 42                                  REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S
## 780                                                                                                              REACTOME_ONCOGENIC_MAPK_SIGNALING
## 642                                                                                                    REACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS
## 198                                                                                                          REACTOME_COLLAGEN_CHAIN_TRIMERIZATION
## 435                                                                                                            REACTOME_GABA_B_RECEPTOR_ACTIVATION
## 724                                                                                                            REACTOME_NERVOUS_SYSTEM_DEVELOPMENT
## 894                                                                                                 REACTOME_RAB_GEFS_EXCHANGE_GTP_FOR_GDP_ON_RABS
## 303                                                                                                        REACTOME_DNA_REPLICATION_PRE_INITIATION
## 886                                                                                 REACTOME_PTK6_REGULATES_RTKS_AND_THEIR_EFFECTORS_AKT1_AND_DOK1
## 1067                                                                                                    REACTOME_SIGNALING_BY_BRAF_AND_RAF_FUSIONS
## 801                                                                                                             REACTOME_PENTOSE_PHOSPHATE_PATHWAY
## 93                                                                               REACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS
## 199                                                                                                                  REACTOME_COLLAGEN_DEGRADATION
## 676                                                                                                                  REACTOME_MITOTIC_PROMETAPHASE
## 537                                                                                                   REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS
## 701                                                                                                                    REACTOME_NCAM1_INTERACTIONS
## 1119                                                                                                          REACTOME_SIGNALING_BY_ROBO_RECEPTORS
## 320                                                                           REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION
## 510                                                                               REACTOME_HSP90_CHAPERONE_CYCLE_FOR_STEROID_HORMONE_RECEPTORS_SHR
## 211                                                                            REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE
## 402                                                                          REACTOME_FORMATION_OF_SENESCENCE_ASSOCIATED_HETEROCHROMATIN_FOCI_SAHF
## 331                                                                                                               REACTOME_ELASTIC_FIBRE_FORMATION
## 442                                                                                                                 REACTOME_GAP_JUNCTION_ASSEMBLY
## 1289                                                                                        REACTOME_TRANSPORT_OF_CONNEXONS_TO_THE_PLASMA_MEMBRANE
## 1311                                                                                                                REACTOME_TRYPTOPHAN_CATABOLISM
## 851                                                                                                                    REACTOME_POTASSIUM_CHANNELS
## 787                                                                                                        REACTOME_OVARIAN_TUMOR_DOMAIN_PROTEASES
## 1169                                                                                     REACTOME_SWITCHING_OF_ORIGINS_TO_A_POST_REPLICATIVE_STATE
## 680                                                                                               REACTOME_MODULATION_BY_MTB_OF_HOST_IMMUNE_SYSTEM
## 500                                                                                                                        REACTOME_HIV_LIFE_CYCLE
## 486                                                                                                                        REACTOME_HDL_REMODELING
## 55                                                                                    REACTOME_ADRENALINE_NORADRENALINE_INHIBITS_INSULIN_SECRETION
## 364                                                                                                                REACTOME_EXTENSION_OF_TELOMERES
## 91                                                                                                      REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION
## 485                                                                                                                         REACTOME_HDL_CLEARANCE
## 1096                                                                                                                     REACTOME_SIGNALING_BY_MET
## 52                                                                                REACTOME_ADORA2B_MEDIATED_ANTI_INFLAMMATORY_CYTOKINES_PRODUCTION
## 640                                                                                                           REACTOME_METABOLISM_OF_CARBOHYDRATES
## 861                                                                                             REACTOME_PREVENTION_OF_PHAGOSOMAL_LYSOSOMAL_FUSION
## 425                                                                                             REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA
## 54                                                                                             REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_12
## 655                                                                                                          REACTOME_METALLOTHIONEINS_BIND_METALS
## 436                                                                                                              REACTOME_GABA_RECEPTOR_ACTIVATION
## 1329                                                                                                             REACTOME_VISUAL_PHOTOTRANSDUCTION
## 811                                                                                                              REACTOME_PHENYLALANINE_METABOLISM
## 1285                                                                                 REACTOME_TRANSLOCATION_OF_SLC2A4_GLUT4_TO_THE_PLASMA_MEMBRANE
## 94                                                                                       REACTOME_ASSEMBLY_OF_ACTIVE_LPL_AND_LIPC_LIPASE_COMPLEXES
## 212                                                                    REACTOME_COOPERATION_OF_PREFOLDIN_AND_TRIC_CCT_IN_ACTIN_AND_TUBULIN_FOLDING
## 627                                                                                                                  REACTOME_MEMBRANE_TRAFFICKING
## 444                                                                                               REACTOME_GAP_JUNCTION_TRAFFICKING_AND_REGULATION
## 896                                                                                                         REACTOME_RAB_REGULATION_OF_TRAFFICKING
## 1061                                                                                                                 REACTOME_SIGNAL_AMPLIFICATION
## 65                                                                                        REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE
## 228                                                                                                      REACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS
## 794                                                                                                         REACTOME_P75NTR_REGULATES_AXONOGENESIS
## 976                                                                                                           REACTOME_RHO_GTPASES_ACTIVATE_IQGAPS
## 781                                                                                                           REACTOME_ORC1_REMOVAL_FROM_CHROMATIN
## 681                                                                                              REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES
## 1299                                                                                   REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION
## 1183                                                                                           REACTOME_SYNTHESIS_OF_IP2_IP_AND_INS_IN_THE_CYTOSOL
## 165                                                                                                            REACTOME_CELL_JUNCTION_ORGANIZATION
## 59                                                                                              REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL
## 407                                                                                REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC
## 7                                                                                                   REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS
## 797                                                                                        REACTOME_PCNA_DEPENDENT_LONG_PATCH_BASE_EXCISION_REPAIR
## 368                                                                 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION
## 922                                                                            REACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION
## 426                                                                                                       REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING
## 566                                                                                        REACTOME_INTRA_GOLGI_AND_RETROGRADE_GOLGI_TO_ER_TRAFFIC
## 834                                                                                  REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE
## 1274                                                                                                  REACTOME_TRANSCRIPTIONAL_REGULATION_BY_VENTX
## 429                                                                                                           REACTOME_G1_S_SPECIFIC_TRANSCRIPTION
## 1095                                                                           REACTOME_SIGNALING_BY_MEMBRANE_TETHERED_FUSIONS_OF_PDGFRA_OR_PDGFRB
## 571                                                                                                                       REACTOME_ION_HOMEOSTASIS
## 583                                                                                                                  REACTOME_JOSEPHIN_DOMAIN_DUBS
## 71                                                                     REACTOME_ANTI_INFLAMMATORY_RESPONSE_FAVOURING_LEISHMANIA_PARASITE_INFECTION
## 817                                                                                                          REACTOME_PHOSPHORYLATION_OF_THE_APC_C
## 1039                                                                                      REACTOME_SEALING_OF_THE_NUCLEAR_ENVELOPE_NE_BY_ESCRT_III
## 593                                                                                                              REACTOME_LAGGING_STRAND_SYNTHESIS
## 523           REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS
## 952                                                                                       REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_METHYLATION
## 1077                                                                                                                    REACTOME_SIGNALING_BY_FGFR
## 1081                                                                                                                   REACTOME_SIGNALING_BY_FGFR2
## 158                                                                                                               REACTOME_CELL_CELL_COMMUNICATION
## 977                                                                                                             REACTOME_RHO_GTPASES_ACTIVATE_KTN1
## 939                                                                                                 REACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION
## 675                                                                                                        REACTOME_MITOTIC_METAPHASE_AND_ANAPHASE
## 290                                                                                                                REACTOME_DISEASES_OF_METABOLISM
## 742                                                                                                REACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS
## 223                                                          REACTOME_CREB1_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII_CAMKK_CAMKIV_CASCASDE
## 23                                                                                                REACTOME_ACTIVATION_OF_AMPK_DOWNSTREAM_OF_NMDARS
## 912                                                                                                               REACTOME_RECYCLING_PATHWAY_OF_L1
## 323                                                                                                         REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE
## 610                                                                                                             REACTOME_MAP2K_AND_MAPK_ACTIVATION
## 960                                                          REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY
## 1267                                                                                                   REACTOME_TRANSCRIPTIONAL_REGULATION_BY_E2F6
## 176                                                                                                                    REACTOME_CHOLINE_CATABOLISM
## 833                                                                                                           REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY
## 343                                                                                                     REACTOME_ER_TO_GOLGI_ANTEROGRADE_TRANSPORT
## 949                                                                                                           REACTOME_REGULATION_OF_TP53_ACTIVITY
## 287                                                                                  REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS
## 83                                                                                                    REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION
## 959                                                                                                   REACTOME_RESOLUTION_OF_ABASIC_SITES_AP_SITES
## 401                                                                                            REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX
## 953                                                                                   REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_PHOSPHORYLATION
## 1097                                                                                   REACTOME_SIGNALING_BY_MODERATE_KINASE_ACTIVITY_BRAF_MUTANTS
## 349                                                                                REACTOME_ERYTHROCYTES_TAKE_UP_CARBON_DIOXIDE_AND_RELEASE_OXYGEN
## 945                                                                                           REACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY
## 687                                                                                                        REACTOME_MRNA_EDITING_C_TO_U_CONVERSION
## 899                                                                                                                       REACTOME_RAP1_SIGNALLING
## 1159                                                                                              REACTOME_SUMOYLATION_OF_IMMUNE_RESPONSE_PROTEINS
## 35                                                                                   REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS
## 53                                                                                              REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_1
## 762                                                                                              REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS
## 853                                                                       REACTOME_POU5F1_OCT4_SOX2_NANOG_REPRESS_GENES_RELATED_TO_DIFFERENTIATION
## 225                                                                                                             REACTOME_CRMPS_IN_SEMA3A_SIGNALING
## 1210                                                                                           REACTOME_TELOMERE_C_STRAND_LAGGING_STRAND_SYNTHESIS
## 763                                                                                                 REACTOME_NS1_MEDIATED_EFFECTS_ON_HOST_PATHWAYS
## 1046                                                                          REACTOME_SEMA4D_MEDIATED_INHIBITION_OF_CELL_ATTACHMENT_AND_MIGRATION
## 1098                                                                                                    REACTOME_SIGNALING_BY_MRAS_COMPLEX_MUTANTS
## 670                                                                                                             REACTOME_MITOCHONDRIAL_TRANSLATION
## 890                                                                                                                    REACTOME_PYRIMIDINE_SALVAGE
## 58                                                                                                                             REACTOME_AGGREPHAGY
## 376                                                                                                      REACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION
## 519                                                                                             REACTOME_INFECTION_WITH_MYCOBACTERIUM_TUBERCULOSIS
## 569                                                                                            REACTOME_INTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION
## 905                                                                                           REACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES
## 172                                                                                                          REACTOME_CHAPERONE_MEDIATED_AUTOPHAGY
## 342                                                                                                   REACTOME_ER_QUALITY_CONTROL_COMPARTMENT_ERQC
## 526                                                                         REACTOME_INLA_MEDIATED_ENTRY_OF_LISTERIA_MONOCYTOGENES_INTO_HOST_CELLS
## 467                                                                                                          REACTOME_GLYCOSAMINOGLYCAN_METABOLISM
## 502                                                                                                          REACTOME_HIV_TRANSCRIPTION_INITIATION
## 1171                                                                                                                REACTOME_SYNDECAN_INTERACTIONS
## 237                                                                                              REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES
## 729                                                                                                                       REACTOME_NEURONAL_SYSTEM
## 1133                                                                                                 REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT
## 1287                                                                                                      REACTOME_TRANSPORT_AND_SYNTHESIS_OF_PAPS
## 473                                                                                                       REACTOME_GP1B_IX_V_ACTIVATION_SIGNALLING
## 1286                                                                                                REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES
## 773                                                                                                            REACTOME_NUCLEOTIDE_EXCISION_REPAIR
## 11                                                                                           REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE
## 399                                                                                             REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE
## 650                                                                                                  REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS
## 746                                                                                         REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE
## 1052                                                                                             REACTOME_SEROTONIN_NEUROTRANSMITTER_RELEASE_CYCLE
## 306                                                                                               REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING
## 256                                                                                                          REACTOME_DEFECTIVE_CHST6_CAUSES_MCDC1
## 263                                                                                             REACTOME_DEFECTIVE_ST3GAL3_CAUSES_MCT12_AND_EIEE15
## 1195                                                                                              REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE
## 465                                                                                                                    REACTOME_GLYCOGEN_SYNTHESIS
## 79                                                                                      REACTOME_APC_C_MEDIATED_DEGRADATION_OF_CELL_CYCLE_PROTEINS
## 97                                                                                                REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX
## 427                                                                                                                       REACTOME_G0_AND_EARLY_G1
## 379                                                                                          REACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS
## 572                                                                                                       REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES
## 1337                                                                                                     REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS
## 432                                                                                                       REACTOME_G2_M_DNA_REPLICATION_CHECKPOINT
## 149                                                                                    REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS
## 1327                                                                                                           REACTOME_VESICLE_MEDIATED_TRANSPORT
## 1284                                                   REACTOME_TRANSLESION_SYNTHESIS_BY_Y_FAMILY_DNA_POLYMERASES_BYPASSES_LESIONS_ON_DNA_TEMPLATE
## 1321                                                                                                REACTOME_UPTAKE_AND_FUNCTION_OF_ANTHRAX_TOXINS
## 848                                                                                               REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY
## 1310                                                                                                                         REACTOME_TRP_CHANNELS
## 570                                                                                                        REACTOME_INWARDLY_RECTIFYING_K_CHANNELS
## 68                                                                                                             REACTOME_ANCHORING_FIBRIL_FORMATION
## 968                                                                                                                REACTOME_RESPONSE_TO_METAL_IONS
## 189                                                                                           REACTOME_CLASS_I_PEROXISOMAL_MEMBRANE_PROTEIN_IMPORT
## 1293                                                                                          REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM
## 796                                                                                                                    REACTOME_PARASITE_INFECTION
## 50                                                                                                   REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY
## 1276                                                                                 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS
## 1050                                                                                                      REACTOME_SEPARATION_OF_SISTER_CHROMATIDS
## 185                                                                                                                       REACTOME_CILIUM_ASSEMBLY
## 1                                                                                                                  REACTOME_2_LTR_CIRCLE_FORMATION
## 732                                                                       REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION
## 931                                                                                REACTOME_REGULATION_OF_INNATE_IMMUNE_RESPONSES_TO_CYTOSOLIC_DNA
## 321                                                                                            REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION
## 87                                                                                                           REACTOME_AQUAPORIN_MEDIATED_TRANSPORT
## 451                                                                                            REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION
## 808                                                                                                          REACTOME_PHASE_3_RAPID_REPOLARISATION
## 1324                                                                         REACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS
## 141                                                                                              REACTOME_CAMK_IV_MEDIATED_PHOSPHORYLATION_OF_CREB
## 860                                                                                             REACTOME_PRESYNAPTIC_FUNCTION_OF_KAINATE_RECEPTORS
## 844                                                                                                      REACTOME_POLO_LIKE_KINASE_MEDIATED_EVENTS
## 289                                                                                                             REACTOME_DISEASES_OF_GLYCOSYLATION
## 1292                                                                        REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS
## 891                                                                                                                   REACTOME_PYRUVATE_METABOLISM
## 365                                                                                                      REACTOME_EXTRA_NUCLEAR_ESTROGEN_SIGNALING
## 933                                                                                                       REACTOME_REGULATION_OF_INSULIN_SECRETION
## 679                                                                                                         REACTOME_MITOTIC_TELOPHASE_CYTOKINESIS
## 700                                                                                                 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH
## 214                                                                                       REACTOME_COPI_INDEPENDENT_GOLGI_TO_ER_RETROGRADE_TRAFFIC
## 1261                                                                              REACTOME_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR_TC_NER
## 1264                                                                                                      REACTOME_TRANSCRIPTION_OF_THE_HIV_GENOME
## 423                                                                                                           REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS
## 717                                                                                                   REACTOME_NEGATIVE_REGULATION_OF_MET_ACTIVITY
## 831                                                                                 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_KEY_METABOLIC_FACTORS
## 1083                                                                                                        REACTOME_SIGNALING_BY_FGFR2_IN_DISEASE
## 1247                                                               REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_CYTOCHROME_C_RELEASE
## 1215                                                                                             REACTOME_TERMINATION_OF_TRANSLESION_DNA_SYNTHESIS
## 1282                                                                                                        REACTOME_TRANSLESION_SYNTHESIS_BY_POLH
## 578                                                                                                 REACTOME_IRF3_MEDIATED_INDUCTION_OF_TYPE_I_IFN
## 1010                                                   REACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN
## 1193                                                                                     REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE
## 250                                                                                           REACTOME_DEFECTIVE_B4GALT1_CAUSES_B4GALT1_CDG_CDG_2D
## 1158                                                                                              REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS
## 8                                                                        REACTOME_ABERRANT_REGULATION_OF_MITOTIC_EXIT_IN_CANCER_DUE_TO_RB1_DEFECTS
## 678                                                                                                            REACTOME_MITOTIC_SPINDLE_CHECKPOINT
## 215                                                                                                   REACTOME_COPI_MEDIATED_ANTEROGRADE_TRANSPORT
## 450                                                                              REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION
## 484                                                                                                                          REACTOME_HDL_ASSEMBLY
## 86                                                                                                              REACTOME_APOPTOTIC_EXECUTION_PHASE
## 963                                                                                               REACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION
## 966                                                                                                       REACTOME_RESPONSE_OF_MTB_TO_PHAGOCYTOSIS
## 594                                                                                                                  REACTOME_LAMININ_INTERACTIONS
## 830                                                                                                  REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB
## 1112                                                                                                                    REACTOME_SIGNALING_BY_PDGF
## 1116                                                                                               REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES
## 1243                                                                                     REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_CYCLE_GENES
## 962                                                     REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES_THROUGH_SYNTHESIS_DEPENDENT_STRAND_ANNEALING_SDSA
## 540                                                                                       REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS
## 592                                                                                                                    REACTOME_L1CAM_INTERACTIONS
## 660                                                                                                              REACTOME_MISCELLANEOUS_SUBSTRATES
## 868                                                                                  REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_C_STRAND_OF_THE_TELOMERE
## 1174                                                                                REACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE
## 190                                                                                                         REACTOME_CLATHRIN_MEDIATED_ENDOCYTOSIS
## 845                                                                                                                  REACTOME_POLYMERASE_SWITCHING
## 846                                                                                  REACTOME_POLYMERASE_SWITCHING_ON_THE_C_STRAND_OF_THE_TELOMERE
## 515                                                                                              REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1
## 557                                                                                      REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING
## 1230                                                                                         REACTOME_TICAM1_RIP1_MEDIATED_IKK_COMPLEX_RECRUITMENT
## 857                                                                                                         REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI
## 686                                                                                                                          REACTOME_MRNA_EDITING
## 589                                                                                                                    REACTOME_KILLING_MECHANISMS
## 433                                                                                                                              REACTOME_G2_PHASE
## 339                                                                                                       REACTOME_EPHB_MEDIATED_FORWARD_SIGNALING
## 284                                                                                 REACTOME_DISEASES_ASSOCIATED_WITH_GLYCOSAMINOGLYCAN_METABOLISM
## 1139                                                                                                                       REACTOME_SNRNP_ASSEMBLY
## 870                                                                                                          REACTOME_PROLACTIN_RECEPTOR_SIGNALING
## 816                                                                                                               REACTOME_PHOSPHORYLATION_OF_EMI1
## 374                                                                                                    REACTOME_FBXW7_MUTANTS_AND_NOTCH1_IN_CANCER
## 574                                                                                                            REACTOME_IRAK1_RECRUITS_IKK_COMPLEX
## 974                                                                                                              REACTOME_RHO_GTPASES_ACTIVATE_CIT
## 472                                                                                                      REACTOME_GOLGI_TO_ER_RETROGRADE_TRANSPORT
## 41                                                                                 REACTOME_ACTIVATION_OF_THE_AP_1_FAMILY_OF_TRANSCRIPTION_FACTORS
## 130                                                                                                      REACTOME_BLOOD_GROUP_SYSTEMS_BIOSYNTHESIS
## 1224                                                                            REACTOME_THE_ROLE_OF_GTSE1_IN_G2_M_PROGRESSION_AFTER_G2_CHECKPOINT
## 982                                                                                                            REACTOME_RHO_GTPASES_ACTIVATE_ROCKS
## 1045                                                                               REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE
## 1156                                                                               REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS
## 877                                                                                                                        REACTOME_PROTEIN_REPAIR
## 884                                                                                    REACTOME_PTK6_REGULATES_PROTEINS_INVOLVED_IN_RNA_PROCESSING
## 196                                                                                                        REACTOME_COHESIN_LOADING_ONTO_CHROMATIN
## 1202                                                                                         REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS
## 403                                                                                              REACTOME_FORMATION_OF_TC_NER_PRE_INCISION_COMPLEX
## 157                                                                                          REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX
## 706                                                                                                      REACTOME_NEF_MEDIATED_CD8_DOWN_REGULATION
## 1212                                                                                                     REACTOME_TELOMERE_EXTENSION_BY_TELOMERASE
## 586                                                                                                    REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM
## 231                                                                               REACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION
## 539                                                                                       REACTOME_INTERACTIONS_OF_REV_WITH_HOST_CELLULAR_PROTEINS
## 424                                                                                                 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_CDC42
## 585                                                                                                           REACTOME_KERATAN_SULFATE_DEGRADATION
## 202                                                                            REACTOME_COMPETING_ENDOGENOUS_RNAS_CERNAS_REGULATE_PTEN_TRANSLATION
## 941                                                                                                   REACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION
## 1117                                                                                                           REACTOME_SIGNALING_BY_RETINOIC_ACID
## 1277                                                                        REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION
## 1147                                                                                    REACTOME_STING_MEDIATED_INDUCTION_OF_HOST_IMMUNE_RESPONSES
## 874                                                                                                                  REACTOME_PROTEIN_LOCALIZATION
## 805                                                                                                          REACTOME_PEROXISOMAL_LIPID_METABOLISM
## 344                                                                                                        REACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING
## 457                                                                                              REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE
## 999                                                                                         REACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION
## 389                                                                                                      REACTOME_FGFR2_MUTANT_RECEPTOR_ACTIVATION
## 1082                                                                                                           REACTOME_SIGNALING_BY_FGFR2_IIIA_TM
## 1170                                                                                                     REACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES
## 909                                                                                            REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES
## 78                               REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1
## 771                                                                                                            REACTOME_NUCLEAR_SIGNALING_BY_ERBB4
## 498                                                                                                    REACTOME_HIV_ELONGATION_ARREST_AND_RECOVERY
## 509                                                                                                        REACTOME_HSF1_DEPENDENT_TRANSACTIVATION
## 534                                                                                                               REACTOME_INTEGRATION_OF_PROVIRUS
## 629                                                                                                          REACTOME_MET_ACTIVATES_PTK2_SIGNALING
## 1298                                                                              REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES
## 337                                                                                                                  REACTOME_EPH_EPHRIN_SIGNALING
## 1227                                                                                           REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR
## 319                                                                                                               REACTOME_DUAL_INCISION_IN_TC_NER
## 1185                                                                                                           REACTOME_SYNTHESIS_OF_KETONE_BODIES
## 213                                                                                         REACTOME_COPI_DEPENDENT_GOLGI_TO_ER_RETROGRADE_TRAFFIC
## 350                                                                                REACTOME_ERYTHROCYTES_TAKE_UP_OXYGEN_AND_RELEASE_CARBON_DIOXIDE
## 1178                                                                     REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL
## 1179                                                                     REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL
## 1256                                                                                                        REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS
## 307                                                                                                     REACTOME_DOWNREGULATION_OF_ERBB2_SIGNALING
## 654                                                                                                                  REACTOME_METALLOPROTEASE_DUBS
## 1234                                                                                 REACTOME_TLR3_MEDIATED_TICAM1_DEPENDENT_PROGRAMMED_CELL_DEATH
## 1300                                                                                                  REACTOME_TRIF_MEDIATED_PROGRAMMED_CELL_DEATH
## 490                                                                                               REACTOME_HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA
## 503                                                                                            REACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE
## 1217                                                      REACTOME_TFAP2_AP_2_FAMILY_REGULATES_TRANSCRIPTION_OF_GROWTH_FACTORS_AND_THEIR_RECEPTORS
## 235                                                                                                REACTOME_CYTOSOLIC_IRON_SULFUR_CLUSTER_ASSEMBLY
## 775                                                                                     REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS
## 812                                                                                            REACTOME_PHOSPHATE_BOND_HYDROLYSIS_BY_NUDT_PROTEINS
## 209                                                                      REACTOME_CONSTITUTIVE_SIGNALING_BY_LIGAND_RESPONSIVE_EGFR_CANCER_VARIANTS
## 454                                                                                                                    REACTOME_GLUCOSE_METABOLISM
## 1071                                                                                                          REACTOME_SIGNALING_BY_EGFR_IN_CANCER
## 869                                                                                            REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND
## 1141                                                                                              REACTOME_SODIUM_COUPLED_PHOSPHATE_COTRANSPORTERS
## 492                                                                                                                    REACTOME_HEDGEHOG_OFF_STATE
## 858                                                                                     REACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM
## 990                                                                                             REACTOME_RNA_POLYMERASE_II_TRANSCRIBES_SNRNA_GENES
## 1105                                                                                                                  REACTOME_SIGNALING_BY_NOTCH2
## 584                                                                                                          REACTOME_KERATAN_SULFATE_BIOSYNTHESIS
## 662                                                                                                                       REACTOME_MISMATCH_REPAIR
## 1180                                                                 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL
## 1211                                                                                               REACTOME_TELOMERE_C_STRAND_SYNTHESIS_INITIATION
## 62                                                                                               REACTOME_ALPHA_PROTEIN_KINASE_1_SIGNALING_PATHWAY
## 575                                                                                             REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX
## 1231                                                                                     REACTOME_TICAM1_TRAF6_DEPENDENT_INDUCTION_OF_TAK1_COMPLEX
## 1252                                                                         REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX_WITHIN_TLR4_COMPLEX
## 146                                                                      REACTOME_CASPASE_ACTIVATION_VIA_DEATH_RECEPTORS_IN_THE_PRESENCE_OF_LIGAND
## 246                                                                                                                 REACTOME_DEADENYLATION_OF_MRNA
## 463                                                                                                                   REACTOME_GLYCOGEN_METABOLISM
## 916                                                                                                                  REACTOME_REGULATION_BY_C_FLIP
## 501                                                                                                          REACTOME_HIV_TRANSCRIPTION_ELONGATION
## 51                                                                                                        REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS
## 964                                                                                            REACTOME_RESPONSE_OF_EIF2AK1_HRI_TO_HEME_DEFICIENCY
## 262                                                                                                           REACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3
## 164                                                                                                REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS
## 1168                                                                                                                REACTOME_SURFACTANT_METABOLISM
## 1246                                                                                     REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DNA_REPAIR_GENES
## 923                                                                                                   REACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION
## 387                                                                                                            REACTOME_FGFR2_ALTERNATIVE_SPLICING
## 155                                                                                                     REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING
## 216                                                                                                      REACTOME_COPII_MEDIATED_VESICLE_TRANSPORT
## 356                                                                                            REACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION
## 85                                                                                                REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS
## 207                                                                                         REACTOME_CONSTITUTIVE_SIGNALING_BY_AKT1_E17K_IN_CANCER
## 1263                                 REACTOME_TRANSCRIPTION_OF_E2F_TARGETS_UNDER_NEGATIVE_CONTROL_BY_P107_RBL1_AND_P130_RBL2_IN_COMPLEX_WITH_HDAC1
## 220                                                                                                                  REACTOME_CREB_PHOSPHORYLATION
## 1237                                                                                                 REACTOME_TNFR1_INDUCED_PROAPOPTOTIC_SIGNALING
## 755                                                                                   REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION
## 723                                                                                                           REACTOME_NEPHRIN_FAMILY_INTERACTIONS
## 1049                                                                                                  REACTOME_SENSING_OF_DNA_DOUBLE_STRAND_BREAKS
## 1328                                                                                                        REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS
## 951                                                                       REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS
## 1229                                                                                             REACTOME_TICAM1_DEPENDENT_ACTIVATION_OF_IRF3_IRF7
## 634                                                                                                            REACTOME_MET_PROMOTES_CELL_MOTILITY
## 879                                                                                              REACTOME_PROTON_COUPLED_MONOCARBOXYLATE_TRANSPORT
## 600                                                                                          REACTOME_LISTERIA_MONOCYTOGENES_ENTRY_INTO_HOST_CELLS
## 876                                                                                              REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES
## 183                                                                                                                 REACTOME_CHYLOMICRON_CLEARANCE
## 527                                                                          REACTOME_INLB_MEDIATED_ENTRY_OF_LISTERIA_MONOCYTOGENES_INTO_HOST_CELL
## 1273                                                         REACTOME_TRANSCRIPTIONAL_REGULATION_BY_THE_AP_2_TFAP2_FAMILY_OF_TRANSCRIPTION_FACTORS
## 462                                                                                                     REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS
## 725                                                                                                                    REACTOME_NETRIN_1_SIGNALING
## 193                                                                                                           REACTOME_CLEC7A_INFLAMMASOME_PATHWAY
## 400                                                                                               REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER
## 1148                                                                                                          REACTOME_STRIATED_MUSCLE_CONTRACTION
## 28                                                                                                                REACTOME_ACTIVATION_OF_C3_AND_C5
## 352                                                                                   REACTOME_ERYTHROPOIETIN_ACTIVATES_PHOSPHOLIPASE_C_GAMMA_PLCG
## 750                                                                           REACTOME_NOTCH2_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS
## 1034                                                                                                      REACTOME_SCAVENGING_BY_CLASS_A_RECEPTORS
## 499                                                                                                                         REACTOME_HIV_INFECTION
## 1226                                                                      REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS
## 590                                                                                                                              REACTOME_KINESINS
## 1102                                                                                      REACTOME_SIGNALING_BY_NOTCH1_HD_DOMAIN_MUTANTS_IN_CANCER
## 588                                                                                                                REACTOME_KETONE_BODY_METABOLISM
## 153                                                                                                          REACTOME_CD22_MEDIATED_BCR_REGULATION
## 159                                                                                                       REACTOME_CELL_CELL_JUNCTION_ORGANIZATION
## 489                                                                                                             REACTOME_HDR_THROUGH_MMEJ_ALT_NHEJ
## 622                                                                                                 REACTOME_MECP2_REGULATES_TRANSCRIPTION_FACTORS
## 628                                                                                                      REACTOME_MET_ACTIVATES_PI3K_AKT_SIGNALING
## 635                                                                                                               REACTOME_MET_RECEPTOR_ACTIVATION
## 756                                                                                                    REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING
## 840                                                                                                          REACTOME_PLATELET_CALCIUM_HOMEOSTASIS
## 893                                                                                                               REACTOME_RA_BIOSYNTHESIS_PATHWAY
## 913                                                                                                      REACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS
## 1115                                                                                                                    REACTOME_SIGNALING_BY_PTK6
## 1167                                                                                                 REACTOME_SUPPRESSION_OF_PHAGOSOMAL_MATURATION
## 1047                                                                                                              REACTOME_SEMAPHORIN_INTERACTIONS
## 748                                                                                                       REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY
## 230                                                                                                            REACTOME_CTLA4_INHIBITORY_SIGNALING
## 802                                                                                                          REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS
## 103                                                                                                      REACTOME_ATTACHMENT_OF_GPI_ANCHOR_TO_UPAR
## 1161                                                                                                  REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS
## 1346                                                                             REACTOME_ZINC_EFFLUX_AND_COMPARTMENTALIZATION_BY_THE_SLC30_FAMILY
## 282                                                                                                     REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE
## 104                                                                                                                     REACTOME_ATTENUATION_PHASE
## 810                                                                                                 REACTOME_PHENYLALANINE_AND_TYROSINE_METABOLISM
## 1309                                                                                                       REACTOME_TRNA_PROCESSING_IN_THE_NUCLEUS
## 1297                                                                                          REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA
## 543                                                                                                                  REACTOME_INTERFERON_SIGNALING
## 496                                                                                             REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM
## 712                                                                                                REACTOME_NEGATIVE_REGULATION_OF_FGFR1_SIGNALING
## 713                                                                                                REACTOME_NEGATIVE_REGULATION_OF_FGFR2_SIGNALING
## 714                                                                                                REACTOME_NEGATIVE_REGULATION_OF_FGFR3_SIGNALING
## 715                                                                                                REACTOME_NEGATIVE_REGULATION_OF_FGFR4_SIGNALING
## 1143                                                                                                     REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING
## 288                                                                                                   REACTOME_DISEASES_OF_CARBOHYDRATE_METABOLISM
## 377                                                                                                        REACTOME_FCERI_MEDIATED_MAPK_ACTIVATION
## 1029                                                                                                        REACTOME_RUNX3_REGULATES_WNT_SIGNALING
## 1044                                                                                                       REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING
## 140                                                                                                           REACTOME_CALNEXIN_CALRETICULIN_CYCLE
## 1072                                                                                                                   REACTOME_SIGNALING_BY_ERBB2
## 507                                                                                                                    REACTOME_HS_GAG_DEGRADATION
## 77                                                                                           REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B
## 453                                                                                                                       REACTOME_GLUCONEOGENESIS
## 910                                                                                                     REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS
## 1296                                                                                                          REACTOME_TRANSPORT_OF_ORGANIC_ANIONS
## 1241                     REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_ADDITIONAL_CELL_CYCLE_GENES_WHOSE_EXACT_ROLE_IN_THE_P53_PATHWAY_REMAIN_UNCERTAIN
## 217                                                                                                      REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY
## 75                                                                                                                 REACTOME_ANTIMICROBIAL_PEPTIDES
## 516                                                              REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL
## 382                                                                                                                         REACTOME_FERTILIZATION
## 538                                                                                 REACTOME_INTERACTION_WITH_CUMULUS_CELLS_AND_THE_ZONA_PELLUCIDA
## 720                                                            REACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_DVL_INTERACTING_PROTEINS
## 1028                                                                                                              REACTOME_RUNX3_REGULATES_P14_ARF
## 988                                                                                             REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION_INITIATION
## 961                                                                                                       REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES
## 1262                                                                 REACTOME_TRANSCRIPTION_OF_E2F_TARGETS_UNDER_NEGATIVE_CONTROL_BY_DREAM_COMPLEX
## 1312                                                                                                        REACTOME_TYPE_I_HEMIDESMOSOME_ASSEMBLY
## 302                                                                                                            REACTOME_DNA_REPLICATION_INITIATION
## 318                                                                                                               REACTOME_DUAL_INCISION_IN_GG_NER
## 815                                                                                                               REACTOME_PHOSPHOLIPID_METABOLISM
## 1078                                                                                                         REACTOME_SIGNALING_BY_FGFR_IN_DISEASE
## 653                                                                                         REACTOME_METAL_SEQUESTRATION_BY_ANTIMICROBIAL_PROTEINS
## 148                                                                         REACTOME_CASPASE_ACTIVATION_VIA_EXTRINSIC_APOPTOTIC_SIGNALLING_PATHWAY
## 699                                                                                                       REACTOME_NADE_MODULATES_DEATH_SIGNALLING
## 219                                                                                                      REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS
## 783                                                                                                               REACTOME_ORGANIC_ANION_TRANSPORT
## 784                                                                                             REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT
## 506                                                                                                                   REACTOME_HS_GAG_BIOSYNTHESIS
## 296                                                                                                                     REACTOME_DNA_DAMAGE_BYPASS
## 438                                                                                                                  REACTOME_GALACTOSE_CATABOLISM
## 1236                                                                                             REACTOME_TNFR1_INDUCED_NFKAPPAB_SIGNALING_PATHWAY
## 449                                                                                       REACTOME_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR_GG_NER
## 533                                                                                                      REACTOME_INTEGRATION_OF_ENERGY_METABOLISM
## 950                                                                                       REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION
## 1220                                                              REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION
## 753                                                                                   REACTOME_NOTCH3_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION
## 1196                                                                                      REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE
## 786                                                                                                         REACTOME_OTHER_SEMAPHORIN_INTERACTIONS
## 782                                                                                                  REACTOME_ORGANELLE_BIOGENESIS_AND_MAINTENANCE
## 661                                                                                            REACTOME_MISCELLANEOUS_TRANSPORT_AND_BINDING_EVENTS
## 1007                                                                                                 REACTOME_RRNA_PROCESSING_IN_THE_MITOCHONDRION
## 1280                                                       REACTOME_TRANSLATION_OF_REPLICASE_AND_ASSEMBLY_OF_THE_REPLICATION_TRANSCRIPTION_COMPLEX
## 76                                                                                            REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES
## 665                                                                                               REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION
## 683                                                                                                                          REACTOME_MRNA_CAPPING
## 1295                                                                                                       REACTOME_TRANSPORT_OF_NUCLEOTIDE_SUGARS
## 440                                                                 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS
## 1248                                                               REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_G1_CELL_CYCLE_ARREST
## 607                                                                                                                     REACTOME_LYSINE_CATABOLISM
## 761                                                                                                                    REACTOME_NRCAM_INTERACTIONS
## 693                                                                                                          REACTOME_MYOCLONIC_EPILEPSY_OF_LAFORA
## 1063                                                                                        REACTOME_SIGNAL_REGULATORY_PROTEIN_FAMILY_INTERACTIONS
## 940                                                                                                       REACTOME_REGULATION_OF_PTEN_LOCALIZATION
## 765                                                                                                            REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN
## 981                                                                                          REACTOME_RHO_GTPASES_ACTIVATE_RHOTEKIN_AND_RHOPHILINS
## 142                                                                                                         REACTOME_CARGO_CONCENTRATION_IN_THE_ER
## 373                                                                                                           REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS
## 552                                                                                                               REACTOME_INTERLEUKIN_2_SIGNALING
## 776                                                                                                                REACTOME_O_LINKED_GLYCOSYLATION
## 1166                                                                                                             REACTOME_SUPPRESSION_OF_APOPTOSIS
## 716                                                                                                   REACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY
## 371                                                                                                                 REACTOME_FATTY_ACID_METABOLISM
## 34                                                                                              REACTOME_ACTIVATION_OF_NIMA_KINASES_NEK9_NEK6_NEK7
## 90                                                                                                               REACTOME_ARMS_MEDIATED_ACTIVATION
## 778                                                                                                                REACTOME_OAS_ANTIVIRAL_RESPONSE
## 898                                                                                                    REACTOME_RAF_INDEPENDENT_MAPK1_3_ACTIVATION
## 979                                                                                                             REACTOME_RHO_GTPASES_ACTIVATE_PAKS
## 267                                                              REACTOME_DEFECTS_OF_CONTACT_ACTIVATION_SYSTEM_CAS_AND_KALLIKREIN_KININ_SYSTEM_KKS
## 759                                                       REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX
## 803                                                                                                            REACTOME_PEPTIDE_HORMONE_METABOLISM
## 1109                                                                                                              REACTOME_SIGNALING_BY_NTRK3_TRKC
## 1214                                                                                                       REACTOME_TERMINAL_PATHWAY_OF_COMPLEMENT
## 757                                                                            REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_LIPOGENESIS
## 576                                                                                                        REACTOME_IRE1ALPHA_ACTIVATES_CHAPERONES
## 73                                                               REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC
## 369                                                                                                                REACTOME_FANCONI_ANEMIA_PATHWAY
## 147                                                                  REACTOME_CASPASE_ACTIVATION_VIA_DEPENDENCE_RECEPTORS_IN_THE_ABSENCE_OF_LIGAND
## 823                                                                                                                         REACTOME_PI_METABOLISM
## 266                                                                                            REACTOME_DEFECTS_IN_VITAMIN_AND_COFACTOR_METABOLISM
## 31                                                                                   REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON
## 2                                                                         REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS
## 466                                                                                                                            REACTOME_GLYCOLYSIS
## 1126                                                                                                                    REACTOME_SIGNALING_BY_VEGF
## 27                                                                                                        REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS
## 261                                                                                             REACTOME_DEFECTIVE_FACTOR_VIII_CAUSES_HEMOPHILIA_A
## 768                                                                                                         REACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN
## 850                                                                                      REACTOME_POSTMITOTIC_NUCLEAR_PORE_COMPLEX_NPC_REFORMATION
## 1040                                                                                                                  REACTOME_SELECTIVE_AUTOPHAGY
## 1283                                                                                                        REACTOME_TRANSLESION_SYNTHESIS_BY_POLK
## 459                                                                                                   REACTOME_GLUTATHIONE_SYNTHESIS_AND_RECYCLING
## 615                                                                                                                 REACTOME_MAPK3_ERK1_ACTIVATION
## 1157                                                                                              REACTOME_SUMOYLATION_OF_DNA_METHYLATION_PROTEINS
## 925                                    REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS
## 1027                                                                                                      REACTOME_RUNX3_REGULATES_NOTCH_SIGNALING
## 721                                                              REACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_WNT_LIGAND_ANTAGONISTS
## 452                                                                                                        REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS
## 873                                                                                 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR
## 1207                                                                                                                          REACTOME_TBC_RABGAPS
## 897                                                                                                                        REACTOME_RAF_ACTIVATION
## 84                                                                                           REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS
## 245                                                                                                    REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY
## 1079                                                                                                                   REACTOME_SIGNALING_BY_FGFR1
## 1084                                                                                                                   REACTOME_SIGNALING_BY_FGFR3
## 1086                                                                                                                   REACTOME_SIGNALING_BY_FGFR4
## 880                                                                                                                       REACTOME_PTEN_REGULATION
## 283                                                        REACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE
## 258                                                                                                     REACTOME_DEFECTIVE_EXT2_CAUSES_EXOSTOSES_2
## 882                                                                                                     REACTOME_PTK6_PROMOTES_HIF1A_STABILIZATION
## 793                                                                                                  REACTOME_P75NTR_RECRUITS_SIGNALLING_COMPLEXES
## 461                                                                                                        REACTOME_GLYCEROPHOSPHOLIPID_CATABOLISM
## 1181                                                                                                        REACTOME_SYNTHESIS_OF_DIPHTHAMIDE_EEF2
## 291                                                                                                       REACTOME_DISEASES_OF_MISMATCH_REPAIR_MMR
## 464                                                                                                             REACTOME_GLYCOGEN_STORAGE_DISEASES
## 852                                                                        REACTOME_POU5F1_OCT4_SOX2_NANOG_ACTIVATE_GENES_RELATED_TO_PROLIFERATION
## 549                                                                                                              REACTOME_INTERLEUKIN_17_SIGNALING
## 310                                                                                         REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING
## 106                                                                                                              REACTOME_AURKA_ACTIVATION_BY_TPX2
## 280                                                                                                                             REACTOME_DIGESTION
## 281                                                                                                              REACTOME_DIGESTION_AND_ABSORPTION
## 579                                                                                                             REACTOME_IRON_UPTAKE_AND_TRANSPORT
## 644                                                                                      REACTOME_METABOLISM_OF_INGESTED_SEMET_SEC_MESEC_INTO_H2SE
## 807                                                                                                                             REACTOME_PEXOPHAGY
## 1099                                                                                                                   REACTOME_SIGNALING_BY_NODAL
## 1288                                                             REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS
## 636                                                                                                                REACTOME_MET_RECEPTOR_RECYCLING
## 948                                                                                                        REACTOME_REGULATION_OF_SIGNALING_BY_CBL
## 478                                                                                                     REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING
## 334                                                                                      REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK
## 497                                                                                                                  REACTOME_HISTIDINE_CATABOLISM
## 956                                                                 REACTOME_REMOVAL_OF_AMINOTERMINAL_PROPEPTIDES_FROM_GAMMA_CARBOXYLATED_PROTEINS
## 1320                                                                                               REACTOME_UPTAKE_AND_ACTIONS_OF_BACTERIAL_TOXINS
## 66                                                                                                            REACTOME_AMINO_ACIDS_REGULATE_MTORC1
## 541                                                                                    REACTOME_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES
## 630                                                                                                                  REACTOME_MET_ACTIVATES_PTPN11
## 1290                                                                                                             REACTOME_TRANSPORT_OF_FATTY_ACIDS
## 770                                                                                                REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY
## 696                                                                                REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI
## 1022                                                                                     REACTOME_RUNX2_REGULATES_GENES_INVOLVED_IN_CELL_MIGRATION
## 652                                                                                                            REACTOME_METAL_ION_SLC_TRANSPORTERS
## 908                                                                              REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES
## 938                                                                                        REACTOME_REGULATION_OF_PLK1_ACTIVITY_AT_G2_M_TRANSITION
## 1140                                                                                                            REACTOME_SODIUM_CALCIUM_EXCHANGERS
## 61                                                                             REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM
## 1343                                                                                              REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD4
## 121                                                                                         REACTOME_BETA_OXIDATION_OF_VERY_LONG_CHAIN_FATTY_ACIDS
## 731                                                                                                            REACTOME_NEUROTRANSMITTER_CLEARANCE
## 1270                                                                                                  REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX2
## 326                                                                                                                   REACTOME_EGFR_DOWNREGULATION
## 488                                                                                              REACTOME_HDR_THROUGH_HOMOLOGOUS_RECOMBINATION_HRR
## 413                                                          REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES
## 970                                                                                                         REACTOME_RETINOID_CYCLE_DISEASE_EVENTS
## 308                                                                                                     REACTOME_DOWNREGULATION_OF_ERBB4_SIGNALING
## 265                                                                                                   REACTOME_DEFECTS_IN_COBALAMIN_B12_METABOLISM
## 188                                                                                                   REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS
## 1221                                                                                                     REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES
## 769                                                                                                  REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY
## 222                                                                     REACTOME_CREB1_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_ADENYLATE_CYCLASE
## 1093                                                                                                            REACTOME_SIGNALING_BY_LRP5_MUTANTS
## 1190                                                                                                                      REACTOME_SYNTHESIS_OF_PE
## 1138                                                                                                            REACTOME_SMOOTH_MUSCLE_CONTRACTION
## 441                                                                               REACTOME_GAP_FILLING_DNA_REPAIR_SYNTHESIS_AND_LIGATION_IN_GG_NER
## 839                                                                                                   REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION
## 3                                                                                                                     REACTOME_ABACAVIR_METABOLISM
## 4                                                                                                       REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM
## 1175                                                                                                REACTOME_SYNTHESIS_OF_5_EICOSATETRAENOIC_ACIDS
## 32                                                                                 REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING
## 525                                                                                         REACTOME_INITIATION_OF_NUCLEAR_ENVELOPE_NE_REFORMATION
## 1326                                                                                                REACTOME_VEGFR2_MEDIATED_VASCULAR_PERMEABILITY
## 394                                                                                                  REACTOME_FGFRL1_MODULATION_OF_FGFR1_SIGNALING
## 57                                                                                                REACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION
## 476                                                                             REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS
## 722                                                                                          REACTOME_NEGATIVE_REGULATORS_OF_DDX58_IFIH1_SIGNALING
## 1149                                                                                                         REACTOME_SULFIDE_OXIDATION_TO_SULFATE
## 695                                                                                                          REACTOME_N_GLYCAN_ANTENNAE_ELONGATION
## 276                                                                                                         REACTOME_DERMATAN_SULFATE_BIOSYNTHESIS
## 1187                                                                                                             REACTOME_SYNTHESIS_OF_LIPOXINS_LX
## 1194                                                                                                 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_ER_MEMBRANE
## 1347                                                                                      REACTOME_ZINC_INFLUX_INTO_CELLS_BY_THE_SLC39_GENE_FAMILY
## 1184                                                                                              REACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL
## 643                                                                                                     REACTOME_METABOLISM_OF_FOLATE_AND_PTERINES
## 785                                                                                                           REACTOME_OTHER_INTERLEUKIN_SIGNALING
## 166                                                                                        REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL
## 370                                                                                                                  REACTOME_FASL_CD95L_SIGNALING
## 613                                                                                   REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES
## 599                                                                                                                             REACTOME_LIPOPHAGY
## 1188                                                                                                                      REACTOME_SYNTHESIS_OF_PA
## 26                                                                                    REACTOME_ACTIVATION_OF_BAD_AND_TRANSLOCATION_TO_MITOCHONDRIA
## 468                                                                                                          REACTOME_GLYCOSPHINGOLIPID_METABOLISM
## 1249                                                               REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_G2_CELL_CYCLE_ARREST
## 295                                                                                                            REACTOME_DISSOLUTION_OF_FIBRIN_CLOT
## 396                                                        REACTOME_FICOLINS_BIND_TO_REPETITIVE_CARBOHYDRATE_STRUCTURES_ON_THE_TARGET_CELL_SURFACE
## 597                                                                                               REACTOME_LECTIN_PATHWAY_OF_COMPLEMENT_ACTIVATION
## 616                                                                                                                 REACTOME_MAPK6_MAPK4_SIGNALING
## 883                                                                                                             REACTOME_PTK6_REGULATES_CELL_CYCLE
## 354                                                                                                        REACTOME_ERYTHROPOIETIN_ACTIVATES_STAT5
## 367                                                                                            REACTOME_EXTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION
## 1336                                                                                                REACTOME_VLDLR_INTERNALISATION_AND_DEGRADATION
## 10                                                                          REACTOME_ABORTIVE_ELONGATION_OF_HIV_1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT
## 80                                                                                                REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A
## 1094                                                                                                            REACTOME_SIGNALING_BY_MAPK_MUTANTS
## 251                                                                                           REACTOME_DEFECTIVE_B4GALT7_CAUSES_EDS_PROGEROID_TYPE
## 471                                                                                   REACTOME_GOLGI_CISTERNAE_PERICENTRIOLAR_STACK_REORGANIZATION
## 767                                                                             REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION
## 37                                                                                                                     REACTOME_ACTIVATION_OF_RAC1
## 69                                                                                     REACTOME_ANCHORING_OF_THE_BASAL_BODY_TO_THE_PLASMA_MEMBRANE
## 9                                                             REACTOME_ABERRANT_REGULATION_OF_MITOTIC_G1_S_TRANSITION_IN_CANCER_DUE_TO_RB1_DEFECTS
## 82                                                                                        REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV_1_INFECTION
## 531                                                                                                            REACTOME_INSULIN_RECEPTOR_RECYCLING
## 49                                                                                                   REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY
## 297                                                                                                      REACTOME_DNA_DAMAGE_RECOGNITION_IN_GG_NER
## 972                                                                                       REACTOME_RETROGRADE_TRANSPORT_AT_THE_TRANS_GOLGI_NETWORK
## 70                                                                                                                  REACTOME_ANDROGEN_BIOSYNTHESIS
## 1265                                                                               REACTOME_TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGENESIS
## 279                                                         REACTOME_DEX_H_BOX_HELICASES_ACTIVATE_TYPE_I_IFN_AND_INFLAMMATORY_CYTOKINES_PRODUCTION
## 619                                                                                                              REACTOME_MATURATION_OF_PROTEIN_3A
## 698                                                                           REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE
## 363                                                                                       REACTOME_EXPORT_OF_VIRAL_RIBONUCLEOPROTEINS_FROM_NUCLEUS
## 983                                                                                                  REACTOME_RHO_GTPASES_ACTIVATE_WASPS_AND_WAVES
## 421                                                                                                       REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS
## 828                                                                                                 REACTOME_PIWI_INTERACTING_RNA_PIRNA_BIOGENESIS
## 1129                                                                                                                   REACTOME_SIGNALLING_TO_ERKS
## 46                                                                                                   REACTOME_ACYL_CHAIN_REMODELING_OF_DAG_AND_TAG
## 573                                                                                              REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS
## 772                                                                                                               REACTOME_NUCLEOBASE_BIOSYNTHESIS
## 92                                                                                                    REACTOME_ASPARTATE_AND_ASPARAGINE_METABOLISM
## 477                                                                                                        REACTOME_GRB7_EVENTS_IN_ERBB2_SIGNALING
## 88                                                                                                       REACTOME_ARACHIDONATE_PRODUCTION_FROM_DAG
## 63                                                                                                      REACTOME_ALTERNATIVE_COMPLEMENT_ACTIVATION
## 13                                                                                       REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS
## 232                                                                                      REACTOME_CYCLIN_A_CDK2_ASSOCIATED_EVENTS_AT_S_PHASE_ENTRY
## 685                                                                                                  REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE
## 777                                                                                                      REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS
## 1051                                                                                                                  REACTOME_SERINE_BIOSYNTHESIS
## 1342                                                                                REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD2_FZD5_AND_ROR2
## 690                                                                                                                 REACTOME_MUCOPOLYSACCHARIDOSES
## 606                                                                                                   REACTOME_LTC4_CYSLTR_MEDIATED_IL4_PRODUCTION
## 1257                                                                                       REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS
## 705                                                                                                      REACTOME_NEF_MEDIATED_CD4_DOWN_REGULATION
## 327                                                                                             REACTOME_EGFR_INTERACTS_WITH_PHOSPHOLIPASE_C_GAMMA
## 888                                                                                                                        REACTOME_PURINE_SALVAGE
## 1163                                                                                               REACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS
## 122                                                          REACTOME_BH3_ONLY_PROTEINS_ASSOCIATE_WITH_AND_INACTIVATE_ANTI_APOPTOTIC_BCL_2_MEMBERS
## 154                                                                                                                   REACTOME_CD28_CO_STIMULATION
## 915                                                                                                       REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR
## 1165                                                                                             REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS
## 1201                                                                                                REACTOME_SYNTHESIS_OF_UDP_N_ACETYL_GLUCOSAMINE
## 1242                                                                      REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CASPASE_ACTIVATORS_AND_CASPASES
## 395                                                                                                          REACTOME_FIBRONECTIN_MATRIX_FORMATION
## 658                                                                                                     REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION
## 1189                                                                                                                      REACTOME_SYNTHESIS_OF_PC
## 277                                                                                             REACTOME_DETOXIFICATION_OF_REACTIVE_OXYGEN_SPECIES
## 885                                                                                 REACTOME_PTK6_REGULATES_RHO_GTPASES_RAS_GTPASE_AND_MAP_KINASES
## 1219                                                                                          REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS
## 902                                                                             REACTOME_RAS_SIGNALING_DOWNSTREAM_OF_NF1_LOSS_OF_FUNCTION_VARIANTS
## 991                                                                                           REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION_TERMINATION
## 829                                                                                                 REACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING
## 872                                                                                                              REACTOME_PROPIONYL_COA_CATABOLISM
## 1125                                                                      REACTOME_SIGNALING_BY_TYPE_1_INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR_IGF1R
## 1121                                                                                               REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX
## 259                                                                                                               REACTOME_DEFECTIVE_F9_ACTIVATION
## 542                                                                                                            REACTOME_INTERFERON_GAMMA_SIGNALING
## 907                                                                      REACTOME_RECOGNITION_OF_DNA_DAMAGE_BY_PCNA_CONTAINING_REPLICATION_COMPLEX
## 926                                                                           REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN
## 954                                                                                         REACTOME_REGULATION_OF_TP53_EXPRESSION_AND_DEGRADATION
## 398                                                                                             REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING
## 749                                                                                   REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION
## 545                                                                                                              REACTOME_INTERLEUKIN_10_SIGNALING
## 659                                                                                                             REACTOME_MICRORNA_MIRNA_BIOGENESIS
## 101                                                                                             REACTOME_ATF6_ATF6_ALPHA_ACTIVATES_CHAPERONE_GENES
## 102                                                                                                  REACTOME_ATF6_ATF6_ALPHA_ACTIVATES_CHAPERONES
## 532                                                                                                   REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE
## 1030                                                                                          REACTOME_RUNX3_REGULATES_YAP1_MEDIATED_TRANSCRIPTION
## 249                                                                                                                       REACTOME_DECTIN_2_FAMILY
## 133                                                                                                  REACTOME_BUDDING_AND_MATURATION_OF_HIV_VIRION
## 577                                                                                                REACTOME_IRF3_MEDIATED_ACTIVATION_OF_TYPE_1_IFN
## 919                                                                           REACTOME_REGULATION_OF_COMMISSURAL_AXON_PATHFINDING_BY_SLIT_AND_ROBO
## 1162                                                                                                  REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS
## 1200                                                                                      REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS
## 1104                                                                    REACTOME_SIGNALING_BY_NOTCH1_T_7_9_NOTCH1_M1580_K2555_TRANSLOCATION_MUTANT
## 1314                                                                                                  REACTOME_TYSND1_CLEAVES_PEROXISOMAL_PROTEINS
## 1036                                                                                                      REACTOME_SCAVENGING_BY_CLASS_F_RECEPTORS
## 138                                                                                                                           REACTOME_CA2_PATHWAY
## 1199                                                                                           REACTOME_SYNTHESIS_OF_PYROPHOSPHATES_IN_THE_CYTOSOL
## 33                                                                                                REACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES
## 412                                                                                       REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES
## 12                                                                                              REACTOME_ACETYLCHOLINE_REGULATES_INSULIN_SECRETION
## 623                                                                                     REACTOME_MECP2_REGULATES_TRANSCRIPTION_OF_NEURONAL_LIGANDS
## 866                                                                                                    REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS
## 892                                                                                         REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE
## 325                                                                                                            REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS
## 806                                                                                                            REACTOME_PEROXISOMAL_PROTEIN_IMPORT
## 191                                                                                               REACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION
## 322                                                                                     REACTOME_E3_UBIQUITIN_LIGASES_UBIQUITINATE_TARGET_PROTEINS
## 241                                                                                                                       REACTOME_DAP12_SIGNALING
## 881                                                                                                                       REACTOME_PTK6_EXPRESSION
## 522                                                                       REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1
## 1003                                                                                                 REACTOME_ROS_AND_RNS_PRODUCTION_IN_PHAGOCYTES
## 409                                                                  REACTOME_FORMYL_PEPTIDE_RECEPTORS_BIND_FORMYL_PEPTIDES_AND_MANY_OTHER_LIGANDS
## 167                                                                                                             REACTOME_CELLULAR_HEXOSE_TRANSPORT
## 827                                                                                                         REACTOME_PINK1_PRKN_MEDIATED_MITOPHAGY
## 789                                                                                       REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS
## 1177                                                                                               REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS
## 470                                                                                                   REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS
## 639                                                                                         REACTOME_METABOLISM_OF_ANGIOTENSINOGEN_TO_ANGIOTENSINS
## 825                                                                                                        REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING
## 143                                                                                   REACTOME_CARGO_RECOGNITION_FOR_CLATHRIN_MEDIATED_ENDOCYTOSIS
## 792                                                                                        REACTOME_P75NTR_NEGATIVELY_REGULATES_CELL_CYCLE_VIA_SC1
## 997                                                                                                             REACTOME_ROBO_RECEPTORS_BIND_AKAP5
## 1000                                                                                                REACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS
## 1306                                                                                         REACTOME_TRNA_MODIFICATION_IN_THE_NUCLEUS_AND_CYTOSOL
## 1318                                                                                                        REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR
## 1088                                                                                                                REACTOME_SIGNALING_BY_HEDGEHOG
## 411                                                                                       REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES
## 551                                                                                                        REACTOME_INTERLEUKIN_2_FAMILY_SIGNALING
## 791                                                                                                  REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING
## 969                                                                                                                         REACTOME_RET_SIGNALING
## 1250 REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_SEVERAL_ADDITIONAL_CELL_DEATH_GENES_WHOSE_SPECIFIC_ROLES_IN_P53_DEPENDENT_APOPTOSIS_REMAIN_UNCERTAIN
## 434                                                                                                                      REACTOME_GAB1_SIGNALOSOME
## 617                                                                                                 REACTOME_MASTL_FACILITATES_MITOTIC_PROGRESSION
## 163                                                                                         REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE
## 718                                                                   REACTOME_NEGATIVE_REGULATION_OF_NMDA_RECEPTOR_MEDIATED_NEURONAL_TRANSMISSION
## 694                                                                                                                            REACTOME_MYOGENESIS
## 621                                                                                       REACTOME_MECP2_REGULATES_NEURONAL_RECEPTORS_AND_CHANNELS
## 72                                                       REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS
## 864                                                                                              REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA
## 114                                                                                                  REACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE
## 596                                                                                                                         REACTOME_LDL_CLEARANCE
## 1068                                                                                             REACTOME_SIGNALING_BY_CTNNB1_PHOSPHO_SITE_MUTANTS
## 175                                                                                                              REACTOME_CHOLESTEROL_BIOSYNTHESIS
## 358                                                                REACTOME_ESTROGEN_DEPENDENT_NUCLEAR_EVENTS_DOWNSTREAM_OF_ESR_MEMBRANE_SIGNALING
## 645                                                                             REACTOME_METABOLISM_OF_NITRIC_OXIDE_NOS3_ACTIVATION_AND_REGULATION
## 511                                                                                                  REACTOME_HUR_ELAVL1_BINDS_AND_STABILIZES_MRNA
## 900                                                                                  REACTOME_RAS_ACTIVATION_UPON_CA2_INFLUX_THROUGH_NMDA_RECEPTOR
## 1218                                         REACTOME_TFAP2A_ACTS_AS_A_TRANSCRIPTIONAL_REPRESSOR_DURING_RETINOIC_ACID_INDUCED_CELL_DIFFERENTIATION
## 201                                                                                               REACTOME_COMMON_PATHWAY_OF_FIBRIN_CLOT_FORMATION
## 736                                                                                               REACTOME_NF_KB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL
## 739                                                                                                                 REACTOME_NICOTINATE_METABOLISM
## 795                                                                                                              REACTOME_P75NTR_SIGNALS_VIA_NF_KB
## 1341                                                                                                       REACTOME_WNT_MEDIATED_ACTIVATION_OF_DVL
## 107                                                                                                                             REACTOME_AUTOPHAGY
## 305                                                                                               REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE
## 581                                                                                                               REACTOME_IRS_MEDIATED_SIGNALLING
## 601                                                                                                                REACTOME_LONG_TERM_POTENTIATION
## 536                                                                                                                    REACTOME_INTEGRIN_SIGNALING
## 842                                                                                                         REACTOME_PLATELET_SENSITIZATION_BY_LDL
## 29                                                                            REACTOME_ACTIVATION_OF_CASPASES_THROUGH_APOPTOSOME_MEDIATED_CLEAVAGE
## 1135                                                                                               REACTOME_SMAC_XIAP_REGULATED_APOPTOTIC_RESPONSE
## 120                                                                                                      REACTOME_BETA_OXIDATION_OF_PRISTANOYL_COA
## 1348                                                                                                                    REACTOME_ZINC_TRANSPORTERS
## 309                                                                              REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY
## 381                                                                                                        REACTOME_FCGR3A_MEDIATED_IL10_SYNTHESIS
## 1001                                                                                      REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN_1_SIGNALING
## 838                                                                                                 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN
## 971                                                                                                    REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING
## 406                                                                                             REACTOME_FORMATION_OF_THE_EARLY_ELONGATION_COMPLEX
## 333                                                                                                            REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY
## 996                                                                                          REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION_TERMINATION
## 1103                                                                                    REACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER
## 335                                                                                                                       REACTOME_ENOS_ACTIVATION
## 156                                                                                                           REACTOME_CD28_DEPENDENT_VAV1_PATHWAY
## 351                                                                               REACTOME_ERYTHROPOIETIN_ACTIVATES_PHOSPHOINOSITIDE_3_KINASE_PI3K
## 1002                                                                                                       REACTOME_RORA_ACTIVATES_GENE_EXPRESSION
## 605                                                                REACTOME_LRR_FLII_INTERACTING_PROTEIN_1_LRRFIP1_ACTIVATES_TYPE_I_IFN_PRODUCTION
## 818                                                                                                                 REACTOME_PHYSIOLOGICAL_FACTORS
## 36                                                                                   REACTOME_ACTIVATION_OF_PPARGC1A_PGC_1ALPHA_BY_PHOSPHORYLATION
## 332                                                                                REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT
## 380                                                                                                                       REACTOME_FCGR_ACTIVATION
## 887                                                                                      REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS
## 1043                                                                    REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION
## 1113                                                                                                        REACTOME_SIGNALING_BY_PDGFR_IN_DISEASE
## 345                                                                                                         REACTOME_ERBB2_REGULATES_CELL_MOTILITY
## 505                                                                                                      REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS
## 1233                                                                                                          REACTOME_TIGHT_JUNCTION_INTERACTIONS
## 317                                                                                                                    REACTOME_DSCAM_INTERACTIONS
## 1123                                                                                                     REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS
## 614                                                                                                                 REACTOME_MAPK1_ERK2_ACTIVATION
## 338                                                                                                    REACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE
## 1064                                                                                                            REACTOME_SIGNAL_TRANSDUCTION_BY_L1
## 1338                                                                                                       REACTOME_VXPX_CARGO_TARGETING_TO_CILIUM
## 691                                                                                                      REACTOME_MULTIFUNCTIONAL_ANION_EXCHANGERS
## 292                                                                                                      REACTOME_DISINHIBITION_OF_SNARE_FORMATION
## 710                                                                                          REACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY
## 150                                                                                                REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS
## 1294                                             REACTOME_TRANSPORT_OF_NUCLEOSIDES_AND_FREE_PURINE_AND_PYRIMIDINE_BASES_ACROSS_THE_PLASMA_MEMBRANE
## 1130                                                                                                                    REACTOME_SIGNALLING_TO_RAS
## 1198                                                                                   REACTOME_SYNTHESIS_OF_PROSTAGLANDINS_PG_AND_THROMBOXANES_TX
## 632                                                                                                           REACTOME_MET_ACTIVATES_RAS_SIGNALING
## 711                                                            REACTOME_NEGATIVE_REGULATION_OF_ACTIVITY_OF_TFAP2_AP_2_FAMILY_TRANSCRIPTION_FACTORS
## 1266                                                                           REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER
## 1172                                                                                    REACTOME_SYNTHESIS_OF_12_EICOSATETRAENOIC_ACID_DERIVATIVES
## 1173                                                                                    REACTOME_SYNTHESIS_OF_15_EICOSATETRAENOIC_ACID_DERIVATIVES
## 841                                                                                                                  REACTOME_PLATELET_HOMEOSTASIS
## 871                                                                                                       REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS
## 145                                                                                                                  REACTOME_CARNITINE_METABOLISM
## 517                                                                                                        REACTOME_INACTIVATION_OF_CDC42_AND_RAC1
## 849                                                                    REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS
## 1087                                                                                                        REACTOME_SIGNALING_BY_FGFR4_IN_DISEASE
## 1122                                                                                     REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER
## 1332                                                                                                       REACTOME_VITAMIN_C_ASCORBATE_METABOLISM
## 139                                                                                                            REACTOME_CALCINEURIN_ACTIVATES_NFAT
## 631                                                                                                           REACTOME_MET_ACTIVATES_RAP1_AND_RAC1
## 1222                                                                                 REACTOME_THE_CANONICAL_RETINOID_CYCLE_IN_RODS_TWILIGHT_VISION
## 957                                                                                                        REACTOME_REPRESSION_OF_WNT_TARGET_GENES
## 1042                                                                                                  REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION
## 708                                        REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS
## 1020                                                                                                     REACTOME_RUNX2_REGULATES_BONE_DEVELOPMENT
## 1245                                                                          REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DEATH_RECEPTORS_AND_LIGANDS
## 1259                                                                                                                      REACTOME_TRAIL_SIGNALING
## 111                                                                                                                  REACTOME_BASIGIN_INTERACTIONS
## 126                                                                                                      REACTOME_BIOSYNTHESIS_OF_EPA_DERIVED_SPMS
## 443                                                                                                              REACTOME_GAP_JUNCTION_DEGRADATION
## 674                                                                                                                REACTOME_MITOTIC_G2_G2_M_PHASES
## 129                                                                                                       REACTOME_BIOTIN_TRANSPORT_AND_METABOLISM
## 195                                                                                                               REACTOME_COENZYME_A_BIOSYNTHESIS
## 264                                                                                                      REACTOME_DEFECTS_IN_BIOTIN_BTN_METABOLISM
## 1334                                                                                                                        REACTOME_VLDL_ASSEMBLY
## 115                                                                                          REACTOME_BETA_OXIDATION_OF_BUTANOYL_COA_TO_ACETYL_COA
## 234                                                                                              REACTOME_CYTOCHROME_C_MEDIATED_APOPTOTIC_RESPONSE
## 152                                                                                                               REACTOME_CD209_DC_SIGN_SIGNALING
## 998                                                                                                    REACTOME_ROLE_OF_ABL_IN_ROBO_SLIT_SIGNALING
## 218                                                                                                                   REACTOME_CREATINE_METABOLISM
## 790                                                                                                                        REACTOME_P38MAPK_EVENTS
## 727                                                                                                             REACTOME_NEUREXINS_AND_NEUROLIGINS
## 131                                                                                 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_GENE_EXPRESSION
## 244                                                                              REACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX
## 329                                                                        REACTOME_EGR2_AND_SOX10_MEDIATED_INITIATION_OF_SCHWANN_CELL_MYELINATION
## 930                                                                                                          REACTOME_REGULATION_OF_IFNG_SIGNALING
## 1009                                                            REACTOME_RUNX1_AND_FOXP3_CONTROL_THE_DEVELOPMENT_OF_REGULATORY_T_LYMPHOCYTES_TREGS
## 1011                                                                             REACTOME_RUNX1_REGULATES_ESTROGEN_RECEPTOR_MEDIATED_TRANSCRIPTION
## 1014                                                                     REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_BCR_SIGNALING
## 1018                                                             REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_INTERLEUKIN_SIGNALING
## 1019                                                                     REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_WNT_SIGNALING
## 1021                                                                                               REACTOME_RUNX2_REGULATES_CHONDROCYTE_MATURATION
## 1345                                                                                           REACTOME_ZBP1_DAI_MEDIATED_INDUCTION_OF_TYPE_I_IFNS
## 704                                                                                                           REACTOME_NEF_AND_SIGNAL_TRANSDUCTION
## 1065                                                                                                                 REACTOME_SIGNALING_BY_ACTIVIN
## 1317                                                                        REACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION
## 22                                                                                            REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION
## 458                                                                                                               REACTOME_GLUTATHIONE_CONJUGATION
## 1033                                                                                                                 REACTOME_SARS_COV_1_INFECTION
## 359                                                                                           REACTOME_ESTROGEN_STIMULATED_SIGNALING_THROUGH_PRKCZ
## 1092                                                                                                                  REACTOME_SIGNALING_BY_LEPTIN
## 843                                                                                        REACTOME_POLB_DEPENDENT_LONG_PATCH_BASE_EXCISION_REPAIR
## 955                                                                                              REACTOME_RELEASE_OF_HH_NP_FROM_THE_SECRETING_CELL
## 1225                                                                        REACTOME_THE_ROLE_OF_NEF_IN_HIV_1_REPLICATION_AND_DISEASE_PATHOGENESIS
## 1340                                                                                                REACTOME_WNT_LIGAND_BIOGENESIS_AND_TRAFFICKING
## 1322                                                                                              REACTOME_UPTAKE_AND_FUNCTION_OF_DIPHTHERIA_TOXIN
## 638                                                                                             REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES
## 774                                                                                                                    REACTOME_NUCLEOTIDE_SALVAGE
## 56                                                                                   REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING
## 270                                                                                              REACTOME_DEGRADATION_OF_CYSTEINE_AND_HOMOCYSTEINE
## 730                                                                                                   REACTOME_NEUROTOXICITY_OF_CLOSTRIDIUM_TOXINS
## 737                                                                                                          REACTOME_NGF_STIMULATED_TRANSCRIPTION
## 1136                                                                               REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION
## 1240                                                                                              REACTOME_TOXICITY_OF_BOTULINUM_TOXIN_TYPE_D_BOTD
## 243                                                                                                     REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING
## 375                                                                                                   REACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING
## 664                                                                                                   REACTOME_MITOCHONDRIAL_CALCIUM_ION_TRANSPORT
## 935                                                                              REACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS
## 975                                                                                                          REACTOME_RHO_GTPASES_ACTIVATE_FORMINS
## 1023                                                                                           REACTOME_RUNX2_REGULATES_OSTEOBLAST_DIFFERENTIATION
## 591                                                                                                REACTOME_KSRP_KHSRP_BINDS_AND_DESTABILIZES_MRNA
## 984                                                                                                 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_ZBP1
## 728                                                                                                              REACTOME_NEUROFASCIN_INTERACTIONS
## 67                                                                               REACTOME_AMPK_INHIBITS_CHREBP_TRANSCRIPTIONAL_ACTIVATION_ACTIVITY
## 15                                                                                          REACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_FRS2_AND_FRS3
## 835                                                                                                          REACTOME_PLASMA_LIPOPROTEIN_CLEARANCE
## 30                                                                                           REACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP
## 224                                                                                                                     REACTOME_CRISTAE_FORMATION
## 672                                                                                                                             REACTOME_MITOPHAGY
## 1331                                                                                                   REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM
## 754                                                                           REACTOME_NOTCH4_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS
## 1085                                                                                                 REACTOME_SIGNALING_BY_FGFR3_FUSIONS_IN_CANCER
## 132                                                                                                  REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM
## 173                                                                         REACTOME_CHK1_CHK2_CDS1_MEDIATED_INACTIVATION_OF_CYCLIN_B_CDK1_COMPLEX
## 278                                                                                                                      REACTOME_DEUBIQUITINATION
## 992                                                                                                   REACTOME_RNA_POLYMERASE_III_CHAIN_ELONGATION
## 993                                                                                                      REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION
## 995                                                                      REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER
## 1005                                                                                         REACTOME_RRNA_MODIFICATION_IN_THE_NUCLEUS_AND_CYTOSOL
## 39                                                                                                           REACTOME_ACTIVATION_OF_RAS_IN_B_CELLS
## 758                                                                 REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_CONTROL_BILE_ACID_HOMEOSTASIS
## 684                                                                                                  REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE
## 1238                                                                                                   REACTOME_TNFR1_MEDIATED_CERAMIDE_PRODUCTION
## 1344                                                                                        REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION
## 514                                                                                                          REACTOME_IKBA_VARIANT_LEADS_TO_EDA_ID
## 528                                                                                                         REACTOME_INOSITOL_PHOSPHATE_METABOLISM
## 99                                                                                                REACTOME_ASYMMETRIC_LOCALIZATION_OF_PCP_PROTEINS
## 1026                                                                                   REACTOME_RUNX3_REGULATES_IMMUNE_RESPONSE_AND_CELL_MIGRATION
## 813                                                                                                REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE_FGFR2
## 814                                                                                                REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE_FGFR4
## 1278                                                                                                REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING
## 1303                                                                                REACTOME_TRISTETRAPROLIN_TTP_ZFP36_BINDS_AND_DESTABILIZES_MRNA
## 179                                                                                            REACTOME_CHREBP_ACTIVATES_METABOLIC_GENE_EXPRESSION
## 530                                                                                                                    REACTOME_INSULIN_PROCESSING
## 668                                                                                          REACTOME_MITOCHONDRIAL_IRON_SULFUR_CLUSTER_BIOGENESIS
## 1016                                                  REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_KERATINOCYTES
## 1315                                                                                                     REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES
## 560                                                                                            REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING
## 1268                                                                                                  REACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2
## 936                                                                                           REACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY
## 125                                                                                    REACTOME_BINDING_OF_TCF_LEF_CTNNB1_TO_TARGET_GENE_PROMOTERS
## 123                                                                                                    REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM
## 743                                                                                                     REACTOME_NONCANONICAL_ACTIVATION_OF_NOTCH3
## 641                                                                                                               REACTOME_METABOLISM_OF_COFACTORS
## 1176                                                                             REACTOME_SYNTHESIS_OF_ACTIVE_UBIQUITIN_ROLES_OF_E1_AND_E2_ENZYMES
## 247                                                                                                             REACTOME_DEATH_RECEPTOR_SIGNALLING
## 702                                                                                                  REACTOME_NECTIN_NECL_TRANS_HETERODIMERIZATION
## 1060                                                                                                               REACTOME_SIALIC_ACID_METABOLISM
## 580                                                                                                                        REACTOME_IRS_ACTIVATION
## 174                                                                                                                     REACTOME_CHL1_INTERACTIONS
## 1004                                                                                               REACTOME_RRNA_MODIFICATION_IN_THE_MITOCHONDRION
## 311                                                                                                        REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION
## 1260                                                                                                  REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING
## 177                                                                                                      REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS
## 255                                                                                                         REACTOME_DEFECTIVE_CHST3_CAUSES_SEDCJD
## 437                                                                                       REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION
## 550                                                                                                              REACTOME_INTERLEUKIN_18_SIGNALING
## 904                                                                                                           REACTOME_RECEPTOR_MEDIATED_MITOPHAGY
## 917                                                                                                   REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT
## 1335                                                                                                                       REACTOME_VLDL_CLEARANCE
## 238                                                                                                         REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION
## 393                                                                                                  REACTOME_FGFR3B_LIGAND_BINDING_AND_ACTIVATION
## 604                                                                                REACTOME_LOSS_OF_MECP2_BINDING_ABILITY_TO_THE_NCOR_SMRT_COMPLEX
## 1305                                                                                               REACTOME_TRNA_MODIFICATION_IN_THE_MITOCHONDRION
## 60                                                                                              REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS
## 415                                                                                                          REACTOME_FRS_MEDIATED_FGFR1_SIGNALING
## 416                                                                                                          REACTOME_FRS_MEDIATED_FGFR2_SIGNALING
## 417                                                                                                          REACTOME_FRS_MEDIATED_FGFR3_SIGNALING
## 418                                                                                                          REACTOME_FRS_MEDIATED_FGFR4_SIGNALING
## 651                                                                                    REACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS
## 800                                                                                                                   REACTOME_PECAM1_INTERACTIONS
## 809                                                                                                     REACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS
## 1012                                                                          REACTOME_RUNX1_REGULATES_EXPRESSION_OF_COMPONENTS_OF_TIGHT_JUNCTIONS
## 1191                                                                                                                      REACTOME_SYNTHESIS_OF_PG
## 524                                                                                                      REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT
## 1197                                                                                             REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE
## 707                                                            REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION
## 920                                                    REACTOME_REGULATION_OF_CYTOSKELETAL_REMODELING_AND_CELL_SPREADING_BY_IPP_COMPLEX_COMPONENTS
## 298                                                                                                                   REACTOME_DNA_DAMAGE_REVERSAL
## 567                                                                                                                   REACTOME_INTRA_GOLGI_TRAFFIC
## 994                                                                      REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION_INITIATION_FROM_TYPE_1_PROMOTER
## 582                                                     REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1
## 330                                                                                                   REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS
## 554                                                                                                              REACTOME_INTERLEUKIN_21_SIGNALING
## 555                                                                                                              REACTOME_INTERLEUKIN_23_SIGNALING
## 564                                                                                                               REACTOME_INTERLEUKIN_9_SIGNALING
## 336                                                                                                REACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS
## 914                                                                                                             REACTOME_REELIN_SIGNALLING_PATHWAY
## 460                                                                                                      REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS
## 274                                                                                                REACTOME_DEPOLYMERISATION_OF_THE_NUCLEAR_LAMINA
## 383                                                                                                   REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION
## 385                                                                                                  REACTOME_FGFR1B_LIGAND_BINDING_AND_ACTIVATION
## 386                                                                                                  REACTOME_FGFR1C_LIGAND_BINDING_AND_ACTIVATION
## 388                                                                                                   REACTOME_FGFR2_LIGAND_BINDING_AND_ACTIVATION
## 390                                                                                                  REACTOME_FGFR2B_LIGAND_BINDING_AND_ACTIVATION
## 391                                                                                                  REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION
## 392                                                                                                   REACTOME_FGFR3_LIGAND_BINDING_AND_ACTIVATION
## 867                                                                                                                   REACTOME_PROCESSING_OF_SMDT1
## 171                                                                                                                          REACTOME_CGMP_EFFECTS
## 740                                                                                             REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE
## 1032                                                                                      REACTOME_SARS_COV_1_GENOME_REPLICATION_AND_TRANSCRIPTION
## 924                                                                                           REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS
## 64                                                                                                                 REACTOME_AMINO_ACID_CONJUGATION
## 134                                                                           REACTOME_BUTYRATE_RESPONSE_FACTOR_1_BRF1_BINDS_AND_DESTABILIZES_MRNA
## 206                                                                                                  REACTOME_CONJUGATION_OF_BENZOATE_WITH_GLYCINE
## 738                                                                                                                REACTOME_NICOTINAMIDE_SALVAGING
## 934                                                                                                           REACTOME_REGULATION_OF_KIT_SIGNALING
## 1216                                                                   REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION
## 1186                                                                                           REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX
## 602                                                                                            REACTOME_LOSS_OF_FUNCTION_OF_MECP2_IN_RETT_SYNDROME
## 878                                                                                                                REACTOME_PROTEIN_UBIQUITINATION
## 1333                                                                                                      REACTOME_VITAMIN_D_CALCIFEROL_METABOLISM
## 649                                                                                                                REACTOME_METABOLISM_OF_STEROIDS
## 512                                                                                                                 REACTOME_HYALURONAN_METABOLISM
## 513                                                                                                     REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION
## 911                                                                                                                 REACTOME_RECYCLING_OF_EIF2_GDP
## 48                                                                                                           REACTOME_ACYL_CHAIN_REMODELLING_OF_PS
## 1090                                                                                                        REACTOME_SIGNALING_BY_INSULIN_RECEPTOR
## 943                                                                                      REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX
## 1101                                                                                                                  REACTOME_SIGNALING_BY_NOTCH1
## 144                                                                                         REACTOME_CARGO_TRAFFICKING_TO_THE_PERICILIARY_MEMBRANE
## 747                                                                                                     REACTOME_NOSTRIN_MEDIATED_ENOS_TRAFFICKING
## 766                                                                                                        REACTOME_NUCLEAR_ENVELOPE_NE_REASSEMBLY
## 901                                                                                                                        REACTOME_RAS_PROCESSING
## 598                                                                                                           REACTOME_LINOLEIC_ACID_LA_METABOLISM
## 1070                                                                                                                    REACTOME_SIGNALING_BY_EGFR
## 1330                                                                                                     REACTOME_VITAMIN_B2_RIBOFLAVIN_METABOLISM
## 178                                                                                       REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM
## 1307                                                                                                                      REACTOME_TRNA_PROCESSING
## 697                                                                                     REACTOME_N_GLYCAN_TRIMMING_AND_ELONGATION_IN_THE_CIS_GOLGI
## 128                    REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN
## 233                                                                                                      REACTOME_CYCLIN_D_ASSOCIATED_EVENTS_IN_G1
## 741                                                                                                              REACTOME_NOD1_2_SIGNALING_PATHWAY
## 751                                                                                   REACTOME_NOTCH2_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION
## 611                                                                                              REACTOME_MAP3K8_TPL2_DEPENDENT_MAPK1_3_ACTIVATION
## 1192                                                                                                                      REACTOME_SYNTHESIS_OF_PI
## 208                                                                                                    REACTOME_CONSTITUTIVE_SIGNALING_BY_EGFRVIII
## 221                                                      REACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING
## 1313                                                                                                                  REACTOME_TYROSINE_CATABOLISM
## 637                                                                                                  REACTOME_METABOLISM_OF_AMINE_DERIVED_HORMONES
## 1228                                                                                                               REACTOME_THYROXINE_BIOSYNTHESIS
## 1056                                                                                                REACTOME_SHC_RELATED_EVENTS_TRIGGERED_BY_IGF1R
## 439                                                                   REACTOME_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION
## 733                                                                                                        REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE
## 1271                                                                                                  REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3
## 1323                                                                                                                           REACTOME_UREA_CYCLE
## 752                                                                           REACTOME_NOTCH3_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS
## 19                                                                                                   REACTOME_ACTIVATED_NTRK3_SIGNALS_THROUGH_PI3K
## 242                                                                                                                       REACTOME_DARPP_32_EVENTS
## 294                                                                                              REACTOME_DISPLACEMENT_OF_DNA_GLYCOSYLASE_BY_APEX1
## 397                                                                                                          REACTOME_FOLDING_OF_ACTIN_BY_CCT_TRIC
## 875                                                                                                                   REACTOME_PROTEIN_METHYLATION
## 1089                                                                                                                   REACTOME_SIGNALING_BY_HIPPO
## 1118                                                                                                           REACTOME_SIGNALING_BY_RNF43_MUTANTS
## 1301                                                                                                              REACTOME_TRIGLYCERIDE_CATABOLISM
## 1302                                                                                                              REACTOME_TRIGLYCERIDE_METABOLISM
## 508                                                                                                                       REACTOME_HSF1_ACTIVATION
## 372                                                                           REACTOME_FATTY_ACIDS_BOUND_TO_GPR40_FFAR1_REGULATE_INSULIN_SECRETION
## 819                                                                                                                   REACTOME_PI_3K_CASCADE_FGFR1
## 820                                                                                                                   REACTOME_PI_3K_CASCADE_FGFR2
## 821                                                                                                                   REACTOME_PI_3K_CASCADE_FGFR3
## 822                                                                                                                   REACTOME_PI_3K_CASCADE_FGFR4
## 96                                                                                                             REACTOME_ASSEMBLY_OF_THE_HIV_VIRION
## 633                                                                                                       REACTOME_MET_INTERACTS_WITH_TNS_PROTEINS
## 16                                                                                                    REACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_FYN
## 764                                                                                                                  REACTOME_NTRK2_ACTIVATES_RAC1
## 1058                                                                                                       REACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING
## 595                                                                                                         REACTOME_LATE_ENDOSOMAL_MICROAUTOPHAGY
## 285                                                                         REACTOME_DISEASES_ASSOCIATED_WITH_GLYCOSYLATION_PRECURSOR_BIOSYNTHESIS
## 340                                                                                                                      REACTOME_EPHRIN_SIGNALING
## 1017                                                  REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_MYELOID_CELLS
## 1107                                                                                                                  REACTOME_SIGNALING_BY_NOTCH4
## 254                                                                                  REACTOME_DEFECTIVE_CHST14_CAUSES_EDS_MUSCULOCONTRACTURAL_TYPE
## 1244                                                                                     REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_DEATH_GENES
## 455                                                                                                                       REACTOME_GLUCURONIDATION
## 927                                                                      REACTOME_REGULATION_OF_GLYCOLYSIS_BY_FRUCTOSE_2_6_BISPHOSPHATE_METABOLISM
## 40                                                                                                                      REACTOME_ACTIVATION_OF_SMO
## 347                                                                                                                      REACTOME_ERK_MAPK_TARGETS
## 946                                                                                           REACTOME_REGULATION_OF_RUNX2_EXPRESSION_AND_ACTIVITY
## 1038                                                                                             REACTOME_SCF_SKP2_MEDIATED_DEGRADATION_OF_P27_P21
## 1073                                                                                                       REACTOME_SIGNALING_BY_ERBB2_ECD_MUTANTS
## 518                                                                                         REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION
## 671                                                                                                     REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION
## 1204                                                                REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLUCAGON_LIKE_PEPTIDE_1_GLP_1
## 1308                                                                                                 REACTOME_TRNA_PROCESSING_IN_THE_MITOCHONDRION
## 1255                                                                                          REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR
## 779                                                                                                           REACTOME_ONCOGENE_INDUCED_SENESCENCE
## 1235                                                         REACTOME_TNF_RECEPTOR_SUPERFAMILY_TNFSF_MEMBERS_MEDIATING_NON_CANONICAL_NF_KB_PATHWAY
## 1164                                                                                                 REACTOME_SUMOYLATION_OF_TRANSCRIPTION_FACTORS
## 1110                                                                                                                   REACTOME_SIGNALING_BY_NTRKS
## 824                                                                                                                   REACTOME_PI3K_AKT_ACTIVATION
## 620                                                                                                REACTOME_MATURATION_OF_SARS_COV_1_SPIKE_PROTEIN
## 1281                                                                                        REACTOME_TRANSLATION_OF_SARS_COV_1_STRUCTURAL_PROTEINS
## 862                                                                                                     REACTOME_PROCESSING_AND_ACTIVATION_OF_SUMO
## 1153                                                                                         REACTOME_SUMO_IS_TRANSFERRED_FROM_E1_TO_E2_UBE2I_UBC9
## 1069                                                                                          REACTOME_SIGNALING_BY_CYTOSOLIC_FGFR1_FUSION_MUTANTS
## 1203                                                                                       REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN
## 1205                                             REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLUCOSE_DEPENDENT_INSULINOTROPIC_POLYPEPTIDE_GIP
## 1053                                                                                                           REACTOME_SHC_MEDIATED_CASCADE_FGFR1
## 1054                                                                                                           REACTOME_SHC_MEDIATED_CASCADE_FGFR3
## 1055                                                                                                           REACTOME_SHC_MEDIATED_CASCADE_FGFR4
## 227                                                                            REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES
## 286                                                                                  REACTOME_DISEASES_ASSOCIATED_WITH_N_GLYCOSYLATION_OF_PROTEINS
## 799                                                                                                                        REACTOME_PD_1_SIGNALING
## 618                                                                                                           REACTOME_MATURATION_OF_NUCLEOPROTEIN
## 469                                                                                         REACTOME_GLYOXYLATE_METABOLISM_AND_GLYCINE_DEGRADATION
## 682                                                                                                      REACTOME_MOLYBDENUM_COFACTOR_BIOSYNTHESIS
## 703                                                                                                                           REACTOME_NEDDYLATION
## 1106                                                                                                                  REACTOME_SIGNALING_BY_NOTCH3
## 136                                                                                                                   REACTOME_CA_DEPENDENT_EVENTS
## 553                                                                                                       REACTOME_INTERLEUKIN_20_FAMILY_SIGNALING
## 1316                                                                                                                      REACTOME_UCH_PROTEINASES
## 257                                                                                                           REACTOME_DEFECTIVE_CHSY1_CAUSES_TPBS
## 313                                                                                               REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR1
## 314                                                                                               REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR2
## 315                                                                                               REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR3
## 316                                                                                               REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR4
## 419                                                                                                                   REACTOME_FRUCTOSE_CATABOLISM
## 656                                                                                                            REACTOME_METHIONINE_SALVAGE_PATHWAY
## 1075                                                                                                                   REACTOME_SIGNALING_BY_ERBB4
## 448                                                                                              REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES
## 612                                                                                                        REACTOME_MAPK_FAMILY_SIGNALING_CASCADES
## 889                                                                                                                 REACTOME_PYRIMIDINE_CATABOLISM
## 494                                                                                                                     REACTOME_HEME_BIOSYNTHESIS
## 1074                                                                                                         REACTOME_SIGNALING_BY_ERBB2_IN_CANCER
## 561                                                                                                        REACTOME_INTERLEUKIN_6_FAMILY_SIGNALING
## 562                                                                                                               REACTOME_INTERLEUKIN_6_SIGNALING
## 648                                                                                                        REACTOME_METABOLISM_OF_STEROID_HORMONES
## 127                                                                               REACTOME_BIOSYNTHESIS_OF_SPECIALIZED_PRORESOLVING_MEDIATORS_SPMS
## 692                                                                                                        REACTOME_MYD88_INDEPENDENT_TLR4_CASCADE
## 1325                                                                                                   REACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION
## 116                                                                                    REACTOME_BETA_OXIDATION_OF_DECANOYL_COA_TO_OCTANOYL_COA_COA
## 119                                                                                        REACTOME_BETA_OXIDATION_OF_OCTANOYL_COA_TO_HEXANOYL_COA
## 14                                                                                                   REACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_CDK5
## 74                                                                               REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION
## 112                                                                                             REACTOME_BBSOME_MEDIATED_CARGO_TARGETING_TO_CILIUM
## 210                                                                                         REACTOME_CONSTITUTIVE_SIGNALING_BY_OVEREXPRESSED_ERBB2
## 236                                                                                          REACTOME_CYTOSOLIC_SENSORS_OF_PATHOGEN_ASSOCIATED_DNA
## 240                                                                                                                    REACTOME_DAP12_INTERACTIONS
## 269                                                                                REACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX
## 529                                                           REACTOME_INSERTION_OF_TAIL_ANCHORED_PROTEINS_INTO_THE_ENDOPLASMIC_RETICULUM_MEMBRANE
## 548                                                                                                              REACTOME_INTERLEUKIN_15_SIGNALING
## 667                                                                    REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION_OF_UNSATURATED_FATTY_ACIDS
## 978                                                                                                   REACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES
## 1091                                                                                                          REACTOME_SIGNALING_BY_KIT_IN_DISEASE
## 1206                                                                REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX
## 414                                                                                           REACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION
## 187                                                                                                           REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE
## 18                                                                                                    REACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_RAS
## 20                                                                                                    REACTOME_ACTIVATED_NTRK3_SIGNALS_THROUGH_RAS
## 1059                                                                                                       REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING
## 260                                                                                               REACTOME_DEFECTIVE_FACTOR_IX_CAUSES_HEMOPHILIA_B
## 446                                                                                                               REACTOME_GDP_FUCOSE_BIOSYNTHESIS
## 608                                                                                                           REACTOME_LYSOSOME_VESICLE_BIOGENESIS
## 1134                                                                                                            REACTOME_SLC_TRANSPORTER_DISORDERS
## 420                                                                                                                   REACTOME_FRUCTOSE_METABOLISM
## 194                                                                                    REACTOME_COBALAMIN_CBL_VITAMIN_B12_TRANSPORT_AND_METABOLISM
## 168                                                                                                      REACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS
## 663                                                                                                              REACTOME_MITOCHONDRIAL_BIOGENESIS
## 854                                                                              REACTOME_PP2A_MEDIATED_DEPHOSPHORYLATION_OF_KEY_METABOLIC_FACTORS
## 719                                                                                               REACTOME_NEGATIVE_REGULATION_OF_NOTCH4_SIGNALING
## 1152                                                                                                    REACTOME_SUMO_IS_PROTEOLYTICALLY_PROCESSED
## 5                                                                                                  REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT
## 137                                                                                                              REACTOME_CA2_ACTIVATED_K_CHANNELS
## 226                                                                       REACTOME_CROSS_PRESENTATION_OF_PARTICULATE_EXOGENOUS_ANTIGENS_PHAGOSOMES
## 271                                                                                                                    REACTOME_DEGRADATION_OF_DVL
## 348                                                                                                                  REACTOME_ERKS_ARE_INACTIVATED
## 565                                                                                                    REACTOME_INTERLEUKIN_RECEPTOR_SHC_SIGNALING
## 657                                                                                                                           REACTOME_METHYLATION
## 726                                                                                                     REACTOME_NETRIN_MEDIATED_REPULSION_SIGNALS
## 903                                                                          REACTOME_REACTIONS_SPECIFIC_TO_THE_COMPLEX_N_GLYCAN_SYNTHESIS_PATHWAY
## 928                                                                                       REACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE
## 1150                                                                                                         REACTOME_SULFUR_AMINO_ACID_METABOLISM
## 760                                                                                                       REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK
## 475                                                                                                        REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING
## 98                                                                       REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS
## 6                                                                                                               REACTOME_ABC_TRANSPORTER_DISORDERS
## 603                                                                                                 REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER
## 947                                                                                           REACTOME_REGULATION_OF_RUNX3_EXPRESSION_AND_ACTIVITY
## 1024                                                                                            REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION
## 1025                                                                                                 REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION
## 17                                                                                                   REACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_PI3K
## 1132                                                                 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS
## 1145                                                                                                                 REACTOME_STABILIZATION_OF_P53
## 1076                                                                                                          REACTOME_SIGNALING_BY_ERYTHROPOIETIN
## 989                                                                                            REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION_TERMINATION
## 169                                                                                                          REACTOME_CELLULAR_RESPONSE_TO_HYPOXIA
## 408                                                                                                     REACTOME_FORMATION_OF_XYLULOSE_5_PHOSPHATE
## 1062                                                                                                                   REACTOME_SIGNAL_ATTENUATION
## 646                                                                                                              REACTOME_METABOLISM_OF_POLYAMINES
## 735                                                              REACTOME_NF_KB_ACTIVATION_THROUGH_FADD_RIP_1_PATHWAY_MEDIATED_BY_CASPASE_8_AND_10
## 804                                                                                                        REACTOME_PERK_REGULATES_GENE_EXPRESSION
## 38                                                                                                REACTOME_ACTIVATION_OF_RAC1_DOWNSTREAM_OF_NMDARS
## 229                                                                                                                     REACTOME_CS_DS_DEGRADATION
## 428                                                                                                           REACTOME_G1_S_DNA_DAMAGE_CHECKPOINTS
## 474                                                                                                      REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE
## 100                                                                      REACTOME_ATF4_ACTIVATES_GENES_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS
## 252                                                                         REACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TN_POLYAGGLUTINATION_SYNDROME_TNPS
## 456                                                                                                    REACTOME_GLUTAMATE_AND_GLUTAMINE_METABOLISM
## 186                                                                                                                       REACTOME_CIRCADIAN_CLOCK
## 384                                                                                                      REACTOME_FGFR1_MUTANT_RECEPTOR_ACTIVATION
## 493                                                                                                                     REACTOME_HEDGEHOG_ON_STATE
## 1080                                                                                                        REACTOME_SIGNALING_BY_FGFR1_IN_DISEASE
## 1251                                                                                               REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY
## 1254                                                                                                      REACTOME_TRAF6_MEDIATED_NF_KB_ACTIVATION
## 45                                                                                                            REACTOME_ACYL_CHAIN_REMODELING_OF_CL
## 826                                                                                                       REACTOME_PI5P_REGULATES_TP53_ACETYLATION
## 43                                                                                            REACTOME_ACTIVATION_OF_THE_PHOTOTRANSDUCTION_CASCADE
## 859                                                                                                             REACTOME_PREGNENOLONE_BIOSYNTHESIS
## 1146                                                                                                                     REACTOME_STAT5_ACTIVATION
## 1253                                                                                                       REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION
## 547                                                                                                              REACTOME_INTERLEUKIN_12_SIGNALING
## 117                                                                                        REACTOME_BETA_OXIDATION_OF_HEXANOYL_COA_TO_BUTANOYL_COA
## 118                                                                                     REACTOME_BETA_OXIDATION_OF_LAUROYL_COA_TO_DECANOYL_COA_COA
## 248                                                                                        REACTOME_DECTIN_1_MEDIATED_NONCANONICAL_NF_KB_SIGNALING
## 1066                                                                                                                     REACTOME_SIGNALING_BY_BMP
## 1223                                                                                                        REACTOME_THE_PHOTOTRANSDUCTION_CASCADE
## 1108                                                                                                              REACTOME_SIGNALING_BY_NTRK2_TRKB
## 1339                                                                                                     REACTOME_WAX_AND_PLASMALOGEN_BIOSYNTHESIS
## 1008                                                                                                                       REACTOME_RSK_ACTIVATION
## 1142                                                                                                              REACTOME_SOS_MEDIATED_SIGNALLING
## 666                                                                      REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION_OF_SATURATED_FATTY_ACIDS
## 272                                                                                                 REACTOME_DEGRADATION_OF_GLI1_BY_THE_PROTEASOME
## 546                                                                                                       REACTOME_INTERLEUKIN_12_FAMILY_SIGNALING
## 422                                                                                                           REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS
## 410                                                                                                           REACTOME_FOXO_MEDIATED_TRANSCRIPTION
## 1160                                                                                               REACTOME_SUMOYLATION_OF_INTRACELLULAR_RECEPTORS
## 929                                                                                                          REACTOME_REGULATION_OF_IFNA_SIGNALING
## 192                                                                                                             REACTOME_CLEC7A_DECTIN_1_SIGNALING
## 1232                                                                                                                       REACTOME_TIE2_SIGNALING
## 1239                                                                                                    REACTOME_TNFR2_NON_CANONICAL_NF_KB_PATHWAY
## 1128                                                                                                           REACTOME_SIGNALING_BY_WNT_IN_CANCER
## 937                                                                   REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS
## 1258                                                                                  REACTOME_TRAFFICKING_OF_MYRISTOYLATED_PROTEINS_TO_THE_CILIUM
## 253                                                                                                 REACTOME_DEFECTIVE_CFTR_CAUSES_CYSTIC_FIBROSIS
## 1057                                                                                                        REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING
## 447                                                    REACTOME_GENE_AND_PROTEIN_EXPRESSION_BY_JAK_STAT_SIGNALING_AFTER_INTERLEUKIN_12_STIMULATION
## 798                                                                                                                        REACTOME_PCP_CE_PATHWAY
## 559                                                                                                              REACTOME_INTERLEUKIN_37_SIGNALING
## 491                                                                                                            REACTOME_HEDGEHOG_LIGAND_BIOGENESIS
## 1304                                                                                                                  REACTOME_TRNA_AMINOACYLATION
## 378                                                                                                       REACTOME_FCERI_MEDIATED_NF_KB_ACTIVATION
## 1114                                                            REACTOME_SIGNALING_BY_PDGFRA_TRANSMEMBRANE_JUXTAMEMBRANE_AND_KINASE_DOMAIN_MUTANTS
## 1151                                                                                                   REACTOME_SUMO_IS_CONJUGATED_TO_E1_UBA2_SAE1
## 1137                                                                                               REACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS
## 268                                                                                                                   REACTOME_DEGRADATION_OF_AXIN
## 47                                                                                                           REACTOME_ACYL_CHAIN_REMODELLING_OF_PI
## 151                                                                                         REACTOME_CD163_MEDIATING_AN_ANTI_INFLAMMATORY_RESPONSE
## 293                                                                                               REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS
## 360                                                                                                                     REACTOME_ETHANOL_OXIDATION
## 81                                                 REACTOME_APEX1_INDEPENDENT_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY
## 544                                                                                                               REACTOME_INTERLEUKIN_1_SIGNALING
## 1124                                                                                                 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR
## 1209                                                                                                                        REACTOME_TCR_SIGNALING
## 312                                                                                    REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR
## 942                                                                                             REACTOME_REGULATION_OF_PTEN_STABILITY_AND_ACTIVITY
## 105                                                                                             REACTOME_AUF1_HNRNP_D0_BINDS_AND_DESTABILIZES_MRNA
## 239                                                                                                                 REACTOME_DAG_AND_IP3_SIGNALING
## 556                                                                                                              REACTOME_INTERLEUKIN_27_SIGNALING
## 558                                                                                                             REACTOME_INTERLEUKIN_35_SIGNALLING
## 944                                                                                                             REACTOME_REGULATION_OF_RAS_BY_GAPS
## 89                                                                                                            REACTOME_ARACHIDONIC_ACID_METABOLISM
## 113                                                                                                REACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING
## 445                                                                                      REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK
## 1182                                                                                                             REACTOME_SYNTHESIS_OF_GDP_MANNOSE
## 918                                                                                 REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF
## 328                                                                                                       REACTOME_EGFR_TRANSACTIVATION_BY_GASTRIN
## 353                                                                                                          REACTOME_ERYTHROPOIETIN_ACTIVATES_RAS
## 1120                                                                                                                 REACTOME_SIGNALING_BY_SCF_KIT
## 135                                                                                                          REACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS
##      pval_iDUX4dmso_WTdmso padj_iDUX4dmso_WTdmso ES_iDUX4dmso_WTdmso
## 21            1.962806e-06          9.083686e-05          -0.6804077
## 24            1.607477e-07          3.143281e-05          -0.6877521
## 108           2.715046e-06          1.118206e-04          -0.6151938
## 109           1.626615e-05          4.263426e-04          -0.6349016
## 110           3.031167e-06          1.135004e-04          -0.7549700
## 170           1.183244e-03          1.715067e-02          -0.4482367
## 181           4.279577e-06          1.518124e-04          -0.5960109
## 205           1.621075e-07          3.143281e-05          -0.6929581
## 275           4.724679e-05          1.044077e-03          -0.6957068
## 299           2.502571e-02          1.747909e-01          -0.4687977
## 300           3.264535e-07          3.143281e-05          -0.6987460
## 341           1.240886e-06          6.690860e-05          -0.5832310
## 346           1.928972e-06          9.083686e-05          -0.6337363
## 404           7.715889e-06          2.363868e-04          -0.6173947
## 483           4.798831e-07          3.593791e-05          -0.6735817
## 487           1.648903e-07          3.143281e-05          -0.8323887
## 504           1.597086e-06          8.280276e-05          -0.6228373
## 521           1.676273e-05          4.263426e-04          -0.6879882
## 624           3.161178e-07          3.143281e-05          -0.6383128
## 625           3.220526e-07          3.143281e-05          -0.6713978
## 709           1.114541e-06          6.260007e-05          -0.6209321
## 788           7.291131e-06          2.340106e-04          -0.5893461
## 847           5.187120e-06          1.748059e-04          -0.5813238
## 855           3.258980e-07          3.143281e-05          -0.7007887
## 856           1.639968e-05          4.263426e-04          -0.5867670
## 865           8.091910e-07          4.742563e-05          -0.6744055
## 906           3.031167e-06          1.135004e-04          -0.7549700
## 958           3.156841e-07          3.143281e-05          -0.6311610
## 980           4.646931e-05          1.044011e-03          -0.5583156
## 986           2.737447e-06          1.118206e-04          -0.6366616
## 987           8.049945e-06          2.411406e-04          -0.5820680
## 1013          2.093342e-05          4.950570e-04          -0.6056671
## 1131          4.579882e-06          1.582995e-04          -0.6679842
## 1213          2.009109e-05          4.924143e-04          -0.5881665
## 1272          2.958676e-06          1.135004e-04          -0.5693014
## 1275          1.229970e-05          3.527659e-04          -0.6256356
## 355           6.632595e-06          2.180668e-04          -0.5092564
## 626           2.056567e-05          4.950451e-04          -0.6605813
## 744           1.978684e-06          9.083686e-05          -0.7002166
## 431           6.461656e-07          4.377679e-05          -0.6727323
## 985           1.594531e-07          3.143281e-05          -0.6580429
## 405           2.410050e-07          3.143281e-05           0.9131373
## 479           1.594531e-07          3.143281e-05          -0.6677623
## 520           2.904978e-07          3.143281e-05          -0.4871438
## 587           2.410050e-07          3.143281e-05           0.9131373
## 832           1.632267e-07          3.143281e-05          -0.7414497
## 162           3.961208e-07          3.559806e-05          -0.4077302
## 161           4.326238e-07          3.585858e-05          -0.4811119
## 430           4.522224e-07          3.585858e-05          -0.5359285
## 160           6.495073e-07          4.377679e-05          -0.3960829
## 482           7.755540e-07          4.742563e-05          -0.5879258
## 647           7.424927e-07          4.742563e-05          -0.3585089
## 1031          2.256469e-04          4.473117e-03          -0.4639407
## 357           2.021592e-06          9.083686e-05          -0.5784570
## 1048          5.753653e-05          1.250956e-03          -0.5592039
## 366           2.487404e-06          1.081619e-04           0.4694275
## 1144          1.619737e-03          2.314461e-02          -0.4191795
## 180           3.780946e-06          1.377491e-04          -0.5221289
## 677           1.812732e-05          4.525115e-04          -0.4979315
## 362           1.038553e-05          3.043411e-04          -0.4795498
## 932           4.628580e-03          5.378729e-02           0.4361836
## 1155          7.531185e-06          2.360939e-04          -0.6102822
## 1111          8.491651e-05          1.788554e-03          -0.4491912
## 1154          6.682675e-05          1.429880e-03          -0.4895905
## 973           5.041348e-02          2.724515e-01          -0.3069271
## 967           1.651372e-02          1.334495e-01           0.3737118
## 1037          2.677202e-01          6.633948e-01          -0.5352821
## 745           3.418376e-05          7.810120e-04          -0.4850463
## 863           1.286778e-05          3.613701e-04          -0.4190481
## 44            5.653121e-03          6.047943e-02          -0.6756948
## 673           8.290818e-04          1.241780e-02          -0.4578803
## 200           1.439417e-05          3.959866e-04           0.6272081
## 1006          1.660017e-05          4.263426e-04          -0.4355312
## 480           2.632257e-04          5.068975e-03          -0.4655378
## 688           2.532239e-05          5.885273e-04          -0.4362949
## 965           5.309793e-04          9.060254e-03          -0.4555847
## 25            2.081866e-03          2.834702e-02          -0.7074114
## 1015          2.013673e-04          4.051390e-03          -0.4801831
## 361           3.054346e-04          5.798955e-03          -0.4647156
## 836           7.352636e-01          9.835183e-01           0.3088468
## 1041          4.193688e-03          5.002736e-02          -0.4012295
## 304           6.203188e-04          9.723136e-03          -0.6945487
## 1319          5.216278e-04          9.014799e-03          -0.8652939
## 204           4.062303e-04          7.292536e-03          -0.8282680
## 734           4.111519e-04          7.292536e-03           0.3279382
## 301           2.198550e-03          2.934302e-02          -0.4479557
## 609           3.163161e-04          5.922141e-03          -0.3619221
## 895           7.236199e-01          9.835183e-01          -0.2629894
## 197           1.542424e-04          3.198749e-03           0.6364581
## 535           1.569989e-04          3.206583e-03           0.5719845
## 1208          5.879058e-04          9.548156e-03          -0.4248772
## 1127          7.500517e-04          1.148943e-02          -0.3905199
## 124           8.180077e-02          3.686281e-01           0.4579748
## 481           2.513975e-04          4.911360e-03          -0.4509158
## 184           8.396363e-01          9.992585e-01          -0.3389029
## 1100          4.082004e-04          7.292536e-03          -0.4220674
## 495           9.224189e-02          3.947367e-01           0.2422828
## 1291          2.553491e-02          1.767374e-01           0.6941777
## 324           3.957484e-04          7.292536e-03           0.5921496
## 837           5.398940e-02          2.799143e-01           0.2983940
## 182           8.547556e-01          9.992585e-01          -0.3073685
## 1269          6.052364e-04          9.712603e-03          -0.4225415
## 921           4.810494e-04          8.421488e-03          -0.4057566
## 1035          1.928652e-01          5.764574e-01          -0.8171700
## 689           5.428922e-04          9.147733e-03          -0.5811964
## 568           5.514194e-04          9.176708e-03           0.7217233
## 563           5.610298e-04          9.222783e-03          -0.6969512
## 669           8.471085e-01          9.992585e-01          -0.2420509
## 95            6.136264e-04          9.723136e-03           0.6231354
## 273           6.661040e-04          1.032078e-02           0.5110084
## 1279          7.934294e-04          1.201734e-02          -0.3596474
## 203           2.554972e-01          6.558699e-01           0.4007289
## 42            7.855906e-03          7.962226e-02          -0.4490114
## 780           9.767029e-04          1.446808e-02           0.5466017
## 642           6.909267e-01          9.691667e-01           0.2796205
## 198           1.174623e-03          1.715067e-02           0.6792577
## 435           8.822105e-01          9.992585e-01          -0.2943614
## 724           9.757472e-01          9.992585e-01          -0.1716840
## 894           3.337389e-01          7.133898e-01          -0.3332165
## 303           7.756757e-02          3.544902e-01          -0.3750907
## 886           8.563502e-01          9.992585e-01           0.3497930
## 1067          1.631111e-03          2.314461e-02           0.5562822
## 801           1.888535e-02          1.430194e-01           0.6736390
## 93            1.736711e-03          2.413491e-02           0.6394198
## 199           1.722129e-03          2.413491e-02           0.5947683
## 676           1.324222e-01          4.936480e-01          -0.3156481
## 537           5.558555e-01          8.941246e-01          -0.4587623
## 701           1.900061e-03          2.613553e-02           0.7520042
## 1119          8.079633e-03          8.067663e-02          -0.3455293
## 320           8.743642e-02          3.834164e-01          -0.8823655
## 510           2.137739e-03          2.881672e-02           0.5130398
## 211           1.140357e-01          4.534518e-01          -0.6439514
## 402           4.766401e-02          2.655004e-01           0.6170744
## 331           2.289065e-03          2.953030e-02           0.6799353
## 442           2.279301e-03          2.953030e-02           0.7037954
## 1289          2.279301e-03          2.953030e-02           0.7037954
## 1311          2.300209e-03          2.953030e-02           0.9571367
## 851           4.296791e-01          7.967091e-01          -0.5119951
## 787           2.364175e-03          3.006517e-02          -0.7642679
## 1169          4.883796e-03          5.532232e-02          -0.4529851
## 680           7.039339e-01          9.722366e-01          -0.5050990
## 500           2.542296e-03          3.202818e-02          -0.4280946
## 486           7.889759e-01          9.912193e-01          -0.3622018
## 55            6.665189e-01          9.578545e-01          -0.4378395
## 364           1.719131e-02          1.360232e-01          -0.5509476
## 91            5.497712e-02          2.839431e-01           0.2788082
## 485           1.001935e-01          4.117708e-01          -0.8731401
## 1096          1.934154e-01          5.768229e-01           0.3330613
## 52            7.261076e-01          9.835183e-01           0.2897549
## 640           3.148404e-03          3.929674e-02           0.3542267
## 861           9.490076e-01          9.992585e-01          -0.2737837
## 425           9.801154e-02          4.040353e-01          -0.6559396
## 54            8.268203e-01          9.952257e-01          -0.3308476
## 655           4.109882e-02          2.456782e-01           0.9796487
## 436           9.128498e-01          9.992585e-01           0.2564486
## 1329          9.298229e-01          9.992585e-01          -0.2159019
## 811           3.768102e-03          4.660001e-02           0.9807717
## 1285          3.851979e-03          4.720425e-02           0.4755933
## 94            6.093327e-01          9.312704e-01           0.4346145
## 212           3.960120e-03          4.809226e-02           0.5745303
## 627           1.772818e-01          5.596625e-01           0.2206295
## 444           4.145923e-03          4.989915e-02           0.5867441
## 896           6.421360e-01          9.470453e-01          -0.2550577
## 1061          9.691966e-01          9.992585e-01          -0.2131839
## 65            4.483035e-03          5.254897e-02           0.9080530
## 228           4.454855e-03          5.254897e-02           0.8201506
## 794           4.752167e-03          5.428746e-02          -0.8991741
## 976           4.722107e-03          5.428746e-02           0.5974246
## 781           1.741066e-02          1.360232e-01          -0.4305709
## 681           5.004666e-03          5.621908e-02           0.6891390
## 1299          5.083308e-03          5.663057e-02           0.3613232
## 1183          5.235923e-03          5.785266e-02           0.8699339
## 165           5.298153e-03          5.806432e-02           0.5293119
## 59            5.379435e-03          5.847967e-02           0.8133950
## 407           5.471657e-03          5.900635e-02           0.6088035
## 7             2.719605e-02          1.835400e-01          -0.8344514
## 797           2.139490e-01          6.110240e-01          -0.4855665
## 368           1.886425e-01          5.714385e-01          -0.3165168
## 922           3.296893e-01          7.110738e-01           0.6721981
## 426           6.559777e-02          3.169383e-01          -0.6212756
## 566           2.306362e-01          6.293473e-01           0.2549545
## 834           5.070192e-01          8.673374e-01           0.2944838
## 1274          7.196759e-01          9.829009e-01           0.3011952
## 429           6.422210e-03          6.763390e-02          -0.7717857
## 1095          6.391842e-03          6.763390e-02          -0.9724373
## 571           7.764416e-01          9.892193e-01          -0.2914782
## 583           8.415237e-01          9.992585e-01          -0.3560108
## 71            6.035641e-01          9.254452e-01           0.2860077
## 817           2.392372e-02          1.697325e-01          -0.7410790
## 1039          6.559854e-03          6.854793e-02           0.5850560
## 593           2.997091e-02          1.951729e-01          -0.6491407
## 523           6.620351e-02          3.187226e-01          -0.6390215
## 952           9.347289e-01          9.992585e-01          -0.3483157
## 1077          5.510613e-01          8.938996e-01          -0.2991744
## 1081          5.510613e-01          8.938996e-01          -0.2991744
## 158           7.045175e-03          7.305305e-02           0.4488276
## 977           2.634385e-01          6.564049e-01          -0.5020327
## 939           7.404300e-03          7.619081e-02          -0.5887742
## 675           2.690403e-01          6.642241e-01          -0.2654308
## 290           7.633599e-03          7.795523e-02           0.3994417
## 742           8.036637e-03          8.067663e-02           0.5197459
## 223           2.173255e-01          6.141610e-01          -0.7358201
## 23            8.284546e-03          8.172834e-02           0.6316031
## 912           8.306218e-03          8.172834e-02           0.5238291
## 323           8.684352e-03          8.421947e-02          -0.7202489
## 610           8.628864e-03          8.421947e-02           0.5741802
## 960           2.764604e-01          6.700072e-01          -0.4406940
## 1267          9.027646e-03          8.692334e-02          -0.7590271
## 176           9.007817e-01          9.992585e-01          -0.4381830
## 833           8.544934e-01          9.992585e-01           0.2647555
## 343           9.274733e-03          8.866908e-02           0.3550939
## 949           9.369304e-03          8.894241e-02          -0.4649505
## 287           9.526315e-03          8.980051e-02           0.7253962
## 83            1.252208e-01          4.741506e-01           0.5253060
## 959           2.593464e-01          6.558699e-01          -0.4315105
## 401           9.890866e-03          9.258950e-02          -0.5306635
## 953           1.033248e-02          9.539851e-02          -0.5397007
## 1097          1.026734e-02          9.539851e-02           0.5522552
## 349           3.647511e-02          2.245134e-01           0.8706520
## 945           9.331606e-01          9.992585e-01           0.2454936
## 687           5.053493e-01          8.655793e-01           0.7476435
## 899           1.504985e-02          1.243222e-01           0.7447784
## 1159          3.755094e-01          7.562630e-01           0.5456910
## 35            1.094795e-02          1.003934e-01           0.4693445
## 53            8.415535e-01          9.992585e-01          -0.3132278
## 762           1.917551e-01          5.756051e-01          -0.6565874
## 853           4.873292e-01          8.484152e-01           0.7566410
## 225           1.138750e-02          1.033333e-01          -0.7498611
## 1210          1.142186e-02          1.033333e-01          -0.6629294
## 763           1.167823e-02          1.049484e-01          -0.5069911
## 1046          1.181327e-02          1.054589e-01          -0.8696228
## 1098          1.196105e-02          1.060756e-01           0.8386436
## 670           1.775122e-02          1.367351e-01          -0.4588657
## 890           8.077396e-01          9.945825e-01           0.3742702
## 58            1.215687e-02          1.071076e-01           0.5320554
## 376           2.662957e-01          6.610804e-01          -0.5170566
## 519           7.344267e-01          9.835183e-01           0.2797162
## 569           7.512148e-01          9.892193e-01           0.2792023
## 905           7.457427e-01          9.877613e-01           0.4034298
## 172           6.380993e-01          9.431555e-01          -0.3572770
## 342           8.968044e-01          9.992585e-01          -0.3250471
## 526           9.631505e-01          9.992585e-01           0.2806724
## 467           1.279806e-02          1.120246e-01           0.5123237
## 502           2.782838e-01          6.700072e-01          -0.4319776
## 1171          1.322964e-02          1.150552e-01           0.5901648
## 237           1.356246e-02          1.155027e-01           0.7742534
## 729           1.362384e-02          1.155027e-01           0.3693334
## 1133          1.349930e-02          1.155027e-01           0.5276371
## 1287          1.338051e-02          1.155027e-01           0.9134162
## 473           1.427823e-02          1.202941e-01           0.7994386
## 1286          1.447773e-02          1.212172e-01           0.3866829
## 773           1.459462e-02          1.214417e-01          -0.4380792
## 11            3.203019e-01          7.078148e-01           0.6768822
## 399           5.021089e-01          8.622201e-01           0.3167679
## 650           3.355805e-01          7.157634e-01           0.2758245
## 746           3.203019e-01          7.078148e-01           0.6768822
## 1052          3.203019e-01          7.078148e-01           0.6768822
## 306           7.862278e-01          9.912193e-01          -0.3481776
## 256           1.755789e-02          1.360232e-01           0.8591640
## 263           1.755789e-02          1.360232e-01           0.8591640
## 1195          1.512525e-02          1.243222e-01           0.7967187
## 465           3.035480e-01          6.895342e-01           0.4607515
## 79            4.694846e-02          2.625997e-01          -0.3907891
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## 733           7.513087e-01          9.892193e-01           0.3111168
## 1271          9.925553e-01          9.992585e-01           0.1562899
## 1323          6.037004e-01          9.254452e-01          -0.6269337
## 752           5.927912e-01          9.217921e-01          -0.3812550
## 19            6.321098e-01          9.399287e-01           0.6842331
## 242           5.456532e-01          8.938996e-01          -0.3692224
## 294           7.828609e-01          9.892193e-01          -0.5347033
## 397           9.174804e-01          9.992585e-01           0.2540899
## 875           9.501774e-01          9.992585e-01           0.2498927
## 1089          5.683319e-01          9.052055e-01           0.3671457
## 1118          4.735194e-01          8.363555e-01           0.7634961
## 1301          4.032581e-01          7.821264e-01           0.4096179
## 1302          4.032581e-01          7.821264e-01           0.4096179
## 508           3.706303e-01          7.490399e-01           0.3581392
## 372           6.749455e-01          9.604041e-01          -0.4678800
## 819           9.137618e-01          9.992585e-01           0.3173450
## 820           9.137618e-01          9.992585e-01           0.3173450
## 821           9.137618e-01          9.992585e-01           0.3173450
## 822           9.137618e-01          9.992585e-01           0.3173450
## 96            9.698124e-01          9.992585e-01          -0.2440506
## 633           4.506627e-01          8.132440e-01          -0.6281578
## 16            6.775551e-01          9.604041e-01           0.5697019
## 764           6.775551e-01          9.604041e-01           0.5697019
## 1058          9.251853e-01          9.992585e-01           0.2441233
## 595           9.171098e-01          9.992585e-01           0.2322161
## 285           9.126882e-01          9.992585e-01          -0.2640601
## 340           4.274367e-01          7.951545e-01          -0.4513852
## 1017          9.385334e-01          9.992585e-01           0.3259811
## 1107          3.786850e-01          7.596241e-01          -0.2979250
## 254           5.616752e-01          8.992140e-01          -0.5777184
## 1244          6.557449e-01          9.544176e-01          -0.3439262
## 455           3.810631e-01          7.626776e-01          -0.6588545
## 927           4.951758e-01          8.557654e-01           0.4347981
## 40            8.651003e-01          9.992585e-01           0.3763395
## 347           8.995831e-01          9.992585e-01           0.2704734
## 946           6.727624e-01          9.596653e-01          -0.2509477
## 1038          6.158986e-01          9.350200e-01          -0.2635700
## 1073          6.986829e-01          9.722366e-01           0.3196867
## 518           9.213268e-01          9.992585e-01           0.2935115
## 671           7.423230e-01          9.877613e-01          -0.3416580
## 1204          9.213268e-01          9.992585e-01           0.2935115
## 1308          6.371772e-01          9.428265e-01           0.4542882
## 1255          5.870849e-01          9.217921e-01           0.4442226
## 779           9.581684e-01          9.992585e-01           0.2191475
## 1235          9.700110e-01          9.992585e-01           0.5147815
## 1164          7.258539e-01          9.835183e-01           0.3657915
## 1110          3.978330e-01          7.806097e-01           0.2824205
## 824           3.936773e-01          7.758436e-01          -0.6006481
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## 1281          9.781784e-01          9.992585e-01          -0.2066853
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## 1153          4.018083e-01          7.821264e-01          -0.5562248
## 1069          9.628395e-01          9.992585e-01           0.2402063
## 1203          6.490207e-01          9.519913e-01          -0.5349336
## 1205          6.490207e-01          9.519913e-01          -0.5349336
## 1053          5.427797e-01          8.938996e-01           0.4165225
## 1054          5.427797e-01          8.938996e-01           0.4165225
## 1055          5.427797e-01          8.938996e-01           0.4165225
## 227           9.734264e-01          9.992585e-01          -0.1833533
## 286           4.163788e-01          7.872071e-01          -0.4413827
## 799           5.430684e-01          8.938996e-01          -0.5330570
## 618           6.307722e-01          9.399287e-01           0.4573819
## 469           7.712740e-01          9.892193e-01           0.2978491
## 682           7.699682e-01          9.892193e-01           0.6152528
## 703           7.469712e-01          9.881425e-01          -0.2220790
## 1106          5.372656e-01          8.938996e-01          -0.3581338
## 136           4.241552e-01          7.931218e-01           0.3829952
## 553           4.234315e-01          7.931218e-01           0.5664058
## 1316          4.218579e-01          7.931218e-01           0.2633291
## 257           6.240585e-01          9.350200e-01           0.6001714
## 313           8.123407e-01          9.945825e-01           0.2982332
## 314           8.123407e-01          9.945825e-01           0.2982332
## 315           8.123407e-01          9.945825e-01           0.2982332
## 316           8.123407e-01          9.945825e-01           0.2982332
## 419           5.723310e-01          9.076497e-01           0.6273179
## 656           9.402569e-01          9.992585e-01          -0.2805819
## 1075          8.027478e-01          9.945825e-01           0.2592549
## 448           7.686403e-01          9.892193e-01          -0.3427181
## 612           5.339560e-01          8.919116e-01           0.2181572
## 889           7.956226e-01          9.912193e-01           0.4159573
## 494           4.348486e-01          8.041113e-01           0.4833487
## 1074          7.572543e-01          9.892193e-01           0.2960978
## 561           4.389716e-01          8.061767e-01           0.6178740
## 562           4.389716e-01          8.061767e-01           0.6178740
## 648           4.378693e-01          8.061767e-01          -0.5402316
## 127           4.457707e-01          8.065758e-01           0.5545776
## 692           4.426420e-01          8.065758e-01           0.2865068
## 1325          7.345827e-01          9.835183e-01           0.3247754
## 116           9.873278e-01          9.992585e-01           0.2356346
## 119           9.873278e-01          9.992585e-01           0.2356346
## 14            6.625309e-01          9.564741e-01           0.6688089
## 74            7.087585e-01          9.768983e-01          -0.2208171
## 112           6.641629e-01          9.564741e-01           0.3723724
## 210           5.702197e-01          9.053665e-01           0.3665616
## 236           8.059951e-01          9.945825e-01          -0.2525562
## 240           8.505214e-01          9.992585e-01           0.2580016
## 269           9.713451e-01          9.992585e-01          -0.1810353
## 529           9.347575e-01          9.992585e-01          -0.2417866
## 548           8.373037e-01          9.992585e-01           0.3927339
## 667           8.551533e-01          9.992585e-01          -0.3488422
## 978           6.355793e-01          9.425312e-01           0.3466092
## 1091          7.540241e-01          9.892193e-01           0.3183666
## 1206          6.643855e-01          9.564741e-01           0.3161134
## 414           8.515214e-01          9.992585e-01          -0.3330792
## 187           9.974306e-01          9.992585e-01           0.1511178
## 18            7.611151e-01          9.892193e-01           0.3709254
## 20            7.611151e-01          9.892193e-01           0.3709254
## 1059          7.611151e-01          9.892193e-01           0.3709254
## 260           6.993149e-01          9.722366e-01           0.3967421
## 446           6.041482e-01          9.254452e-01          -0.6267409
## 608           9.543087e-01          9.992585e-01           0.2009583
## 1134          8.963180e-01          9.992585e-01          -0.2203238
## 420           9.106806e-01          9.992585e-01           0.3192640
## 194           6.225671e-01          9.350200e-01           0.5139057
## 168           8.022965e-01          9.945825e-01           0.2095995
## 663           7.794798e-01          9.892193e-01          -0.2453946
## 854           9.470718e-01          9.992585e-01           0.2943112
## 719           7.126975e-01          9.777803e-01          -0.2475156
## 1152          8.485640e-01          9.992585e-01          -0.4907629
## 5             6.763280e-01          9.604041e-01          -0.2437262
## 137           4.828961e-01          8.450569e-01          -0.7585690
## 226           5.638610e-01          9.005742e-01           0.6316692
## 271           6.023472e-01          9.254452e-01          -0.2668474
## 348           7.668912e-01          9.892193e-01           0.3352708
## 565           8.650308e-01          9.992585e-01           0.3451767
## 657           9.263471e-01          9.992585e-01          -0.2563175
## 726           7.652381e-01          9.892193e-01           0.6176093
## 903           9.017998e-01          9.992585e-01           0.4054204
## 928           9.116661e-01          9.992585e-01           0.1937139
## 1150          8.315382e-01          9.981421e-01           0.2542275
## 760           8.563063e-01          9.992585e-01          -0.2593731
## 475           8.111486e-01          9.945825e-01           0.3319172
## 98            8.491255e-01          9.992585e-01          -0.2540105
## 6             8.757196e-01          9.992585e-01          -0.2143807
## 603           9.008635e-01          9.992585e-01           0.5497001
## 947           9.423409e-01          9.992585e-01           0.1897620
## 1024          9.008635e-01          9.992585e-01           0.5497001
## 1025          9.008635e-01          9.992585e-01           0.5497001
## 17            5.192187e-01          8.781767e-01          -0.7403599
## 1132          5.893870e-01          9.217921e-01          -0.4450173
## 1145          9.417648e-01          9.992585e-01           0.1899651
## 1076          9.234840e-01          9.992585e-01          -0.2642292
## 989           5.533452e-01          8.941246e-01          -0.3942159
## 169           4.825675e-01          8.450569e-01          -0.2827874
## 408           4.810167e-01          8.450569e-01           0.5355475
## 1062          4.819441e-01          8.450569e-01           0.4625824
## 646           9.851379e-01          9.992585e-01          -0.1729844
## 735           7.451029e-01          9.877613e-01          -0.3515731
## 804           9.496558e-01          9.992585e-01          -0.2184878
## 38            4.884052e-01          8.484152e-01           0.6689522
## 229           9.230657e-01          9.992585e-01           0.3114232
## 428           8.915661e-01          9.992585e-01          -0.2125194
## 474           8.334176e-01          9.992585e-01          -0.2871764
## 100           7.746567e-01          9.892193e-01          -0.3015357
## 252           8.511466e-01          9.992585e-01           0.5745501
## 456           5.187539e-01          8.781767e-01           0.3946016
## 186           8.695999e-01          9.992585e-01          -0.2609276
## 384           8.345423e-01          9.992585e-01           0.2830481
## 493           7.123070e-01          9.777803e-01          -0.2431722
## 1080          9.058180e-01          9.992585e-01           0.2372031
## 1251          6.764880e-01          9.604041e-01          -0.5204371
## 1254          7.266541e-01          9.835183e-01           0.3114452
## 45            8.399545e-01          9.992585e-01          -0.4188484
## 826           6.688947e-01          9.596653e-01           0.5748251
## 43            5.502661e-01          8.938996e-01           0.7251500
## 859           5.490507e-01          8.938996e-01          -0.5302318
## 1146          8.407208e-01          9.992585e-01          -0.4972025
## 1253          6.294998e-01          9.399287e-01          -0.4544300
## 547           9.672423e-01          9.992585e-01           0.1837505
## 117           7.830096e-01          9.892193e-01           0.3860665
## 118           7.830096e-01          9.892193e-01           0.3860665
## 248           9.910614e-01          9.992585e-01          -0.1647559
## 1066          8.829461e-01          9.992585e-01          -0.3558414
## 1223          9.133128e-01          9.992585e-01          -0.2871547
## 1108          9.040652e-01          9.992585e-01           0.2607728
## 1339          8.524914e-01          9.992585e-01          -0.3742506
## 1008          5.978679e-01          9.252881e-01           0.6140990
## 1142          5.231568e-01          8.815192e-01           0.4451541
## 666           9.780372e-01          9.992585e-01           0.2356852
## 272           8.873086e-01          9.992585e-01          -0.2116877
## 546           9.610174e-01          9.992585e-01          -0.1939609
## 422           9.753065e-01          9.992585e-01           0.1799493
## 410           6.648489e-01          9.564741e-01           0.2886364
## 1160          5.509212e-01          8.938996e-01          -0.5827375
## 929           5.546929e-01          8.941246e-01           0.4954882
## 192           8.552944e-01          9.992585e-01          -0.2136835
## 1232          7.914874e-01          9.912193e-01           0.3260222
## 1239          9.755798e-01          9.992585e-01          -0.1800079
## 1128          5.626120e-01          8.996452e-01           0.3433220
## 937           9.222478e-01          9.992585e-01           0.1875044
## 1258          9.481397e-01          9.992585e-01          -0.3863295
## 253           9.803037e-01          9.992585e-01          -0.1766011
## 1057          7.746468e-01          9.892193e-01           0.3467559
## 447           9.530547e-01          9.992585e-01           0.1920950
## 798           9.985172e-01          9.992585e-01          -0.1449309
## 559           5.934323e-01          9.217921e-01           0.4167851
## 491           9.873393e-01          9.992585e-01          -0.1698678
## 1304          7.069258e-01          9.753695e-01           0.2541477
## 378           8.098918e-01          9.945825e-01          -0.2255513
## 1114          8.310360e-01          9.981421e-01           0.3104402
## 1151          6.722799e-01          9.596653e-01          -0.4692491
## 1137          9.901736e-01          9.992585e-01          -0.2380273
## 268           9.514111e-01          9.992585e-01          -0.1949457
## 47            8.863243e-01          9.992585e-01           0.5567695
## 151           5.996552e-01          9.254452e-01           0.5290427
## 293           8.911240e-01          9.992585e-01          -0.2009031
## 360           9.641312e-01          9.992585e-01          -0.2923685
## 81            6.208234e-01          9.350200e-01          -0.6895887
## 544           9.924404e-01          9.992585e-01          -0.1621018
## 1124          7.904929e-01          9.912193e-01          -0.2238282
## 1209          8.794365e-01          9.992585e-01          -0.2085131
## 312           8.118331e-01          9.945825e-01          -0.2228306
## 942           9.825521e-01          9.992585e-01          -0.1744650
## 105           9.680391e-01          9.992585e-01          -0.1850914
## 239           6.546013e-01          9.539487e-01           0.3130356
## 556           8.682768e-01          9.992585e-01          -0.3998664
## 558           8.682768e-01          9.992585e-01          -0.3998664
## 944           7.721004e-01          9.892193e-01          -0.2345046
## 89            6.337438e-01          9.408444e-01           0.3242817
## 113           8.697520e-01          9.992585e-01          -0.2067552
## 445           8.435926e-01          9.992585e-01           0.2865644
## 1182          9.869584e-01          9.992585e-01          -0.2613076
## 918           8.827096e-01          9.992585e-01          -0.2391434
## 328           6.712228e-01          9.596653e-01           0.3866943
## 353           7.660085e-01          9.892193e-01           0.3356013
## 1120          8.773258e-01          9.992585e-01           0.2561741
## 135           8.563736e-01          9.992585e-01          -0.2100366
##      NES_iDUX4dmso_WTdmso nMoreExtreme_iDUX4dmso_WTdmso
## 21             -2.1945697                            11
## 24             -2.3374073                             0
## 108            -2.1265094                            16
## 109            -2.0839390                            99
## 110            -2.1909237                            17
## 170            -1.7033639                          7746
## 181            -2.0990618                            26
## 205            -2.2990375                             0
## 275            -2.0610326                           281
## 299            -1.5301139                        153579
## 300            -2.2675331                             1
## 341            -2.1533520                             7
## 346            -2.1538283                            11
## 404            -2.0982893                            47
## 483            -2.3189431                             2
## 487            -2.6145025                             0
## 504            -2.1529301                             9
## 521            -2.1122697                           100
## 624            -2.2633399                             1
## 625            -2.2714337                             1
## 709            -2.1630492                             6
## 788            -2.0755895                            45
## 847            -2.0878572                            32
## 855            -2.2873120                             1
## 856            -2.0440333                           102
## 865            -2.2489819                             4
## 906            -2.1909237                            17
## 958            -2.2453912                             1
## 980            -1.9796848                           293
## 986            -2.1539163                            16
## 987            -2.0707399                            50
## 1013           -2.0490574                           129
## 1131           -2.1544992                            27
## 1213           -2.0410767                           125
## 1272           -2.0857701                            18
## 1275           -2.0863459                            75
## 355            -1.9776937                            43
## 626            -2.0895361                           124
## 744            -2.1993546                            11
## 431            -2.2546324                             3
## 985            -2.2835644                             0
## 405             2.6160448                             0
## 479            -2.3172929                             0
## 520            -1.9920550                             1
## 587             2.6160448                             0
## 832            -2.4061132                             0
## 162            -1.8220824                             2
## 161            -1.9845917                             2
## 430            -2.0812744                             2
## 160            -1.7897520                             4
## 482            -2.1706858                             4
## 647            -1.6668932                             5
## 1031           -1.7925742                          1491
## 357            -2.1249303                            12
## 1048           -1.9694333                           362
## 366             2.0362584                             7
## 1144           -1.6458703                         10822
## 180            -2.0174020                            24
## 677            -1.9272576                           119
## 362            -1.9069675                            69
## 932             1.6868560                         16756
## 1155           -2.0921803                            46
## 1111           -1.7978794                           574
## 1154           -1.8713811                           438
## 973            -1.2951956                        356952
## 967             1.5062863                         57769
## 1037           -1.1886487                       1504427
## 745            -1.8867453                           226
## 863            -1.7852699                            91
## 44             -1.7500698                         32736
## 673            -1.7330113                          5415
## 200             2.2251034                            54
## 1006           -1.8124541                           115
## 480            -1.7893216                          1734
## 688            -1.8046041                           175
## 965            -1.7478537                          3495
## 25             -1.8322168                         12055
## 1015           -1.8211595                          1316
## 361            -1.7828845                          2010
## 836             0.7844593                       3149874
## 1041           -1.5753909                         28021
## 304            -1.9186449                          3640
## 1319           -1.8492287                          2909
## 204            -1.9015430                          2296
## 734             1.5666933                          1082
## 301            -1.6735975                         14259
## 609            -1.5863277                          2334
## 895            -0.8318824                       4398226
## 197             2.1192142                           606
## 535             2.0606514                           594
## 1208           -1.6940560                          3969
## 1127           -1.6237535                          5236
## 124             1.4187013                        331075
## 481            -1.7677497                          1677
## 184            -0.6924698                       4642575
## 1100           -1.7016937                          2778
## 495             1.1709535                        234128
## 1291            1.6635618                        110965
## 324             2.0276513                          1537
## 837             1.3011573                        172337
## 182            -0.6825432                       4803217
## 1269           -1.6890402                          4093
## 921            -1.6674691                          3324
## 1035           -1.2272836                        993044
## 689            -1.8860674                          3325
## 568             2.0676631                          2287
## 563            -1.9252818                          3292
## 669            -0.7369665                       5091953
## 95              2.0254616                          2438
## 273             1.9071197                          2470
## 1279           -1.5581357                          5776
## 203             1.1656197                       1055317
## 42             -1.6025487                         49837
## 780             1.9286398                          3741
## 642             0.8358939                       2829180
## 198             2.0038435                          4830
## 435            -0.6536595                       4957497
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## 240             0.7010933                       3579905
## 269            -0.6501984                       6179611
## 529            -0.6010203                       5368634
## 548             0.6756197                       3946253
## 667            -0.6755606                       4676240
## 978             0.8564852                       2741586
## 1091            0.7629494                       3276730
## 1206            0.8416811                       2812014
## 414            -0.6805704                       4708291
## 187             0.4329370                       4138630
## 18              0.7443721                       3449343
## 20              0.7443721                       3449343
## 1059            0.7443721                       3449343
## 260             0.7961810                       3169267
## 446            -0.9412837                       3110702
## 608             0.6007423                       3907667
## 1134           -0.7061861                       5469593
## 420             0.5985112                       4197466
## 194             0.8840713                       2934189
## 168             0.8253136                       2863737
## 663            -0.8009460                       4783581
## 854             0.5517333                       4365199
## 719            -0.8521232                       4455444
## 1152           -0.7370624                       4369176
## 5              -0.8806418                       4314748
## 137            -1.0117734                       2416236
## 226             0.9712233                       2735878
## 271            -0.9148110                       3759078
## 348             0.7455458                       3390784
## 565             0.6470888                       3987059
## 657            -0.6060855                       5267718
## 726             0.8235817                       3825089
## 903             0.6233543                       4375572
## 928             0.7418517                       3325240
## 1150            0.7283358                       3450294
## 760            -0.7062533                       5010010
## 475             0.7043183                       3626590
## 98             -0.7202628                       5014295
## 6              -0.7496348                       5508600
## 603             0.7330248                       4503021
## 947             0.6869345                       3561174
## 1024            0.7330248                       4503021
## 1025            0.7330248                       4503021
## 17             -0.9874863                       2597981
## 1132           -0.9092899                       3258879
## 1145            0.6876697                       3558997
## 1076           -0.6066192                       5221773
## 989            -0.9321584                       3146624
## 169            -0.9851045                       3030818
## 408             1.0039691                       2217079
## 1062            0.9815860                       2154739
## 646            -0.5879080                       6128472
## 735            -0.7807040                       4187034
## 804            -0.5949258                       5556172
## 38              1.0285479                       2369763
## 229             0.5838124                       4254551
## 428            -0.7316416                       5573645
## 474            -0.7138479                       4786604
## 100            -0.7657927                       4467860
## 252             0.7661624                       4254508
## 456             0.9456427                       2254326
## 186            -0.6880638                       5053645
## 384             0.6994231                       3599818
## 493            -0.8564165                       4493969
## 1080            0.6445756                       3812652
## 1251           -0.8691301                       3576949
## 1254            0.7910591                       3112991
## 45             -0.6994768                       4441283
## 826             0.8838227                       3245506
## 43              0.9669872                       2750538
## 859            -0.9617377                       2960055
## 1146           -0.7467338                       4328792
## 1253           -0.8800398                       3442297
## 547             0.6163220                       3793440
## 117             0.7237431                       3609011
## 118             0.7237431                       3609011
## 248            -0.5739356                       6224470
## 1066           -0.6454273                       4760160
## 1223           -0.6136814                       5095088
## 1108            0.6249289                       3928757
## 1339           -0.6788182                       4595972
## 1008            0.9442083                       2900881
## 1142            0.9446038                       2338998
## 666             0.5001169                       4372738
## 272            -0.7402182                       5581499
## 546            -0.6255965                       5875366
## 422             0.5849137                       3876580
## 410             0.8514916                       2734396
## 1160           -0.9731718                       2913011
## 929             0.9288716                       2556664
## 192            -0.7765517                       5471185
## 1232            0.7249796                       3499535
## 1239           -0.6270667                       6127236
## 1128            0.9141266                       2381257
## 937             0.7502362                       3248212
## 1258           -0.5802169                       4881882
## 253            -0.6128474                       6147913
## 1057            0.7358056                       3463393
## 447             0.6396186                       3750617
## 798            -0.5281483                       6395829
## 559             0.8844056                       2653195
## 491            -0.5871736                       6182129
## 1304            0.8398021                       2791840
## 378            -0.7997635                       5123987
## 1114            0.6903297                       3674398
## 1151           -0.8511269                       3624411
## 1137           -0.4609588                       5414572
## 268            -0.6595288                       5908420
## 47              0.7424519                       4430346
## 151             0.9101114                       2826204
## 293            -0.7679197                       5853994
## 360            -0.5302999                       5197847
## 81             -0.9197680                       3106374
## 544            -0.5857133                       6331440
## 1124           -0.8200475                       5076380
## 1209           -0.7598504                       5633078
## 312            -0.8027512                       5172038
## 942            -0.6100599                       6180616
## 105            -0.6397961                       6061283
## 239             0.8506427                       2755263
## 556            -0.6677770                       4591038
## 558            -0.6677770                       4591038
## 944            -0.8200031                       4856797
## 89              0.8634301                       2682323
## 113            -0.7776294                       5661915
## 445             0.6867371                       3665964
## 1182           -0.4739614                       5320914
## 918            -0.6939945                       5241799
## 328             0.8205537                       3000991
## 353             0.7462806                       3386881
## 1120            0.6669078                       3734517
## 135            -0.7847130                       5554518
##      pval_iDUX4t02dox_iDUX4dmso padj_iDUX4t02dox_iDUX4dmso
## 21                 2.852660e-03               0.1215904296
## 24                 2.942654e-02               0.3885065526
## 108                4.940597e-02               0.4561592346
## 109                4.284977e-02               0.4278628528
## 110                1.137503e-02               0.2893121512
## 170                3.240996e-01               0.8235836258
## 181                7.539372e-02               0.5632842719
## 205                3.933231e-01               0.8673814453
## 275                1.046785e-01               0.6161859524
## 299                6.183149e-01               0.9910730565
## 300                5.262645e-02               0.4667135248
## 341                1.118350e-01               0.6240588431
## 346                8.966647e-04               0.0863359974
## 404                2.017817e-02               0.3358046741
## 483                3.131380e-02               0.3951992313
## 487                3.176368e-03               0.1259336352
## 504                8.779115e-01               0.9999157747
## 521                1.618136e-02               0.3183391168
## 624                9.245820e-02               0.5812956713
## 625                1.513540e-01               0.6791653207
## 709                2.262326e-01               0.7486148757
## 788                2.437931e-02               0.3692506665
## 847                1.181036e-02               0.2948214631
## 855                8.157735e-03               0.2431459232
## 856                2.668596e-03               0.1215904296
## 865                7.240248e-01               0.9999157747
## 906                1.137503e-02               0.2893121512
## 958                7.120001e-02               0.5484434760
## 980                4.754525e-03               0.1732188944
## 986                1.961174e-02               0.3304578560
## 987                9.664229e-03               0.2714037604
## 1013               1.284252e-01               0.6632840918
## 1131               3.298549e-03               0.1270412439
## 1213               7.576091e-02               0.5632842719
## 1272               1.262743e-01               0.6572116169
## 1275               2.380051e-01               0.7486148757
## 355                5.875011e-01               0.9765122468
## 626                3.941441e-02               0.4228640993
## 744                9.511339e-01               0.9999157747
## 431                9.165784e-01               0.9999157747
## 985                6.169405e-02               0.5027002095
## 405                1.155138e-01               0.6278261809
## 479                6.491490e-02               0.5177827668
## 520                9.441636e-01               0.9999157747
## 587                1.155138e-01               0.6278261809
## 832                3.554117e-02               0.4182648121
## 162                9.927665e-01               0.9999157747
## 161                3.512796e-01               0.8414349377
## 430                4.506941e-01               0.9036433714
## 160                9.570802e-01               0.9999157747
## 482                7.826515e-01               0.9999157747
## 647                9.929347e-01               0.9999157747
## 1031               9.247996e-01               0.9999157747
## 357                2.385083e-01               0.7486148757
## 1048               2.054003e-01               0.7324858312
## 366                2.572628e-05               0.0057798369
## 1144               2.553436e-01               0.7683107688
## 180                1.101291e-01               0.6211465933
## 677                7.417057e-01               0.9999157747
## 362                1.681964e-01               0.6965831126
## 932                1.700073e-07               0.0002291698
## 1155               5.156596e-01               0.9388563131
## 1111               4.235617e-01               0.8893475831
## 1154               9.747410e-01               0.9999157747
## 973                8.473257e-01               0.9999157747
## 967                6.684571e-07               0.0003411122
## 1037               7.591517e-07               0.0003411122
## 745                8.679039e-01               0.9999157747
## 863                4.642543e-01               0.9082640030
## 44                 6.625536e-01               0.9996419724
## 673                2.083142e-01               0.7389673344
## 200                5.898775e-02               0.4906450688
## 1006               9.969071e-01               0.9999157747
## 480                3.298805e-01               0.8235836258
## 688                4.465161e-01               0.9010533651
## 965                1.345097e-01               0.6695222512
## 25                 2.752579e-01               0.7928368867
## 1015               8.232126e-01               0.9999157747
## 361                1.366707e-01               0.6695222512
## 836                2.886420e-03               0.1215904296
## 1041               8.366556e-02               0.5654643762
## 304                8.730684e-01               0.9999157747
## 1319               1.100169e-01               0.6211465933
## 204                8.413555e-01               0.9999157747
## 734                3.703978e-01               0.8500800785
## 301                7.740735e-01               0.9999157747
## 609                9.823678e-01               0.9999157747
## 895                9.953416e-01               0.9999157747
## 197                3.828453e-02               0.4228640993
## 535                8.181333e-03               0.2431459232
## 1208               9.941511e-01               0.9999157747
## 1127               9.974797e-01               0.9999157747
## 124                1.158787e-05               0.0039051134
## 481                7.672908e-01               0.9999157747
## 184                1.387022e-02               0.3183391168
## 1100               3.271642e-01               0.8235836258
## 495                2.063457e-05               0.0055630806
## 1291               5.382203e-01               0.9469659727
## 324                2.749586e-03               0.1215904296
## 837                3.991631e-05               0.0076867415
## 182                1.018952e-02               0.2803158881
## 1269               9.082416e-01               0.9999157747
## 921                4.984942e-01               0.9318062329
## 1035               5.079940e-02               0.4626864672
## 689                9.141452e-02               0.5812956713
## 568                1.399418e-02               0.3183391168
## 563                2.356583e-01               0.7486148757
## 669                1.870154e-01               0.7192424650
## 95                 2.189348e-03               0.1215627598
## 273                5.439971e-03               0.1833270195
## 1279               9.993170e-01               0.9999726407
## 203                8.066002e-05               0.0135912132
## 42                 5.059972e-01               0.9369288940
## 780                4.684368e-01               0.9111873150
## 642                3.076750e-03               0.1256805867
## 198                8.258774e-04               0.0856371303
## 435                4.372391e-02               0.4302177664
## 724                9.999726e-01               0.9999726407
## 894                4.353963e-01               0.8974305401
## 303                6.635536e-01               0.9996419724
## 886                2.690615e-01               0.7850540091
## 1067               4.932093e-01               0.9274805086
## 801                2.614404e-01               0.7736862236
## 93                 6.481801e-01               0.9978528237
## 199                9.976503e-04               0.0885018814
## 676                2.720948e-01               0.7894817923
## 537                5.149083e-02               0.4658364956
## 701                1.403384e-01               0.6695222512
## 1119               9.299280e-01               0.9999157747
## 320                3.757529e-02               0.4186073226
## 510                8.322421e-01               0.9999157747
## 211                8.512262e-01               0.9999157747
## 402                7.734426e-01               0.9999157747
## 331                2.173539e-03               0.1215627598
## 442                6.334178e-01               0.9978528237
## 1289               6.334178e-01               0.9978528237
## 1311               8.478740e-01               0.9999157747
## 851                1.705285e-01               0.6965831126
## 787                9.104688e-01               0.9999157747
## 1169               2.780018e-01               0.7928659456
## 680                1.876060e-01               0.7192424650
## 500                2.366587e-01               0.7486148757
## 486                2.153172e-04               0.0322497258
## 55                 1.176217e-01               0.6329482521
## 364                2.995219e-01               0.8012539842
## 91                 4.655203e-01               0.9082640030
## 485                9.613134e-03               0.2714037604
## 1096               4.658165e-02               0.4421976735
## 52                 5.097368e-01               0.9388563131
## 640                9.437128e-01               0.9999157747
## 861                1.753717e-01               0.7056748006
## 425                9.176438e-01               0.9999157747
## 54                 9.357653e-02               0.5812956713
## 655                6.462704e-02               0.5177827668
## 436                5.509123e-02               0.4791159947
## 1329               5.738286e-04               0.0703200902
## 811                3.826623e-01               0.8610341080
## 1285               5.592247e-01               0.9661763563
## 94                 2.361351e-01               0.7486148757
## 212                7.620435e-01               0.9999157747
## 627                6.124469e-01               0.9863541554
## 444                8.998984e-01               0.9999157747
## 896                5.983697e-01               0.9824632139
## 1061               1.695675e-02               0.3183391168
## 65                 8.227952e-01               0.9999157747
## 228                6.104859e-01               0.9855509630
## 794                4.276000e-01               0.8936508880
## 976                8.599363e-01               0.9999157747
## 781                2.626550e-01               0.7736862236
## 681                4.227589e-03               0.1582997060
## 1299               8.898195e-01               0.9999157747
## 1183               6.036019e-01               0.9850111205
## 165                2.634436e-01               0.7736862236
## 59                 4.717998e-01               0.9124625316
## 407                8.002985e-01               0.9999157747
## 7                  4.675507e-04               0.0630258366
## 797                4.138418e-01               0.8826879864
## 368                2.767594e-01               0.7928659456
## 922                2.229582e-01               0.7486148757
## 426                9.214747e-01               0.9999157747
## 566                9.466396e-01               0.9999157747
## 834                7.170611e-04               0.0805498687
## 1274               7.946412e-01               0.9999157747
## 429                4.286639e-01               0.8939037813
## 1095               4.535711e-02               0.4336268255
## 571                1.726212e-02               0.3183391168
## 583                2.040998e-01               0.7324858312
## 71                 3.123618e-01               0.8166480451
## 817                4.653136e-01               0.9082640030
## 1039               5.341926e-01               0.9469659727
## 593                3.659217e-01               0.8500800785
## 523                7.348903e-01               0.9999157747
## 952                3.858046e-01               0.8610341080
## 1077               3.752208e-01               0.8500800785
## 1081               3.752208e-01               0.8500800785
## 158                5.699001e-01               0.9736697075
## 977                6.899926e-01               0.9999157747
## 939                2.365891e-02               0.3665771881
## 675                6.112602e-01               0.9856204701
## 290                4.395207e-01               0.8974305401
## 742                1.516896e-03               0.1080193331
## 223                1.858720e-01               0.7192424650
## 23                 7.059013e-01               0.9999157747
## 912                3.593064e-01               0.8452792276
## 323                1.375885e-01               0.6695222512
## 610                4.350740e-01               0.8974305401
## 960                6.727335e-01               0.9999157747
## 1267               3.413945e-01               0.8336952727
## 176                8.297264e-03               0.2431459232
## 833                1.050467e-03               0.0885018814
## 343                8.723367e-01               0.9999157747
## 949                7.993565e-01               0.9999157747
## 287                4.803231e-01               0.9194675010
## 83                 1.045340e-01               0.6161859524
## 959                4.535019e-01               0.9038739416
## 401                2.676583e-01               0.7834707443
## 953                7.537651e-01               0.9999157747
## 1097               5.632838e-01               0.9685032969
## 349                5.417719e-02               0.4759855253
## 945                6.971271e-01               0.9999157747
## 687                1.570089e-01               0.6827353779
## 899                5.249445e-01               0.9388563131
## 1159               1.825065e-01               0.7192424650
## 35                 8.138689e-01               0.9999157747
## 53                 1.091074e-01               0.6211465933
## 762                1.700113e-01               0.6965831126
## 853                2.015130e-01               0.7289733035
## 225                5.981696e-01               0.9824632139
## 1210               8.117504e-02               0.5654643762
## 763                7.054097e-01               0.9999157747
## 1046               3.514302e-01               0.8414349377
## 1098               6.338850e-01               0.9978528237
## 670                2.116038e-02               0.3478560292
## 890                1.607131e-01               0.6855735956
## 58                 3.582619e-01               0.8447378353
## 376                1.579034e-03               0.1080193331
## 519                1.429785e-03               0.1080193331
## 569                1.671681e-03               0.1080193331
## 905                1.682794e-03               0.1080193331
## 172                2.248015e-01               0.7486148757
## 342                2.836082e-01               0.7928659456
## 526                3.844723e-01               0.8610341080
## 467                5.174328e-01               0.9388563131
## 502                5.777708e-02               0.4837484611
## 1171               9.049693e-02               0.5812956713
## 237                1.468241e-01               0.6778041935
## 729                2.196459e-01               0.7486148757
## 1133               1.701212e-01               0.6965831126
## 1287               1.317907e-01               0.6695222512
## 473                2.369407e-01               0.7486148757
## 1286               2.726975e-01               0.7894817923
## 773                7.667025e-02               0.5632842719
## 11                 2.525042e-03               0.1215627598
## 399                2.155697e-03               0.1215627598
## 650                2.306331e-03               0.1215627598
## 746                2.525042e-03               0.1215627598
## 1052               2.525042e-03               0.1215627598
## 306                6.539311e-01               0.9978528237
## 256                7.897680e-02               0.5632842719
## 263                7.897680e-02               0.5632842719
## 1195               8.134157e-01               0.9999157747
## 465                8.476428e-01               0.9999157747
## 79                 1.419772e-01               0.6695222512
## 97                 3.845616e-01               0.8610341080
## 427                4.542291e-01               0.9038739416
## 379                2.158332e-01               0.7486148757
## 572                2.968225e-02               0.3885065526
## 1337               1.792974e-01               0.7118501607
## 432                1.428039e-01               0.6695222512
## 149                8.181653e-02               0.5654643762
## 1327               9.726844e-02               0.5987116843
## 1284               7.356149e-01               0.9999157747
## 1321               3.992167e-02               0.4228640993
## 848                7.355576e-01               0.9999157747
## 1310               1.151108e-01               0.6278261809
## 570                3.658686e-01               0.8500800785
## 68                 6.512821e-01               0.9978528237
## 968                1.364486e-01               0.6695222512
## 189                8.134138e-03               0.2431459232
## 1293               8.987313e-01               0.9999157747
## 796                3.957293e-01               0.8686914740
## 50                 1.683513e-02               0.3183391168
## 1276               3.944398e-01               0.8673814453
## 1050               8.938044e-01               0.9999157747
## 185                4.860024e-01               0.9238589263
## 1                  2.365787e-01               0.7486148757
## 732                5.743378e-01               0.9740798329
## 931                2.439397e-01               0.7486148757
## 321                1.030939e-01               0.6158033337
## 87                 4.575726e-01               0.9052225602
## 451                3.181959e-01               0.8232783686
## 808                1.000989e-01               0.6087542254
## 1324               4.575726e-01               0.9052225602
## 141                1.512622e-01               0.6791653207
## 860                3.400058e-01               0.8318108785
## 844                1.766697e-01               0.7087819745
## 289                2.275428e-01               0.7486148757
## 1292               6.027640e-01               0.9848798660
## 891                8.096319e-01               0.9999157747
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## 233                5.141934e-01               0.9388563131
## 741                5.152408e-01               0.9388563131
## 751                4.633331e-01               0.9082640030
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## 1192               8.319764e-01               0.9999157747
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## 1228               2.181641e-01               0.7486148757
## 1056               4.647631e-01               0.9082640030
## 439                6.862055e-01               0.9999157747
## 733                2.108562e-01               0.7460213919
## 1271               7.504705e-01               0.9999157747
## 1323               3.276796e-01               0.8235836258
## 752                2.791366e-01               0.7928659456
## 19                 2.185824e-01               0.7486148757
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## 819                2.923018e-01               0.7928659456
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## 16                 7.804526e-01               0.9999157747
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## 889                3.928874e-01               0.8673814453
## 494                4.188419e-01               0.8835663657
## 1074               4.060792e-01               0.8747219243
## 561                9.028223e-01               0.9999157747
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## 1059               5.239271e-01               0.9388563131
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##      ES_iDUX4t02dox_iDUX4dmso NES_iDUX4t02dox_iDUX4dmso
## 21                  0.5563530                 1.7558127
## 24                  0.4464371                 1.4836124
## 108                 0.4166624                 1.4079919
## 109                 0.4523006                 1.4523064
## 110                 0.5861952                 1.6659544
## 170                 0.2887597                 1.0718939
## 181                 0.3891468                 1.3396522
## 205                 0.3201478                 1.0389571
## 275                 0.4649140                 1.3488095
## 299                 0.2824846                 0.9020057
## 300                 0.4499172                 1.4283608
## 341                 0.3496743                 1.2614678
## 346                 0.5462863                 1.8154339
## 404                 0.4599430                 1.5284954
## 483                 0.4364728                 1.4690050
## 487                 0.5723595                 1.7595193
## 504                -0.2162093                -0.7697143
## 521                 0.5344252                 1.6060493
## 624                 0.3769171                 1.3065188
## 625                 0.3755268                 1.2423657
## 709                 0.3402042                 1.1585765
## 788                 0.4314885                 1.4854152
## 847                 0.4416274                 1.5502914
## 855                 0.5168088                 1.6502296
## 856                 0.5022516                 1.7104346
## 865                -0.2489846                -0.8538063
## 906                 0.5861952                 1.6659544
## 958                 0.3862085                 1.3431471
## 980                 0.4752487                 1.6473688
## 986                 0.4638768                 1.5346566
## 987                 0.4535887                 1.5774802
## 1013                0.3843342                 1.2715036
## 1131                0.5522930                 1.7429998
## 1213                0.3966786                 1.3456990
## 1272                0.3480267                 1.2459518
## 1275                0.3546788                 1.1568583
## 355                 0.2470761                 0.9369944
## 626                 0.4781700                 1.4801507
## 744                 0.2098023                 0.6449640
## 431                -0.2104917                -0.7255214
## 985                 0.4054320                 1.3753943
## 405                -0.4865844                -1.3475802
## 479                 0.4032952                 1.3681452
## 520                -0.1863064                -0.7912492
## 587                -0.4865844                -1.3475802
## 832                 0.4669974                 1.4825858
## 162                 0.1717292                 0.7484606
## 161                -0.2423735                -1.0388499
## 430                -0.2483998                -0.9993399
## 160                 0.1843779                 0.8125739
## 482                 0.2310931                 0.8336799
## 647                -0.1684285                -0.8197075
## 1031               -0.1945899                -0.7787042
## 357                 0.3167423                 1.1369430
## 1048                0.3412421                 1.1747386
## 366                 0.4717524                 1.8478133
## 1144               -0.2693205                -1.0961901
## 180                 0.3297196                 1.2442124
## 677                 0.2291655                 0.8662003
## 362                -0.2794507                -1.1525592
## 932                 0.6417376                 2.2660329
## 1155                0.2875876                 0.9638954
## 1111                0.2595555                 1.0141760
## 1154                0.1849215                 0.6903864
## 973                 0.2047774                 0.8431461
## 967                 0.5724234                 2.0986404
## 1037                0.9527777                 2.0790067
## 745                -0.2036491                -0.8207272
## 863                -0.2244625                -0.9952765
## 44                 -0.3250110                -0.8536438
## 673                -0.2905411                -1.1378284
## 200                 0.4292512                 1.4000916
## 1006               -0.1607594                -0.6954254
## 480                 0.2842510                 1.0670287
## 688                -0.2329002                -1.0011104
## 965                -0.3016947                -1.1983188
## 25                 -0.4397319                -1.1549593
## 1015                0.2210697                 0.8189830
## 361                -0.3011271                -1.1960644
## 836                 0.7558923                 1.8005242
## 1041               -0.3066880                -1.2482837
## 304                -0.2516609                -0.7076612
## 1319               -0.6487496                -1.3920459
## 204                 0.3108498                 0.7009049
## 734                 0.2421479                 1.0333524
## 301                -0.2214875                -0.8556459
## 609                 0.1778084                 0.7601505
## 895                 0.1646117                 0.5095469
## 197                 0.4837500                 1.4871202
## 535                 0.4921063                 1.6280489
## 1208                0.1684373                 0.6556178
## 1127                0.1627725                 0.6603928
## 124                 0.7391371                 2.1230429
## 481                 0.2239470                 0.8572632
## 184                 0.8069976                 1.6238156
## 1100                0.2700859                 1.0628664
## 495                 0.3881693                 1.6733963
## 1291               -0.4059457                -0.9390749
## 324                 0.5573559                 1.7589780
## 837                 0.4619673                 1.8179755
## 182                 0.7689067                 1.6777914
## 1269                0.2011879                 0.7851317
## 921                -0.2300371                -0.9820504
## 1035                0.9183979                 1.3815678
## 689                 0.4231278                 1.3433120
## 568                 0.6216142                 1.6586396
## 563                 0.4406405                 1.1927038
## 669                -0.3905598                -1.2168965
## 95                  0.5996521                 1.8020687
## 273                 0.4813569                 1.6453912
## 1279               -0.1540558                -0.6952182
## 203                 0.7533462                 2.0391202
## 42                 -0.2638487                -0.9714704
## 780                 0.3053469                 0.9909246
## 642                 0.6473022                 1.7980166
## 198                 0.6930457                 1.9010680
## 435                 0.6997464                 1.5268802
## 724                 0.1473086                 0.6465618
## 894                 0.3168799                 1.0118337
## 303                -0.2436410                -0.8970673
## 886                 0.6706664                 1.2039633
## 1067                0.3090660                 0.9753917
## 801                -0.4806277                -1.1790735
## 93                 -0.2955922                -0.8753441
## 199                 0.6201769                 1.8637495
## 676                 0.2904518                 1.1014894
## 537                -0.7322091                -1.4995064
## 701                 0.5453515                 1.3297890
## 1119               -0.1872409                -0.8187761
## 320                -0.9288927                -1.3960074
## 510                 0.2368265                 0.7799169
## 211                -0.3182662                -0.6829155
## 402                -0.3126872                -0.7670829
## 331                 0.6865824                 1.8319931
## 442                 0.3381296                 0.8741077
## 1289                0.3381296                 0.8741077
## 1311                0.4072408                 0.6764739
## 851                 0.6484986                 1.3048889
## 787                 0.2718562                 0.6310575
## 1169               -0.2945078                -1.0984281
## 680                 0.7643530                 1.2696785
## 500                 0.3018755                 1.1291283
## 486                 0.9153805                 1.8419004
## 55                  0.7162147                 1.3686071
## 364                 0.3907889                 1.1224731
## 91                  0.2437073                 0.9952133
## 485                 0.9676379                 1.4556405
## 1096                0.4338104                 1.4286244
## 52                  0.3722454                 0.9623012
## 640                 0.1924212                 0.7647708
## 861                 0.6456123                 1.2990811
## 425                -0.2831173                -0.6074953
## 54                  0.6732062                 1.4149958
## 655                -0.9676660                -1.2905998
## 436                 0.6645240                 1.4983704
## 1329                0.6466503                 1.9109178
## 811                 0.7348152                 1.1053999
## 1285                0.2781907                 0.9400664
## 94                  0.6458755                 1.2341968
## 212                -0.2608932                -0.8128845
## 627                 0.2152223                 0.9506417
## 444                -0.2299740                -0.7031330
## 896                 0.2682951                 0.9203785
## 1061                0.6606818                 1.6454288
## 65                 -0.3861153                -0.7000433
## 228                 0.4219291                 0.8868426
## 794                -0.5871997                -1.0646177
## 976                 0.2523723                 0.7248955
## 781                -0.3043722                -1.1129809
## 681                 0.7006127                 1.7790926
## 1299                0.2048282                 0.7962432
## 1183               -0.4626725                -0.8966258
## 165                 0.3666176                 1.1424898
## 59                  0.4765529                 1.0016549
## 407                -0.2648214                -0.7750327
## 7                   0.9521741                 1.7093188
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## 439                -0.3188850                -0.8375539
## 733                 0.5358529                 1.2438706
## 1271               -0.2340136                -0.8526892
## 1323                0.7604376                 1.1439442
## 752                 0.5034796                 1.1687228
## 19                  0.8905782                 1.1878005
## 242                 0.4861572                 1.2107750
## 294                 0.8040169                 1.2095016
## 397                -0.5337683                -1.2347670
## 875                -0.5679467                -1.2186643
## 1089                0.5226957                 1.2133290
## 1118                0.8901499                 1.1872293
## 1301                0.5123092                 1.2203131
## 1302                0.5123092                 1.2203131
## 508                 0.3014272                 0.8268338
## 372                 0.5173752                 0.9287789
## 819                -0.6513193                -1.1808693
## 820                -0.6513193                -1.1808693
## 821                -0.6513193                -1.1808693
## 822                -0.6513193                -1.1808693
## 96                 -0.3901363                -0.8371298
## 633                 0.6743185                 1.1201207
## 16                  0.5154704                 0.7754343
## 764                 0.5154704                 0.7754343
## 1058                0.2269876                 0.5269042
## 595                -0.3469242                -0.9111992
## 285                -0.2972628                -0.7093234
## 340                 0.2127593                 0.4797302
## 1017               -0.7253617                -1.2107706
## 1107                0.1942728                 0.6687914
## 254                -0.3123635                -0.5213959
## 1244               -0.4544724                -1.1430917
## 455                 0.3513282                 0.5835966
## 927                 0.2724289                 0.5726117
## 40                  0.7307923                 1.2139303
## 347                 0.2966397                 0.6472820
## 946                -0.2532479                -0.9125213
## 1038               -0.2433094                -0.8625386
## 1073                0.4367517                 1.0403360
## 518                -0.3568367                -0.6915236
## 671                 0.3664102                 0.8261827
## 1204               -0.3568367                -0.6915236
## 1308                0.2726369                 0.4894309
## 1255                0.2977438                 0.5689554
## 779                 0.3507412                 0.8354604
## 1235               -0.8710921                -1.1617969
## 1164               -0.3934181                -0.8056892
## 1110                0.3391167                 1.1318398
## 824                 0.4201668                 0.7542729
## 620                -0.1883841                -0.3650746
## 1281                0.3726992                 0.9087924
## 862                -0.4433748                -0.8592283
## 1153               -0.4433748                -0.8592283
## 1069                0.4280912                 0.8997946
## 1203               -0.3566838                -0.5953751
## 1205               -0.3566838                -0.5953751
## 1053               -0.2438314                -0.5231982
## 1054               -0.2438314                -0.5231982
## 1055               -0.2438314                -0.5231982
## 227                -0.2732451                -0.9465423
## 286                 0.4740994                 1.1005227
## 799                -0.6612055                -1.1987934
## 618                -0.5168594                -0.9370878
## 469                -0.4690184                -1.1505938
## 682                 0.8563169                 1.1421049
## 703                 0.2898765                 1.0919677
## 1106                0.4434498                 1.1463736
## 136                 0.3514893                 0.8753846
## 553                -0.3672595                -0.6658569
## 1316                0.2413872                 0.8473672
## 257                -0.5878943                -0.8835303
## 313                -0.2226562                -0.5150708
## 314                -0.2226562                -0.5150708
## 315                -0.2226562                -0.5150708
## 316                -0.2226562                -0.5150708
## 419                 0.5009638                 0.7536117
## 656                -0.2632376                -0.5390897
## 1075                0.3137587                 0.8492665
## 448                -0.5174914                -1.1558482
## 612                -0.1821242                -0.7734872
## 889                 0.6639344                 1.1028716
## 494                 0.5238962                 1.0541678
## 1074                0.4290046                 1.0460878
## 561                -0.3671808                -0.6128966
## 562                -0.3671808                -0.6128966
## 648                 0.3770986                 0.7205938
## 127                -0.5416542                -0.9820419
## 692                 0.2676748                 0.8594856
## 1325               -0.2216614                -0.5127696
## 116                -0.5315881                -1.0301791
## 119                -0.5315881                -1.0301791
## 14                  0.8132762                 1.0846998
## 74                  0.1629774                 0.6368111
## 112                -0.3607530                -0.7740810
## 210                 0.4529106                 1.0513375
## 236                 0.1823769                 0.5436052
## 240                 0.4158186                 1.0559040
## 269                -0.2304759                -0.8541778
## 529                -0.4264910                -1.0727126
## 548                -0.5010711                -0.8363858
## 667                -0.3195456                -0.6192563
## 978                 0.3032691                 0.7039759
## 1091               -0.3136074                -0.7254685
## 1206                0.3069942                 0.7645694
## 414                 0.3451608                 0.6945220
## 187                -0.2227942                -0.6170214
## 18                  0.5065722                 0.9680035
## 20                  0.5065722                 0.9680035
## 1059                0.5065722                 0.9680035
## 260                 0.5979199                 1.1425589
## 446                 0.7590725                 1.1418907
## 608                -0.3781586                -1.0929965
## 1134                0.3091692                 0.9697109
## 420                -0.6129890                -1.1113749
## 194                -0.6840189                -1.1417614
## 168                 0.2912157                 1.0453155
## 663                -0.2853955                -0.9568151
## 854                -0.5816754                -1.0546020
## 719                -0.2443011                -0.8660540
## 1152                0.4748692                 0.7143570
## 5                   0.1910473                 0.6746051
## 137                 0.7199143                 0.9601792
## 226                -0.3975155                -0.5974152
## 271                -0.2371726                -0.8371789
## 348                -0.3474378                -0.7455102
## 565                -0.4514678                -0.8185301
## 657                -0.1930916                -0.4607519
## 726                 0.6329764                 0.8442266
## 903                -0.5521525                -0.8298149
## 928                 0.2994214                 1.0479077
## 1150               -0.3539918                -0.9803691
## 760                 0.3810101                 1.0166411
## 475                 0.4228236                 0.8507927
## 98                 -0.2863697                -0.8276979
## 6                   0.2356408                 0.8054757
## 603                -0.5042827                -0.6725741
## 947                -0.2949681                -1.0317013
## 1024               -0.5042827                -0.6725741
## 1025               -0.5042827                -0.6725741
## 17                 -0.5036403                -0.6717174
## 1132                0.4718439                 0.9494297
## 1145               -0.2231425                -0.7804788
## 1076                0.3271316                 0.7376171
## 989                 0.3052077                 0.7084760
## 169                -0.1607855                -0.5770997
## 408                -0.4845826                -0.8785687
## 1062                0.4870737                 0.9800747
## 646                -0.2785942                -0.9744305
## 735                 0.2515519                 0.5488983
## 804                 0.2824631                 0.7536900
## 38                  0.3814926                 0.5738883
## 229                -0.6130324                -1.1114536
## 428                -0.2947582                -1.0449261
## 474                -0.3953199                -0.9943109
## 100                 0.3650440                 0.9091425
## 252                 0.5430407                 0.7242756
## 456                 0.4236681                 0.9552878
## 186                 0.3599457                 0.9305051
## 384                 0.2510788                 0.5828269
## 493                -0.2079370                -0.7549386
## 1080                0.3280531                 0.8330379
## 1251               -0.2649822                -0.4423072
## 1254               -0.2749822                -0.6745851
## 45                 -0.3943873                -0.6583096
## 826                -0.4388090                -0.6594741
## 43                  0.7997859                 1.0667071
## 859                 0.3359196                 0.6030344
## 1146                0.4964661                 0.7468456
## 1253               -0.2890126                -0.5600854
## 547                -0.1892225                -0.6136783
## 117                -0.5406073                -0.9801437
## 118                -0.5406073                -0.9801437
## 248                -0.2225702                -0.7988604
## 1066                0.5166762                 0.9275241
## 1223                0.5037686                 1.0588589
## 1108                0.4462770                 1.0062665
## 1339                0.4890308                 0.8778957
## 1008                0.6130604                 0.9222412
## 1142                0.4249183                 0.8550075
## 666                -0.4904120                -1.0043249
## 272                -0.1919500                -0.6916483
## 546                -0.1849982                -0.6124808
## 422                 0.3054086                 0.9178110
## 410                -0.2777751                -0.7922217
## 1160               -0.4810115                -0.8029023
## 929                 0.4266124                 0.7658437
## 192                -0.1659118                -0.6225297
## 1232                0.4294648                 0.9026815
## 1239               -0.2482152                -0.8909067
## 1128                0.3630556                 0.9041903
## 937                 0.1624597                 0.5916795
## 1258               -0.6750910                -1.0145758
## 253                -0.1876951                -0.6709687
## 1057                0.4590830                 0.9237525
## 447                -0.1834757                -0.5906921
## 798                -0.2635158                -0.9916677
## 559                 0.3116827                 0.6271584
## 491                -0.2290230                -0.8153316
## 1304               -0.2526336                -0.8071248
## 378                 0.1616457                 0.5603173
## 1114                0.4015308                 0.8439678
## 1151               -0.3187211                -0.5778547
## 1137               -0.5205550                -1.0087978
## 268                -0.2237815                -0.7790111
## 47                 -0.6466809                -0.8624942
## 151                 0.3521900                 0.5850281
## 293                 0.2537646                 0.9474051
## 360                 0.5281982                 0.9482081
## 81                  0.6865096                 0.9156260
## 544                -0.1654662                -0.6171404
## 1124                0.2134599                 0.7641964
## 1209               -0.2272732                -0.8552786
## 312                 0.1819380                 0.6405762
## 942                -0.2117788                -0.7630966
## 105                -0.2311172                -0.8227873
## 239                -0.3086550                -0.8106848
## 556                -0.4001714                -0.6679644
## 558                -0.4001714                -0.6679644
## 944                 0.1914707                 0.6544919
## 89                  0.3238159                 0.8064639
## 113                -0.2322222                -0.9033922
## 445                -0.3505142                -0.8108451
## 1182               -0.3934331                -0.7133108
## 918                -0.2028287                -0.6006413
## 328                 0.3315284                 0.6670912
## 353                 0.3386415                 0.7117824
## 1120               -0.2321552                -0.5839183
## 135                -0.1679424                -0.6487915
##      nMoreExtreme_iDUX4t02dox_iDUX4dmso pval_iDUX4t06dox_iDUX4dmso
## 21                                16134               1.812929e-07
## 24                               169109               1.781399e-07
## 108                              285637               1.770185e-07
## 109                              243562               1.802803e-07
## 110                               62666               1.867439e-07
## 170                             1952292               1.696221e-07
## 181                              438934               1.757405e-07
## 205                             2243028               1.796551e-07
## 275                              579552               1.857309e-07
## 299                             3508546               1.806001e-07
## 300                              298149               1.809270e-07
## 341                              664195               1.721743e-07
## 346                                5152               1.781399e-07
## 404                              115960               1.781399e-07
## 483                              180763               1.772672e-07
## 487                               17835               1.827529e-07
## 504                             3703517               1.770185e-07
## 521                               90309               1.839796e-07
## 624                              539830               1.752544e-07
## 625                              868459               1.784349e-07
## 709                             1311821               1.764869e-07
## 788                              141933               1.757405e-07
## 847                               69299               1.743385e-07
## 855                               46289               1.806001e-07
## 856                               15473               1.764869e-07
## 865                             3104521               1.793306e-07
## 906                               62666               1.867439e-07
## 958                              416241               1.750177e-07
## 980                               27759               1.752544e-07
## 986                              112530               1.784349e-07
## 987                               56497               1.750177e-07
## 1013                             736895               1.784349e-07
## 1131                              18656               1.812929e-07
## 1213                             438638               1.767471e-07
## 1272                             747324               1.727785e-07
## 1275                            1359516               1.793306e-07
## 355                             3580469               3.349899e-07
## 626                              221743               3.647450e-07
## 744                             5340824               5.482586e-07
## 431                             3921875               7.160839e-07
## 985                              357194               7.069883e-07
## 405                              526746               3.068056e-05
## 479                              375842               1.590724e-06
## 520                             3492161               3.332035e-05
## 587                              526746               3.068056e-05
## 832                              201354               4.233691e-05
## 162                             6828644               8.816807e-02
## 161                             1284560               4.313181e-02
## 430                             1760228               5.740387e-03
## 160                             6684741               5.111084e-02
## 482                             4648220               4.476531e-06
## 647                             2659781               1.481253e-01
## 1031                            3628070               6.249461e-02
## 357                             1413382               2.070842e-06
## 1048                            1195820               3.163328e-06
## 366                                 159               8.980867e-01
## 1144                             987432               4.325844e-06
## 180                              669244               8.971960e-04
## 677                             4511321               4.867409e-06
## 362                              642175               7.920825e-06
## 932                                   0               1.532359e-03
## 1155                            2971898               2.290536e-05
## 1111                            2629971               9.366599e-06
## 1154                            5889109               8.932512e-03
## 973                             5478834               1.087349e-05
## 967                                   3               8.584617e-02
## 1037                                  3               5.633218e-03
## 745                             3384919               1.321795e-05
## 863                             1614274               6.652976e-01
## 44                              3053880               1.528399e-01
## 673                              831183               1.905103e-01
## 200                              336945               9.282256e-01
## 1006                            3600383               1.255327e-02
## 480                             1998821               1.938253e-05
## 688                             1626728               6.868586e-01
## 965                              530805               2.514008e-05
## 25                              1268734               3.846059e-01
## 1015                            4953238               2.801772e-05
## 361                              539333               3.087674e-05
## 836                               15398               4.148732e-05
## 1041                             323540               4.891531e-05
## 304                             3968109               1.241291e-01
## 1319                             523194               4.283914e-01
## 204                             4453387               7.054436e-01
## 734                             2483586               4.641602e-01
## 301                             3117943               1.292739e-01
## 609                             6600536               4.844087e-02
## 895                             5599754               1.278431e-04
## 197                              214975               9.743950e-01
## 535                               46943               2.733731e-01
## 1208                            6156757               1.612867e-04
## 1127                            6367348               1.639670e-04
## 124                                  63               6.419439e-02
## 481                             4701588               2.076606e-04
## 184                               72340               2.266696e-04
## 1100                            2040866               2.715006e-04
## 495                                 139               6.889829e-01
## 1291                            2533393               1.272425e-01
## 324                               15551               3.763122e-01
## 837                                 248               6.830217e-01
## 182                               53688               3.974787e-04
## 1269                            5634995               4.269705e-04
## 921                             1832182               1.445636e-03
## 1035                             256492               4.572645e-04
## 689                              517899               1.117600e-01
## 568                               76127               4.619509e-01
## 563                             1285514               3.175499e-01
## 669                              828381               5.153181e-01
## 95                                12218               7.731208e-01
## 273                               31591               7.649138e-01
## 1279                            3363642               5.839060e-04
## 203                                 439               7.982921e-01
## 42                              2098503               7.689445e-04
## 780                             2671384               9.893725e-01
## 642                               16872               9.110949e-04
## 198                                4516               7.231089e-01
## 435                              230382               1.015229e-03
## 724                             6944441               1.063105e-03
## 894                             2470598               1.094256e-03
## 303                             2751931               4.685660e-01
## 886                             1384005               1.304949e-03
## 1067                            2789652               9.917546e-01
## 801                             1219637               8.329828e-02
## 93                              2910871               6.824228e-01
## 199                                5567               5.825754e-01
## 676                             1658255               4.628316e-01
## 537                              246363               1.588647e-03
## 701                              751611               7.198851e-01
## 1119                            3305843               1.643834e-03
## 320                              186069               3.906521e-01
## 510                             4768266               6.059860e-01
## 211                             4048080               1.813872e-03
## 402                             3608163               1.854435e-03
## 331                               11823               8.551699e-01
## 442                             3425539               6.140481e-01
## 1289                            3425539               6.140481e-01
## 1311                            4322237               3.601625e-01
## 851                              889401               1.900092e-03
## 787                             4839604               6.411784e-03
## 1169                            1144783               1.660966e-01
## 680                              956365               2.054853e-03
## 500                             1431472               2.019380e-01
## 486                                1122               5.398839e-03
## 55                               609474               2.206363e-03
## 364                             1654263               3.358224e-01
## 91                              2988118               3.603996e-03
## 485                               48537               2.255177e-03
## 1096                             266885               2.526934e-03
## 52                              2756669               2.579150e-03
## 640                             5929367               2.725087e-01
## 861                              914661               2.837608e-03
## 425                             4363935               2.898527e-03
## 54                               490767               2.931161e-03
## 655                              323309               2.986487e-03
## 436                              291603               3.038685e-03
## 1329                               3189               3.068190e-03
## 811                             1932112               1.497850e-01
## 1285                            3233127               1.631240e-01
## 94                              1223570               3.459404e-03
## 212                             3375460               2.137039e-01
## 627                             4292297               3.622690e-03
## 444                             4007055               6.613865e-01
## 896                             3479357               3.808050e-03
## 1061                              91110               3.949308e-03
## 65                              3995949               2.053013e-01
## 228                             3201731               8.718692e-01
## 794                             2076662               1.741840e-01
## 976                             4749440               5.258986e-01
## 781                             1092999               8.398607e-01
## 681                               22789               7.981089e-01
## 1299                            5505906               1.354121e-01
## 1183                            2908529               2.625225e-01
## 165                             1484730               2.168104e-01
## 59                              2474383               1.926809e-01
## 407                             3604072               5.923994e-01
## 7                                  2404               2.796208e-02
## 797                             2223630               1.082606e-01
## 368                             1652815               4.597934e-01
## 922                             1136581               4.012670e-01
## 426                             4898106               5.283536e-03
## 566                             5900711               5.250835e-03
## 834                                4001               5.195177e-03
## 1274                            3676723               5.248535e-03
## 429                             2028040               6.846595e-03
## 1095                             224604               4.091814e-01
## 571                               93353               5.506783e-03
## 583                             1057574               5.491209e-03
## 71                              1729392               5.713824e-03
## 817                             2212839               5.715275e-03
## 1039                            2950353               4.536702e-01
## 593                             1952185               2.110959e-01
## 523                             3459115               5.855138e-03
## 952                             1966729               6.162543e-03
## 1077                            2106946               6.311188e-03
## 1081                            2106946               6.311188e-03
## 158                             3309628               7.407272e-01
## 977                             3667661               6.630965e-03
## 939                              130340               7.022917e-02
## 675                             2226917               1.011866e-01
## 290                             2622000               4.019386e-01
## 742                                8533               2.037332e-01
## 223                              911313               7.325345e-03
## 23                              3840086               6.776813e-01
## 912                             2017583               5.725637e-01
## 323                              731352               6.696188e-01
## 610                             2402919               3.865050e-01
## 960                             3638159               2.111248e-01
## 1267                            1615162               7.108086e-01
## 176                               41893               9.930147e-01
## 833                                5625               1.075692e-02
## 343                             5364259               8.694255e-02
## 949                             4621436               8.578529e-02
## 287                             2553161               5.939032e-02
## 83                               559853               8.216217e-03
## 959                             2467039               2.925972e-01
## 401                             1500111               9.647276e-02
## 953                             4206848               4.394904e-02
## 1097                            3124656               7.023983e-01
## 349                              276180               8.712309e-03
## 945                             3689970               9.823630e-01
## 687                              784963               5.394255e-01
## 899                             2765952               9.112855e-03
## 1159                             879429               9.360752e-03
## 35                              4648928               7.642834e-01
## 53                               574890               9.736082e-03
## 762                              880939               9.726353e-03
## 853                             1007461               9.839371e-03
## 225                             3151778               2.235204e-01
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##      NES_iDUX4t06dox_iDUX4dmso nMoreExtreme_iDUX4t06dox_iDUX4dmso
## 21                   2.6617292                                  0
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## 669                 -0.9581828                            2358463
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## 787                  1.7540889                              32909
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## 313                  1.0698602                            1986041
## 314                  1.0698602                            1986041
## 315                  1.0698602                            1986041
## 316                  1.0698602                            1986041
## 419                 -1.0806868                            1964958
## 656                 -1.0795784                            1950502
## 1075                 1.0534934                            2069615
## 448                 -0.6620592                            4287779
## 612                  0.8150592                            5341999
## 889                 -1.0267784                            2396801
## 494                 -0.7731599                            3717050
## 1074                 0.9482891                            2728117
## 561                 -1.0438261                            2279635
## 562                 -1.0438261                            2279635
## 648                  1.0154426                            2325657
## 127                  0.4515515                            4924149
## 692                 -0.7189954                            4024483
## 1325                 0.9965702                            2404909
## 116                 -1.0567615                            2127796
## 119                 -1.0567615                            2127796
## 14                  -1.0396164                            2206532
## 74                  -0.9877557                            1873589
## 112                 -0.9952198                            2374807
## 210                  0.9925234                            2433934
## 236                  1.0156588                            2352404
## 240                  1.0070565                            2359964
## 269                 -0.9881951                            2010157
## 529                  0.9980513                            2408275
## 548                 -1.0423418                            2289674
## 667                 -1.0412865                            2218670
## 978                 -0.9901708                            2316098
## 1091                 1.0274515                            2224694
## 1206                 1.0122286                            2322750
## 414                  0.9888395                            2451260
## 187                 -0.9063673                            2772243
## 18                   0.9051017                            2919433
## 20                   0.9051017                            2919433
## 1059                 0.9051017                            2919433
## 260                 -0.7273711                            3998556
## 446                  0.9636480                            2854503
## 608                  0.5983056                            5066346
## 1134                 0.6419682                            5229996
## 420                 -1.0006960                            2524642
## 194                  0.7349661                            3850226
## 168                  0.9700966                            2937471
## 663                  0.9663676                            2803698
## 854                 -0.7527023                            3917670
## 719                 -0.8744401                            2988745
## 1152                -0.7222471                            4420965
## 5                   -0.9593156                            2246987
## 137                 -0.8176983                            3869848
## 226                  0.6185749                            4477159
## 271                 -0.7722177                            3744600
## 348                 -0.6732332                            4242257
## 565                 -0.7272105                            4046202
## 657                  0.6671673                            4445074
## 726                  0.6698036                            4980689
## 903                  0.5417414                            4730594
## 928                  0.7787567                            4852290
## 1150                -0.9496049                            2477565
## 760                 -0.7875215                            3589970
## 475                  0.9513788                            2659137
## 98                   0.9560984                            2754196
## 6                   -0.9599454                            2264181
## 603                 -0.9864931                            2604915
## 947                 -0.9602473                            2280787
## 1024                -0.9864931                            2604915
## 1025                -0.9864931                            2604915
## 17                   0.7614910                            4293138
## 1132                -0.7109340                            4063510
## 1145                -0.9557187                            2317324
## 1076                 0.6385273                            4541198
## 989                  0.8902861                            3078304
## 169                  0.6661117                            5415394
## 408                 -0.5186339                            4859676
## 1062                -0.8536155                            3245220
## 646                 -0.9490964                            2370615
## 735                 -0.9409897                            2657108
## 804                  0.8575572                            3451900
## 38                  -0.9490134                            2955466
## 229                  0.8534943                            3206023
## 428                 -0.9195227                            2609178
## 474                  0.9313097                            2840377
## 100                  0.7538165                            4068825
## 252                  0.7734874                            4202272
## 456                 -0.8948425                            2917684
## 186                  0.8281803                            3623042
## 384                  0.7313959                            4094526
## 493                 -0.6960617                            4094853
## 1080                 0.9015009                            3075989
## 1251                -0.4266011                            5025058
## 1254                -0.7064052                            4057309
## 45                   0.8260020                            3377611
## 826                  0.7461967                            3906973
## 43                   0.8220446                            3837979
## 859                  0.4742875                            4888660
## 1146                 0.7634516                            3816870
## 1253                -0.5406928                            4779447
## 547                  0.6094045                            5294702
## 117                 -0.9197949                            3014796
## 118                 -0.9197949                            3014796
## 248                 -0.9316036                            2503646
## 1066                -0.9289340                            2960933
## 1223                -0.9197794                            2814270
## 1108                 0.6392391                            4537993
## 1339                -0.6370401                            4463122
## 1008                 0.5632287                            4667824
## 1142                 0.6691661                            4271762
## 666                 -0.8849417                            3061088
## 272                  0.7199071                            5171835
## 546                  0.6014981                            5365734
## 422                  0.8807540                            3459570
## 410                 -0.7822424                            3627535
## 1160                -0.7226786                            4170739
## 929                 -0.4940898                            4913937
## 192                 -0.9052039                            2723525
## 1232                 0.8485937                            3275220
## 1239                -0.8962531                            2805081
## 1128                 0.8438649                            3460775
## 937                 -0.6919750                            4044450
## 1258                 0.7722419                            3771649
## 253                 -0.6989105                            4093349
## 1057                 0.7193232                            4006170
## 447                  0.5714949                            5361325
## 798                  0.6460605                            5646376
## 559                 -0.5305613                            4785549
## 491                 -0.7247824                            3994711
## 1304                 0.8298914                            3929162
## 378                 -0.7064839                            4056198
## 1114                 0.8116328                            3500518
## 1151                -0.8359877                            3487008
## 1137                 0.6890644                            4129096
## 268                 -0.8588330                            3114359
## 47                   0.8517502                            3615293
## 151                  0.6394506                            4320588
## 293                 -0.8123763                            3496863
## 360                 -0.6838061                            4255362
## 81                   0.6783725                            4914226
## 544                 -0.8576800                            3137669
## 1124                -0.7274601                            3959271
## 1209                -0.7404836                            3909761
## 312                 -0.7254512                            3977907
## 942                 -0.8409718                            3264857
## 105                 -0.7796642                            3700779
## 239                 -0.7581456                            3768853
## 556                 -0.5790604                            4719922
## 558                 -0.5790604                            4719922
## 944                 -0.7695648                            3763901
## 89                   0.5462784                            5007161
## 113                  0.8398143                            4503700
## 445                  0.7522791                            3931271
## 1182                -0.7552943                            3904374
## 918                 -0.7559837                            3800315
## 328                  0.7136147                            4037847
## 353                  0.6448136                            4431653
## 1120                 0.6364839                            4666660
## 135                 -0.7615458                            3801157
##      pval_iDUX4t14dox_iDUX4dmso padj_iDUX4t14dox_iDUX4dmso
## 21                 1.651335e-07               1.326828e-05
## 24                 6.414010e-07               4.550571e-05
## 108                1.586762e-07               1.326828e-05
## 109                2.086253e-03               4.610276e-02
## 110                5.263267e-05               2.027110e-03
## 170                4.730379e-06               2.198811e-04
## 181                2.803109e-04               8.396869e-03
## 205                1.625957e-07               1.326828e-05
## 275                9.172200e-05               3.170289e-03
## 299                4.594541e-06               2.198811e-04
## 300                1.646174e-07               1.326828e-05
## 341                1.513929e-06               8.211066e-05
## 346                1.603503e-07               1.326828e-05
## 404                8.819264e-06               3.962789e-04
## 483                1.590519e-07               1.326828e-05
## 487                1.673299e-07               1.326828e-05
## 504                3.510869e-03               7.394767e-02
## 521                1.353355e-05               5.874347e-04
## 624                1.559407e-07               1.326828e-05
## 625                1.607926e-07               1.326828e-05
## 709                7.892764e-07               5.319723e-05
## 788                2.365956e-05               9.664570e-04
## 847                1.545415e-07               1.326828e-05
## 855                1.640907e-07               1.326828e-05
## 856                1.420698e-06               8.211066e-05
## 865                4.494300e-04               1.262149e-02
## 906                5.263267e-05               2.027110e-03
## 958                1.555905e-07               1.326828e-05
## 980                1.559407e-07               1.326828e-05
## 986                1.607926e-07               1.326828e-05
## 987                1.555905e-07               1.326828e-05
## 1013               3.215851e-06               1.605544e-04
## 1131               1.651335e-07               1.326828e-05
## 1213               3.454614e-04               9.908127e-03
## 1272               1.522824e-06               8.211066e-05
## 1275               1.621320e-07               1.326828e-05
## 355                1.013366e-04               3.415042e-03
## 626                1.624367e-04               5.340602e-03
## 744                7.088096e-03               1.308870e-01
## 431                9.627736e-04               2.403368e-02
## 985                2.057260e-06               1.066610e-04
## 405                9.411939e-04               2.393829e-02
## 479                6.330030e-07               4.550571e-05
## 520                5.770868e-03               1.111304e-01
## 587                9.411939e-04               2.393829e-02
## 832                9.877042e-07               6.340121e-05
## 162                4.297492e-02               4.393730e-01
## 161                2.233129e-01               7.710392e-01
## 430                1.090432e-01               6.729214e-01
## 160                1.363329e-02               2.149498e-01
## 482                6.948936e-05               2.489704e-03
## 647                1.109783e-01               6.729214e-01
## 1031               4.274256e-01               8.693553e-01
## 357                1.519774e-06               8.211066e-05
## 1048               1.394504e-05               5.874347e-04
## 366                4.468492e-01               8.693553e-01
## 1144               1.555785e-03               3.554572e-02
## 180                2.514142e-04               7.702418e-03
## 677                6.268114e-05               2.347060e-03
## 362                6.961086e-03               1.303270e-01
## 932                3.528789e-01               8.546409e-01
## 1155               1.981323e-02               2.568099e-01
## 1111               1.332714e-03               3.097410e-02
## 1154               1.216871e-01               6.863358e-01
## 973                1.761391e-04               5.653227e-03
## 967                1.171377e-01               6.827239e-01
## 1037               9.125025e-01               9.840427e-01
## 745                1.254707e-02               2.037765e-01
## 863                2.793468e-01               8.147261e-01
## 44                 3.598614e-02               3.915365e-01
## 673                2.200688e-01               7.709968e-01
## 200                6.737969e-01               9.275145e-01
## 1006               5.418981e-02               5.180700e-01
## 480                6.419552e-04               1.730711e-02
## 688                1.622176e-01               7.183352e-01
## 965                1.970717e-02               2.568099e-01
## 25                 1.083149e-01               6.729214e-01
## 1015               7.018454e-05               2.489704e-03
## 361                1.440524e-02               2.181828e-01
## 836                2.453816e-01               7.897166e-01
## 1041               1.674610e-02               2.353970e-01
## 304                5.693835e-02               5.367336e-01
## 1319               1.277322e-01               6.897841e-01
## 204                2.326701e-01               7.855933e-01
## 734                4.302465e-02               4.393730e-01
## 301                8.367293e-01               9.714996e-01
## 609                9.542427e-03               1.649127e-01
## 895                1.172413e-03               2.822165e-02
## 197                9.979658e-01               9.999775e-01
## 535                6.574503e-01               9.222092e-01
## 1208               1.898487e-03               4.265267e-02
## 1127               4.342367e-03               9.005401e-02
## 124                2.466496e-01               7.897166e-01
## 481                1.052187e-03               2.578815e-02
## 184                6.827473e-01               9.343587e-01
## 1100               1.311943e-03               3.097410e-02
## 495                1.220997e-02               2.007201e-01
## 1291               2.033614e-04               6.375143e-03
## 324                3.613161e-01               8.590581e-01
## 837                1.762289e-01               7.446914e-01
## 182                8.432519e-01               9.740391e-01
## 1269               5.291461e-04               1.455692e-02
## 921                1.927568e-02               2.568099e-01
## 1035               3.841430e-01               8.693553e-01
## 689                8.491244e-02               6.377932e-01
## 568                6.322720e-01               9.140425e-01
## 563                3.207581e-04               9.399607e-03
## 669                9.477101e-01               9.928250e-01
## 95                 4.153216e-01               8.693553e-01
## 273                9.967352e-01               9.999775e-01
## 1279               5.317767e-03               1.063478e-01
## 203                2.015892e-01               7.530348e-01
## 42                 1.277534e-02               2.050137e-01
## 780                9.465315e-01               9.928250e-01
## 642                3.188376e-01               8.424793e-01
## 198                9.116456e-01               9.839057e-01
## 435                8.516526e-02               6.377932e-01
## 724                7.548247e-02               6.166689e-01
## 894                1.376393e-02               2.149498e-01
## 303                7.443780e-01               9.402207e-01
## 886                4.124440e-01               8.693553e-01
## 1067               9.872656e-01               9.999775e-01
## 801                9.113204e-04               2.393829e-02
## 93                 6.135425e-01               9.052815e-01
## 199                8.025359e-01               9.659719e-01
## 676                7.257813e-01               9.402207e-01
## 537                1.020956e-01               6.729214e-01
## 701                9.060877e-01               9.823495e-01
## 1119               2.154775e-02               2.766320e-01
## 320                1.532068e-01               7.097002e-01
## 510                2.555797e-01               7.938283e-01
## 211                4.267473e-01               8.693553e-01
## 402                1.004753e-01               6.704983e-01
## 331                2.761549e-01               8.147261e-01
## 442                5.032880e-01               8.771748e-01
## 1289               5.032880e-01               8.771748e-01
## 1311               1.717129e-01               7.335627e-01
## 851                2.091469e-01               7.543500e-01
## 787                1.947364e-01               7.525063e-01
## 1169               8.242131e-01               9.693014e-01
## 680                1.311742e-01               6.907142e-01
## 500                3.100550e-02               3.541985e-01
## 486                8.391205e-01               9.714996e-01
## 55                 2.214474e-01               7.710392e-01
## 364                1.677252e-01               7.293339e-01
## 91                 9.666049e-02               6.677251e-01
## 485                2.550408e-01               7.938283e-01
## 1096               1.843760e-01               7.525063e-01
## 52                 3.916389e-01               8.693553e-01
## 640                9.998603e-01               9.999775e-01
## 861                1.943395e-01               7.525063e-01
## 425                4.304883e-01               8.693553e-01
## 54                 2.079406e-01               7.543500e-01
## 655                7.286271e-03               1.309586e-01
## 436                3.507490e-01               8.546409e-01
## 1329               3.470146e-01               8.546409e-01
## 811                3.552015e-01               8.550206e-01
## 1285               1.974111e-01               7.525063e-01
## 94                 8.197700e-02               6.357732e-01
## 212                3.938424e-01               8.693553e-01
## 627                4.860299e-02               4.776146e-01
## 444                6.067959e-01               9.027578e-01
## 896                3.228811e-02               3.612913e-01
## 1061               5.186176e-01               8.804170e-01
## 65                 9.083432e-03               1.611114e-01
## 228                4.796284e-01               8.719109e-01
## 794                1.473477e-01               6.939872e-01
## 976                4.598947e-01               8.693553e-01
## 781                7.725208e-01               9.553743e-01
## 681                1.897602e-01               7.525063e-01
## 1299               4.288355e-01               8.693553e-01
## 1183               7.346696e-01               9.402207e-01
## 165                3.108946e-01               8.424793e-01
## 59                 5.109565e-01               8.771748e-01
## 407                4.280833e-01               8.693553e-01
## 7                  3.406388e-01               8.546409e-01
## 797                3.243045e-02               3.612913e-01
## 368                3.012516e-03               6.549794e-02
## 922                3.090732e-03               6.613186e-02
## 426                5.190328e-01               8.804170e-01
## 566                1.189333e-01               6.836857e-01
## 834                7.108934e-01               9.402207e-01
## 1274               7.205747e-03               1.309586e-01
## 429                2.358414e-01               7.855933e-01
## 1095               5.291065e-02               5.094540e-01
## 571                7.785292e-02               6.284176e-01
## 583                1.435187e-01               6.939872e-01
## 71                 5.727264e-01               8.990131e-01
## 817                4.264985e-01               8.693553e-01
## 1039               5.618582e-01               8.941970e-01
## 593                2.774911e-01               8.147261e-01
## 523                4.258096e-01               8.693553e-01
## 952                9.827696e-02               6.677251e-01
## 1077               1.100380e-01               6.729214e-01
## 1081               1.100380e-01               6.729214e-01
## 158                4.727483e-01               8.719109e-01
## 977                1.962939e-02               2.568099e-01
## 939                1.975489e-01               7.525063e-01
## 675                9.268217e-01               9.863597e-01
## 290                9.294342e-01               9.872949e-01
## 742                7.741758e-01               9.556676e-01
## 223                1.908397e-01               7.525063e-01
## 23                 4.873895e-01               8.719109e-01
## 912                6.993207e-01               9.401387e-01
## 323                4.252483e-01               8.693553e-01
## 610                4.050097e-01               8.693553e-01
## 960                9.725961e-02               6.677251e-01
## 1267               2.768856e-01               8.147261e-01
## 176                8.027603e-01               9.659719e-01
## 833                8.143867e-01               9.693014e-01
## 343                4.761681e-01               8.719109e-01
## 949                7.892520e-02               6.295336e-01
## 287                4.493327e-01               8.693553e-01
## 83                 1.586493e-01               7.183352e-01
## 959                1.293904e-01               6.897841e-01
## 401                9.919675e-02               6.677251e-01
## 953                5.743471e-03               1.111304e-01
## 1097               4.863105e-01               8.719109e-01
## 349                7.527046e-01               9.402207e-01
## 945                4.721029e-03               9.642345e-02
## 687                3.524436e-01               8.546409e-01
## 899                1.347732e-01               6.939872e-01
## 1159               6.583199e-02               5.731250e-01
## 35                 4.909168e-01               8.719109e-01
## 53                 5.303830e-01               8.832770e-01
## 762                1.092691e-01               6.729214e-01
## 853                2.410993e-01               7.855933e-01
## 225                3.514268e-01               8.546409e-01
## 1210               1.711343e-02               2.353970e-01
## 763                4.618592e-01               8.693553e-01
## 1046               2.473220e-01               7.897166e-01
## 1098               7.889860e-02               6.295336e-01
## 670                4.195147e-01               8.693553e-01
## 890                5.364728e-03               1.063478e-01
## 58                 2.948170e-01               8.331517e-01
## 376                1.998496e-01               7.525063e-01
## 519                2.371539e-01               7.855933e-01
## 569                1.401578e-01               6.939872e-01
## 905                6.036652e-02               5.498248e-01
## 172                6.268672e-02               5.671255e-01
## 342                1.488391e-02               2.229279e-01
## 526                4.838258e-01               8.719109e-01
## 467                4.350068e-01               8.693553e-01
## 502                5.978650e-03               1.135102e-01
## 1171               7.128546e-01               9.402207e-01
## 237                1.401993e-01               6.939872e-01
## 729                4.851467e-01               8.719109e-01
## 1133               4.840992e-01               8.719109e-01
## 1287               2.579029e-01               7.973694e-01
## 473                4.197272e-01               8.693553e-01
## 1286               3.215982e-01               8.424793e-01
## 773                2.444201e-01               7.897166e-01
## 11                 1.304859e-01               6.897841e-01
## 399                2.480214e-01               7.897166e-01
## 650                7.381654e-01               9.402207e-01
## 746                1.304859e-01               6.897841e-01
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## 99                 7.117099e-01               9.402207e-01
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## 1278               6.703763e-01               9.275145e-01
## 1303               1.964735e-01               7.525063e-01
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## 1016               4.519104e-01               8.693553e-01
## 1315               5.521489e-01               8.936941e-01
## 560                4.602591e-01               8.693553e-01
## 1268               3.542924e-01               8.546409e-01
## 936                5.041476e-01               8.771748e-01
## 125                1.207084e-01               6.863358e-01
## 123                3.062773e-01               8.424793e-01
## 743                1.592181e-01               7.183352e-01
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## 702                9.145269e-01               9.846503e-01
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## 580                1.237704e-01               6.897841e-01
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## 1004               6.414633e-01               9.140425e-01
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## 1260               8.229965e-01               9.693014e-01
## 177                1.332743e-01               6.939872e-01
## 255                1.332743e-01               6.939872e-01
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## 550                1.438085e-01               6.939872e-01
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## 917                1.482703e-01               6.939872e-01
## 1335               5.383319e-01               8.893032e-01
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## 1305               9.166318e-01               9.861290e-01
## 60                 4.750623e-01               8.719109e-01
## 415                4.089734e-01               8.693553e-01
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## 651                5.087027e-01               8.771748e-01
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## 809                9.476182e-01               9.928250e-01
## 1012               9.497231e-01               9.928250e-01
## 1191               4.354955e-01               8.693553e-01
## 524                8.479632e-01               9.761095e-01
## 1197               1.986016e-01               7.525063e-01
## 707                2.498306e-01               7.905439e-01
## 920                5.799417e-01               8.990131e-01
## 298                2.963412e-01               8.357071e-01
## 567                4.496982e-01               8.693553e-01
## 994                7.318173e-01               9.402207e-01
## 582                4.203918e-01               8.693553e-01
## 330                9.201839e-01               9.863597e-01
## 554                4.333595e-01               8.693553e-01
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## 564                4.333595e-01               8.693553e-01
## 336                1.550093e-01               7.131488e-01
## 914                1.546663e-01               7.131488e-01
## 460                1.986761e-01               7.525063e-01
## 274                9.286299e-01               9.872185e-01
## 383                4.645013e-01               8.693553e-01
## 385                4.645013e-01               8.693553e-01
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## 867                1.609616e-01               7.183352e-01
## 171                8.850430e-01               9.812204e-01
## 740                8.850430e-01               9.812204e-01
## 1032               8.362025e-01               9.714996e-01
## 924                1.612142e-01               7.183352e-01
## 64                 4.120463e-01               8.693553e-01
## 134                5.122960e-01               8.771748e-01
## 206                4.120463e-01               8.693553e-01
## 738                3.247638e-01               8.442219e-01
## 934                5.726718e-01               8.990131e-01
## 1216               2.760965e-01               8.147261e-01
## 1186               8.801805e-01               9.812204e-01
## 602                8.212852e-01               9.693014e-01
## 878                7.367327e-01               9.402207e-01
## 1333               3.465460e-01               8.546409e-01
## 649                4.112612e-01               8.693553e-01
## 512                8.322592e-01               9.693014e-01
## 513                8.322592e-01               9.693014e-01
## 911                9.256096e-01               9.863597e-01
## 48                 1.657594e-01               7.254666e-01
## 1090               5.771379e-01               8.990131e-01
## 943                4.391698e-01               8.693553e-01
## 1101               1.847327e-01               7.525063e-01
## 144                9.976802e-01               9.999775e-01
## 747                5.827289e-01               8.997922e-01
## 766                9.138411e-01               9.846503e-01
## 901                6.884048e-01               9.373357e-01
## 598                8.984579e-01               9.812653e-01
## 1070               8.529298e-01               9.761095e-01
## 1330               3.134031e-01               8.424793e-01
## 178                1.730511e-01               7.335627e-01
## 1307               9.458384e-01               9.928250e-01
## 697                7.481005e-01               9.402207e-01
## 128                3.863913e-01               8.693553e-01
## 233                6.902809e-01               9.373357e-01
## 741                5.923180e-01               9.024182e-01
## 751                7.775707e-01               9.563552e-01
## 611                4.703360e-01               8.697023e-01
## 1192               9.879900e-01               9.999775e-01
## 208                6.695971e-01               9.275145e-01
## 221                8.958825e-01               9.812204e-01
## 1313               5.547182e-01               8.936941e-01
## 637                3.936068e-01               8.693553e-01
## 1228               3.936068e-01               8.693553e-01
## 1056               8.250668e-01               9.693014e-01
## 439                5.447978e-01               8.936941e-01
## 733                6.219986e-01               9.084009e-01
## 1271               5.111774e-01               8.771748e-01
## 1323               9.639345e-01               9.999775e-01
## 752                4.899113e-01               8.719109e-01
## 19                 2.777718e-01               8.147261e-01
## 242                4.670545e-01               8.693553e-01
## 294                3.039920e-01               8.424793e-01
## 397                6.878935e-01               9.373357e-01
## 875                4.145151e-01               8.693553e-01
## 1089               4.256485e-01               8.693553e-01
## 1118               2.786184e-01               8.147261e-01
## 1301               6.002196e-01               9.027578e-01
## 1302               6.002196e-01               9.027578e-01
## 508                7.192699e-01               9.402207e-01
## 372                9.546830e-01               9.952921e-01
## 819                4.121944e-01               8.693553e-01
## 820                4.121944e-01               8.693553e-01
## 821                4.121944e-01               8.693553e-01
## 822                4.121944e-01               8.693553e-01
## 96                 1.995693e-01               7.525063e-01
## 633                1.828907e-01               7.525063e-01
## 16                 2.018219e-01               7.530348e-01
## 764                2.018219e-01               7.530348e-01
## 1058               2.027831e-01               7.530348e-01
## 595                2.082794e-01               7.543500e-01
## 285                7.919620e-01               9.629292e-01
## 340                6.242028e-01               9.096491e-01
## 1017               7.532925e-01               9.402207e-01
## 1107               6.226904e-01               9.084271e-01
## 254                8.839330e-01               9.812204e-01
## 1244               7.417731e-01               9.402207e-01
## 455                6.696073e-01               9.275145e-01
## 927                8.534628e-01               9.761095e-01
## 40                 9.678266e-01               9.999775e-01
## 347                9.794094e-01               9.999775e-01
## 946                7.238318e-01               9.402207e-01
## 1038               7.995748e-01               9.659719e-01
## 1073               5.735610e-01               8.990131e-01
## 518                8.712243e-01               9.812204e-01
## 671                7.567177e-01               9.404578e-01
## 1204               8.712243e-01               9.812204e-01
## 1308               9.481295e-01               9.928250e-01
## 1255               4.676900e-01               8.693553e-01
## 779                6.046015e-01               9.027578e-01
## 1235               3.209160e-01               8.424793e-01
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## 1110               9.811870e-01               9.999775e-01
## 824                5.923241e-01               9.024182e-01
## 620                2.267631e-01               7.797874e-01
## 1281               5.561172e-01               8.936941e-01
## 862                9.231157e-01               9.863597e-01
## 1153               9.231157e-01               9.863597e-01
## 1069               7.555289e-01               9.404578e-01
## 1203               2.418555e-01               7.855933e-01
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## 1053               5.608793e-01               8.936941e-01
## 1054               5.608793e-01               8.936941e-01
## 1055               5.608793e-01               8.936941e-01
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## 286                5.971491e-01               9.024182e-01
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## 682                8.179924e-01               9.693014e-01
## 703                4.041668e-01               8.693553e-01
## 1106               5.025989e-01               8.771748e-01
## 136                4.903576e-01               8.719109e-01
## 553                5.250791e-01               8.825519e-01
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## 419                7.569709e-01               9.404578e-01
## 656                7.157902e-01               9.402207e-01
## 1075               5.123369e-01               8.771748e-01
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## 648                3.372369e-01               8.521577e-01
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## 1325               8.280800e-01               9.693014e-01
## 116                7.950595e-01               9.629292e-01
## 119                7.950595e-01               9.629292e-01
## 14                 6.337294e-01               9.140425e-01
## 74                 6.055723e-01               9.027578e-01
## 112                8.533814e-01               9.761095e-01
## 210                8.861123e-01               9.812204e-01
## 236                5.067265e-01               8.771748e-01
## 240                7.524252e-01               9.402207e-01
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## 529                3.968371e-01               8.693553e-01
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## 1091               8.864043e-01               9.812204e-01
## 1206               7.040698e-01               9.402207e-01
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## 1059               8.488953e-01               9.761095e-01
## 260                3.275430e-01               8.442219e-01
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## 194                6.904855e-01               9.373357e-01
## 168                5.124020e-01               8.771748e-01
## 663                4.415126e-01               8.693553e-01
## 854                9.400768e-01               9.928250e-01
## 719                7.134261e-01               9.402207e-01
## 1152               9.054224e-01               9.823495e-01
## 5                  6.667201e-01               9.275145e-01
## 137                6.995245e-01               9.401387e-01
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## 348                9.496003e-01               9.928250e-01
## 565                5.267718e-01               8.831945e-01
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## 726                8.282319e-01               9.693014e-01
## 903                7.074079e-01               9.402207e-01
## 928                6.441694e-01               9.140425e-01
## 1150               7.408762e-01               9.402207e-01
## 760                6.497347e-01               9.161531e-01
## 475                4.137649e-01               8.693553e-01
## 98                 6.173420e-01               9.064634e-01
## 6                  4.596948e-01               8.693553e-01
## 603                8.739070e-01               9.812204e-01
## 947                9.513343e-01               9.932068e-01
## 1024               8.739070e-01               9.812204e-01
## 1025               8.739070e-01               9.812204e-01
## 17                 3.125469e-01               8.424793e-01
## 1132               3.010032e-01               8.424793e-01
## 1145               8.967830e-01               9.812204e-01
## 1076               8.287101e-01               9.693014e-01
## 989                9.011241e-01               9.819246e-01
## 169                3.825651e-01               8.693553e-01
## 408                7.296360e-01               9.402207e-01
## 1062               6.852615e-01               9.353696e-01
## 646                9.486459e-01               9.928250e-01
## 735                6.358933e-01               9.140425e-01
## 804                3.344312e-01               8.473933e-01
## 38                 7.218013e-01               9.402207e-01
## 229                7.862021e-01               9.629292e-01
## 428                8.053429e-01               9.666984e-01
## 474                7.451720e-01               9.402207e-01
## 100                3.683939e-01               8.614542e-01
## 252                7.885431e-01               9.629292e-01
## 456                5.362567e-01               8.869620e-01
## 186                4.424927e-01               8.693553e-01
## 384                3.892404e-01               8.693553e-01
## 493                4.579320e-01               8.693553e-01
## 1080               3.808732e-01               8.693553e-01
## 1251               4.651592e-01               8.693553e-01
## 1254               4.644001e-01               8.693553e-01
## 45                 4.695454e-01               8.697023e-01
## 826                6.530153e-01               9.188566e-01
## 43                 7.222792e-01               9.402207e-01
## 859                4.801855e-01               8.719109e-01
## 1146               4.797486e-01               8.719109e-01
## 1253               8.032586e-01               9.659719e-01
## 547                6.397663e-01               9.140425e-01
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## 118                7.388287e-01               9.402207e-01
## 248                8.586497e-01               9.761095e-01
## 1066               6.524786e-01               9.188566e-01
## 1223               9.484270e-01               9.928250e-01
## 1108               5.809563e-01               8.990131e-01
## 1339               6.091507e-01               9.027578e-01
## 1008               7.511774e-01               9.402207e-01
## 1142               7.201036e-01               9.402207e-01
## 666                8.966242e-01               9.812204e-01
## 272                5.320274e-01               8.832770e-01
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## 410                5.570636e-01               8.936941e-01
## 1160               9.020812e-01               9.819246e-01
## 929                9.249030e-01               9.863597e-01
## 192                8.882403e-01               9.812204e-01
## 1232               8.584780e-01               9.761095e-01
## 1239               8.511620e-01               9.761095e-01
## 1128               8.707436e-01               9.812204e-01
## 937                5.835600e-01               9.000446e-01
## 1258               7.446416e-01               9.402207e-01
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## 1304               6.440273e-01               9.140425e-01
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## 1151               8.938026e-01               9.812204e-01
## 1137               9.413772e-01               9.928250e-01
## 268                8.320522e-01               9.693014e-01
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## 360                7.981025e-01               9.657470e-01
## 81                 8.713153e-01               9.812204e-01
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## 1124               6.924059e-01               9.385856e-01
## 1209               8.093147e-01               9.672124e-01
## 312                6.977490e-01               9.401387e-01
## 942                6.984463e-01               9.401387e-01
## 105                7.202885e-01               9.402207e-01
## 239                7.484063e-01               9.402207e-01
## 556                7.500592e-01               9.402207e-01
## 558                7.500592e-01               9.402207e-01
## 944                7.107122e-01               9.402207e-01
## 89                 9.749930e-01               9.999775e-01
## 113                7.936058e-01               9.629292e-01
## 445                8.822493e-01               9.812204e-01
## 1182               8.710781e-01               9.812204e-01
## 918                8.583350e-01               9.761095e-01
## 328                7.940981e-01               9.629292e-01
## 353                7.900252e-01               9.629292e-01
## 1120               9.101695e-01               9.838881e-01
## 135                9.394743e-01               9.928250e-01
##      ES_iDUX4t14dox_iDUX4dmso NES_iDUX4t14dox_iDUX4dmso
## 21                  0.8631754                 2.5332975
## 24                  0.7496076                 2.3061778
## 108                 0.7883597                 2.4632024
## 109                 0.6297885                 1.8774810
## 110                 0.7991278                 2.1377630
## 170                 0.6210612                 2.1221007
## 181                 0.6227321                 1.9800331
## 205                 0.7795796                 2.3466510
## 275                 0.7759587                 2.1131496
## 299                 0.7540814                 2.2367725
## 300                 0.8238772                 2.4309042
## 341                 0.6649777                 2.2103705
## 346                 0.8223015                 2.5298215
## 404                 0.7119254                 2.1902480
## 483                 0.7622696                 2.3730035
## 487                 0.8700656                 2.4942422
## 504                 0.5757138                 1.7987977
## 521                 0.7822704                 2.1976023
## 624                 0.7760741                 2.4835042
## 625                 0.8152097                 2.4976548
## 709                 0.7309616                 2.3005217
## 788                 0.6690170                 2.1272000
## 847                 0.7550403                 2.4454131
## 855                 0.8488529                 2.5178858
## 856                 0.7126250                 2.2428117
## 865                 0.6560696                 1.9839789
## 906                 0.7991278                 2.1377630
## 958                 0.7687432                 2.4677048
## 980                 0.7689436                 2.4606859
## 986                 0.7846402                 2.4039954
## 987                 0.7414478                 2.3800853
## 1013                0.7297834                 2.2359241
## 1131                0.8491786                 2.4922189
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## 664                 0.5081921                 1.2337644
## 935                 0.5733212                 1.1817033
## 975                 0.2731553                 0.8991377
## 1023               -0.3608049                -0.8410953
## 591                 0.6160122                 1.4711244
## 984                -0.6374751                -1.4360102
## 728                 0.7276104                 1.0915626
## 67                  0.8417559                 1.1225182
## 15                  0.4677106                 0.8845163
## 835                 0.4458759                 1.0824762
## 30                  0.2559385                 0.6213554
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## 672                 0.5247803                 1.2936373
## 1331                0.4424195                 0.8770571
## 754                 0.8171250                 1.3526682
## 1085                0.5106549                 0.9110667
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## 993                -0.3397873                -0.7654228
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## 1005                0.3281266                 0.9781880
## 39                  0.3344696                 0.5536808
## 758                -0.9471092                -1.2632773
## 684                 0.5264042                 1.2779790
## 1238                0.8152034                 1.0871093
## 1344               -0.4435468                -0.8133925
## 514                -0.6510977                -1.3469218
## 528                -0.3742825                -0.9468244
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## 1026               -0.6864180                -1.0408016
## 813                 0.6633704                 1.0981429
## 814                 0.6633704                 1.0981429
## 1278                0.3492595                 0.8191766
## 1303                0.5358395                 1.2796607
## 179                 0.7086261                 1.2642698
## 530                 0.4646881                 1.0682738
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## 560                 0.3722338                 0.9862141
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## 936                -0.3642942                -0.9616000
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## 123                 0.5101141                 1.1467657
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## 641                 0.7653079                 1.3653967
## 1176                0.3374871                 0.8438221
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## 1060                0.4515719                 0.8539955
## 580                -0.8603555                -1.3045396
## 174                 0.6369539                 1.1363985
## 1004               -0.6792291                -0.9059723
## 311                -0.3530001                -0.9658615
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## 177                -0.7881320                -1.3301924
## 255                -0.7881320                -1.3301924
## 437                 0.8017045                 1.3271412
## 550                 0.9282655                 1.2378826
## 904                 0.6607938                 1.3619979
## 917                -0.7266592                -1.3325745
## 1335                0.7310493                 0.9748861
## 238                 0.2763238                 0.7525058
## 393                -0.8331906                -1.1113299
## 604                -0.3891891                -0.6568652
## 1305                0.3579692                 0.5925819
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## 417                 0.5107833                 1.0528031
## 418                 0.5107833                 1.0528031
## 651                 0.3197261                 0.9531450
## 800                -0.5459682                -1.1294411
## 809                 0.2086474                 0.6123505
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## 1191                0.7072872                 1.0610737
## 524                 0.3518787                 0.6654594
## 1197               -0.4960130                -1.2547667
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## 920                -0.4377059                -0.9054796
## 298                 0.6217752                 1.1758775
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## 555                -0.3167702                -0.4803122
## 564                -0.7018634                -1.0642211
## 336                -0.4508348                -1.2899546
## 914                -0.8412823                -1.2756192
## 460                 0.4588820                 1.2600789
## 274                 0.2577354                 0.5794040
## 383                 0.6938300                 1.0408852
## 385                 0.6938300                 1.0408852
## 386                 0.6938300                 1.0408852
## 388                 0.6938300                 1.0408852
## 390                 0.6938300                 1.0408852
## 391                 0.6938300                 1.0408852
## 392                 0.6938300                 1.0408852
## 867                 0.5953023                 1.3382736
## 171                -0.4307744                -0.6531745
## 740                -0.4307744                -0.6531745
## 1032               -0.3701323                -0.6787622
## 924                -0.8373856                -1.2697108
## 64                 -0.7940043                -1.0590622
## 134                 0.3891401                 0.9447358
## 206                -0.7940043                -1.0590622
## 738                -0.5525521                -1.1430611
## 934                -0.4676495                -0.9163382
## 1216                0.7189480                 1.1901461
## 1186               -0.3244438                -0.6357331
## 602                 0.3487350                 0.6913360
## 878                 0.2674692                 0.7973604
## 1333                0.6841341                 1.1325152
## 649                 0.3371615                 1.0286674
## 512                 0.4171796                 0.6905988
## 513                 0.4171796                 0.6905988
## 911                 0.2906811                 0.5762493
## 48                 -0.8346981                -1.2656358
## 1090               -0.3018441                -0.9159046
## 943                -0.4733546                -1.0252306
## 1101                0.4803323                 1.2849466
## 144                -0.1485941                -0.4412480
## 747                 0.5697640                 0.9431869
## 766                 0.2131493                 0.6883261
## 901                 0.3580443                 0.8049041
## 598                -0.3338214                -0.6121740
## 1070                0.2500502                 0.6973923
## 1330                0.8434690                 1.1248026
## 178                -0.5095014                -1.2888885
## 1307                0.2032782                 0.6463413
## 697                -0.5420861                -0.8219541
## 128                 0.3793029                 1.0499421
## 233                -0.2998614                -0.8336749
## 741                 0.3753725                 0.8804236
## 751                 0.5298779                 0.7949240
## 611                 0.4382288                 0.9851634
## 1192                0.5059957                 0.6747674
## 208                 0.3741672                 0.8202671
## 221                 0.2760690                 0.6206188
## 1313                0.7229122                 0.9640349
## 637                 0.8032120                 1.0711182
## 1228                0.8032120                 1.0711182
## 1056                0.3469178                 0.6877336
## 439                 0.3781850                 0.9181396
## 733                 0.3815577                 0.8577635
## 1271               -0.2646889                -0.9659813
## 1323                0.3557507                 0.5336979
## 752                 0.4305261                 0.9678472
## 19                 -0.8612420                -1.1487455
## 242                 0.4119745                 0.9838534
## 294                -0.7629043                -1.1567762
## 397                -0.3515659                -0.8195576
## 875                 0.5081935                 1.0474652
## 1089               -0.4280182                -1.0283916
## 1118               -0.8608137                -1.1481743
## 1301                0.3804219                 0.8745538
## 1302                0.3804219                 0.8745538
## 508                 0.3038801                 0.7882614
## 372                -0.2922648                -0.5359661
## 819                 0.6024143                 1.0747760
## 820                 0.6024143                 1.0747760
## 821                 0.6024143                 1.0747760
## 822                 0.6024143                 1.0747760
## 96                  0.6221574                 1.2823622
## 633                 0.7698368                 1.2743874
## 16                 -0.8145269                -1.2350505
## 764                -0.8145269                -1.2350505
## 1058               -0.5234766                -1.2577477
## 595                 0.5193799                 1.2609256
## 285                 0.3205847                 0.7206928
## 340                 0.3909127                 0.8569775
## 1017               -0.4543702                -0.7668764
## 1107                0.2781026                 0.8842524
## 254                -0.3735169                -0.6304139
## 1244                0.3255581                 0.7635857
## 455                 0.5205012                 0.8616373
## 927                 0.3204987                 0.6605972
## 40                  0.3089381                 0.5114159
## 347                 0.2253125                 0.4799696
## 946                 0.2593500                 0.8190802
## 1038                0.2459359                 0.7656174
## 1073               -0.3681722                -0.9087888
## 518                -0.3293806                -0.6454065
## 671                 0.3419144                 0.7495610
## 1204               -0.3293806                -0.6454065
## 1308               -0.2979681                -0.5464250
## 1255                0.5360425                 1.0137430
## 779                -0.3587266                -0.8854735
## 1235               -0.8396146                -1.1198983
## 1164               -0.4281056                -0.8856194
## 1110               -0.1752805                -0.6167448
## 824                 0.5111963                 0.9120326
## 620                 0.6598223                 1.2478307
## 1281                0.3878018                 0.9095761
## 862                -0.2984673                -0.5848332
## 1153               -0.2984673                -0.5848332
## 1069                0.3641679                 0.7506063
## 1203                0.7367181                 1.2195626
## 1205                0.7367181                 1.2195626
## 1053                0.4439073                 0.9149614
## 1054                0.4439073                 0.9149614
## 1055                0.4439073                 0.9149614
## 227                -0.2125739                -0.7373432
## 286                 0.3904214                 0.8776897
## 799                 0.4505294                 0.8037959
## 618                -0.6684812                -1.2258856
## 469                -0.3709633                -0.9156782
## 682                -0.5910064                -0.7882987
## 703                 0.2973615                 1.0306678
## 1106               -0.3579597                -0.9627695
## 136                 0.4035785                 0.9638026
## 553                -0.5316544                -0.9749674
## 1316                0.2545802                 0.8245304
## 257                -0.7879632                -1.1947725
## 313                 0.4156185                 0.9111386
## 314                 0.4156185                 0.9111386
## 315                 0.4156185                 0.9111386
## 316                 0.4156185                 0.9111386
## 419                -0.5364554                -0.8134165
## 656                 0.3962649                 0.7855597
## 1075                0.3680908                 0.9439260
## 448                 0.3532871                 0.7525861
## 612                -0.2189238                -0.9338389
## 889                 0.4248769                 0.7033410
## 494                -0.3748063                -0.7753595
## 1074               -0.3581811                -0.9060928
## 561                -0.5861183                -0.9892380
## 562                -0.5861183                -0.9892380
## 648                 0.6006814                 1.1359856
## 127                 0.3269766                 0.5833637
## 692                -0.2807169                -0.9478587
## 1325               -0.3022699                -0.7046407
## 116                -0.3673875                -0.7198794
## 119                -0.3673875                -0.7198794
## 14                 -0.6830835                -0.9111134
## 74                 -0.2250420                -0.9380476
## 112                 0.3205403                 0.6606830
## 210                -0.2710899                -0.6513428
## 236                -0.3080778                -0.9617991
## 240                -0.2965672                -0.7828262
## 269                 0.2204058                 0.7138468
## 529                 0.4473615                 1.0492715
## 548                 0.2811079                 0.4653458
## 667                 0.3191816                 0.6036240
## 978                -0.3205820                -0.7702566
## 1091               -0.2773636                -0.6465800
## 1206                0.3322817                 0.7935357
## 414                 0.4347326                 0.8618186
## 187                -0.4101516                -1.1403039
## 18                  0.3513731                 0.6645034
## 20                  0.3513731                 0.6645034
## 1059                0.3513731                 0.6645034
## 260                 0.6056112                 1.1453088
## 446                 0.7556222                 1.1335860
## 608                 0.3211512                 0.8421731
## 1134               -0.1868486                -0.6153810
## 420                -0.3721877                -0.6825316
## 194                -0.4948556                -0.8352067
## 168                 0.2900199                 0.9594121
## 663                 0.3384696                 1.0039758
## 854                -0.3045411                -0.5584787
## 719                 0.2641532                 0.8223290
## 1152               -0.4126881                -0.6257506
## 5                   0.2645526                 0.8616368
## 137                 0.6505353                 0.8675172
## 226                 0.4375669                 0.6564388
## 271                 0.2598871                 0.8059148
## 348                 0.2625627                 0.5411822
## 565                -0.5307790                -0.9733622
## 657                -0.3025324                -0.7268890
## 726                -0.5858672                -0.7814440
## 903                 0.5732060                 0.8599249
## 928                 0.2705635                 0.8737346
## 1150               -0.2872313                -0.7985609
## 760                -0.3097950                -0.8612923
## 475                -0.5101653                -1.0553758
## 98                  0.3294678                 0.8639821
## 6                   0.3142217                 0.9923761
## 603                -0.5629550                -0.7508831
## 947                 0.2032011                 0.6251510
## 1024               -0.5629550                -0.7508831
## 1025               -0.5629550                -0.7508831
## 17                  0.8438972                 1.1253737
## 1132                0.5887261                 1.1670968
## 1145                0.2231557                 0.6865416
## 1076               -0.3020233                -0.7040657
## 989                -0.2640213                -0.6343592
## 169                 0.3338075                 1.0505770
## 408                 0.4379587                 0.7813683
## 1062               -0.3949734                -0.8170790
## 646                 0.2044661                 0.6290428
## 735                -0.3811287                -0.8585507
## 804                 0.4362083                 1.1050778
## 38                 -0.5579353                -0.8459860
## 229                -0.3964355                -0.7269980
## 428                 0.2446503                 0.7616153
## 474                 0.3244166                 0.7609082
## 100                 0.4503286                 1.0754485
## 252                 0.6059957                 0.8081217
## 456                 0.4241629                 0.9298700
## 186                 0.4072511                 1.0039157
## 384                 0.4718889                 1.0608332
## 493                 0.3125618                 0.9938186
## 1080                0.4374439                 1.0620054
## 1251                0.6278090                 1.0392747
## 1254               -0.4028432                -0.9943701
## 45                  0.6257205                 1.0358174
## 826                -0.5956645                -0.9031939
## 43                  0.6391863                 0.8523828
## 859                 0.5691022                 1.0153433
## 1146                0.6867717                 1.0302963
## 1253                0.3749222                 0.7090384
## 547                 0.2970557                 0.8567997
## 117                -0.4204108                -0.7709649
## 118                -0.4204108                -0.7709649
## 248                -0.2152946                -0.7739227
## 1066                0.4788133                 0.8542576
## 1223               -0.2564587                -0.5554595
## 1108               -0.3870821                -0.9023519
## 1339               -0.4871730                -0.8933958
## 1008                0.5476117                 0.8215282
## 1142               -0.3808984                -0.7879623
## 666                -0.3003215                -0.6212733
## 272                 0.2983377                 0.9422114
## 546                 0.3135465                 0.9202146
## 422                -0.2120781                -0.6678197
## 410                 0.3504094                 0.9089580
## 1160               -0.3606148                -0.6086381
## 929                 0.3237001                 0.5775180
## 192                 0.2188333                 0.7166007
## 1232               -0.3079763                -0.6670406
## 1239               -0.2167353                -0.7791016
## 1128               -0.2628547                -0.6798825
## 937                 0.2733703                 0.9170361
## 1258               -0.5442279                -0.8252017
## 253                 0.2867467                 0.8992407
## 1057               -0.4328734                -0.8954826
## 447                 0.3079272                 0.8827438
## 798                 0.2147003                 0.7049029
## 559                 0.2801148                 0.5553025
## 491                 0.2776870                 0.8676234
## 1304                0.2992342                 0.8522128
## 378                 0.2721897                 0.8710306
## 1114               -0.2551655                -0.5526586
## 1151               -0.3367246                -0.6174980
## 1137               -0.2854694                -0.5593644
## 268                 0.2408735                 0.7379927
## 47                  0.5162741                 0.6884740
## 151                 0.4134710                 0.6844596
## 293                 0.2276411                 0.7821615
## 360                 0.4017570                 0.7167804
## 81                 -0.5642398                -0.7525968
## 544                 0.2180821                 0.7102846
## 1124                0.2572727                 0.8490065
## 1209                0.2360324                 0.7749405
## 312                 0.2592518                 0.8420641
## 942                 0.2644509                 0.8351897
## 105                 0.2620619                 0.8188032
## 239                 0.3131628                 0.7602817
## 556                 0.4684998                 0.7755543
## 558                 0.4684998                 0.7755543
## 944                 0.2619929                 0.8274269
## 89                 -0.2035208                -0.5264135
## 113                -0.2153359                -0.8395906
## 445                 0.2891606                 0.6339117
## 1182               -0.3504236                -0.6426197
## 918                 0.2553827                 0.6831794
## 328                -0.3499367                -0.7239120
## 353                 0.3495286                 0.7204324
## 1120               -0.2500035                -0.6324351
## 135                 0.2019425                 0.6789099
##      nMoreExtreme_iDUX4t14dox_iDUX4dmso pval_iDUX4t14dox_WTt14dox
## 21                                    0              2.049588e-02
## 24                                    3              5.594109e-04
## 108                                   0              3.696044e-03
## 109                               12751              2.298186e-06
## 110                                 303              4.873237e-05
## 170                                  31              5.911052e-02
## 181                                1788              2.841542e-06
## 205                                   0              1.702705e-04
## 275                                 533              2.479655e-04
## 299                                  27              8.879907e-02
## 300                                   0              2.009793e-03
## 341                                   9              1.224641e-04
## 346                                   0              5.193872e-03
## 404                                  54              1.710422e-02
## 483                                   0              2.620773e-03
## 487                                   0              1.482390e-03
## 504                               22125              9.759586e-05
## 521                                  79              1.963913e-04
## 624                                   0              1.251001e-03
## 625                                   0              6.771482e-03
## 709                                   4              1.085766e-02
## 788                                 150              4.811956e-03
## 847                                   0              1.164123e-03
## 855                                   0              1.746268e-03
## 856                                   8              4.052651e-02
## 865                                2771              4.709772e-05
## 906                                 303              4.873237e-05
## 958                                   0              3.068725e-03
## 980                                   0              2.625995e-01
## 986                                   0              2.499257e-02
## 987                                   0              6.844763e-03
## 1013                                 19              2.067896e-02
## 1131                                  0              1.869797e-02
## 1213                               2182              5.500858e-06
## 1272                                  9              4.138034e-03
## 1275                                  0              5.347362e-03
## 355                                 698              3.648812e-02
## 626                                 973              2.646181e-05
## 744                               42359              2.926676e-04
## 431                                5954              3.081480e-05
## 985                                  12              2.014260e-03
## 405                                4098              8.047312e-03
## 479                                   3              3.416114e-02
## 520                               41953              1.689682e-01
## 587                                4098              8.047312e-03
## 832                                   5              1.732477e-03
## 162                              351839              1.741651e-07
## 161                             1639695              1.773794e-07
## 430                              752158              1.780395e-07
## 160                              113661              1.733567e-07
## 482                                 458              4.467269e-03
## 647                              973452              2.097631e-03
## 1031                            1339909              1.780376e-07
## 357                                   9              9.938074e-03
## 1048                                 88              1.646738e-02
## 366                             1286173              7.196282e-04
## 1144                              10844              9.969287e-01
## 180                                1725              8.344621e-04
## 677                                 430              2.470143e-03
## 362                               49128              2.631925e-01
## 932                             2293166              2.446458e-02
## 1155                             124232              5.302032e-05
## 1111                               9466              2.173284e-02
## 1154                             827350              1.246752e-06
## 973                                1328              5.938981e-01
## 967                              784053              1.049440e-01
## 1037                            4896929              4.658994e-01
## 745                               86677              3.241141e-01
## 863                             2133902              9.388475e-04
## 44                               159784              2.117615e-06
## 673                              717172              2.671206e-06
## 200                             2582116              4.388614e-04
## 1006                             401941              9.544598e-02
## 480                                4385              3.447483e-02
## 688                             1194911              2.487206e-03
## 965                              134420              4.104298e-01
## 25                               480937              5.646973e-06
## 1015                                473              1.221849e-01
## 361                               98256              3.239289e-01
## 836                             1111502              6.707439e-02
## 1041                             116732              6.775600e-01
## 304                              246489              1.161505e-05
## 1319                             596531              1.098517e-05
## 204                             1256965              1.552041e-05
## 734                              340963              1.675839e-05
## 301                             2786444              1.797979e-05
## 609                               75826              2.137928e-05
## 895                                7029              1.075189e-01
## 197                             4015600              5.764803e-04
## 535                             2485693              1.290176e-02
## 1208                              13432              3.999856e-02
## 1127                              32176              1.257280e-01
## 124                             1430193              1.325598e-01
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## 1120                            4095051              9.576853e-01
## 135                             6266141              9.460654e-01
##      padj_iDUX4t14dox_WTt14dox ES_iDUX4t14dox_WTt14dox NES_iDUX4t14dox_WTt14dox
## 21                2.381763e-01              -0.4897030               -1.5567010
## 24                2.285109e-02              -0.5515692               -1.8463407
## 108               8.444521e-02              -0.4963929               -1.6896402
## 109               3.830399e-04              -0.6718410               -2.1609765
## 110               2.856141e-03              -0.7252561               -2.0541045
## 170               3.985303e-01              -0.3588803               -1.3412530
## 181               3.830399e-04              -0.6169327               -2.1320122
## 205               8.500915e-03              -0.5915903               -1.9335953
## 275               1.152612e-02              -0.6693579               -1.9565562
## 299               4.558670e-01              -0.4235071               -1.3543314
## 300               5.430445e-02              -0.5557318               -1.7771717
## 341               6.349291e-03              -0.5150675               -1.8732319
## 346               1.060809e-01              -0.4986141               -1.6690771
## 404               2.162825e-01              -0.4633852               -1.5511505
## 483               6.429040e-02              -0.5076136               -1.7209888
## 487               4.440583e-02              -0.5866205               -1.8165344
## 504               5.262369e-03              -0.5716501               -1.9458037
## 521               9.454836e-03              -0.6549858               -1.9669400
## 624               3.832613e-02              -0.5056662               -1.7597090
## 625               1.254341e-01              -0.4944518               -1.6477276
## 709               1.644509e-01              -0.4617390               -1.5839326
## 788               1.013518e-01              -0.4766159               -1.6529374
## 847               3.649392e-02              -0.4955864               -1.7527942
## 855               5.008445e-02              -0.5549450               -1.7849806
## 856               3.372206e-01              -0.4184921               -1.4355800
## 865               2.856141e-03              -0.6109552               -2.0069738
## 906               2.856141e-03              -0.7252561               -2.0541045
## 958               7.257266e-02              -0.4830407               -1.6866307
## 980               6.458125e-01              -0.3237266               -1.1303546
## 986               2.673808e-01              -0.4532473               -1.5104163
## 987               1.254341e-01              -0.4605460               -1.6134660
## 1013              2.382499e-01              -0.4597890               -1.5322161
## 1131              2.191728e-01              -0.4930382               -1.5673031
## 1213              6.343433e-04              -0.6132649               -2.0874535
## 1272              9.089592e-02              -0.4531798               -1.6353777
## 1275              1.075857e-01              -0.5108360               -1.6780846
## 355               3.257350e-01              -0.3609852               -1.3823926
## 626               1.877396e-03              -0.6650923               -2.0595308
## 744               1.315053e-02              -0.6234315               -1.9305235
## 431               2.076917e-03              -0.6136152               -2.0257503
## 985               5.430445e-02              -0.5083595               -1.7371923
## 405               1.355972e-01               0.6900486                1.8417273
## 479               3.165320e-01              -0.4269128               -1.4588684
## 520               5.640465e-01              -0.2883914               -1.1649934
## 587               1.355972e-01               0.6900486                1.8417273
## 832               5.008445e-02              -0.5594047               -1.7889175
## 162               4.799944e-05              -0.4544271               -2.0181601
## 161               4.799944e-05              -0.5101370               -2.0796740
## 430               4.799944e-05              -0.5526964               -2.1165502
## 160               4.799944e-05              -0.4372669               -1.9652516
## 482               9.558537e-02              -0.4462084               -1.6228006
## 647               5.544328e-02              -0.2973776               -1.3805627
## 1031              4.799944e-05              -0.5643031               -2.1498256
## 357               1.557735e-01              -0.4298534               -1.5553580
## 1048              2.144011e-01              -0.4423638               -1.5341484
## 366               2.694608e-02               0.4507164                1.7716810
## 1144              9.999349e-01              -0.1564710               -0.6060352
## 180               2.960144e-02              -0.4476355               -1.7053571
## 677               6.325950e-02              -0.4261372               -1.6262527
## 362               6.458125e-01              -0.2816840               -1.1053529
## 932               2.659537e-01               0.4400431                1.5424429
## 1155              2.977975e-03              -0.5874405               -1.9834523
## 1111              2.421147e-01              -0.3574609               -1.4121710
## 1154              2.801036e-04              -0.5461428               -2.0574305
## 973               8.635925e-01              -0.2263214               -0.9452161
## 967               4.795406e-01               0.3555631                1.2981157
## 1037              8.008903e-01              -0.4594930               -1.0093201
## 745               7.007523e-01              -0.2793652               -1.0716570
## 863               3.163916e-02              -0.3721830               -1.5701571
## 44                3.830399e-04              -0.8444292               -2.1609710
## 673               3.830399e-04              -0.5431293               -2.0256505
## 200               1.908339e-02               0.6247482                2.0152128
## 1006              4.646762e-01              -0.2986934               -1.2291364
## 480               3.165320e-01              -0.3683541               -1.3956131
## 688               6.325950e-02              -0.3792979               -1.5508190
## 965               7.681363e-01              -0.2708027               -1.0241091
## 25                6.343433e-04              -0.8316686               -2.1283155
## 1015              5.021500e-01              -0.3326342               -1.2431629
## 361               7.007523e-01              -0.2839435               -1.0738042
## 836               4.148434e-01              -0.6086706               -1.4607594
## 1041              8.880437e-01              -0.2317533               -0.8976149
## 304               1.118363e-03              -0.7773419               -2.1204105
## 1319              1.118363e-03              -0.9319742               -1.9704506
## 204               1.394768e-03              -0.8912627               -2.0237687
## 734               1.411894e-03               0.4191734                1.8197966
## 301               1.425692e-03              -0.5325928               -1.9604802
## 609               1.601070e-03              -0.3923572               -1.7062629
## 895               4.839310e-01               0.4514190                1.3824976
## 197               2.285575e-02               0.6661894                2.0267096
## 535               1.890389e-01               0.5120737                1.6760523
## 1208              3.356077e-01              -0.3440385               -1.3537847
## 1127              5.104858e-01              -0.2910190               -1.1964506
## 124               5.105366e-01               0.4803003                1.3704134
## 481               3.278082e-01              -0.3551077               -1.3732955
## 184               5.994085e-01              -0.6234025               -1.2606634
## 1100              3.591314e-01              -0.3341929               -1.3302165
## 495               9.168095e-01               0.2045546                0.8988862
## 1291              8.330596e-01               0.4017349                0.9225632
## 324               2.191728e-01               0.5327105                1.6625654
## 837               5.066376e-01               0.3112561                1.2301448
## 182               8.343359e-01              -0.4316465               -0.9481525
## 1269              2.916398e-01              -0.3512294               -1.3857893
## 921               8.192193e-01              -0.2410128               -0.9786345
## 1035              1.197097e-01              -0.9731156               -1.4536930
## 689               4.976499e-01              -0.4078409               -1.3042323
## 568               7.733431e-01               0.3803016                1.0150183
## 563               4.207052e-01              -0.5257806               -1.4342088
## 669               1.565803e-01              -0.5518492               -1.6572183
## 95                1.147227e-01               0.6155321                1.8322503
## 273               1.553175e-01               0.4972891                1.6838657
## 1279              9.702635e-01              -0.1937645               -0.8321863
## 203               4.148434e-01               0.5699877                1.5408582
## 42                6.923428e-01              -0.3113593               -1.0943781
## 780               3.619808e-01               0.4693590                1.5062379
## 642               9.230728e-01              -0.2839097               -0.7946606
## 198               1.042295e-01               0.6882970                1.8832396
## 435               5.021500e-01               0.6418584                1.4307033
## 724               9.999349e-01              -0.1498557               -0.6706973
## 894               4.509426e-01               0.4477790                1.4137650
## 303               2.094658e-02              -0.5171996               -1.8178735
## 886               5.649973e-01               0.7190114                1.3309475
## 1067              3.896133e-01               0.4784421                1.4931963
## 801               5.204597e-01               0.5774297                1.3929570
## 93                5.649973e-01               0.4626406                1.3072775
## 199               2.928308e-01               0.5454726                1.6237048
## 676               2.581684e-02              -0.4477489               -1.7146541
## 537               9.168095e-01              -0.3878499               -0.7843218
## 701               2.162825e-01               0.7182782                1.7692505
## 1119              9.457918e-01              -0.2062624               -0.8580756
## 320               2.829764e-02              -0.9914255               -1.4810453
## 510               5.649973e-01               0.3837854                1.2502182
## 211               4.719063e-01              -0.6579160               -1.3910158
## 402               4.185986e-01               0.6455289                1.5572356
## 331               2.928308e-01               0.6309459                1.6839834
## 442               6.612859e-01               0.4483229                1.1631715
## 1289              6.612859e-01               0.4483229                1.1631715
## 1311              4.293032e-01               0.8417667                1.4395670
## 851               5.649973e-01               0.6468863                1.3372060
## 787               8.699108e-01              -0.3814815               -0.8919207
## 1169              3.140268e-02              -0.4961188               -1.7653356
## 680               7.856443e-01               0.6202161                1.0606770
## 500               8.343359e-01              -0.2532989               -0.9560857
## 486               7.989486e-01              -0.5075405               -1.0263639
## 55                6.032698e-01               0.6558199                1.2904808
## 364               3.393170e-02              -0.6529716               -1.8700776
## 91                3.402143e-02               0.4049074                1.6694070
## 485               4.185986e-01              -0.8964083               -1.3391035
## 1096              2.384918e-01               0.4964287                1.6171647
## 52                5.338737e-01               0.5261712                1.3651486
## 640               3.985303e-01               0.3310291                1.3230406
## 861               5.967834e-01               0.6271470                1.2964021
## 425               8.343359e-01               0.4272897                0.9200204
## 54                5.595590e-01               0.6278468                1.3518506
## 655               4.944375e-01              -0.9423489               -1.2568538
## 436               5.105366e-01               0.6137109                1.4093550
## 1329              9.006972e-01              -0.2811696               -0.8371323
## 811               7.007523e-01               0.7496891                1.1523127
## 1285              7.995907e-01               0.2963606                0.9915780
## 94                6.562481e-01              -0.6212194               -1.1912883
## 212               9.083980e-01               0.2696651                0.7965397
## 627               7.802314e-01               0.2219561                1.0043805
## 444               4.919838e-01               0.4811344                1.3978309
## 896               6.458125e-01               0.3352872                1.1396208
## 1061              6.171996e-01               0.4998955                1.2547572
## 65                6.688148e-01               0.6457409                1.1953179
## 228               1.329473e-01               0.8423244                1.8136538
## 794               5.105366e-01              -0.7350427               -1.3211230
## 976               6.586523e-01               0.4092513                1.1676934
## 781               5.430445e-02              -0.4928957               -1.7210414
## 681               3.896133e-01               0.6238130                1.5930388
## 1299              2.064218e-01               0.3863318                1.5057342
## 1183              4.646762e-01               0.7427414                1.4615194
## 165               6.235723e-01               0.3901854                1.2027264
## 59                8.699108e-01               0.3973873                0.8556360
## 407               8.828871e-01               0.2944912                0.8237238
## 7                 4.673836e-01              -0.7606915               -1.3672227
## 797               6.429040e-02              -0.7180030               -1.8019245
## 368               5.338737e-01              -0.3303617               -1.2160651
## 922               7.964461e-01               0.6142796                1.0505246
## 426               8.763900e-01              -0.3710207               -0.8674630
## 566               7.366315e-01               0.2622673                1.0351457
## 834               8.192193e-01               0.3194786                0.9509899
## 1274              5.105366e-01              -0.5330087               -1.3376565
## 429               1.254341e-01              -0.7729126               -1.6977760
## 1095              2.712735e-01              -0.9409918               -1.4057047
## 571               7.835843e-01               0.3861028                1.0017418
## 583               4.944375e-01               0.7217653                1.4202440
## 71                7.997047e-01               0.3405017                0.9804941
## 817               3.628504e-01              -0.7084636               -1.4978874
## 1039              4.610798e-01               0.5089336                1.4521112
## 593               6.883877e-02              -0.7455692               -1.7893049
## 523               3.443516e-01              -0.6710691               -1.5237805
## 952               5.809226e-01               0.7580791                1.2964467
## 1077              8.828871e-01               0.2754143                0.8378771
## 1081              8.828871e-01               0.2754143                0.8378771
## 158               8.008903e-01               0.2910667                0.9855780
## 977               7.007523e-01              -0.4814436               -1.1256365
## 939               3.530001e-01              -0.5217069               -1.4941421
## 675               7.680011e-02              -0.3745134               -1.5312568
## 290               4.176533e-01               0.3784830                1.3716909
## 742               1.558164e-01               0.5721943                1.7523791
## 223               9.702635e-01               0.3629690                0.6207399
## 23                6.457654e-01               0.4484507                1.1969068
## 912               5.817215e-01               0.4133106                1.2573911
## 323               4.066404e-01              -0.6289785               -1.4705798
## 610               2.162825e-01               0.6035126                1.7219679
## 960               8.634113e-02              -0.6812362               -1.7747660
## 1267              2.964288e-01              -0.7080080               -1.5552067
## 176               4.177037e-01               0.9042401                1.3898659
## 833               7.838296e-01               0.4070593                1.0026614
## 343               2.977555e-01               0.3716916                1.4331664
## 949               1.355972e-01              -0.4759458               -1.6200418
## 287               5.338737e-01               0.5818198                1.3714634
## 83                5.301098e-01               0.5596010                1.3783995
## 959               9.089592e-02              -0.6569645               -1.7667009
## 401               9.391514e-01              -0.2532785               -0.7787448
## 953               6.418781e-01              -0.3853437               -1.1668411
## 1097              2.144011e-01               0.5920626                1.7201086
## 349               3.863487e-01               0.8648539                1.4790500
## 945               6.926968e-01              -0.5040627               -1.1445630
## 687               1.969185e-01               0.9931419                1.3244568
## 899               4.245267e-01               0.6930588                1.5448291
## 1159              9.179750e-01              -0.4088468               -0.7840296
## 35                6.612859e-01               0.3527949                1.1379895
## 53                6.762737e-01               0.5211103                1.1615555
## 762               8.725027e-01              -0.4627754               -0.8874463
## 853               2.856222e-01               0.9864981                1.3155966
## 225               2.534895e-01              -0.7231536               -1.5884756
## 1210              2.931147e-01              -0.6380029               -1.5673969
## 763               5.649973e-01              -0.3930503               -1.2417351
## 1046              9.587108e-01              -0.3829253               -0.6882477
## 1098              4.185986e-01               0.7697665                1.5146976
## 670               3.768623e-01              -0.4264083               -1.4209772
## 890               5.817215e-01              -0.7021671               -1.2620344
## 58                5.640465e-01               0.4393591                1.2977836
## 376               8.817096e-01              -0.3770784               -0.8562228
## 519               6.101605e-01               0.4723492                1.2606916
## 569               7.205465e-01               0.4078679                1.0738169
## 905               8.419033e-01              -0.5283382               -0.9496044
## 172               9.504797e-01               0.2840815                0.6853013
## 342               7.007523e-01               0.5805409                1.1423515
## 526               5.105366e-01               0.7439527                1.3771157
## 467               7.007523e-01               0.3659899                1.1056585
## 502               5.600873e-01               0.5070871                1.3350369
## 1171              5.266129e-01               0.4990788                1.3655222
## 237               3.933792e-01               0.7350278                1.5826279
## 729               4.170046e-01               0.3660409                1.3577551
## 1133              5.178307e-01               0.4552473                1.3447142
## 1287              4.058682e-01               0.8561321                1.4641343
## 473               5.105366e-01               0.6758105                1.3969964
## 1286              3.484091e-01               0.4017014                1.4446911
## 773               2.547734e-01              -0.4293196               -1.4940240
## 11                9.456065e-01              -0.4504491               -0.7464839
## 399               6.457654e-01               0.4237554                1.1852899
## 650               8.343359e-01               0.2685050                0.9382128
## 746               9.456065e-01              -0.4504491               -0.7464839
## 1052              9.456065e-01              -0.4504491               -0.7464839
## 306               8.828871e-01               0.3801674                0.8185588
## 256               6.404368e-01               0.6720114                1.2439467
## 263               6.404368e-01               0.6720114                1.2439467
## 1195              3.774453e-01               0.7679785                1.5875209
## 465               2.064218e-01               0.7559724                1.7819754
## 79                1.254341e-01              -0.4538808               -1.6052896
## 97                1.254341e-01              -0.4750287               -1.6295210
## 427               1.254341e-01              -0.7722379               -1.6962939
## 379               9.999349e-01              -0.1690606               -0.5633831
## 572               7.880566e-01               0.3769420                0.9923967
## 1337              5.105366e-01               0.9359194                1.2481447
## 432               1.892231e-01              -0.9935705               -1.3251704
## 149               9.798022e-01              -0.2779660               -0.6311706
## 1327              6.181786e-01               0.2390787                1.0890673
## 1284              2.856222e-01              -0.5515115               -1.5620170
## 1321              1.329473e-01              -0.7928442               -1.6762913
## 848               7.398369e-01               0.3887975                1.0510434
## 1310              3.985303e-01               0.8159771                1.5104387
## 570               5.894852e-01               0.7014837                1.2985023
## 68                2.856222e-01               0.8349721                1.6430051
## 968               8.343359e-01              -0.6537244               -0.9765691
## 189               7.007523e-01               0.5216831                1.1232638
## 1293              4.328563e-01              -0.3728839               -1.3306912
## 796               8.828871e-01               0.2722877                0.8446163
## 50                5.649973e-01               0.7153592                1.3241870
## 1276              1.402902e-01               0.9130334                1.6900977
## 1050              1.438125e-01              -0.3803652               -1.4967296
## 185               9.587108e-01              -0.2166326               -0.7858520
## 1                 5.105366e-01              -0.6620813               -1.3388810
## 732               4.509426e-01               0.3886715                1.3580999
## 931               8.799779e-01              -0.4078476               -0.8623023
## 321               1.488434e-01              -0.7857675               -1.6613291
## 87                5.835090e-01               0.5372999                1.2961503
## 451               6.316661e-01               0.5232028                1.2332918
## 808               7.108698e-01               0.7430947                1.1421767
## 1324              5.835090e-01               0.5372999                1.2961503
## 141               9.610570e-01               0.3505532                0.6489019
## 860               8.181388e-01               0.4917296                0.9675944
## 844               3.812141e-01              -0.9740677               -1.2991587
## 289               6.316661e-01               0.3554173                1.1739387
## 1292              5.105366e-01              -0.4041134               -1.2846228
## 891               7.205465e-01               0.3970137                1.0732544
## 365               9.006972e-01               0.2744797                0.8107611
## 933               6.762737e-01               0.3962265                1.1409565
## 679               1.553175e-01              -0.7598197               -1.6690161
## 700               3.356077e-01               0.5485528                1.5937004
## 214               6.235723e-01               0.3684362                1.1884427
## 1261              3.278082e-01              -0.4439684               -1.4656892
## 1264              7.799472e-01               0.3348621                1.0116211
## 423               6.458125e-01               0.4825340                1.1885695
## 717               9.391514e-01               0.2908903                0.7165159
## 831               5.407667e-01               0.7777805                1.3301395
## 1083              9.508455e-01              -0.2744069               -0.7267369
## 1247              4.148434e-01              -0.8372609               -1.3875080
## 1215              2.420383e-01              -0.5867258               -1.6004536
## 1282              5.338737e-01              -0.5223233               -1.3108401
## 578               6.612859e-01              -0.5360639               -1.1775152
## 1010              4.148434e-01              -0.5577307               -1.4530077
## 1193              9.999349e-01              -0.1978019               -0.4000010
## 250               4.689046e-01               0.7383704                1.4529183
## 1158              3.710872e-01              -0.4620132               -1.4503447
## 8                 4.511558e-01              -0.6707470               -1.4181442
## 678               1.829070e-01              -0.4712852               -1.5845333
## 215               4.646762e-01               0.3618148                1.3145249
## 450               5.817215e-01               0.5278701                1.3002405
## 484               9.215902e-01              -0.4063083               -0.7791615
## 86                5.338737e-01               0.4244688                1.3084031
## 963               1.829070e-01              -0.4326915               -1.5441235
## 966               5.596786e-01               0.5160417                1.3388678
## 594               4.280135e-01               0.5916434                1.5350160
## 830               7.996099e-01               0.4601381                0.9907481
## 1112              6.061978e-01               0.4052803                1.2329609
## 1116              6.612859e-01               0.2563800                1.0797242
## 1243              6.458125e-01              -0.4435251               -1.1746282
## 962               8.150266e-01               0.5312315                0.9833520
## 540               3.877473e-01              -0.4644916               -1.4383488
## 592               7.995907e-01               0.2837952                0.9916402
## 660               4.280135e-01              -0.9624946               -1.2837231
## 868               7.205465e-01              -0.5234704               -1.1067608
## 1174              4.280135e-01              -0.9624946               -1.2837231
## 190               9.952601e-01               0.1885664                0.6979334
## 845               1.892231e-01              -0.7983265               -1.6144002
## 846               1.892231e-01              -0.7983265               -1.6144002
## 515               8.414775e-01               0.3893721                0.8941726
## 557               9.006972e-01               0.3135196                0.7869465
## 1230              8.414775e-01               0.3893721                0.8941726
## 857               3.231278e-01               0.7482292                1.6678040
## 686               4.917488e-01               0.8711405                1.3389899
## 589               1.969185e-01              -0.8276018               -1.5870596
## 433               1.980312e-01              -0.9569697               -1.4295734
## 339               9.702635e-01               0.2308163                0.6646487
## 284               7.995907e-01               0.3671981                0.9800451
## 1139              2.928308e-01              -0.4618972               -1.5019744
## 870               7.007523e-01              -0.6358767               -1.1428878
## 816               2.064218e-01              -0.9554126               -1.4272474
## 374               6.171996e-01              -0.7381816               -1.2233139
## 574               8.041580e-01               0.4528667                0.9750917
## 974               5.338737e-01               0.5564756                1.3707012
## 472               7.704456e-01               0.2716235                1.0158425
## 41                2.100070e-01              -0.8228236               -1.5778966
## 130               3.356077e-01               0.9802829                1.3073080
## 1224              7.997047e-01              -0.2793930               -0.9970552
## 982               6.234965e-01               0.4770086                1.2375965
## 1045              6.181786e-01               0.4973942                1.2484789
## 1156              2.144011e-01              -0.4729175               -1.5612598
## 877               8.828871e-01               0.4838222                0.8274198
## 884               6.931638e-01              -0.6934313               -1.1491537
## 196               2.162825e-01              -0.7596567               -1.6061236
## 1202              2.162825e-01               0.7875209                1.7553852
## 403               6.888102e-01              -0.3627621               -1.1153696
## 157               2.177969e-01              -0.9912130               -1.3220261
## 706               2.191728e-01               0.8291786                1.7140302
## 1212              2.191728e-01              -0.6937769               -1.6220813
## 586               4.512879e-01               0.6019614                1.5109466
## 231               5.915471e-01              -0.5238268               -1.2571413
## 539               3.393358e-01              -0.4737601               -1.4773154
## 424               8.041580e-01               0.4752625                0.9824353
## 585               7.007523e-01               0.4890818                1.1231509
## 202               8.343359e-01              -0.5894450               -0.9768278
## 941               8.343359e-01              -0.5894450               -0.9768278
## 1117              6.171996e-01              -0.4912093               -1.2327554
## 1277              3.877473e-01              -0.5800480               -1.4843954
## 1147              6.656870e-01              -0.4984995               -1.1655141
## 874               6.562481e-01              -0.3096246               -1.1173338
## 805               2.399553e-01               0.7589125                1.7428029
## 344               5.021500e-01              -0.8600214               -1.2847468
## 457               9.893229e-01              -0.3088330               -0.5922369
## 999               6.032698e-01              -0.6540196               -1.2541878
## 389               8.699108e-01               0.3535099                0.8527863
## 1082              8.699108e-01               0.3535099                0.8527863
## 1170              7.997047e-01               0.5082119                1.0000271
## 909               8.473487e-01              -0.2787187               -0.9288114
## 78                4.610798e-01              -0.3813500               -1.3178795
## 771               9.999349e-01              -0.2286215               -0.5021888
## 498               8.699108e-01              -0.3267485               -0.8912950
## 509               5.236906e-01               0.5007242                1.3700244
## 534               6.334721e-01              -0.5555545               -1.2203281
## 629               2.661572e-01               0.6504535                1.7124859
## 1298              5.338737e-01               0.6382732                1.3743004
## 337               9.457918e-01               0.2293055                0.7764493
## 1227              6.117085e-01               0.5541103                1.2724854
## 319               3.356077e-01              -0.4795212               -1.4848896
## 1185              7.681363e-01               0.5776439                1.0692650
## 213               8.771121e-01               0.2535434                0.8859339
## 350               4.066404e-01               0.9091104                1.3973518
## 1178              4.386288e-01              -0.7763766               -1.3954141
## 1179              4.386288e-01              -0.7763766               -1.3954141
## 1256              3.278082e-01               0.6775212                1.6688586
## 307               8.700285e-01              -0.3452432               -0.8835086
## 654               6.612859e-01               0.4733906                1.1660476
## 1234              8.725027e-01               0.5030439                0.8602923
## 1300              8.725027e-01               0.5030439                0.8602923
## 490               5.817215e-01              -0.5422422               -1.2677865
## 503               5.817215e-01              -0.5422422               -1.2677865
## 1217              6.976764e-01              -0.6402966               -1.1508319
## 235               9.952601e-01              -0.2547587               -0.5596016
## 775               5.649973e-01               0.6453172                1.3339626
## 812               4.610798e-01               0.8275895                1.4153216
## 209               8.581923e-01               0.3621908                0.8737275
## 454               9.165519e-01               0.2377469                0.8358999
## 1071              8.581923e-01               0.3621908                0.8737275
## 869               2.928308e-01              -0.7339911               -1.5518597
## 1141              5.338737e-01               0.9245607                1.2329966
## 492               9.999349e-01               0.1389547                0.4956857
## 858               7.457189e-01               0.5910091                1.0940050
## 990               6.234965e-01               0.4291539                1.2244802
## 1105              6.171996e-01               0.5341456                1.2590861
## 584               3.322507e-01               0.7438415                1.6580238
## 662               2.928332e-01              -0.7334464               -1.5507079
## 1180              3.863487e-01              -0.7279195               -1.4720209
## 1211              5.817215e-01              -0.9054865               -1.2076888
## 62                5.105366e-01               0.7916299                1.3538244
## 575               5.105366e-01               0.7916299                1.3538244
## 1231              5.105366e-01               0.7916299                1.3538244
## 1252              5.105366e-01               0.7916299                1.3538244
## 146               9.168095e-01               0.3841139                0.7558350
## 246               9.168095e-01               0.3032346                0.7611306
## 463               2.916398e-01               0.6423435                1.6911343
## 916               9.168095e-01               0.3841139                0.7558350
## 501               9.245775e-01              -0.2753261               -0.7968314
## 51                6.181786e-01               0.4888506                1.2483837
## 964               6.457654e-01               0.6626207                1.2265638
## 262               7.007523e-01               0.7472669                1.1485896
## 164               5.835090e-01               0.5059213                1.2919772
## 1168              4.646762e-01               0.8226239                1.4068295
## 1246              5.266129e-01              -0.4426113               -1.2937679
## 923               6.235723e-01               0.6814156                1.2613547
## 387               9.893229e-01              -0.2360114               -0.6250507
## 155               4.511148e-01              -0.7711677               -1.3860521
## 216               3.165320e-01               0.4808747                1.5511288
## 356               2.856222e-01              -0.7139450               -1.5682480
## 85                9.663537e-01               0.2439182                0.6750171
## 207               9.587108e-01               0.2889402                0.6635360
## 1263              3.542703e-01              -0.7714654               -1.4794092
## 220               9.948050e-01              -0.3387650               -0.5614011
## 1237              8.828871e-01               0.4178226                0.8221649
## 755               7.880566e-01              -0.5837647               -1.0492247
## 723               9.999349e-01               0.2047271                0.5228141
## 1049              8.650296e-01              -0.5129111               -0.9218765
## 1328              6.612859e-01              -0.3645931               -1.1369023
## 951               5.417713e-01              -0.7728148               -1.2807080
## 1229              2.928308e-01               0.8623443                1.5962681
## 634               2.931147e-01               0.5692464                1.6391773
## 879               7.007523e-01              -0.6843459               -1.1340974
## 600               8.880437e-01               0.3339681                0.8056447
## 876               9.331724e-01              -0.2836759               -0.7738028
## 183               9.006972e-01              -0.5829336               -0.8708179
## 527               8.699108e-01               0.3712040                0.8524505
## 1273              5.105366e-01              -0.5633163               -1.3519129
## 462               5.266129e-01               0.6051477                1.3896900
## 725               5.613604e-01              -0.4683977               -1.2776816
## 193               9.215902e-01              -0.4878549               -0.8084727
## 400               7.609862e-01              -0.3693843               -1.0461877
## 1148              6.354372e-01               0.5077039                1.2247547
## 28                6.888102e-01               0.6363105                1.1778615
## 352               6.171996e-01              -0.8050969               -1.2026976
## 750               5.165258e-01               0.6088740                1.3982474
## 1034              4.728751e-01               0.5975609                1.4719017
## 499               8.343359e-01              -0.2344446               -0.9647500
## 1226              4.839310e-01               0.5937244                1.4624517
## 590               3.165320e-01              -0.4993331               -1.5120071
## 1102              3.165320e-01               0.7961231                1.6456999
## 588               6.612859e-01               0.6100325                1.2003832
## 153               7.704456e-01              -0.7923275               -1.0567634
## 159               6.234965e-01               0.4768810                1.2372655
## 489               7.366315e-01              -0.5406260               -1.0932704
## 622               8.429047e-01              -0.7143163               -0.9527164
## 628               8.880437e-01              -0.5924973               -0.8851047
## 635               8.303354e-01              -0.6664523               -0.9955827
## 756               7.997047e-01              -0.4088826               -1.0045117
## 840               9.470026e-01               0.3178324                0.6843419
## 893               9.377725e-01              -0.4168639               -0.7492469
## 913               9.470026e-01               0.3178324                0.6843419
## 1115              5.105366e-01              -0.4284184               -1.2972735
## 1167              6.354372e-01               0.5354553                1.2296451
## 1047              8.725027e-01              -0.2811098               -0.8936107
## 748               9.886092e-01               0.2535462                0.5822556
## 230               3.231559e-01              -0.6297832               -1.5472036
## 802               8.803336e-01              -0.6742392               -0.8992636
## 103               8.041580e-01               0.4982004                0.9803271
## 1161              3.373563e-01              -0.4742762               -1.4789245
## 1346              9.477346e-01              -0.5882983               -0.7846404
## 282               5.585651e-01               0.7246408                1.3413679
## 104               5.585651e-01               0.5174788                1.3425963
## 810               8.041580e-01               0.5978053                1.0223507
## 1309              4.148434e-01              -0.4258097               -1.3917463
## 1297              7.135692e-01              -0.3557268               -1.0855197
## 543               8.192193e-01               0.2594026                0.9681836
## 496               8.609072e-01               0.3611774                0.8712829
## 712               5.105366e-01               0.6006986                1.4159646
## 713               5.105366e-01               0.6006986                1.4159646
## 714               5.105366e-01               0.6006986                1.4159646
## 715               5.105366e-01               0.6006986                1.4159646
## 1143              6.409383e-01               0.5477722                1.2209849
## 288               3.356077e-01               0.6605656                1.6580455
## 377               3.356077e-01              -0.5761473               -1.5258637
## 1029              7.880566e-01              -0.7004334               -1.0463456
## 1044              6.457654e-01               0.4545823                1.1968048
## 140               6.171996e-01               0.5357852                1.2629508
## 1072              7.366315e-01              -0.3531654               -1.0605654
## 507               7.172388e-01               0.5351287                1.1061872
## 77                4.646762e-01              -0.6005085               -1.4040157
## 453               6.316661e-01               0.4410943                1.2206806
## 910               8.303354e-01               0.7413202                0.9886267
## 1296              8.303354e-01               0.7413202                0.9886267
## 1241              8.350198e-01               0.4393144                0.9081254
## 217               3.463602e-01              -0.5382884               -1.5066640
## 75                8.981617e-01               0.5482554                0.8426982
## 516               3.484091e-01               0.5981769                1.6170625
## 382               4.177037e-01               0.9652808                1.2873011
## 538               4.177037e-01               0.9652808                1.2873011
## 720               4.613281e-01              -0.9534934               -1.2717177
## 1028              5.105366e-01              -0.7366032               -1.3239278
## 988               3.500619e-01              -0.5368220               -1.5025596
## 961               8.699108e-01               0.4386523                0.8631521
## 1262              3.530001e-01              -0.7724153               -1.4812306
## 1312              7.799472e-01              -0.5514801               -1.0575518
## 302               6.409383e-01              -0.7229846               -1.1981294
## 318               3.542703e-01              -0.5428782               -1.5007317
## 815               4.610798e-01               0.4108679                1.3688426
## 1078              9.906308e-01              -0.2196871               -0.6358046
## 653               6.137500e-01               0.8943420                1.1926970
## 148               8.828871e-01              -0.4010888               -0.8480123
## 699               3.619808e-01              -0.8572041               -1.4205579
## 219               8.699108e-01               0.6047096                0.9294713
## 783               7.135692e-01              -0.8285469               -1.1050709
## 784               7.135692e-01              -0.8285469               -1.1050709
## 506               9.215902e-01               0.3598123                0.7437832
## 296               3.628504e-01              -0.4896018               -1.4702876
## 438               6.171996e-01               0.6880269                1.2735926
## 1236              8.886494e-01               0.3323712                0.8017925
## 449               4.066404e-01              -0.4196843               -1.3921487
## 533               6.882559e-01               0.3588281                1.1198863
## 950               4.509426e-01              -0.5656789               -1.4196468
## 1220              8.303354e-01               0.4339001                0.9342535
## 753               8.192193e-01              -0.4889414               -0.9887523
## 1196              9.331724e-01              -0.4229003               -0.7600964
## 786               7.007523e-01              -0.5947067               -1.1404459
## 782               9.999349e-01               0.1621740                0.6263090
## 661               4.536809e-01               0.8304031                1.4201332
## 1007              9.702635e-01              -0.3564229               -0.6406138
## 1280              6.662934e-01               0.6056376                1.1917352
## 76                8.828871e-01              -0.2513340               -0.8889202
## 665               9.817654e-01               0.2335484                0.6233365
## 683               8.315689e-01               0.3613798                0.9228598
## 1295              6.688148e-01               0.8557651                1.1412507
## 440               7.007523e-01               0.5808613                1.1429820
## 1248              3.812141e-01              -0.8513406               -1.4108409
## 607               6.951953e-01               0.5571162                1.1516386
## 761               9.863579e-01               0.5415774                0.7222491
## 693               4.386288e-01               0.7935341                1.4688949
## 1063              8.657873e-01               0.4193118                0.8667771
## 940               6.404368e-01               0.6312599                1.2421532
## 765               3.768623e-01              -0.4403641               -1.4319541
## 981               7.880566e-01               0.5179613                1.0192113
## 142               3.774453e-01               0.5622443                1.5726582
## 373               3.812141e-01               0.6289804                1.6062347
## 552               8.343359e-01              -0.6559997               -0.9799680
## 776               4.613281e-01               0.5728458                1.4862456
## 1166              5.105366e-01               0.7497750                1.3878933
## 716               8.063449e-01               0.3467546                0.9596058
## 371               4.245267e-01               0.4033057                1.3906539
## 34                3.838279e-01              -0.8506305               -1.4096642
## 90                3.985303e-01               0.8580059                1.4673389
## 778               3.856388e-01               0.8655891                1.4803073
## 898               3.856388e-01              -0.7012014               -1.4825331
## 979               6.171996e-01               0.4618376                1.2484941
## 267               9.329675e-01               0.3168367                0.7275988
## 759               9.702635e-01              -0.2801911               -0.6550994
## 803               8.597366e-01               0.3117748                0.8809780
## 1109              8.828871e-01              -0.3624000               -0.8473074
## 1214              6.049077e-01               0.6948317                1.2861888
## 757               4.386288e-01              -0.8893891               -1.3286178
## 576               4.369293e-01               0.5021479                1.4711782
## 73                3.896133e-01               0.5638288                1.5603349
## 369               9.282404e-01              -0.3770864               -0.7625555
## 147               4.689046e-01              -0.8752412               -1.3074828
## 823               6.017502e-01               0.4361005                1.2557761
## 266               6.404368e-01               0.6318554                1.2433250
## 31                3.959593e-01               0.7854529                1.5455644
## 2                 9.858241e-01               0.2732572                0.5883647
## 466               9.863579e-01               0.2034803                0.6967385
## 1126              9.709149e-01              -0.2142298               -0.7376344
## 27                5.747444e-01              -0.5191432               -1.2753915
## 261               9.384781e-01               0.3599107                0.7082094
## 768               4.610798e-01              -0.4474850               -1.3655250
## 850               4.148434e-01              -0.4893629               -1.4304245
## 1040              7.671076e-01               0.3124129                1.0272887
## 1283              4.509426e-01              -0.5930387               -1.4232441
## 459               3.985303e-01               0.7832477                1.5412250
## 615               3.985303e-01              -0.7943673               -1.4277496
## 1157              3.985303e-01              -0.7938860               -1.4268845
## 925               9.282404e-01              -0.5487749               -0.8197898
## 1027              9.282404e-01              -0.5487749               -0.8197898
## 721               5.649973e-01               0.7660344                1.3100515
## 452               6.316661e-01               0.6361739                1.2518226
## 873               6.316661e-01               0.6361739                1.2518226
## 1207              7.543755e-01               0.3609799                1.0394620
## 897               8.699546e-01               0.3105640                0.8594521
## 84                8.294086e-01               0.5198088                0.9622075
## 245               9.702635e-01              -0.2227699               -0.7165395
## 1079              8.041580e-01               0.3702024                0.9604884
## 1084              8.041580e-01               0.3702024                0.9604884
## 1086              8.041580e-01               0.3702024                0.9604884
## 880               4.058682e-01              -0.3603579               -1.3383940
## 283               4.066404e-01              -0.5974810               -1.4678459
## 258               8.828871e-01               0.4405148                0.8154280
## 882               9.012414e-01              -0.5781459               -0.8636657
## 793               8.725027e-01              -0.4630926               -0.8880546
## 461               6.458125e-01               0.7813505                1.2009779
## 1181              4.148434e-01               0.9064036                1.3931913
## 291               4.159962e-01              -0.8992497               -1.3433482
## 464               4.440809e-01               0.7040040                1.5158288
## 852               4.177037e-01               0.9040362                1.3895524
## 549               8.192193e-01              -0.3242700               -0.9737918
## 310               5.817215e-01               0.5275683                1.2994970
## 106               7.007523e-01              -0.3592303               -1.1045104
## 280               9.168095e-01              -0.4106628               -0.7875120
## 281               9.168095e-01              -0.4106628               -0.7875120
## 579               8.390239e-01               0.3123355                0.9074225
## 644               9.457918e-01              -0.3991827               -0.7174678
## 807               8.699108e-01               0.4676858                0.8657238
## 1099              4.185986e-01              -0.8963104               -1.3389572
## 1288              9.282404e-01              -0.3379164               -0.7672987
## 636               9.014807e-01              -0.4245106               -0.8140674
## 948               9.006972e-01               0.3515211                0.7835409
## 478               8.041580e-01               0.4335264                0.9663309
## 334               9.245775e-01               0.3082652                0.7436406
## 497               9.906308e-01              -0.5330047               -0.7108928
## 956               5.994085e-01               0.6980485                1.2921434
## 1320              4.229485e-01              -0.5891421               -1.4473595
## 66                7.463842e-01               0.3860192                1.0435329
## 541               5.402943e-01              -0.4544064               -1.2869913
## 630               9.904459e-01               0.3338336                0.5709134
## 1290              7.856443e-01               0.6949625                1.0681949
## 770               9.391514e-01              -0.3356492               -0.7372854
## 696               4.280135e-01               0.7645275                1.5043887
## 1022              8.526768e-01              -0.4827038               -0.9256622
## 652               8.176247e-01               0.5300133                0.9810969
## 908               7.366315e-01              -0.3367048               -1.0569783
## 938               7.981636e-01              -0.3103946               -1.0038474
## 1140              4.944375e-01              -0.9419203               -1.2562821
## 61                6.409383e-01               0.5482153                1.2219727
## 1343              8.725027e-01               0.3414210                0.8409822
## 121               4.386288e-01               0.7305218                1.5100925
## 731               4.386288e-01               0.8949625                1.3756057
## 1270              4.386288e-01              -0.3603922               -1.3140169
## 326               9.026583e-01              -0.3086418               -0.8174045
## 488               5.768183e-01              -0.4687643               -1.2605953
## 413               7.701866e-01              -0.5256556               -1.0629968
## 970               7.135692e-01               0.7380493                1.1344217
## 308               4.501007e-01               0.7903094                1.4629257
## 265               8.030276e-01               0.6790997                1.0438129
## 188               6.656870e-01               0.5469121                1.1775858
## 1221              4.509426e-01               0.8918596                1.3708365
## 769               4.512879e-01              -0.4548093               -1.3771866
## 222               8.828871e-01               0.3929213                0.8122243
## 1093              6.334721e-01               0.7944774                1.2211547
## 1190              9.006972e-01               0.6487355                0.8651555
## 1138              9.012414e-01              -0.2806422               -0.8355622
## 441               4.536809e-01              -0.5517126               -1.4118825
## 839               4.536809e-01               0.5497060                1.4860304
## 3                 7.007523e-01               0.7489818                1.1512255
## 4                 7.007523e-01               0.7489818                1.1512255
## 1175              6.704370e-01               0.6983276                1.1942613
## 32                8.803336e-01               0.3834265                0.8255763
## 525               4.558670e-01              -0.5507337               -1.4093775
## 1326              9.000875e-01               0.3112259                0.7947812
## 394               4.591506e-01               0.9552079                1.2738679
## 57                4.610798e-01               0.7807430                1.4452177
## 476               4.610798e-01               0.6536263                1.5010187
## 722               8.642600e-01              -0.3518078               -0.9003081
## 1149              7.383981e-01              -0.8101157               -1.0804884
## 695               5.105366e-01               0.7950257                1.3596318
## 276               5.737242e-01              -0.7085045               -1.2734247
## 1187              4.646762e-01               0.9522075                1.2698665
## 1194              4.646762e-01               0.7788799                1.4417688
## 1347              4.646762e-01               0.8815208                1.3549451
## 1184              4.662480e-01              -0.6886764               -1.3926623
## 643               7.338497e-01              -0.4963600               -1.0903018
## 785               4.671150e-01              -0.8111294               -1.3442030
## 166               7.326604e-01               0.3225380                1.0556890
## 370               8.511588e-01               0.5346309                0.9143116
## 613               4.917488e-01              -0.5469952               -1.3727575
## 599               8.828871e-01               0.4452069                0.8241136
## 1188              7.802314e-01               0.5241026                1.0312959
## 26                6.816301e-01              -0.4795031               -1.1507680
## 468               8.908583e-01               0.3250068                0.8005511
## 1249              6.612859e-01              -0.5580904               -1.1799569
## 295               4.719063e-01              -0.5967401               -1.3952050
## 396               4.719063e-01               0.9489927                1.2655793
## 597               4.719063e-01               0.9489927                1.2655793
## 616               4.719063e-01              -0.3576265               -1.2870523
## 883               4.719063e-01              -0.8083190               -1.3395456
## 354               9.083980e-01               0.6384483                0.8514365
## 367               9.640820e-01               0.3786396                0.6475394
## 1336              4.728751e-01               0.6808131                1.4658952
## 10                9.384781e-01              -0.2946281               -0.7539801
## 80                5.899760e-01              -0.5243137               -1.2583097
## 1094              9.233544e-01               0.6223746                0.8300005
## 251               9.670323e-01               0.3085116                0.6377373
## 471               8.343359e-01              -0.4129298               -0.9376298
## 767               7.366315e-01              -0.4280068               -1.0741402
## 37                7.040771e-01              -0.5121873               -1.1250680
## 69                7.630177e-01              -0.3307915               -1.0384153
## 9                 4.839310e-01              -0.6816642               -1.3784821
## 82                4.839310e-01              -0.7537601               -1.3547645
## 531               4.839310e-01               0.6376907                1.4644235
## 49                7.630177e-01               0.7978997                1.0640813
## 297               9.316533e-01              -0.2719756               -0.7871348
## 972               7.090298e-01               0.3802464                1.0949410
## 70                4.919838e-01               0.9436348                1.2584340
## 1265              9.587108e-01              -0.2718629               -0.7082610
## 279               9.999349e-01              -0.2985203               -0.5365430
## 619               7.366315e-01               0.8120446                1.0829449
## 698               6.171996e-01               0.4669158                1.2461900
## 363               4.861504e-01              -0.4463617               -1.3404362
## 983               4.913819e-01               0.4953202                1.4132688
## 421               6.664335e-01               0.4032117                1.1504610
## 828               6.976764e-01              -0.5685051               -1.1496484
## 1129              8.303354e-01               0.3487056                0.9306891
## 46                4.917488e-01              -0.9442778               -1.2594264
## 573               4.917488e-01              -0.8666644               -1.2946703
## 772               4.917488e-01              -0.5888590               -1.3767787
## 92                4.919838e-01               0.7619064                1.4103494
## 477               4.919838e-01              -0.9434205               -1.2582831
## 88                7.770618e-01              -0.7098604               -1.0604281
## 63                5.894700e-01               0.8175777                1.2566611
## 13                4.944375e-01               0.6113053                1.4409665
## 232               4.944375e-01              -0.3693930               -1.2810806
## 685               4.944375e-01              -0.5854175               -1.3687321
## 777               4.944375e-01               0.6677189                1.4377015
## 1051              4.944375e-01               0.7597591                1.4063748
## 1342              4.944375e-01               0.6292152                1.4449599
## 690               6.171996e-01               0.6879691                1.2734857
## 606               4.960722e-01               0.9410630                1.2550042
## 1257              4.973521e-01               0.6443746                1.4363118
## 705               4.976499e-01               0.6651193                1.4321042
## 327               5.021500e-01              -0.8600214               -1.2847468
## 888               5.066376e-01               0.6391896                1.4247544
## 1163              5.066376e-01              -0.5269240               -1.3484464
## 122               5.105366e-01              -0.8515453               -1.2720847
## 154               5.105366e-01              -0.5575831               -1.3381535
## 915               5.105366e-01              -0.6979794               -1.3384878
## 1165              5.105366e-01              -0.4301517               -1.3025221
## 1201              5.105366e-01               0.6571566                1.4149593
## 1242              5.649973e-01               0.9147021                1.2198493
## 395               6.027942e-01               0.7468837                1.2773006
## 658               8.928049e-01               0.2400978                0.8679519
## 1189              8.414820e-01              -0.4905794               -0.9407651
## 277               6.404368e-01               0.4301840                1.2032714
## 885               5.649973e-01              -0.5226953               -1.2841180
## 1219              6.234965e-01               0.4695790                1.2362873
## 902               8.444904e-01               0.4867559                0.9010240
## 991               5.402943e-01              -0.3659719               -1.2407736
## 829               8.343359e-01               0.4412860                0.9122010
## 872               7.135692e-01               0.7401929                1.1377165
## 1125              9.827465e-01               0.2395446                0.6117278
## 1121              9.331724e-01               0.2545311                0.7633935
## 259               5.266129e-01               0.8484459                1.3041071
## 542               5.266129e-01               0.4572223                1.3395567
## 907               5.266129e-01              -0.4798170               -1.3088308
## 926               5.266129e-01              -0.4374780               -1.2907559
## 954               5.266129e-01              -0.5266968               -1.3218160
## 398               9.587108e-01               0.2823255                0.6654966
## 749               9.215902e-01               0.2950476                0.7534667
## 545               5.301098e-01               0.8469091                1.3017450
## 659               5.301098e-01              -0.5664429               -1.3243687
## 101               7.704456e-01               0.5744727                1.0633949
## 102               7.704456e-01               0.5744727                1.0633949
## 532               9.999349e-01               0.1927170                0.5000032
## 1030              8.444904e-01               0.5388634                0.9215499
## 249               6.235723e-01              -0.8853408               -1.1808195
## 133               8.700285e-01               0.3200317                0.8541589
## 577               9.245775e-01              -0.6210887               -0.8283744
## 919               9.457918e-01              -0.5942992               -0.7926440
## 1162              5.407667e-01              -0.4197552               -1.2710408
## 1200              5.338737e-01               0.4939313                1.3514383
## 1104              5.817215e-01               0.8205788                1.2612739
## 1314              6.418781e-01               0.6265254                1.2328369
## 1036              7.981636e-01               0.5127264                1.0089104
## 138               9.215902e-01              -0.3029603               -0.7892764
## 1199              8.343359e-01              -0.7303901               -0.9741546
## 33                8.828871e-01              -0.4010895               -0.8480139
## 412               8.700285e-01              -0.6903129               -0.9207019
## 12                8.303354e-01              -0.4826771               -0.9760843
## 623               6.465172e-01              -0.7146226               -1.1842720
## 866               7.784559e-01              -0.3897318               -1.0321625
## 892               9.331724e-01              -0.2525686               -0.7979214
## 325               7.981636e-01              -0.5794328               -1.0414389
## 806               8.041580e-01               0.3434577                0.9705040
## 191               9.663537e-01               0.3453081                0.6391928
## 322               7.964461e-01              -0.3355093               -1.0075434
## 241               5.585651e-01              -0.5290801               -1.2998038
## 881               5.585651e-01               0.9189884                1.2255655
## 522               5.595590e-01              -0.6770037               -1.2982636
## 1003              5.595590e-01               0.5878106                1.3498764
## 409               5.596786e-01               0.7714408                1.3192975
## 167               5.613604e-01               0.8345361                1.2827271
## 827               5.613604e-01               0.5699767                1.3435470
## 789               6.235723e-01               0.5265641                1.2412148
## 1177              8.303354e-01              -0.4235120               -0.9616585
## 470               9.999349e-01              -0.1411768               -0.4371693
## 639               9.168095e-01               0.3824124                0.7524868
## 825               5.640465e-01              -0.7651842               -1.2680626
## 143               9.331724e-01              -0.2370353               -0.8191527
## 792               5.649973e-01              -0.7125979               -1.2807819
## 997               5.649973e-01               0.6449605                1.3332252
## 1000              5.649973e-01              -0.6401502               -1.2945312
## 1306              5.649973e-01               0.5516380                1.3307386
## 1318              5.651133e-01               0.3807105                1.2460916
## 1088              9.999349e-01               0.1576857                0.5783993
## 411               6.418781e-01              -0.7218929               -1.1963203
## 551               6.873542e-01              -0.5476203               -1.1578203
## 791               9.457918e-01              -0.2454623               -0.7705512
## 969               9.906308e-01               0.2303367                0.5673613
## 1250              6.781051e-01              -0.6092811               -1.1683946
## 434               5.663283e-01              -0.6698110               -1.2844705
## 617               7.326604e-01              -0.5182563               -1.0957367
## 163               8.803336e-01              -0.3010359               -0.8712391
## 718               7.186256e-01               0.5662238                1.1141792
## 694               8.725027e-01              -0.3843161               -0.8726573
## 621               6.418781e-01               0.5670217                1.2208848
## 72                9.014807e-01              -0.4009269               -0.8107666
## 864               7.107924e-01              -0.3923819               -1.0982730
## 114               5.747444e-01              -0.5646671               -1.2821761
## 596               5.747444e-01               0.5460784                1.3173270
## 1068              5.747444e-01              -0.5646671               -1.2821761
## 175               6.171996e-01              -0.5154748               -1.2370972
## 358               5.768183e-01              -0.5636706               -1.2799133
## 645               5.768183e-01               0.5731818                1.3162821
## 511               5.809226e-01              -0.6053439               -1.2798639
## 900               5.809226e-01               0.6110007                1.3155785
## 1218              5.809226e-01              -0.7555746               -1.2521376
## 201               8.008903e-01               0.4037490                0.9739800
## 736               8.419033e-01              -0.4381458               -0.9263611
## 739               8.315689e-01               0.3920729                0.9241928
## 795               8.419033e-01              -0.4381458               -0.9263611
## 1341              5.814243e-01              -0.7042559               -1.2657886
## 107               7.856443e-01               0.2773987                1.0027944
## 305               9.906308e-01              -0.2879547               -0.5823107
## 581               9.999349e-01               0.2164552                0.5331687
## 601               8.343359e-01               0.4649022                0.9148050
## 536               5.817215e-01               0.4986688                1.2937937
## 842               5.817215e-01              -0.5610521               -1.2739676
## 29                8.642600e-01              -0.5140608               -0.9239430
## 1135              8.642600e-01              -0.5140608               -0.9239430
## 120               5.865298e-01               0.7527868                1.2873959
## 1348              7.283833e-01               0.6595783                1.1279933
## 309               7.517467e-01               0.4567952                1.0490063
## 381               9.215902e-01              -0.3253995               -0.7809320
## 1001              8.008903e-01              -0.6901102               -1.0309242
## 838               9.316533e-01               0.3510789                0.7257300
## 971               6.457654e-01               0.5238676                1.2030345
## 406               9.476539e-01               0.2638421                0.7041900
## 333               6.612859e-01               0.5521862                1.1889418
## 996               8.643502e-01              -0.4753569               -0.9115733
## 1103              9.587108e-01               0.2560719                0.6834514
## 335               6.027942e-01               0.6242866                1.2904894
## 156               6.049077e-01              -0.5710425               -1.2543491
## 351               8.041580e-01              -0.6835217               -1.0210818
## 1002              7.398369e-01              -0.7284030               -1.0881280
## 605               8.343359e-01              -0.5868353               -0.9725030
## 818               7.741438e-01              -0.7110628               -1.0622243
## 36                9.168095e-01              -0.4923995               -0.8160041
## 332               8.880437e-01               0.3008008                0.8131604
## 380               6.171996e-01              -0.7382715               -1.2234629
## 887               6.171996e-01              -0.5651844               -1.2414812
## 1043              6.171996e-01              -0.5872715               -1.2416539
## 1113              6.171996e-01              -0.5019665               -1.2331932
## 345               6.181786e-01              -0.6454172               -1.2376913
## 505               6.194942e-01              -0.2912816               -1.1349314
## 1233              9.670323e-01              -0.5645092               -0.7529118
## 317               8.036844e-01              -0.6222082               -1.0311229
## 1123              9.222972e-01              -0.2606231               -0.8126952
## 614               8.330596e-01               0.5692539                0.9735228
## 338               8.799779e-01              -0.3381976               -0.8654784
## 1064              8.414820e-01              -0.3493734               -0.9252775
## 1338              9.587108e-01               0.2719781                0.6699319
## 691               6.228584e-01               0.8879126                1.1841227
## 292               8.414775e-01               0.4938932                0.9142357
## 710               9.670323e-01               0.3226083                0.6348082
## 150               6.234965e-01              -0.8864123               -1.1822487
## 1294              6.234965e-01               0.7346457                1.2563715
## 1130              9.702635e-01               0.2722423                0.6251902
## 1198              9.457918e-01              -0.3989283               -0.7170105
## 632               8.303354e-01               0.4361682                0.9391371
## 711               9.215902e-01              -0.5566935               -0.8316191
## 1266              8.343359e-01              -0.3668438               -0.9387865
## 1172              7.802314e-01               0.6981779                1.0731372
## 1173              7.802314e-01               0.6981779                1.0731372
## 841               9.999349e-01              -0.1932064               -0.5591660
## 871               6.293582e-01               0.5576855                1.2430818
## 145               6.612859e-01               0.6520091                1.2069209
## 517               9.886092e-01              -0.3320676               -0.5968390
## 849               6.316661e-01               0.4895465                1.2287808
## 1087              9.405260e-01              -0.3814877               -0.7315640
## 1122              7.283833e-01               0.7301846                1.1223331
## 1332              6.334721e-01               0.6352326                1.2499705
## 139               8.041580e-01               0.5020475                0.9878973
## 631               9.384781e-01               0.3192785                0.7116723
## 1222              7.039006e-01               0.6758148                1.1557604
## 957               7.981636e-01               0.5531321                1.0238916
## 1042              6.612859e-01              -0.4874943               -1.1699463
## 708               6.404368e-01               0.4674237                1.2127286
## 1020              6.404368e-01              -0.5016754               -1.2039797
## 1245              6.404368e-01               0.7231990                1.2367956
## 1259              6.404368e-01               0.7235750                1.2374387
## 111               7.135692e-01               0.4540202                1.0952513
## 126               7.802314e-01               0.6981779                1.0731372
## 443               6.458125e-01               0.5058564                1.1924028
## 674               7.880488e-01              -0.2579957               -1.0066688
## 129               6.409383e-01               0.7208518                1.2327815
## 195               6.409383e-01               0.7888532                1.2125099
## 264               6.409383e-01               0.7208518                1.2327815
## 1334              6.409383e-01               0.7891505                1.2129670
## 115               9.026583e-01              -0.5753483               -0.8594866
## 234               8.346649e-01              -0.4123641               -0.9363452
## 152               9.999349e-01              -0.2179592               -0.5469977
## 998               6.612859e-01               0.6108313                1.2019550
## 218               8.828871e-01               0.6712387                0.8951659
## 790               9.282404e-01               0.3402244                0.7325555
## 727               9.999349e-01              -0.2150962               -0.5029046
## 131               6.457654e-01              -0.6673815               -1.1995127
## 244               6.457654e-01               0.4970839                1.1991357
## 329               6.457654e-01              -0.5265523               -1.1956296
## 930               6.457654e-01               0.6651356                1.2312191
## 1009              6.457654e-01              -0.8699100               -1.1602387
## 1011              6.457654e-01              -0.8699100               -1.1602387
## 1014              6.457654e-01              -0.8699100               -1.1602387
## 1018              6.457654e-01              -0.8699100               -1.1602387
## 1019              6.457654e-01              -0.8699100               -1.1602387
## 1021              6.457654e-01              -0.8699100               -1.1602387
## 1345              8.880437e-01              -0.3680938               -0.8358218
## 704               6.458125e-01              -0.6657236               -1.1965329
## 1065              6.458125e-01              -0.7156015               -1.1858943
## 1317              6.458125e-01               0.6595786                1.2209326
## 22                8.886494e-01               0.3483537                0.7999762
## 458               6.923428e-01               0.4353558                1.1295285
## 1033              8.343359e-01               0.3246030                0.9172265
## 359               7.007523e-01               0.6227750                1.1528063
## 1092              9.484497e-01               0.3671456                0.6796158
## 843               7.007523e-01              -0.5955731               -1.1421072
## 955               7.205465e-01               0.8204029                1.0940916
## 1225              7.135692e-01               0.4018241                1.0862586
## 1340              9.261406e-01               0.3309723                0.7377377
## 1322              9.504797e-01               0.3648221                0.6753148
## 638               9.999349e-01               0.1507206                0.6440152
## 774               7.135692e-01               0.4528431                1.0924117
## 56                8.303354e-01               0.4054331                0.9310560
## 270               9.457918e-01              -0.3558077               -0.7195251
## 730               8.436275e-01              -0.7134591               -0.9515730
## 737               8.802095e-01              -0.4900184               -0.8807306
## 1136              8.699108e-01              -0.3904184               -0.8865136
## 1240              8.436275e-01              -0.7134591               -0.9515730
## 243               6.612859e-01              -0.5189706               -1.1784140
## 375               6.612859e-01              -0.2999608               -1.1091324
## 664               6.612859e-01               0.4553113                1.1627339
## 935               6.612859e-01               0.5497239                1.1836401
## 975               6.612859e-01              -0.3081997               -1.1091716
## 1023              6.612859e-01              -0.5173867               -1.1748176
## 591               8.886494e-01              -0.3341374               -0.8385625
## 984               9.331724e-01              -0.3418943               -0.7510033
## 728               7.178264e-01               0.7361871                1.1315594
## 67                9.168095e-01               0.6307330                0.8411472
## 15                7.186256e-01               0.5662520                1.1142347
## 835               8.725027e-01               0.3307435                0.8446236
## 30                7.799472e-01              -0.4026157               -1.0303301
## 224               6.688148e-01               0.4154206                1.1496314
## 672               6.834645e-01               0.4393782                1.1399646
## 1331              9.006972e-01              -0.4034627               -0.8158946
## 754               9.006972e-01               0.4647367                0.7947804
## 1085              8.041580e-01               0.5366616                0.9934034
## 132               8.005396e-01               0.4148594                0.9779049
## 173               6.972324e-01              -0.5208904               -1.1441851
## 278               8.303354e-01              -0.2474012               -0.9694647
## 992               8.700285e-01              -0.5027072               -0.9035366
## 993               9.083980e-01              -0.3638122               -0.7991480
## 995               8.700285e-01              -0.5027072               -0.9035366
## 1005              9.384781e-01              -0.2460146               -0.7956359
## 39                6.728369e-01               0.6974700                1.1927946
## 758               9.999349e-01               0.5042863                0.6725176
## 684               9.893229e-01              -0.2412557               -0.6173952
## 1238              8.343359e-01              -0.7286755               -0.9718679
## 1344              8.315689e-01               0.5123010                0.9483100
## 514               9.863579e-01              -0.2986484               -0.6039358
## 528               9.378561e-01               0.2932399                0.7223035
## 99                9.587108e-01              -0.2261525               -0.7697862
## 1026              6.821061e-01              -0.7664059               -1.1448988
## 813               9.457918e-01               0.4030020                0.6892033
## 814               9.457918e-01               0.4030020                0.6892033
## 1278              8.187109e-01               0.3850147                0.9483614
## 1303              9.670323e-01               0.2577717                0.6470169
## 179               6.834645e-01               0.6392032                1.1832160
## 530               6.834645e-01               0.4747463                1.1452496
## 668               9.877841e-01               0.3402659                0.5819136
## 1016              9.634461e-01              -0.4942297               -0.7383072
## 1315              9.569042e-01              -0.2140190               -0.8078226
## 560               7.427631e-01               0.3743385                1.0470654
## 1268              7.205465e-01               0.3972602                1.0739209
## 936               8.828871e-01              -0.3338228               -0.8542828
## 125               9.500770e-01              -0.5865838               -0.7823536
## 123               8.419033e-01              -0.3951718               -0.9239292
## 743               9.510944e-01               0.3952581                0.6759599
## 641               8.343359e-01              -0.5381789               -0.9672914
## 1176              6.882559e-01               0.4309394                1.1345588
## 247               9.999349e-01              -0.1790407               -0.6019624
## 702               6.888102e-01               0.7593333                1.1671363
## 1060              6.888102e-01               0.5937069                1.1682586
## 580               9.906308e-01               0.3669882                0.5640807
## 174               8.880437e-01              -0.4764668               -0.8563736
## 1004              9.510944e-01               0.5837977                0.7785542
## 311               6.931638e-01              -0.4259381               -1.1280510
## 1260              9.999349e-01               0.1755310                0.5718092
## 177               7.609862e-01              -0.6524443               -1.0812300
## 255               7.609862e-01              -0.6524443               -1.0812300
## 437               8.700285e-01               0.5102617                0.8726360
## 550               7.757779e-01               0.7893270                1.0526487
## 904               8.642600e-01              -0.4271165               -0.9030421
## 917               8.008903e-01              -0.5730468               -1.0299610
## 1335              9.906308e-01               0.5345049                0.7128173
## 238               8.414775e-01               0.3135117                0.9027748
## 393               8.828871e-01              -0.6656665               -0.8878299
## 604               9.999349e-01               0.2718696                0.4649442
## 1305              8.018235e-01              -0.6232236               -1.0328056
## 60                6.976764e-01              -0.6400913               -1.1504629
## 415               7.007523e-01               0.5252541                1.1309528
## 416               7.007523e-01               0.5252541                1.1309528
## 417               7.007523e-01               0.5252541                1.1309528
## 418               7.007523e-01               0.5252541                1.1309528
## 651               7.989486e-01               0.3124161                0.9919583
## 800               7.007523e-01              -0.5615965               -1.1356776
## 809               7.007523e-01               0.3510322                1.0955558
## 1012              7.007523e-01              -0.7526475               -1.1243458
## 1191              7.007523e-01               0.7479756                1.1496789
## 524               7.013358e-01               0.5793969                1.1401004
## 1197              7.704456e-01               0.4142119                1.0202795
## 707               8.187109e-01               0.4272558                0.9523538
## 920               8.429047e-01              -0.4594536               -0.9291210
## 298               7.039006e-01              -0.5920719               -1.1353932
## 567               8.699108e-01               0.3053390                0.8627924
## 994               9.039688e-01              -0.3802558               -0.8039657
## 582               8.041580e-01               0.4348709                0.9693279
## 330               8.763900e-01              -0.6804544               -0.9075531
## 554               8.776508e-01               0.5858521                0.9004863
## 555               7.599423e-01               0.7139811                1.0974275
## 564               8.776508e-01               0.5858521                0.9004863
## 336               8.419033e-01              -0.3344381               -0.9245202
## 914               8.325291e-01              -0.6623794               -0.9894984
## 460               7.221103e-01               0.3687713                1.0713845
## 274               7.135692e-01              -0.4729697               -1.1058242
## 383               7.135692e-01               0.7382320                1.1347025
## 385               7.135692e-01               0.7382320                1.1347025
## 386               7.135692e-01               0.7382320                1.1347025
## 388               7.135692e-01               0.7382320                1.1347025
## 390               7.135692e-01               0.7382320                1.1347025
## 391               7.135692e-01               0.7382320                1.1347025
## 392               7.135692e-01               0.7382320                1.1347025
## 867               7.135692e-01               0.4663787                1.0993462
## 171               9.906308e-01               0.3686127                0.5665776
## 740               9.906308e-01               0.3686127                0.5665776
## 1032              7.166635e-01              -0.6239322               -1.1214195
## 924               8.294086e-01              -0.6690788               -0.9995064
## 64                9.457918e-01              -0.5917274               -0.7892139
## 134               9.663537e-01              -0.2688378               -0.6879804
## 206               9.457918e-01              -0.5917274               -0.7892139
## 738               9.670323e-01              -0.3248916               -0.6570056
## 934               7.205465e-01              -0.5819071               -1.1159006
## 1216              7.205465e-01              -0.6723704               -1.1142516
## 1186              7.324898e-01               0.5580832                1.0981607
## 602               9.504797e-01              -0.3485678               -0.7048844
## 878               8.414775e-01              -0.2898255               -0.9373250
## 1333              9.168095e-01              -0.4949061               -0.8201579
## 649               9.999349e-01               0.1798396                0.5858449
## 512               9.759915e-01              -0.3837254               -0.6359094
## 513               9.759915e-01              -0.3837254               -0.6359094
## 911               9.670323e-01               0.3083785                0.6374623
## 48                9.670323e-01              -0.4870231               -0.7275416
## 1090              7.427527e-01               0.3641692                1.0486458
## 943               7.283833e-01              -0.5205106               -1.1005030
## 1101              8.414775e-01               0.3187221                0.9006090
## 144               9.906308e-01               0.2152853                0.6083288
## 747               7.303853e-01               0.6582179                1.1256667
## 766               7.303853e-01              -0.2990762               -1.0545179
## 901               7.599423e-01               0.4411904                1.0399724
## 598               9.026583e-01               0.4189452                0.7755010
## 1070              8.739813e-01              -0.2945057               -0.8844085
## 1330              7.326604e-01               0.8146164                1.0863747
## 178               7.799472e-01              -0.4213053               -1.0350307
## 1307              7.338497e-01              -0.3036302               -1.0530108
## 697               9.014807e-01               0.5341908                0.8210801
## 128               7.366315e-01               0.3611856                1.0581912
## 233               7.366315e-01              -0.3977733               -1.0696870
## 741               9.331724e-01               0.2955318                0.7279488
## 751               9.999349e-01               0.2857449                0.4392054
## 611               8.828871e-01               0.3446471                0.8124009
## 1192              7.997047e-01              -0.7689670               -1.0256064
## 208               9.391514e-01              -0.3262651               -0.7408422
## 221               7.856443e-01               0.4247006                1.0011027
## 1313              8.799779e-01              -0.6768110               -0.9026937
## 637               9.670323e-01              -0.5612945               -0.7486241
## 1228              9.670323e-01              -0.5612945               -0.7486241
## 1056              7.406165e-01               0.5191891                1.0732378
## 439               7.427631e-01               0.4105648                1.0484642
## 733               9.999349e-01               0.2010680                0.4739568
## 1271              9.606419e-01              -0.2211840               -0.7697160
## 1323              7.463842e-01              -0.7253201               -1.0835225
## 752               8.981617e-01               0.3363059                0.7927390
## 19                9.165519e-01              -0.6330904               -0.8443817
## 242               8.828871e-01               0.3262728                0.8189575
## 294               8.041580e-01              -0.6859373               -1.0246905
## 397               9.906308e-01              -0.2543530               -0.5775533
## 875               8.828871e-01               0.3770386                0.8118221
## 1089              8.343359e-01              -0.4066884               -0.9508556
## 1118              8.187109e-01              -0.7516074               -1.0024531
## 1301              8.343359e-01               0.3744737                0.9033581
## 1302              8.343359e-01               0.3744737                0.9033581
## 508               8.642600e-01               0.3189623                0.8727083
## 372               9.817654e-01              -0.3430335               -0.6165485
## 819               8.041580e-01               0.5389955                0.9977237
## 820               8.041580e-01               0.5389955                0.9977237
## 821               8.041580e-01               0.5389955                0.9977237
## 822               8.041580e-01               0.5389955                0.9977237
## 96                8.700285e-01               0.3950008                0.8504974
## 633               8.867499e-01              -0.5283576               -0.8755937
## 16                8.315689e-01              -0.6633366               -0.9909283
## 764               8.315689e-01              -0.6633366               -0.9909283
## 1058              7.997047e-01              -0.4317406               -1.0094287
## 595               7.681363e-01               0.4005948                1.0230038
## 285               7.799472e-01               0.4292608                1.0118519
## 340               7.551269e-01              -0.4698633               -1.0669072
## 1017              9.384781e-01              -0.4619549               -0.7655512
## 1107              8.315689e-01              -0.2775706               -0.9626344
## 254               7.609862e-01              -0.6524443               -1.0812300
## 1244              7.609862e-01              -0.4300364               -1.0564808
## 455               8.700285e-01              -0.5547023               -0.9192521
## 927               9.893229e-01               0.2671150                0.5751397
## 40                8.763900e-01               0.4997856                0.8547200
## 347               7.671076e-01              -0.4822851               -1.0593851
## 946               7.675412e-01              -0.2992437               -1.0303536
## 1038              7.681363e-01              -0.3035522               -1.0291488
## 1073              7.681363e-01              -0.4373980               -1.0497193
## 518               8.828871e-01               0.4137709                0.8141921
## 671               9.999349e-01               0.2111134                0.4848109
## 1204              8.828871e-01               0.4137709                0.8141921
## 1308              9.999349e-01               0.2588462                0.4791450
## 1255              7.704456e-01               0.5323179                1.0474614
## 779               7.915359e-01              -0.4247021               -1.0192500
## 1235              8.699108e-01              -0.6926704               -0.9238462
## 1164              9.587108e-01              -0.3376688               -0.6828441
## 1110              9.999349e-01              -0.1744273               -0.5864514
## 824               8.192193e-01              -0.5576421               -1.0022735
## 620               9.215902e-01               0.3775204                0.7428606
## 1281              7.799472e-01               0.4098146                1.0094482
## 862               9.006972e-01              -0.4263735               -0.8176398
## 1153              9.006972e-01              -0.4263735               -0.8176398
## 1069              9.858241e-01              -0.2890558               -0.6111437
## 1203              8.148675e-01               0.5917667                1.0120237
## 1205              8.148675e-01               0.5917667                1.0120237
## 1053              7.856443e-01               0.4686481                1.0090714
## 1054              7.856443e-01               0.4686481                1.0090714
## 1055              7.856443e-01               0.4686481                1.0090714
## 227               9.367166e-01              -0.2425602               -0.8046043
## 286               9.179750e-01               0.3198409                0.7539277
## 799               9.014807e-01              -0.4580208               -0.8232200
## 618               9.026583e-01              -0.4557425               -0.8191251
## 469               9.999349e-01              -0.2088131               -0.5011343
## 682               9.734875e-01              -0.5529361               -0.7374762
## 703               9.999349e-01              -0.1731915               -0.6585859
## 1106              8.414775e-01              -0.3558650               -0.9271044
## 136               8.699546e-01               0.3397677                0.8528302
## 553               8.968925e-01              -0.4683557               -0.8417954
## 1316              8.725027e-01               0.2561487                0.8922089
## 257               8.343359e-01              -0.6523044               -0.9744478
## 313               9.587108e-01               0.2870435                0.6591804
## 314               9.587108e-01               0.2870435                0.6591804
## 315               9.587108e-01               0.2870435                0.6591804
## 316               9.587108e-01               0.2870435                0.6591804
## 419               9.510944e-01               0.4548767                0.6991701
## 656               8.303354e-01               0.4551822                0.9409264
## 1075              9.702635e-01               0.2405222                0.6502079
## 448               8.828871e-01              -0.3839042               -0.8432821
## 612               7.989486e-01              -0.2474271               -0.9995130
## 889               7.997047e-01               0.6091303                1.0417184
## 494               9.006972e-01               0.3782201                0.7818348
## 1074              8.041580e-01              -0.4041163               -0.9928021
## 561               8.192193e-01               0.5859777                1.0021234
## 562               8.192193e-01               0.5859777                1.0021234
## 648               8.343359e-01               0.4662050                0.9173687
## 127               9.033554e-01               0.4183200                0.7743438
## 692               9.331724e-01              -0.2482383               -0.8028277
## 1325              8.113260e-01              -0.4352924               -0.9884079
## 116               9.670323e-01              -0.3423997               -0.6566065
## 119               9.670323e-01              -0.3423997               -0.6566065
## 14                8.679086e-01               0.6973853                0.9300350
## 74                9.702635e-01              -0.2008128               -0.7933232
## 112               9.316533e-01              -0.3590129               -0.7590522
## 210               9.851785e-01              -0.2659054               -0.6216986
## 236               8.699108e-01              -0.2997511               -0.9001608
## 240               8.725027e-01              -0.3431325               -0.8781073
## 269               8.880437e-01              -0.2493456               -0.8818876
## 529               8.642600e-01              -0.3661659               -0.8995685
## 548               9.457918e-01               0.4078045                0.6974163
## 667               9.906308e-01               0.2861433                0.5630546
## 978               9.906308e-01              -0.2523539               -0.5900147
## 1091              9.391514e-01              -0.3250547               -0.7380938
## 1206              9.587108e-01               0.2690785                0.6753974
## 414               8.414820e-01               0.4345164                0.8982074
## 187               8.192193e-01              -0.3614693               -0.9720589
## 18                8.192193e-01               0.4869421                0.9581737
## 20                8.192193e-01               0.4869421                0.9581737
## 1059              8.192193e-01               0.4869421                0.9581737
## 260               9.391514e-01               0.3584816                0.7053974
## 446               8.725027e-01               0.5937835                0.9126773
## 608               9.384781e-01               0.2655843                0.7349757
## 1134              8.246224e-01              -0.3065246               -0.9683807
## 420               8.803336e-01               0.4490671                0.8312591
## 194               9.391514e-01              -0.4568920               -0.7571610
## 168               8.886494e-01              -0.2438168               -0.8822133
## 663               9.702635e-01               0.2197767                0.6938971
## 854               8.303354e-01              -0.5512268               -0.9907430
## 719               8.315689e-01              -0.2837434               -0.9619902
## 1152              8.315689e-01               0.6512444                1.0009979
## 5                 8.343359e-01              -0.2694813               -0.9588933
## 137               8.343359e-01              -0.7336048               -0.9784423
## 226               8.343359e-01               0.6443477                0.9903973
## 271               8.343359e-01              -0.2809735               -0.9486878
## 348               8.343359e-01              -0.4470716               -0.9452327
## 565               8.343359e-01              -0.5361229               -0.9635961
## 657               8.343359e-01              -0.4006027               -0.9366269
## 726               8.343359e-01               0.7273896                0.9700488
## 903               8.343359e-01               0.6420379                0.9868470
## 928               8.343359e-01              -0.2709416               -0.9553174
## 1150              8.343359e-01               0.3429784                0.9154032
## 760               8.350198e-01              -0.3474597               -0.9343844
## 475               8.382574e-01              -0.4653825               -0.9411107
## 98                9.999349e-01              -0.2049931               -0.5737738
## 6                 9.999349e-01              -0.1819805               -0.6265936
## 603               9.999349e-01              -0.5047150               -0.6731614
## 947               9.367166e-01              -0.2409467               -0.8065527
## 1024              9.999349e-01              -0.5047150               -0.6731614
## 1025              9.999349e-01              -0.5047150               -0.6731614
## 17                9.457918e-01              -0.5923703               -0.7900714
## 1132              8.725027e-01              -0.4362769               -0.8822524
## 1145              9.999349e-01              -0.1782247               -0.5965952
## 1076              8.429047e-01              -0.4056149               -0.9210200
## 989               8.450484e-01              -0.3921612               -0.9168904
## 169               9.999349e-01              -0.1673955               -0.5742274
## 408               8.725027e-01               0.4600881                0.8516597
## 1062              9.160980e-01               0.3673032                0.7592679
## 646               9.906308e-01              -0.2026801               -0.6784581
## 735               9.663537e-01               0.2888867                0.6439289
## 804               9.587108e-01               0.2550080                0.6806117
## 38                8.802095e-01               0.5826367                0.8955440
## 229               9.457918e-01              -0.3993537               -0.7177751
## 428               9.006972e-01              -0.2539153               -0.8608621
## 474               8.660648e-01              -0.3649226               -0.8965141
## 100               9.999349e-01               0.2003889                0.5029840
## 252               8.635925e-01               0.7029576                0.9374662
## 456               8.679086e-01               0.3749275                0.8610015
## 186               9.576150e-01               0.2635681                0.6838262
## 384               9.571866e-01               0.2856519                0.6733377
## 493               9.652451e-01              -0.2199565               -0.7628245
## 1080              9.932213e-01               0.2207375                0.5636999
## 1251              8.828871e-01              -0.5353774               -0.8872269
## 1254              9.457918e-01              -0.3039719               -0.7295076
## 45                9.999349e-01              -0.3072815               -0.5092267
## 826               8.699108e-01              -0.6255091               -0.9344195
## 43                9.026583e-01               0.6425204                0.8568669
## 859               9.906308e-01               0.3028094                0.5605243
## 1146              9.750904e-01               0.4077170                0.6266831
## 1253              8.725027e-01               0.4283429                0.8428659
## 547               8.729254e-01               0.2819224                0.8634042
## 117               9.999349e-01              -0.2693545               -0.4841221
## 118               9.999349e-01              -0.2693545               -0.4841221
## 248               9.988087e-01              -0.1937235               -0.6645420
## 1066              9.906308e-01              -0.3166617               -0.5691493
## 1223              9.006972e-01              -0.3852119               -0.8144442
## 1108              8.744424e-01              -0.3829850               -0.8696347
## 1339              8.793522e-01              -0.4919168               -0.8841427
## 1008              8.803336e-01               0.5800643                0.8915902
## 1142              9.160980e-01               0.3673032                0.7592679
## 666               9.948050e-01              -0.2757091               -0.5575474
## 272               9.999349e-01              -0.1872923               -0.6448834
## 546               8.886494e-01               0.2677118                0.8355164
## 422               9.316533e-01               0.2567520                0.7642719
## 410               9.999349e-01               0.1977659                0.5411044
## 1160              9.000875e-01              -0.5168181               -0.8564705
## 929               9.999349e-01              -0.2713600               -0.4877266
## 192               9.670323e-01              -0.2133411               -0.7634901
## 1232              9.906308e-01               0.2598125                0.5594163
## 1239              9.886092e-01              -0.2057577               -0.7058235
## 1128              9.331724e-01               0.2905691                0.7293397
## 937               9.516608e-01              -0.2183167               -0.8017480
## 1258              9.006972e-01              -0.5797508               -0.8660633
## 253               9.999349e-01              -0.1191856               -0.4072872
## 1057              9.999349e-01              -0.2059988               -0.4165771
## 447               9.160980e-01               0.2621973                0.7976677
## 798               9.999349e-01              -0.1451326               -0.5208551
## 559               9.083980e-01               0.3705580                0.7659961
## 491               9.999349e-01              -0.1178939               -0.4012914
## 1304              9.670323e-01               0.2290632                0.6920017
## 378               9.906308e-01              -0.1994191               -0.6963106
## 1114              9.999349e-01               0.1969916                0.4241532
## 1151              9.999349e-01              -0.2619855               -0.4708774
## 1137              9.702635e-01               0.3163930                0.6225782
## 268               9.999349e-01              -0.1786925               -0.5954809
## 47                9.827465e-01               0.5450064                0.7268221
## 151               9.999349e-01               0.2419591                0.4137921
## 293               9.316533e-01              -0.2242192               -0.8446793
## 360               9.316533e-01               0.3927997                0.7271035
## 81                9.610570e-01              -0.5717960               -0.7626304
## 544               9.999349e-01              -0.1881949               -0.6696526
## 1124              9.999349e-01              -0.1459494               -0.5266836
## 1209              9.391514e-01              -0.2279221               -0.8179719
## 312               9.999349e-01              -0.1223501               -0.4340554
## 942               9.670323e-01              -0.2181753               -0.7512193
## 105               9.999349e-01              -0.1564582               -0.5325581
## 239               9.760832e-01               0.2446106                0.6246650
## 556               9.671531e-01              -0.3987993               -0.6608899
## 558               9.671531e-01              -0.3987993               -0.6608899
## 944               9.817654e-01              -0.2096841               -0.7219826
## 89                9.407213e-01               0.2841129                0.7131344
## 113               9.999349e-01              -0.1723268               -0.6386149
## 445               9.999349e-01              -0.1446973               -0.3285607
## 1182              9.817654e-01              -0.3429498               -0.6163980
## 918               9.457918e-01               0.2549005                0.7202691
## 328               9.999349e-01              -0.1955902               -0.3955285
## 353               9.904459e-01               0.2651565                0.5709227
## 1120              9.999349e-01              -0.2278278               -0.5597099
## 135               9.932213e-01              -0.1927317               -0.7094475
##      nMoreExtreme_iDUX4t14dox_WTt14dox pval_WTt14dox_WTdmso
## 21                              116004         3.587033e-06
## 24                                3155         3.028282e-06
## 108                              20828         6.926290e-06
## 109                                 12         1.199850e-05
## 110                                276         1.631834e-06
## 170                             331907         7.313937e-06
## 181                                 15         5.952006e-05
## 205                                961         8.757264e-06
## 275                               1408         2.351188e-06
## 299                             502406         3.351627e-05
## 300                              11370         2.509239e-06
## 341                                687         2.955251e-04
## 346                              29301         2.493879e-06
## 404                              96495         3.028282e-06
## 483                              14776         1.525369e-02
## 487                               8402         2.159073e-03
## 504                                549         2.852211e-04
## 521                               1114         5.413382e-07
## 624                               7039         3.537645e-07
## 625                              38211         3.743604e-06
## 709                              61164         8.847922e-04
## 788                              27087         8.850944e-07
## 847                               6544         7.230318e-06
## 855                               9877         2.328067e-06
## 856                             228299         4.469185e-04
## 865                                265         7.321430e-04
## 906                                276         1.631834e-06
## 958                              17264         1.767814e-06
## 980                            1477414         1.104884e-04
## 986                             141034         3.048364e-05
## 987                              38507         5.264607e-05
## 1013                            116692         1.037513e-04
## 1131                            105828         1.076110e-06
## 1213                                30         5.327915e-05
## 1272                             23250         9.656446e-06
## 1275                             30200         1.071690e-06
## 355                             204943         1.915549e-02
## 626                                149         1.798928e-07
## 744                               1658         3.957641e-06
## 431                                173         1.958443e-03
## 985                              11349         6.700207e-03
## 405                              34764         2.047851e-04
## 479                             192491         7.497488e-03
## 520                             951849         9.041459e-01
## 587                              34764         2.047851e-04
## 832                               9801         2.015636e-03
## 162                                  0         1.000018e-03
## 161                                  0         5.470141e-02
## 430                                  0         9.203207e-03
## 160                                  0         4.164096e-04
## 482                              25096         1.489597e-02
## 647                              12294         9.999914e-01
## 1031                                 0         3.144418e-01
## 357                              55842         9.796564e-04
## 1048                             92699         1.433853e-05
## 366                               3147         9.980713e-01
## 1144                           5601814         9.038371e-01
## 180                               4686         5.082275e-03
## 677                              13872         2.925583e-05
## 362                            1479288         8.203227e-01
## 932                             107126         2.093845e-02
## 1155                               298         4.528553e-02
## 1111                            122219         8.110090e-02
## 1154                                 6         1.194151e-01
## 973                            3360238         3.130021e-04
## 967                             460006         1.452457e-01
## 1037                           2600836         8.077557e-01
## 745                            1820647         8.353862e-01
## 863                               5320         8.325476e-01
## 44                                  11         2.435462e-01
## 673                                 14         8.857503e-01
## 200                               1909         9.941075e-01
## 1006                            538797         8.858697e-01
## 480                             193578         6.144468e-03
## 688                              14029         6.741850e-01
## 965                            2304767         8.814485e-01
## 25                                  31         4.062539e-02
## 1015                            686072         3.939078e-04
## 361                            1819021         9.104434e-01
## 836                             378296         3.290721e-01
## 1041                           3807258         8.944295e-01
## 304                                 65         3.766608e-01
## 1319                                60         7.149700e-01
## 204                                 86         7.499408e-01
## 734                                 71         3.718942e-01
## 301                                100         3.118293e-01
## 609                                121         8.183715e-04
## 895                             465885         9.216790e-01
## 197                               2496         7.884189e-01
## 535                              56211         2.864620e-01
## 1208                            224891         1.323567e-03
## 1127                            709590         9.789258e-03
## 124                             572166         3.597713e-01
## 481                             209400         5.641912e-03
## 184                            1113416         2.393581e-01
## 1100                            260814         1.781507e-02
## 495                            3169792         7.624752e-03
## 1291                           2327461         7.454563e-01
## 324                              80475         7.193977e-01
## 837                             543060         2.929411e-01
## 182                            3011690         2.860746e-01
## 1269                            161637         3.149113e-04
## 921                            2842967         9.600071e-01
## 1035                             31650         2.122860e-01
## 689                             676746         9.483614e-01
## 568                            1811719         3.425586e-02
## 563                             407885         3.065538e-02
## 669                              58033         2.502787e-04
## 95                               25019         9.347659e-01
## 273                              42778         7.442420e-01
## 1279                           5055410         8.164920e-01
## 203                             288713         8.568034e-01
## 42                             1739509         9.828924e-01
## 780                             205595         9.249663e-01
## 642                            4289080         6.708340e-01
## 198                              21691         7.159811e-01
## 435                             536754         3.837656e-01
## 724                            5757711         3.956693e-01
## 894                             366940         1.104400e-02
## 303                               2796         4.413007e-01
## 886                             782677         5.241749e-01
## 1067                            245224         9.100403e-01
## 801                             609397         3.776665e-01
## 93                              743142         3.425240e-01
## 199                             129605         2.584805e-01
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## 1289                           1219574         2.161661e-01
## 1311                            356588         6.615382e-01
## 851                             773607         2.618522e-01
## 787                            3419755         6.612919e-01
## 1169                              5106         7.481599e-01
## 680                            2068149         2.621904e-01
## 500                            3059050         5.764408e-01
## 486                            2516501         5.680697e-01
## 55                              932216         6.041415e-01
## 364                               5865         2.502774e-01
## 91                                4610         8.423967e-01
## 485                             366902         2.824075e-01
## 1096                             90919         8.989796e-01
## 52                              649962         6.921978e-01
## 640                             264766         5.151746e-01
## 861                             897460         4.185721e-01
## 425                            2388797         5.304536e-01
## 54                              726828         4.046783e-01
## 655                             578085         9.546358e-01
## 436                             581525         3.524280e-01
## 1329                           4007604         7.799613e-01
## 811                            1576664         5.458530e-01
## 1285                           1999497         1.933982e-01
## 94                             1479497         7.628945e-01
## 212                            3124113         2.240653e-02
## 627                            1824443         1.741944e-01
## 444                             490343         2.476469e-01
## 896                            1151593         2.236933e-01
## 1061                            943555         7.493116e-01
## 65                             1334273         4.679585e-01
## 228                              33492         1.676354e-01
## 794                             727771         1.797189e-01
## 976                            1176823         3.967865e-01
## 781                              11299         5.357121e-01
## 681                             244184         4.616643e-01
## 1299                             67431         6.545904e-01
## 1183                            431668         7.431696e-01
## 165                             993494         1.257673e-01
## 59                             2728149         3.881783e-01
## 407                            2891762         3.747210e-01
## 7                               530942         6.853875e-01
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## 368                             850584         2.198510e-02
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## 426                            3597796         7.955470e-01
## 566                            1645815         6.866395e-01
## 834                            2176278         5.703124e-01
## 1274                            752026         1.874552e-01
## 429                              38245         5.397468e-01
## 1095                            132013         6.960601e-01
## 571                            1879222         8.459404e-01
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## 71                             1994828         7.170296e-01
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## 1081                           2901530         3.480081e-01
## 158                            2041010         1.988411e-01
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## 939                             254520         4.246249e-01
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## 290                             300095         3.357756e-01
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## 223                            4171630         9.986457e-01
## 23                             1099292         3.447147e-01
## 912                             818357         2.023882e-01
## 323                             354152         4.103391e-01
## 610                              76178         9.832953e-01
## 960                              21798         1.676113e-01
## 1267                            174316         4.372779e-01
## 176                             334100         3.450146e-03
## 833                            1891819         1.617889e-01
## 343                             138388         9.455616e-01
## 949                              44594         2.870059e-02
## 287                             661424         1.645502e-01
## 83                              637551         7.332584e-01
## 959                              23745         2.327414e-01
## 401                            4526598         2.539078e-01
## 953                            1424251         9.107047e-02
## 1097                             72085         9.860241e-01
## 349                             257003         5.182706e-01
## 945                            1739827         1.673676e-01
## 687                              70288         3.877691e-03
## 899                             324166         7.072062e-01
## 1159                           4061806         7.537148e-01
## 35                             1213500         4.764084e-01
## 53                             1301462         7.981126e-01
## 762                            3426221         6.759978e-01
## 853                             136799         3.220477e-02
## 225                             128070         7.433908e-01
## 1210                            172813         4.617108e-01
## 763                             964778         9.940566e-01
## 1046                           4563316         2.472853e-01
## 1098                            319609         3.892221e-01
## 670                             285088         4.333668e-03
## 890                            1027306         4.402231e-01
## 58                              727180         7.723651e-02
## 376                            3662833         4.139327e-01
## 519                             905370         1.969486e-01
## 569                            1555457         6.953050e-01
## 905                            3058932         1.434946e-01
## 172                            3615392         3.586563e-01
## 342                            1497368         3.538628e-01
## 526                             624552         3.816351e-01
## 467                            1402714         5.391747e-01
## 502                             715022         4.005747e-01
## 1171                            619294         2.445544e-01
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## 729                             298484         9.134459e-01
## 1133                            599440         2.271367e-01
## 1287                            292515         3.551984e-01
## 473                             608604         8.320444e-01
## 1286                            189955         8.887328e-01
## 773                             130822         5.078044e-01
## 11                             4276004         8.468526e-01
## 399                            1122269         8.979892e-01
## 650                            2397917         9.081161e-01
## 746                            4276004         8.468526e-01
## 1052                           4276004         8.468526e-01
## 306                            2930701         3.104433e-01
## 256                            1124897         2.280203e-01
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## 1195                            229537         2.204854e-01
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## 572                            1921109         9.621765e-01
## 1337                            641651         3.952061e-02
## 432                              66166         2.922981e-01
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## 1284                            156563         5.612964e-03
## 1321                             42169         1.803131e-01
## 848                            1647441         8.078665e-02
## 1310                            279040         7.861203e-02
## 570                             904847         6.561827e-01
## 68                              125754         9.751738e-01
## 968                            2825520         8.971740e-01
## 189                            1472445         1.566455e-01
## 1293                            431330         9.784922e-01
## 796                            2890833         6.634292e-01
## 50                              807381         1.574331e-01
## 1276                             38847         5.274801e-01
## 1050                             49186         2.319404e-01
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## 1                               746099         6.505331e-01
## 732                             371742         6.742672e-01
## 931                            3592349         6.554063e-03
## 321                              50890         8.454782e-01
## 87                              841758         7.312435e-01
## 451                            1029953         7.131740e-01
## 808                            1642178         5.598407e-01
## 1324                            841758         7.312435e-01
## 141                            3949207         7.902084e-01
## 860                            2247552         7.079218e-01
## 844                             261086         3.578320e-01
## 289                            1029547         6.872182e-01
## 1292                            763387         9.977567e-01
## 891                            1552625         2.535500e-01
## 365                            3033662         1.005973e-01
## 933                            1273704         6.660269e-01
## 679                              54344         5.468685e-02
## 700                             171777         7.811368e-01
## 214                             997299         3.376344e-01
## 1261                            210624         2.983716e-01
## 1264                           1855842         4.717634e-01
## 423                            1152568         3.808387e-01
## 717                            3456939         2.111136e-01
## 831                             730377         6.465720e-01
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## 1247                            353506         6.280946e-01
## 1215                            122432         7.957718e-03
## 1282                            858610         8.308951e-03
## 578                            1562481         8.626227e-03
## 1010                            380546         8.519159e-03
## 1193                           5505234         5.428622e-01
## 250                             451484         5.400303e-01
## 1158                            279150         9.936552e-01
## 8                               475772         4.264284e-01
## 678                              68962         8.309911e-01
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## 830                            2041813         3.806875e-01
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## 1116                           1210507         2.049865e-01
## 1243                           1492165         8.619714e-01
## 962                            2268049         5.572417e-01
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## 592                            2004761         2.314139e-01
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## 868                            1990968         7.775076e-02
## 1174                            376515         2.682896e-01
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## 410                            4172370         1.903330e-01
## 1160                           3687684         3.897377e-01
## 929                            5292802         4.373020e-01
## 192                            4923820         5.426702e-01
## 1232                           4171132         8.613316e-01
## 1239                           5197561         6.846309e-01
## 1128                           3388687         5.097419e-01
## 937                            4683491         5.587847e-01
## 1258                           3638684         7.384838e-01
## 253                            5634289         7.492062e-01
## 1057                           5496976         4.806974e-01
## 447                            3164539         8.068383e-01
## 798                            5612006         6.271065e-01
## 559                            3245942         8.684256e-01
## 491                            5635017         8.078921e-01
## 1304                           3775553         9.727044e-01
## 378                            5274529         6.831379e-01
## 1114                           4425240         8.937013e-01
## 1151                           5322010         3.316650e-01
## 1137                           4006960         8.771208e-01
## 268                            5539011         8.148055e-01
## 47                             4549127         9.185029e-01
## 151                            4697011         5.266734e-01
## 293                            4338345         6.416299e-01
## 360                            3554006         6.613978e-01
## 81                             4284450         3.042853e-01
## 544                            5409556         7.735885e-01
## 1124                           5611215         9.852925e-01
## 1209                           4473781         5.220930e-01
## 312                            5621386         9.955804e-01
## 942                            4926034         7.354656e-01
## 105                            5611767         7.055217e-01
## 239                            3897034         4.874452e-01
## 556                            4654614         7.824495e-01
## 558                            4654614         7.824495e-01
## 944                            5114933         9.621280e-01
## 89                             3476669         5.413713e-01
## 113                            5536188         9.540230e-01
## 445                            5605156         9.071088e-01
## 1182                           4895019         4.523014e-01
## 918                            3524117         9.839573e-01
## 328                            5506901         5.036388e-01
## 353                            4133503         8.441962e-01
## 1120                           5411372         5.009046e-01
## 135                            5314444         6.614923e-01
##      padj_WTt14dox_WTdmso ES_WTt14dox_WTdmso NES_WTt14dox_WTdmso
## 21           0.0002963833          0.7022825           2.1654044
## 24           0.0002721416          0.6576017           2.1352856
## 108          0.0004694851          0.6364857           2.1018309
## 109          0.0006739158          0.6710387           2.0935823
## 110          0.0002601888          0.8015492           2.2010813
## 170          0.0004694851          0.5474629           1.9835113
## 181          0.0025881624          0.5850964           1.9616896
## 205          0.0005365814          0.6632144           2.1028964
## 275          0.0002601888          0.7712793           2.1860065
## 299          0.0016135689          0.6610630           2.0506036
## 300          0.0002601888          0.7040835           2.1840522
## 341          0.0104833644          0.5156340           1.8186683
## 346          0.0002601888          0.6607237           2.1454228
## 404          0.0002721416          0.6587860           2.1391311
## 483          0.2636150455          0.4722286           1.5530760
## 487          0.0559698171          0.5953994           1.7882201
## 504          0.0103912975          0.5686639           1.8778668
## 521          0.0002417661          0.7715416           2.2468887
## 624          0.0002384373          0.6680097           2.2554690
## 625          0.0002963833          0.6588613           2.1297540
## 709          0.0259282588          0.5390737           1.7940849
## 788          0.0002417661          0.6504882           2.1886821
## 847          0.0004694851          0.6011401           2.0625787
## 855          0.0002601888          0.6985615           2.1794511
## 856          0.0140103752          0.5535859           1.8423828
## 865          0.0224301994          0.5773735           1.8398814
## 906          0.0002601888          0.8015492           2.2010813
## 958          0.0002601888          0.6259018           2.1204024
## 980          0.0045132833          0.5654985           1.9157708
## 986          0.0015219238          0.6274920           2.0283534
## 987          0.0023940100          0.5758707           1.9573700
## 1013         0.0043705245          0.6050269           1.9557356
## 1131         0.0002417661          0.7177916           2.2132248
## 1213         0.0023940100          0.5991922           1.9786787
## 1272         0.0005659517          0.5758660           2.0155808
## 1275         0.0002417661          0.6903909           2.2000270
## 355          0.3227700025          0.3887674           1.4425197
## 626          0.0002384373          0.7795509           2.3413001
## 744          0.0002963833          0.7194231           2.1607124
## 431          0.0527996333          0.5502112           1.7619053
## 985          0.1480635983          0.4918757           1.6306715
## 405          0.0078871532          0.7566902           1.9737885
## 479          0.1630098926          0.4886178           1.6198711
## 520          0.9999914219          0.2046226           0.7997340
## 587          0.0078871532          0.7566902           1.9737885
## 832          0.0532760299          0.5731138           1.7777870
## 162          0.0280838340          0.3454194           1.4780828
## 161          0.6356681642          0.3271652           1.2899832
## 430          0.1824400412          0.4071050           1.5105615
## 160          0.0133647660          0.3460643           1.4975759
## 482          0.2607762526          0.4274064           1.5074846
## 647          0.9999914219         -0.1502856          -0.6983159
## 1031         0.9999914219          0.2912633           1.0752315
## 357          0.0280838340          0.4965575           1.7425472
## 1048         0.0007731335          0.6069588           2.0422199
## 366          0.9999914219         -0.1602257          -0.6364005
## 1144         0.9999914219          0.2083037           0.7815076
## 180          0.1223376188          0.4242250           1.5660748
## 677          0.0015168021          0.5114967           1.8915324
## 362          0.9999914219         -0.2149873          -0.8459874
## 932          0.3484571171          0.4309095           1.4873477
## 1155         0.5549536177          0.4352535           1.4256315
## 1111         0.8257109269          0.3307949           1.2651746
## 1154         0.9586165079          0.3388987           1.2374951
## 973          0.0106125120          0.4053287           1.6356040
## 967          0.9999914219          0.3391063           1.2157506
## 1037         0.9999914219         -0.3258985          -0.7159652
## 745          0.9999914219         -0.2158455          -0.8301548
## 863          0.9999914219          0.2101510           0.8562689
## 44           0.9999914219          0.4825414           1.1982512
## 673          0.9999914219          0.2155348           0.7793164
## 200          0.9999914219          0.1698580           0.5412763
## 1006         0.9999914219         -0.2015662          -0.8315976
## 480          0.1403854628          0.4236299           1.5556312
## 688          0.9999914219          0.2305174           0.9114232
## 965          0.9999914219          0.2148965           0.7876408
## 25           0.5215526774          0.6154812           1.5283685
## 1015         0.0129509188          0.4881446           1.7685953
## 361          0.9999914219          0.2090962           0.7663814
## 836          0.9999914219          0.4812106           1.1217410
## 1041         0.9999914219          0.2100943           0.7882254
## 304          0.9999914219          0.4031985           1.0667317
## 1319         0.9999914219          0.3923456           0.8078293
## 204          0.9999914219          0.3529264           0.7791206
## 734          0.9999914219          0.2462845           1.0310714
## 301          0.9999914219          0.3030587           1.0817478
## 609          0.0245147715          0.3630241           1.5226664
## 895          0.9999914219         -0.2209887          -0.6876539
## 197          0.9999914219          0.2635335           0.7914954
## 535          0.9999914219          0.3450407           1.1153360
## 1208         0.0364115940          0.4282687           1.6317105
## 1127         0.1912452156          0.3615177           1.4370252
## 124          0.9999914219          0.3830246           1.0748174
## 481          0.1311258251          0.4118411           1.5427797
## 184          0.9999914219          0.6187117           1.2200520
## 1100         0.3039836957          0.3678032           1.4171004
## 495          0.1631454949          0.3263676           1.3808100
## 1291         0.9999914219          0.3545865           0.7827854
## 324          0.9999914219          0.2726200           0.8405911
## 837          0.9999914219          0.2805835           1.0810536
## 182          0.9999914219          0.5482646           1.1717471
## 1269         0.0106125120          0.4502384           1.7198343
## 921          0.9999914219          0.1919223           0.7538256
## 1035         0.9999914219          0.8143214           1.2058894
## 689          0.9999914219         -0.2076290          -0.6630674
## 568          0.4688303597          0.5922580           1.5448754
## 563          0.4534711528          0.5884174           1.5567602
## 669          0.0093715468          0.6707177           1.9532685
## 95           0.9999914219         -0.2188644          -0.6607331
## 273          0.9999914219          0.2519383           0.8416393
## 1279         0.9999914219          0.2098690           0.8699218
## 203          0.9999914219          0.2686803           0.7108403
## 42           0.9999914219          0.1850425           0.6309611
## 780          0.9999914219          0.2191702           0.6949369
## 642          0.9999914219         -0.3061214          -0.8533416
## 198          0.9999914219          0.3067402           0.8222909
## 435          0.9999914219         -0.4887214          -1.0736702
## 724          0.9999914219          0.2366130           1.0198945
## 894          0.2096804732         -0.5081907          -1.6324844
## 303          0.9999914219          0.2953289           1.0070175
## 886          0.9999914219          0.5594274           0.9843912
## 1067         0.9999914219          0.2273854           0.7011157
## 801          0.9999914219          0.4623337           1.0777374
## 93           0.9999914219          0.3925401           1.0900692
## 199          0.9999914219          0.3935624           1.1555628
## 676          0.9999914219          0.3235275           1.2004475
## 537          0.9999914219          0.5231604           1.0316322
## 701          0.9999914219          0.3769461           0.8992722
## 1119         0.9999914219          0.2145171           0.8624143
## 320          0.9999914219          0.5872292           0.8695995
## 510          0.9999914219          0.3437118           1.1059168
## 211          0.9999914219         -0.4150103          -0.8791959
## 402          0.9999914219          0.3495294           0.8147813
## 331          0.9999914219         -0.4843252          -1.2966179
## 442          0.9999914219          0.4848904           1.2255809
## 1289         0.9999914219          0.4848904           1.2255809
## 1311         0.9999914219          0.5439315           0.8858979
## 851          0.9999914219         -0.5972513          -1.2133072
## 787          0.9999914219          0.3743850           0.8505732
## 1169         0.9999914219          0.2453122           0.8467313
## 680          0.9999914219          0.7261520           1.1826794
## 500          0.9999914219          0.2571235           0.9406708
## 486          0.9999914219          0.4739832           0.9346584
## 55           0.9999914219         -0.4558908          -0.8810686
## 364          0.9999914219          0.4225596           1.1734323
## 91           0.9999914219         -0.2062541          -0.8560122
## 485          0.9999914219          0.7791356           1.1537844
## 1096         0.9999914219          0.2257225           0.7262778
## 52           0.9999914219         -0.3198144          -0.8295787
## 640          0.9999914219          0.2499714           0.9729146
## 861          0.9999914219          0.5372332           1.0593827
## 425          0.9999914219         -0.4452457          -0.9432493
## 54           0.9999914219         -0.4990712          -1.0572783
## 655          0.9999914219         -0.5228296          -0.6970675
## 436          0.9999914219         -0.4853902          -1.1007350
## 1329         0.9999914219         -0.2667461          -0.7916570
## 811          0.9999914219          0.6569468           0.9728410
## 1285         0.9999914219          0.3609820           1.1920506
## 94           0.9999914219         -0.3847059          -0.7434944
## 212          0.3553412026          0.5387256           1.5688803
## 627          0.9999914219          0.2569466           1.1148372
## 444          0.9999914219          0.4090835           1.1704807
## 896          0.9999914219         -0.3333633          -1.1530102
## 1061         0.9999914219         -0.3129996          -0.7824201
## 65           0.9999914219          0.5842224           1.0280214
## 228          0.9999914219         -0.6254474          -1.3250052
## 794          0.9999914219          0.7208064           1.2683601
## 976          0.9999914219          0.3727107           1.0458755
## 781          0.9999914219          0.2817779           0.9545947
## 681          0.9999914219         -0.3910174          -0.9964687
## 1299         0.9999914219         -0.2325784          -0.9164801
## 1183         0.9999914219         -0.3936634          -0.7608061
## 165          0.9631989249          0.4260286           1.2970456
## 59           0.9999914219          0.5251257           1.0812199
## 407          0.9999914219          0.3877668           1.0648207
## 7            0.9999914219          0.4851562           0.8537004
## 797          0.9999914219          0.5283568           1.2871472
## 368          0.3528084627          0.4086086           1.4585014
## 922          0.9999914219         -0.7344941          -1.2381787
## 426          0.9999914219         -0.3150149          -0.7348891
## 566          0.9999914219          0.2339889           0.9004705
## 834          0.9999914219          0.3153562           0.9259368
## 1274         0.9999914219         -0.5072766          -1.2680636
## 429          0.9999914219         -0.4255620          -0.9349155
## 1095         0.9999914219          0.5864065           0.8683812
## 571          0.9999914219          0.2816529           0.7118896
## 583          0.9999914219          0.6183098           1.1580376
## 71           0.9999914219          0.2924828           0.8289725
## 817          0.9999914219         -0.5327932          -1.1287180
## 1039         0.9999914219          0.4254393           1.1938388
## 593          0.9999914219          0.4200267           0.9791164
## 523          0.9999914219         -0.3925772          -0.8902601
## 952          0.9999914219          0.7081755           1.1534012
## 1077         0.9999914219          0.3586110           1.0770507
## 1081         0.9999914219          0.3586110           1.0770507
## 158          0.9999914219          0.3543830           1.1838721
## 977          0.9999914219          0.4536958           1.0307609
## 939          0.9999914219         -0.3577347          -1.0205277
## 675          0.9999914219          0.2739433           1.0831213
## 290          0.9999914219          0.2995788           1.0669260
## 742          0.9999914219         -0.2790776          -0.8684098
## 223          0.9999914219         -0.2424725          -0.4087497
## 23           0.9999914219          0.4198178           1.0950737
## 912          0.9999914219          0.4017946           1.2067482
## 323          0.9999914219         -0.4473972          -1.0437200
## 610          0.9999914219         -0.1874745          -0.5405530
## 960          0.9999914219          0.5080880           1.2842138
## 1267         0.9999914219          0.4841346           1.0346890
## 176          0.0877508760         -0.9833721          -1.4958055
## 833          0.9999914219          0.5450556           1.3003272
## 343          0.9999914219         -0.1946685          -0.7594478
## 949          0.4298710960          0.4478308           1.4788465
## 287          0.9999914219          0.5726017           1.3009057
## 83           0.9999914219          0.3342495           0.7974118
## 959          0.9999914219          0.4608327           1.2020589
## 401          0.9999914219         -0.3754344          -1.1513542
## 953          0.8646948551          0.4651954           1.3658891
## 1097         0.9999914219          0.1871076           0.5353572
## 349          0.9999914219          0.6094573           0.9926194
## 945          0.9999914219         -0.5797554          -1.3147302
## 687          0.0967986630         -0.9982851          -1.3309732
## 899          0.9999914219          0.3806982           0.8136254
## 1159         0.9999914219          0.4166966           0.7804345
## 35           0.9999914219          0.3096139           0.9866280
## 53           0.9999914219          0.3447694           0.7368386
## 762          0.9999914219          0.4541485           0.8505785
## 853          0.4613736361         -0.9841372          -1.3121103
## 225          0.9999914219          0.3667451           0.7838049
## 1210         0.9999914219         -0.4075661          -0.9976844
## 763          0.9999914219          0.1698824           0.5205860
## 1046         0.9999914219         -0.6834207          -1.2433650
## 1098         0.9999914219         -0.5615586          -1.0852855
## 670          0.1062142586          0.5221956           1.6879851
## 890          0.9999914219         -0.5745717          -1.0453332
## 58           0.8252600322          0.4793273           1.3959003
## 376          0.9999914219          0.4764264           1.0517592
## 519          0.9999914219          0.4762442           1.2422593
## 569          0.9999914219          0.3240139           0.8323880
## 905          0.9999914219         -0.7465872          -1.3582855
## 172          0.9999914219          0.4695651           1.0945944
## 342          0.9999914219          0.5964416           1.1170804
## 526          0.9999914219          0.6221987           1.0948461
## 467          0.9999914219          0.3173976           0.9463849
## 502          0.9999914219          0.4084946           1.0494181
## 1171         0.9999914219          0.4420910           1.1851310
## 237          0.9999914219          0.4658624           0.9591984
## 729          0.9999914219          0.2091121           0.7606287
## 1133         0.9999914219          0.4077576           1.1874745
## 1287         0.9999914219          0.6824769           1.1115461
## 473          0.9999914219          0.3564837           0.7029585
## 1286         0.9999914219          0.2173634           0.7685165
## 773          0.9999914219          0.2871786           0.9696304
## 11           0.9999914219         -0.3935235          -0.6633850
## 399          0.9999914219          0.2473559           0.6792476
## 650          0.9999914219          0.2157351           0.7424691
## 746          0.9999914219         -0.3935235          -0.6633850
## 1052         0.9999914219         -0.3935235          -0.6633850
## 306          0.9999914219          0.5590497           1.1510685
## 256          0.9999914219          0.6946170           1.2222762
## 263          0.9999914219          0.6946170           1.2222762
## 1195         0.9999914219          0.6283007           1.2389607
## 465          0.9999914219         -0.3883995          -0.9060860
## 79           0.9999914219          0.2446287           0.8393483
## 97           0.9999914219          0.2409984           0.8020639
## 427          0.9999914219          0.5691569           1.2163980
## 379          0.9999914219          0.3660250           1.1831674
## 572          0.9999914219         -0.2153758          -0.5678771
## 1337         0.5172212513         -0.9804930          -1.3072517
## 432          0.9999914219         -0.8540193          -1.1386294
## 149          0.9999914219          0.3579849           0.7902877
## 1327         0.9999914219          0.2525142           1.1018178
## 1284         0.1311258251          0.6310363           1.7328471
## 1321         0.9999914219          0.6237190           1.2842211
## 848          0.8257109269          0.5346061           1.4143932
## 1310         0.8257109269          0.7901237           1.3903337
## 570          0.9999914219         -0.4594303          -0.8358534
## 68           0.9999914219         -0.2559537          -0.4946639
## 968          0.9999914219          0.4772727           0.7067703
## 189          0.9999914219         -0.6328031          -1.3405882
## 1293         0.9999914219         -0.1849976          -0.6612918
## 796          0.9999914219          0.2849048           0.8730595
## 50           0.9999914219         -0.7374199          -1.3416070
## 1276         0.9999914219         -0.5257393          -0.9564911
## 1050         0.9999914219          0.2945002           1.1220505
## 185          0.9959058422          0.3492789           1.2288010
## 1            0.9999914219          0.4387532           0.8651876
## 732          0.9999914219          0.2570190           0.8845510
## 931          0.1472479558          0.8153829           1.6788519
## 321          0.9999914219          0.3353399           0.6904560
## 87           0.9999914219          0.3420664           0.7973846
## 451          0.9999914219          0.3565732           0.8101062
## 808          0.9999914219         -0.6402450          -0.9738755
## 1324         0.9999914219          0.3420664           0.7973846
## 141          0.9999914219          0.4297537           0.7562121
## 860          0.9999914219         -0.4094197          -0.7912571
## 844          0.9999914219          0.8212219           1.0949019
## 289          0.9999914219          0.2663798           0.8687720
## 1292         0.9999914219          0.1557536           0.4802476
## 891          0.9999914219         -0.4324348          -1.1744019
## 365          0.8980476784         -0.4513606          -1.3512714
## 933          0.9999914219          0.3042476           0.8623170
## 679          0.6356681642          0.6944236           1.4841172
## 700          0.9999914219         -0.2683182          -0.7890669
## 214          0.9999914219          0.3384575           1.0785422
## 1261         0.9999914219          0.3458020           1.1073390
## 1264         0.9999914219         -0.3216618          -0.9864484
## 423          0.9999914219         -0.4357236          -1.0666113
## 717          0.9999914219          0.5196522           1.2397230
## 831          0.9999914219          0.5510225           0.8974471
## 1083         0.9999914219          0.2558861           0.6573685
## 1247         0.9999914219         -0.5146766          -0.8676197
## 1215         0.1676094307          0.6447942           1.7059149
## 1282         0.1723148630          0.6994773           1.7040194
## 578          0.1735545355          0.7827632           1.6729158
## 1010         0.1735545355          0.6738521           1.7031895
## 1193         0.9999914219         -0.4596609          -0.9337944
## 250          0.9999914219         -0.4855902          -0.9384667
## 1158         0.9999914219          0.1709820           0.5205553
## 8            0.9999914219         -0.4893229          -1.0366265
## 678          0.9999914219          0.2400622           0.7829397
## 215          0.9999914219         -0.2083497          -0.7685736
## 450          0.9999914219          0.3015569           0.7194177
## 484          0.9999914219          0.6830467           1.2792839
## 86           0.9999914219          0.3401316           1.0355317
## 963          0.9631989249          0.3588932           1.2423808
## 966          0.9999914219          0.5127015           1.2958745
## 594          0.9999914219          0.2632615           0.6654046
## 830          0.9999914219          0.5283505           1.0878597
## 1112         0.9999914219          0.3000753           0.9012450
## 1116         0.9999914219          0.2746354           1.1197398
## 1243         0.9999914219          0.2725373           0.7001453
## 962          0.9999914219         -0.5097454          -0.9273929
## 540          0.9999914219          0.2962206           0.8896678
## 592          0.9999914219          0.3334262           1.1475123
## 660          0.9999914219         -0.8660236          -1.1546342
## 868          0.8252600322         -0.6955461          -1.4735088
## 1174         0.9999914219         -0.8660236          -1.1546342
## 190          0.9999914219          0.2690339           0.9766893
## 845          0.9999914219          0.5727296           1.1293788
## 846          0.9999914219          0.5727296           1.1293788
## 515          0.9999914219          0.4903595           1.0825180
## 557          0.9999914219          0.4842006           1.1795769
## 1230         0.9999914219          0.4903595           1.0825180
## 857          0.9999914219         -0.5351275          -1.1756196
## 686          0.1956102262         -0.9693689          -1.4745052
## 589          0.9999914219          0.5072788           0.9500867
## 433          0.9999914219          0.7489178           1.1090365
## 339          0.9999914219         -0.2451783          -0.7141702
## 284          0.9999914219          0.2531474           0.6603224
## 1139         0.9999914219          0.3775648           1.1909528
## 870          0.9999914219          0.4459251           0.7846679
## 816          0.9999914219         -0.3446622          -0.5242650
## 374          0.9999914219          0.7095014           1.1555607
## 574          0.9999914219          0.4376624           0.9011353
## 974          0.9999914219         -0.2856212          -0.6991744
## 472          0.9999914219          0.2363819           0.8663890
## 41           0.9586165079          0.7214525           1.3512143
## 130          0.9999914219          0.7024652           0.9365684
## 1224         0.9999914219          0.3071452           1.0632448
## 982          0.9999914219          0.3372992           0.8525380
## 1045         0.9999914219          0.3124169           0.7610890
## 1156         0.9999914219          0.3065466           0.9816340
## 877          0.9999914219          0.3942892           0.6421765
## 884          0.9631989249          0.7991239           1.3015284
## 196          0.8262648054          0.6895991           1.4198664
## 1202         0.9999914219         -0.4008521          -0.8806306
## 403          0.9999914219          0.2349833           0.7006499
## 157          0.9999914219          0.9284030           1.2378021
## 706          0.9999914219         -0.4402185          -0.8942974
## 1212         0.7324729651          0.6430036           1.4608534
## 586          0.9999914219         -0.3859489          -0.9647751
## 231          0.9999914219          0.3005866           0.7006918
## 539          0.9999914219          0.2866704           0.8669582
## 424          0.9999914219          0.4222136           0.8325729
## 585          0.9999914219          0.4701971           1.0380075
## 202          0.9999914219         -0.7168533          -1.2084405
## 941          0.9999914219         -0.7168533          -1.2084405
## 1117         0.9999914219         -0.2575195          -0.6437339
## 1277         0.9999914219         -0.3226970          -0.8223608
## 1147         0.2373069642          0.7286578           1.6554530
## 874          0.2394362053          0.4362882           1.5270465
## 805          0.9999914219         -0.3507409          -0.7953865
## 344          0.9999914219         -0.7688550          -1.1695039
## 457          0.9999914219         -0.3936923          -0.7608620
## 999          0.9999914219          0.5396375           1.0106916
## 389          0.9999914219          0.4028127           0.9389891
## 1082         0.9999914219          0.4028127           0.9389891
## 1170         0.9999914219          0.5864735           1.0984111
## 909          0.9999914219          0.3079850           0.9955546
## 78           0.9999914219          0.2190323           0.7343634
## 771          0.2454289868          0.7650995           1.6351652
## 498          0.9999914219         -0.4561732          -1.2388703
## 509          0.9999914219         -0.2861698          -0.7876871
## 534          0.9999914219         -0.2867276          -0.6299108
## 629          0.9999914219          0.2941507           0.7556697
## 1298         0.9999914219          0.5302687           1.0918093
## 337          0.9999914219          0.2590097           0.8652625
## 1227         0.9999914219          0.3186891           0.7035383
## 319          0.8257109269          0.4588071           1.3779794
## 1185         0.9999914219          0.4598270           0.8091302
## 213          0.9999914219          0.2521025           0.8676303
## 350          0.9999914219         -0.7448542          -1.1329964
## 1178         0.9999914219          0.6599261           1.1612328
## 1179         0.9999914219          0.6599261           1.1612328
## 1256         0.9999914219         -0.2106289          -0.5156003
## 307          0.9999914219          0.4162959           1.0337499
## 654          0.8980476784          0.5838429           1.3928614
## 1234         0.9999914219         -0.6744313          -1.1369274
## 1300         0.9999914219         -0.6744313          -1.1369274
## 490          0.9999914219          0.4598926           1.0448396
## 503          0.9999914219          0.4598926           1.0448396
## 1217         0.9181100202         -0.7721775          -1.4048426
## 235          0.2552304022          0.7629109           1.6304878
## 775          0.9999914219          0.6589937           1.2994850
## 812          0.2584925136         -0.9207560          -1.5521710
## 209          0.9999914219          0.3674050           0.8564510
## 454          0.9999914219          0.2582400           0.8939498
## 1071         0.9999914219          0.3674050           0.8564510
## 869          0.9631989249         -0.6524059          -1.3821165
## 1141         0.9999914219         -0.7421222          -0.9894415
## 492          0.9999914219          0.3456740           1.2130584
## 858          0.9999914219          0.5721551           1.0067874
## 990          0.9999914219         -0.3638884          -1.0492147
## 1105         0.9999914219          0.5804323           1.3186963
## 584          0.9999914219         -0.5089646          -1.1181425
## 662          0.9999914219          0.3793778           0.7811289
## 1180         0.9999914219          0.6033724           1.1898041
## 1211         0.8257109269         -0.9594855          -1.2792433
## 62           0.9999914219          0.7572153           1.2332721
## 575          0.9999914219          0.7572153           1.2332721
## 1231         0.9999914219          0.7572153           1.2332721
## 1252         0.9999914219          0.7572153           1.2332721
## 146          0.9999914219         -0.5999811          -1.1595420
## 246          0.9999914219          0.1768366           0.4307974
## 463          0.9999914219          0.2773535           0.7125179
## 916          0.9999914219         -0.5999811          -1.1595420
## 501          0.9999914219         -0.4434080          -1.2784968
## 51           0.9999914219          0.2603670           0.6465457
## 964          0.9999914219         -0.3369798          -0.6130761
## 262          0.7192217816          0.9067989           1.3428350
## 164          0.9999914219          0.5317637           1.3204806
## 1168         0.9999914219         -0.5056830          -0.8524588
## 1246         0.9999914219         -0.3150156          -0.9175963
## 923          0.9999914219          0.7433691           1.3080624
## 387          0.9999914219          0.2618149           0.6725994
## 155          0.4602514014         -0.8486292          -1.5439331
## 216          0.9999914219          0.1837357           0.5854995
## 356          0.9999914219          0.6048231           1.2926237
## 85           0.9999914219          0.3685255           1.0002804
## 207          0.9999914219          0.4794949           1.0585334
## 1263         0.9999914219          0.5373386           1.0063859
## 220          0.9999914219          0.7625992           1.2420407
## 1237         0.9999914219         -0.3964404          -0.7661730
## 755          0.9999914219         -0.5352069          -0.9737158
## 723          0.9999914219          0.3012794           0.7481397
## 1049         0.9999914219          0.4800273           0.8446754
## 1328         0.9999914219          0.2220041           0.6713922
## 951          0.9999914219         -0.5967149          -1.0059164
## 1229         0.9999914219          0.5631079           0.9908674
## 634          0.9999914219          0.3219415           0.9124662
## 879          0.9999914219          0.3790437           0.6173461
## 600          0.9999914219          0.4605116           1.0734900
## 876          0.9999914219          0.3288845           0.8701209
## 183          0.9999914219          0.7978942           1.1815632
## 527          0.9999914219          0.5424960           1.1976146
## 1273         0.9999914219         -0.3029538          -0.7248692
## 462          0.9999914219          0.2785196           0.6148601
## 725          0.9999914219          0.3664912           0.9696160
## 193          0.9999914219          0.6435486           1.0481437
## 400          0.9999914219          0.2273774           0.6243859
## 1148         0.9999914219          0.5034241           1.1735225
## 28           0.9999914219          0.6299430           1.1084732
## 352          0.9999914219          0.5814751           0.8610786
## 750          0.8806369151          0.6365640           1.4052792
## 1034         0.5549536177          0.6358166           1.5168537
## 499          0.9999914219          0.2093695           0.8329695
## 1226         0.9999914219          0.3441352           0.8209959
## 590          0.9999914219          0.3828220           1.1240273
## 1102         0.9999914219          0.5824622           1.1485707
## 588          0.9999914219          0.3355617           0.6284764
## 153          0.9999914219          0.8422294           1.1229103
## 159          0.9999914219          0.3725725           0.9416926
## 489          0.9999914219          0.3615019           0.7128541
## 622          0.9999914219          0.8021436           1.0694656
## 628          0.9999914219          0.7602916           1.1258793
## 635          0.9999914219          0.7238422           1.0719031
## 756          0.9999914219         -0.3408890          -0.8344648
## 840          0.9999914219         -0.2496244          -0.5288272
## 893          0.9999914219         -0.6819930          -1.2407674
## 913          0.9999914219         -0.2496244          -0.5288272
## 1115         0.9999914219         -0.2639061          -0.7967101
## 1167         0.9999914219          0.3596330           0.7939260
## 1047         0.9999914219          0.2766786           0.8531055
## 748          0.9999914219          0.4441894           0.9805928
## 230          0.9999914219          0.4400081           1.0497179
## 802          0.9999914219          0.9247588           1.2329435
## 103          0.9999914219          0.5688912           1.0654810
## 1161         0.9999914219          0.2167138           0.6553931
## 1346         0.9999914219         -0.6055734          -0.8073866
## 282          0.9999914219          0.7198627           1.2666996
## 104          0.9999914219         -0.3265135          -0.8469559
## 810          0.9999914219          0.6570877           1.0701948
## 1309         0.9999914219          0.2606651           0.8265074
## 1297         0.9999914219          0.2805021           0.8300807
## 543          0.9999914219          0.1994292           0.7295999
## 496          0.9999914219          0.3761119           0.8767473
## 712          0.9631989249          0.5921157           1.3452401
## 713          0.9631989249          0.5921157           1.3452401
## 714          0.9631989249          0.5921157           1.3452401
## 715          0.9631989249          0.5921157           1.3452401
## 1143         0.9999914219          0.5820272           1.2439044
## 288          0.9999914219          0.3111201           0.7579298
## 377          0.9999914219          0.4541985           1.1668307
## 1029         0.9999914219         -0.8012436          -1.2187701
## 1044         0.9999914219         -0.3941064          -1.0391325
## 140          0.9999914219          0.4806016           1.0918889
## 1072         0.9999914219          0.3183866           0.9272076
## 507          0.9999914219         -0.2751520          -0.5589672
## 77           0.9999914219          0.2868308           0.6516569
## 453          0.9999914219          0.2283685           0.6198554
## 910          0.9999914219          0.7684887           1.0245949
## 1296         0.9999914219          0.7684887           1.0245949
## 1241         0.9999914219          0.4011500           0.7910370
## 217          0.9999914219          0.4024468           1.0923521
## 75           0.9999914219         -0.4160475          -0.6328492
## 516          0.9999914219          0.2164345           0.5726151
## 382          0.3490115013         -0.9894962          -1.3192554
## 538          0.3490115013         -0.9894962          -1.3192554
## 720          0.9999914219          0.8508039           1.1343423
## 1028         0.9999914219         -0.4501126          -0.8189016
## 988          0.9999914219          0.2552974           0.6929479
## 961          0.9999914219         -0.4430720          -0.8562947
## 1262         0.9999914219          0.6292772           1.1785786
## 1312         0.9999914219          0.6834480           1.2800355
## 302          0.9999914219          0.4681049           0.7623997
## 318          0.5206651827          0.5661797           1.5177807
## 815          0.9999914219         -0.3390308          -1.1499068
## 1078         0.9999914219          0.2594724           0.7281138
## 653          0.9999914219         -0.8321543          -1.1094777
## 148          0.9999914219         -0.5419345          -1.1480838
## 699          0.9999914219          0.4935006           0.8037614
## 219          0.9999914219          0.7950923           1.1774140
## 783          0.8262648054          0.9581994           1.2775284
## 784          0.8262648054          0.9581994           1.2775284
## 506          0.9999914219          0.4134751           0.8153413
## 296          0.8262648054          0.4750047           1.3833119
## 438          0.9999914219         -0.6492997          -1.1812877
## 1236         0.9999914219          0.5071756           1.1822674
## 449          0.9999914219          0.3190917           1.0266997
## 533          0.9999914219          0.2504032           0.7720883
## 950          0.9999914219          0.4661561           1.1356179
## 1220         0.9999914219          0.5751776           1.1842756
## 753          0.9999914219         -0.3454304          -0.7017367
## 1196         0.9999914219          0.4894257           0.8612132
## 786          0.9999914219          0.6750197           1.2642500
## 782          0.9999914219          0.2237466           0.8443529
## 661          0.9631989249         -0.8025267          -1.3528650
## 1007         0.9999914219          0.3173001           0.5583341
## 1280         0.9999914219          0.6209746           1.1630286
## 76           0.9999914219          0.2566860           0.8807183
## 665          0.9999914219          0.2935228           0.7656394
## 683          0.9999914219         -0.4981857          -1.2695762
## 1295         0.4185168329          0.9864952           1.3152541
## 440          0.9999914219          0.3530643           0.6612572
## 1248         0.9999914219          0.6199653           1.0097338
## 607          0.9999914219         -0.4224173          -0.8581345
## 761          0.9999914219         -0.8282958          -1.1043333
## 693          0.9999914219          0.6341377           1.1158544
## 1063         0.9999914219          0.3669068           0.7235120
## 940          0.9999914219          0.5997854           1.1233430
## 765          0.9999914219          0.2701653           0.8521827
## 981          0.9999914219          0.5501568           1.0303933
## 142          0.9999914219         -0.2264278          -0.6387689
## 373          0.9631989249         -0.5315271          -1.3545436
## 552          0.9999914219         -0.5536961          -0.8422261
## 776          0.9999914219          0.2638346           0.6668530
## 1166         0.3830548392          0.8551515           1.5047592
## 716          0.9999914219          0.4516481           1.2258980
## 371          0.9999914219         -0.2798880          -0.9817509
## 34           0.9999914219         -0.3270930          -0.5513993
## 90           0.9999914219         -0.5564992          -0.9381225
## 778          0.9999914219         -0.2730204          -0.4602460
## 898          0.9999914219          0.4569778           0.9409053
## 979          0.9999914219          0.3442048           0.9106535
## 267          0.9999914219          0.4892484           1.0800650
## 759          0.9999914219         -0.3830935          -0.8937078
## 803          0.9999914219          0.2987616           0.8296499
## 1109         0.9999914219         -0.3779812          -0.8817813
## 1214         0.9999914219          0.4827949           0.8495455
## 757          0.9999914219          0.6957675           1.0303287
## 576          0.9999914219         -0.2488322          -0.7384918
## 73           0.9999914219         -0.2710264          -0.7555110
## 369          0.9999914219          0.5639515           1.1120691
## 147          0.9999914219         -0.7858062          -1.1952883
## 823          0.9999914219         -0.4134140          -1.2042173
## 266          0.9999914219         -0.3977804          -0.7687627
## 31           0.9999914219          0.5212655           0.9762825
## 2            0.9999914219         -0.2235761          -0.4736441
## 466          0.9999914219          0.2900284           0.9792525
## 1126         0.9999914219          0.2462770           0.8227268
## 27           0.9999914219         -0.3638343          -0.8906330
## 261          0.6395763771          0.7744406           1.4504563
## 768          0.9999914219          0.3145598           0.9308667
## 850          0.9999914219          0.3456161           0.9795661
## 1040         0.7055089340          0.4259974           1.3832478
## 1283         0.4641216077          0.6671418           1.5551617
## 459          0.8930893728         -0.7408817          -1.4318509
## 615          0.9999914219         -0.6169926          -1.1225107
## 1157         0.9999914219          0.4643365           0.8170653
## 925          0.9999914219          0.5165094           0.7648740
## 1027         0.9999914219          0.5165094           0.7648740
## 721          0.9999914219         -0.6066814          -1.0227175
## 452          0.9999914219         -0.3854447          -0.7449222
## 873          0.9999914219         -0.3854447          -0.7449222
## 1207         0.9999914219          0.4122868           1.1685283
## 897          0.9999914219          0.3392961           0.9209436
## 84           0.9999914219         -0.5027404          -0.9146486
## 245          0.9999914219          0.2533439           0.7904109
## 1079         0.9999914219          0.4273880           1.0802411
## 1084         0.9999914219          0.4273880           1.0802411
## 1086         0.9999914219          0.4273880           1.0802411
## 880          0.9999914219          0.2107578           0.7588664
## 283          0.5850426553          0.6319213           1.5075610
## 258          0.9999914219         -0.4090783          -0.7442467
## 882          0.9999914219          0.4734134           0.7010551
## 793          0.9999914219          0.3718577           0.6964554
## 461          0.9631989249         -0.8638829          -1.3140507
## 1181         0.9999914219         -0.3831362          -0.5827877
## 291          0.9999914219          0.8364426           1.2386477
## 464          0.9999914219          0.3504412           0.7215491
## 852          0.9999914219          0.8458047           1.2525115
## 549          0.4179360871          0.5308810           1.5460353
## 310          0.9999914219         -0.3601629          -0.8816457
## 106          0.9999914219          0.3327890           0.9922774
## 280          0.9586165079          0.7200172           1.3485262
## 281          0.9586165079          0.7200172           1.3485262
## 579          0.9999914219          0.4233964           1.2114330
## 644          0.9999914219          0.6918656           1.2174348
## 807          0.9999914219         -0.4739270          -0.8622277
## 1099         0.9999914219          0.7537314           1.1161647
## 1288         0.9999914219          0.4585975           1.0124001
## 636          0.9999914219          0.3926183           0.7353382
## 948          0.9631989249          0.6308707           1.3482923
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## 956          0.9999914219          0.4106203           0.7225441
## 1320         0.9999914219          0.4280963           1.0213001
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## 541          0.9999914219         -0.2284428          -0.6444534
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## 770          0.9999914219         -0.3943121          -0.8662629
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## 908          0.9999914219          0.2938327           0.8945747
## 938          0.9999914219          0.3919316           1.2295593
## 1140         0.9999914219         -0.8598071          -1.1463460
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## 731          0.9999914219         -0.5550963          -0.8443560
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## 970          0.9999914219         -0.7026158          -1.0687476
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## 1190         0.9999914219          0.5755627           0.7673744
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## 839          0.9999914219         -0.2699037          -0.7330015
## 3            0.9999914219         -0.3369427          -0.5125230
## 4            0.9999914219         -0.3369427          -0.5125230
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## 695          0.4637494423         -0.8900506          -1.5004091
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## 1187         0.9999914219         -0.7717042          -1.0288820
## 1194         0.9999914219          0.6389072           1.1242470
## 1347         0.9999914219         -0.6644511          -1.0106954
## 1184         0.9999914219          0.6592700           1.3000298
## 643          0.9181100202          0.6475057           1.3838445
## 785          0.9999914219          0.3660446           0.5961747
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## 1188         0.9999914219         -0.5919506          -1.1440221
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## 367          0.9631989249          0.7984067           1.3003603
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## 80           0.9999914219          0.3074199           0.7166208
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## 251          0.9999914219         -0.2267685          -0.4606768
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## 767          0.4783919128          0.6351567           1.5473258
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## 9            0.9999914219          0.3610877           0.7120372
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## 972          0.9999914219         -0.2843785          -0.8283549
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## 1265         0.9999914219         -0.1971664          -0.5114374
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## 619          0.9999914219         -0.9209003          -1.2277992
## 698          0.9999914219          0.3593963           0.9374672
## 363          0.9999914219          0.2689791           0.7833228
## 983          0.9999914219          0.2840141           0.7969811
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## 46           0.9999914219          0.8692390           1.1589212
## 573          0.9999914219          0.5758340           0.8527249
## 772          0.9999914219          0.3456565           0.7853043
## 92           0.9999914219          0.3479399           0.6122492
## 477          0.9999914219         -0.8651661          -1.1534910
## 88           0.9631989249          0.8654005           1.2815300
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## 777          0.9411855979         -0.6652224          -1.4092681
## 1051         0.9999914219          0.5691306           1.0014653
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## 690          0.9999914219          0.4429638           0.7794571
## 606          0.9999914219         -0.9172562          -1.2229406
## 1257         0.9999914219         -0.2833834          -0.6225640
## 705          0.9999914219         -0.4273293          -0.9052935
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## 888          0.9999914219          0.3101054           0.6627550
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## 1201         0.9999914219         -0.4277742          -0.9062361
## 1242         0.9999914219          0.7440514           0.9920137
## 395          0.9999914219         -0.5479305          -0.9236777
## 658          0.9999914219          0.2733270           0.9711318
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## 885          0.9999914219         -0.5290420          -1.2950463
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## 991          0.9999914219         -0.2121192          -0.7194546
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## 1121         0.9999914219         -0.2566146          -0.7809674
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## 398          0.9999914219         -0.2066151          -0.4820064
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## 545          0.9999914219          0.5576758           0.8258353
## 659          0.9999914219          0.3069103           0.6972760
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## 102          0.9999914219          0.5941268           1.0454495
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## 577          0.5332361991          0.9787781           1.3049653
## 919          0.5332361991          0.9789925           1.3052511
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## 1104         0.9999914219         -0.5698201          -0.8667523
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## 12           0.9999914219          0.5537293           1.0919117
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## 881          0.9144598454         -0.9479100          -1.2638100
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## 1019         0.9999914219          0.7961415           1.0614632
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## 22           0.9631989249          0.6127564           1.3527215
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## 843          0.9999914219         -0.6932688          -1.3398327
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## 774          0.9999914219         -0.2809996          -0.6723401
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## 1240         0.9999914219         -0.9095391          -1.2126517
## 243          0.9999914219         -0.3213823          -0.7288090
## 375          0.9999914219          0.2706825           0.9704403
## 664          0.9999914219         -0.2054982          -0.5236916
## 935          0.9999914219         -0.6309218          -1.3366026
## 975          0.9999914219          0.3235687           1.1294843
## 1023         0.9999914219          0.5426203           1.1978890
## 591          0.9999914219          0.4125252           1.0049659
## 984          0.9999914219         -0.2704442          -0.5941378
## 728          0.9999914219         -0.8208799          -1.2486389
## 67           0.9999914219         -0.6628081          -0.8836953
## 15           0.9999914219         -0.5382733          -1.0402836
## 835          0.9999914219          0.3136962           0.7789732
## 30           0.9999914219         -0.2063414          -0.5258404
## 224          0.9999914219         -0.4424721          -1.2334319
## 672          0.8980476784          0.5492557           1.3882668
## 1331         0.9999914219         -0.4282685          -0.8700212
## 754          0.9999914219          0.4137251           0.6738316
## 1085         0.9999914219         -0.4990982          -0.9080223
## 132          0.9999914219          0.2675040           0.6077479
## 173          0.9999914219         -0.3261421          -0.7165004
## 278          0.9999914219          0.2727672           1.0350915
## 992          0.9999914219          0.5509174           0.9694166
## 993          0.9999914219         -0.4339555          -0.9533552
## 995          0.9999914219          0.5509174           0.9694166
## 1005         0.9999914219         -0.3141749          -1.0150622
## 39           0.9999914219         -0.7293588          -1.2295217
## 758          0.9999914219         -0.8317256          -1.1089061
## 684          0.9999914219          0.3750226           0.9312595
## 1238         0.9999914219          0.5245445           0.6993539
## 1344         0.9999914219          0.6199560           1.0908996
## 514          0.9999914219          0.3177167           0.6265130
## 528          0.9999914219          0.3921751           0.9356036
## 99           0.9999914219          0.2836485           0.9366764
## 1026         0.9999914219          0.6563036           0.9718885
## 813          0.9999914219          0.6221675           1.0133205
## 814          0.9999914219          0.6221675           1.0133205
## 1278         0.9999914219         -0.5073484          -1.2419422
## 1303         0.9999914219          0.3903832           0.9510252
## 179          0.9999914219         -0.7399824          -1.3462691
## 530          0.9999914219          0.4910474           1.1446714
## 668          0.9999914219          0.6089028           0.9917164
## 1016         0.9999914219          0.7963122           1.1792205
## 1315         0.9999914219          0.2426915           0.8878724
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## 936          0.9999914219         -0.2549201          -0.6496384
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## 123          0.9999914219          0.4382312           0.9956267
## 743          0.9999914219          0.6485752           1.0563306
## 641          0.9999914219         -0.2795320          -0.5085597
## 1176         0.9999914219          0.3611831           0.9278752
## 247          0.9999914219         -0.2420163          -0.8137123
## 702          0.9999914219         -0.7909520          -1.2031156
## 1060         0.9999914219         -0.4491480          -0.8680373
## 580          0.9999914219          0.4547599           0.6734320
## 174          0.9999914219          0.5514033           0.9702716
## 1004         0.9999914219          0.5419078           0.7225038
## 311          0.9999914219          0.3836044           0.9854753
## 1260         0.9999914219          0.3307763           1.0642958
## 177          0.9999914219          0.6680249           1.0880081
## 255          0.9999914219          0.6680249           1.0880081
## 437          0.9999914219          0.4414516           0.7189897
## 550          0.9999914219         -0.5650589          -0.7533703
## 904          0.9631989249          0.6572730           1.3533079
## 917          0.9999914219         -0.5920029          -1.0770462
## 1335         0.9999914219         -0.6499464          -0.8665473
## 238          0.9999914219          0.2678461           0.7591455
## 393          0.9999914219         -0.8077170          -1.0768965
## 604          0.9999914219         -0.3233490          -0.5450878
## 1305         0.9999914219          0.6156433           1.0026946
## 60           0.9999914219         -0.5717697          -1.0402355
## 415          0.9999914219         -0.3212477          -0.6805606
## 416          0.9999914219         -0.3212477          -0.6805606
## 417          0.9999914219         -0.3212477          -0.6805606
## 418          0.9999914219         -0.3212477          -0.6805606
## 651          0.9999914219          0.2768380           0.8684902
## 800          0.9999914219          0.3477702           0.6857761
## 809          0.9999914219          0.2232864           0.6884768
## 1012         0.9999914219          0.6915062           1.0240183
## 1191         0.9999914219         -0.6083877          -0.9254174
## 524          0.9999914219          0.6763613           1.2667628
## 1197         0.9631989249         -0.5521507          -1.3516142
## 707          0.9999914219         -0.3763119          -0.8267184
## 920          0.9999914219          0.6361568           1.2544524
## 298          0.9999914219          0.6309964           1.1817983
## 567          0.9999914219         -0.3706077          -1.0572509
## 994          0.9999914219         -0.4457302          -0.9442756
## 582          0.9999914219          0.6122068           1.3084039
## 330          0.9999914219         -0.8617363          -1.1489182
## 554          0.9999914219          0.4819897           0.7137554
## 555          0.9999914219          0.5576758           0.8258353
## 564          0.9999914219          0.4819897           0.7137554
## 336          0.9999914219          0.2321525           0.6223404
## 914          0.9999914219         -0.3993182          -0.6074022
## 460          0.9999914219          0.2998008           0.8577982
## 274          0.9999914219          0.2830342           0.6430314
## 383          0.9999914219          0.7158493           1.0600669
## 385          0.9999914219          0.7158493           1.0600669
## 386          0.9999914219          0.7158493           1.0600669
## 388          0.9999914219          0.7158493           1.0600669
## 390          0.9999914219          0.7158493           1.0600669
## 391          0.9999914219          0.7158493           1.0600669
## 392          0.9999914219          0.7158493           1.0600669
## 867          0.9999914219         -0.1999570          -0.4664740
## 171          0.9999914219          0.6009863           0.8899717
## 740          0.9999914219          0.6009863           0.8899717
## 1032         0.9999914219          0.6413283           1.1285073
## 924          0.9586165079         -0.8743568          -1.3299825
## 64           0.9999914219         -0.6625938          -0.8834095
## 134          0.9999914219          0.3589886           0.8914438
## 206          0.9999914219         -0.6625938          -0.8834095
## 738          0.9999914219         -0.2362661          -0.4799711
## 934          0.9999914219          0.4655456           0.8719243
## 1216         0.9999914219         -0.3244297          -0.5469096
## 1186         0.9999914219         -0.3138363          -0.6065297
## 602          0.9999914219         -0.3395170          -0.6897239
## 878          0.9999914219          0.3241826           1.0170184
## 1333         0.9999914219         -0.7336528          -1.2367604
## 649          0.9999914219         -0.1705391          -0.5655331
## 512          0.9999914219          0.5305597           0.8641195
## 513          0.9999914219          0.5305597           0.8641195
## 911          0.9999914219         -0.5753166          -1.1687473
## 48           0.9999914219          0.5712676           0.8459627
## 1090         0.9999914219         -0.3277495          -0.9546884
## 943          0.9999914219          0.2441235           0.5026438
## 1101         0.9999914219          0.3818599           1.0604106
## 144          0.9999914219          0.2492951           0.6922831
## 747          0.9999914219          0.6244907           1.0171042
## 766          0.9999914219          0.3515449           1.2024684
## 901          0.9999914219          0.4420023           1.0041943
## 598          0.9999914219          0.7309871           1.2862745
## 1070         0.9999914219          0.3313949           0.9650904
## 1330         0.9999914219         -0.8863880          -1.1817853
## 178          0.9999914219          0.3986265           0.9509946
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## 697          0.9999914219          0.7377787           1.0925411
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## 741          0.9999914219          0.5139529           1.2261264
## 751          0.9999914219          0.8023156           1.1881107
## 611          0.9999914219          0.4822511           1.0956363
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## 221          0.9999914219         -0.2152209          -0.5020826
## 1313         0.9999914219          0.6666667           0.8888397
## 637          0.9999914219         -0.6934620          -0.9245648
## 1228         0.9999914219         -0.6934620          -0.9245648
## 1056         0.9999914219         -0.3288250          -0.6680031
## 439          0.9999914219          0.2979449           0.7398595
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## 1271         0.9999914219          0.2229107           0.7526360
## 1323         0.9999914219          0.5357287           0.7933348
## 752          0.7476774272          0.6411263           1.4565883
## 19           0.9999914219         -0.5453376          -0.7270766
## 242          0.9999914219          0.5080338           1.2376377
## 294          0.9999914219         -0.7126930          -1.0840760
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## 875          0.9999914219         -0.2768835          -0.5865753
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## 1302         0.9999914219          0.4814673           1.1223393
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## 821          0.9999914219          0.4759694           0.8375351
## 822          0.9999914219          0.4759694           0.8375351
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## 40           0.9999914219         -0.4840232          -0.8159455
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## 1054         0.9999914219         -0.2845244          -0.6027626
## 1055         0.9999914219         -0.2845244          -0.6027626
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## 682          0.9999914219          0.7172562           0.9562886
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## 656          0.9999914219         -0.5688323          -1.1555745
## 1075         0.9999914219          0.4869140           1.2882155
## 448          0.9999914219          0.5944765           1.2705109
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## 562          0.9999914219         -0.4944455          -0.8335150
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## 240          0.9999914219          0.3167989           0.7866779
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## 1091         0.9999914219         -0.3324540          -0.7539168
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## 20           0.9999914219         -0.5068724          -0.9795973
## 1059         0.9999914219         -0.5068724          -0.9795973
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## 446          0.9999914219         -0.5521012          -0.8398001
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## 663          0.9999914219         -0.3111877          -0.9996426
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## 719          0.9999914219          0.2635070           0.8666277
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## 5            0.9999914219          0.2415632           0.8337909
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## 475          0.9999914219         -0.5292028          -1.0750677
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## 6            0.9999914219          0.2664986           0.8902803
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## 1025         0.9999914219          0.5063237           0.6750609
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## 804          0.9999914219          0.3331922           0.8691152
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## 428          0.9999914219          0.2681297           0.8818312
## 474          0.9999914219          0.2218182           0.5291869
## 100          0.9999914219          0.3666057           0.8931001
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## 384          0.9999914219          0.5226214           1.1873546
## 493          0.9999914219          0.1897695           0.6385128
## 1080         0.9999914219          0.3196287           0.7937050
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## 1254         0.9999914219          0.3339191           0.7783925
## 45           0.9999914219          0.5397346           0.8790626
## 826          0.9999914219          0.7705832           1.1411196
## 43           0.9999914219          0.7770632           1.0360270
## 859          0.9999914219          0.2759388           0.4855531
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## 1253         0.9999914219         -0.4505802          -0.8708051
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## 118          0.9999914219          0.6240928           1.0981790
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## 1223         0.9999914219         -0.2232239          -0.4728979
## 1108         0.9999914219         -0.4838522          -1.0972474
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## 1008         0.9999914219          0.7445109           1.1025104
## 1142         0.9999914219         -0.4482711          -0.9106561
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## 272          0.9999914219          0.2531033           0.8455312
## 546          0.9999914219          0.2504947           0.7723707
## 422          0.9999914219          0.2267655           0.6658203
## 410          0.9999914219         -0.4517087          -1.2433358
## 1160         0.9999914219         -0.6600132          -1.1126219
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for(curr_pathway in fgsea_ms_total_protein_reactome_table$pathway[1:6]){make_protein_pathway_plots(curr_pathway,category='significant')}
## Warning in dir.create(paste0(GSEA_DIR, "/MS_total_protein/", category, "/")):
## 'Y:\DUX4_multiomics\Analysis\fGSEA_res\\MS_total_protein\significant' already
## exists
## Warning in dir.create(paste0(GSEA_DIR, "/MS_total_protein/",
## category, "/", : 'Y:\DUX4_multiomics\Analysis\fGSEA_res\
## \MS_total_protein\significant\REACTOME_ACTIVATED_PKN1_STIMULATES_TRANSCRIPTION_OF_AR_ANDROGEN_RECEPTOR_REGULATED_GENES_KLK2_AND_KLK3'
## already exists

## Warning in dir.create(paste0(GSEA_DIR, "/MS_total_protein/", category, "/")):
## 'Y:\DUX4_multiomics\Analysis\fGSEA_res\\MS_total_protein\significant' already
## exists
## Warning in dir.create(paste0(GSEA_DIR, "/MS_total_protein/",
## category, "/", : 'Y:\DUX4_multiomics\Analysis\fGSEA_res\
## \MS_total_protein\significant\REACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS'
## already exists

## Warning in dir.create(paste0(GSEA_DIR, "/MS_total_protein/", category, "/")):
## 'Y:\DUX4_multiomics\Analysis\fGSEA_res\\MS_total_protein\significant' already
## exists
## Warning in dir.create(paste0(GSEA_DIR, "/MS_total_protein/",
## category, "/", : 'Y:\DUX4_multiomics\Analysis\fGSEA_res\
## \MS_total_protein\significant\REACTOME_B_WICH_COMPLEX_POSITIVELY_REGULATES_RRNA_EXPRESSION'
## already exists

## Warning in dir.create(paste0(GSEA_DIR, "/MS_total_protein/", category, "/")):
## 'Y:\DUX4_multiomics\Analysis\fGSEA_res\\MS_total_protein\significant' already
## exists
## Warning in dir.create(paste0(GSEA_DIR, "/MS_total_protein/",
## category, "/", : 'Y:\DUX4_multiomics\Analysis\fGSEA_res\
## \MS_total_protein\significant\REACTOME_BASE_EXCISION_REPAIR' already exists

## Warning in dir.create(paste0(GSEA_DIR, "/MS_total_protein/", category, "/")):
## 'Y:\DUX4_multiomics\Analysis\fGSEA_res\\MS_total_protein\significant' already
## exists
## Warning in dir.create(paste0(GSEA_DIR, "/MS_total_protein/",
## category, "/", : 'Y:\DUX4_multiomics\Analysis\fGSEA_res\
## \MS_total_protein\significant\REACTOME_BASE_EXCISION_REPAIR_AP_SITE_FORMATION'
## already exists

## Warning in dir.create(paste0(GSEA_DIR, "/MS_total_protein/", category, "/")):
## 'Y:\DUX4_multiomics\Analysis\fGSEA_res\\MS_total_protein\significant' already
## exists
## Warning in dir.create(paste0(GSEA_DIR, "/MS_total_protein/",
## category, "/", : 'Y:\DUX4_multiomics\Analysis\fGSEA_res\
## \MS_total_protein\significant\REACTOME_CELLULAR_SENESCENCE' already exists

#for(curr_pathway in fgsea_RNAseq_lengthScaled_reactome_table$pathway[grep('DAMAGE',fgsea_RNAseq_lengthScaled_reactome_table$pathway)]){make_pathway_plots(curr_pathway,category='other')}
#for(curr_pathway in fgsea_RNAseq_lengthScaled_reactome_table$pathway[grep('SPLIC',fgsea_RNAseq_lengthScaled_reactome_table$pathway)]){make_pathway_plots(curr_pathway,category='other')}
#for(curr_pathway in fgsea_RNAseq_lengthScaled_reactome_table$pathway[grep('SENESC',fgsea_RNAseq_lengthScaled_reactome_table$pathway)]){make_pathway_plots(curr_pathway,category='other')}
intersect(fgsea_ms_total_protein_reactome_table$pathway[fgsea_ms_total_protein_reactome_table$padj_iDUX4t14dox_iDUX4dmso<0.05 & fgsea_ms_total_protein_reactome_table$padj_iDUX4t06dox_iDUX4dmso<0.05 & fgsea_ms_total_protein_reactome_table$padj_WTt14dox_WTdmso>0.05], fgsea_RNAseq_lengthScaled_reactome_table$pathway[fgsea_RNAseq_lengthScaled_reactome_table$padj_iDUX4t14dox_iDUX4dmso<0.05 & fgsea_RNAseq_lengthScaled_reactome_table$padj_WTt14dox_WTdmso>0.05])
## [1] "REACTOME_HDACS_DEACETYLATE_HISTONES"    
## [2] "REACTOME_HDMS_DEMETHYLATE_HISTONES"     
## [3] "REACTOME_ESR_MEDIATED_SIGNALING"        
## [4] "REACTOME_HATS_ACETYLATE_HISTONES"       
## [5] "REACTOME_HCMV_LATE_EVENTS"              
## [6] "REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS"
## [7] "REACTOME_HCMV_EARLY_EVENTS"             
## [8] "REACTOME_HCMV_INFECTION"

Comparison with Jagannathan 2016/2019

RNA-seq from https://pubmed.ncbi.nlm.nih.gov/28171552/, proteomics from https://pubmed.ncbi.nlm.nih.gov/30644821/

Jagannathan_RNAseq = as.data.frame(read_delim('C:/Users/hilla34/OneDrive - Pfizer/Documents/Projects/DUX4_FSHD/Jagannathan_supplement/ddw271_supp/Jagannathan-Suppl-Table1.txt',delim='\t'))
## Rows: 21042 Columns: 17
## ── Column specification ────────────────────────────────────────────────────────
## Delimiter: "\t"
## chr  (2): Ensembl ID, genes
## dbl (15): iDUX4_logFC, iDUX4_logCPM, iDUX4_LR, iDUX4_pval, iDUX4_fdr, enDUX4...
## 
## ℹ Use `spec()` to retrieve the full column specification for this data.
## ℹ Specify the column types or set `show_col_types = FALSE` to quiet this message.
Jagannathan_iDUX4_RNAseq = Jagannathan_RNAseq[,c(1:2,grep('iDUX4',colnames(Jagannathan_RNAseq)))]
merged_Jagannathan_Brennan_RNAseq = merge(Jagannathan_iDUX4_RNAseq,limma_res_lengthScaled_conditions_contrasts$iDUX4t14dox_iDUX4dmso,by.x='Ensembl ID',by.y='Row.names',all=FALSE)
ggplot(merged_Jagannathan_Brennan_RNAseq,aes(x=iDUX4_logFC,y=log2FC,color = log10(reference_mean+0.5))) + geom_point(alpha = 0.5) + xlab('Jagannathan 2016') + ylab('present data, iDUX4 t14 vs DMSO')

ggsave('Y:/DUX4_multiomics/Analysis/Jagannathan_comparison/RNAseq.pdf',device='pdf',width=10,height=10)

Jagannathan_2019 = as.data.frame(read_delim('Y:/DUX4_multiomics/Analysis/Jagannathan_comparison/Jagannathan 2019 data.txt',delim='\t'))
## Rows: 21282 Columns: 4
## ── Column specification ────────────────────────────────────────────────────────
## Delimiter: "\t"
## chr (1): geneid
## dbl (3): iDUX4_logFC, iDUX4_logFC_UF, hl.ratio
## 
## ℹ Use `spec()` to retrieve the full column specification for this data.
## ℹ Specify the column types or set `show_col_types = FALSE` to quiet this message.
Jagannathan_2019_RNAseq_merged = merge(limma_res_lengthScaled_conditions_contrasts$iDUX4t14dox_iDUX4dmso,Jagannathan_2019[,c('geneid','iDUX4_logFC')],by.x='external_gene_name',by.y='geneid',all=FALSE)
ggplot(Jagannathan_2019_RNAseq_merged,aes(x=iDUX4_logFC,y=log2FC,color = log10(reference_mean+0.5))) + geom_point(alpha = 0.5) + xlab('Jagannathan 2019') + ylab('present data, iDUX4 t14 vs DMSO')
## Warning: Removed 2946 rows containing missing values (geom_point).

ggsave('Y:/DUX4_multiomics/Analysis/Jagannathan_comparison/RNAseq.pdf',device='pdf',width=10,height=10)
## Warning: Removed 2946 rows containing missing values (geom_point).
cor(Jagannathan_2019_RNAseq_merged$iDUX4_logFC, Jagannathan_2019_RNAseq_merged$log2FC,method='pearson',use='pairwise.complete.obs')
## [1] 0.9231956
Jagannathan_2019_MS_merged = merge(ms_total_protein_conditions_contrasts$iDUX4t14dox_iDUX4dmso,Jagannathan_2019[,c('geneid','hl.ratio')],by.x='hgnc_symbol',by.y='geneid',all=FALSE)
ggplot(Jagannathan_2019_MS_merged,aes(x=hl.ratio,y=log2FC,color = reference_mean)) + geom_point(alpha = 0.5) + xlab('Jagannathan 2019') + ylab('present data, iDUX4 t14 vs DMSO')
## Warning: Removed 876 rows containing missing values (geom_point).

ggsave('Y:/DUX4_multiomics/Analysis/Jagannathan_comparison/MS.pdf',device='pdf',width=10,height=10)
## Warning: Removed 876 rows containing missing values (geom_point).
cor(Jagannathan_2019_MS_merged$hl.ratio, Jagannathan_2019_MS_merged$log2FC,method='pearson',use='pairwise.complete.obs')
## [1] 0.3086512

MAJIQ splicing

MAJIQ_contrasts = gsub('.deltapsi.tsv','',list.files(paste0(MAJIQ_DIR,'/dpsi_out/'),pattern='.deltapsi.tsv'),fixed=TRUE)

MAJIQ_tsv = list()
MAJIQ_dpsi_contrasts = list()
for(contrast_idx in 1:length(MAJIQ_contrasts)){
  curr_contrast = MAJIQ_contrasts[contrast_idx]
  curr_reference = strsplit(curr_contrast,'_')[[1]][2]
  curr_numerator = strsplit(curr_contrast,'_')[[1]][2]
  # curr_condition_means = cpm_condition_means[,c(curr_numerator,curr_reference)]
  #colnames(curr_condition_means) = c('numerator_mean','reference_mean')
  MAJIQ_tsv[[contrast_idx]] = read.table(paste0(MAJIQ_DIR,'dpsi_out/',curr_contrast,'.deltapsi.tsv'),sep='\t',header=TRUE)
  MAJIQ_dpsi_contrasts[[contrast_idx]] = read.table(paste0(MAJIQ_DIR,'dpsi_out/',curr_contrast,'.deltapsi.split.tsv'),sep='\t',header=TRUE)
}
names(MAJIQ_dpsi_contrasts) = MAJIQ_contrasts
names(MAJIQ_tsv) = MAJIQ_contrasts


for(contrast_idx in 1:length(MAJIQ_contrasts)){
  curr_contrast = MAJIQ_contrasts[contrast_idx]
  curr_reference = strsplit(curr_contrast,'_')[[1]][1]
  ggplot(MAJIQ_dpsi_contrasts[[curr_contrast]],aes(x=E.dPSI..per.LSV.junction,y=P..dPSI...0.20..per.LSV.junction,color=is_IR)) + geom_point(alpha=0.5,shape=16) + ggtitle(paste('MAJIQ dPSI:',curr_contrast)) + xlab('E(dPSI)') + ylab('Prob dPSI > 20%') + scale_color_manual(values = c("#008837","#7b3294"),name='Intron Retention') + theme_bw()
  #ggsave(paste('Y:/DUX4_multiomics/Analysis/volcano_plots_lessthan1/',curr_contrast,'.pdf',sep=''),device='pdf',width=10,height=8)
}

MAJIQ barplots

MAJIQ_conditions_to_plot = c('iDUX4t00_iDUX4t02','iDUX4t00_iDUX4t06','iDUX4t00_iDUX4t14','WTt00_WTt14')
dPSI20_counts = unlist(lapply(MAJIQ_dpsi_contrasts,function(x) sum(x$P..dPSI...0.20..per.LSV.junction>0.95 & x$E.dPSI..per.LSV.junction>0)))
dPSI20_IR_counts = unlist(lapply(MAJIQ_dpsi_contrasts,function(x) sum(x$P..dPSI...0.20..per.LSV.junction>0.95 & x$E.dPSI..per.LSV.junction>0 & x$is_IR==TRUE)))
dPSI20_IR_percent = dPSI20_IR_counts/dPSI20_counts
barplot(dPSI20_counts,las=3,main='Junction count dPSI>20, increased')

barplot(dPSI20_IR_counts,las=3,main='Intron retention count dPSI>20, increased')

barplot(dPSI20_IR_percent,las=3,main='Fraction junction counts with dPSI>20 that are intron retention')

dPSI20_counts = unlist(lapply(MAJIQ_dpsi_contrasts,function(x) sum(x$P..dPSI...0.20..per.LSV.junction>0.95)))
dPSI20_IR_counts = unlist(lapply(MAJIQ_dpsi_contrasts,function(x) sum(x$P..dPSI...0.20..per.LSV.junction>0.95 & x$is_IR==TRUE)))
dPSI20_IR_percent = dPSI20_IR_counts/dPSI20_counts
barplot(dPSI20_counts,las=3,main='Junction count dPSI>20')

barplot(dPSI20_IR_counts,ylim=c(0,200),las=3,main='Intron retention count dPSI>20')

barplot(dPSI20_IR_percent,las=3,main='Fraction junction counts with dPSI>20 that are intron retention')

dPSI20_counts_to_plot = as.data.frame(dPSI20_counts[names(dPSI20_counts) %in% MAJIQ_conditions_to_plot])
dPSI20_counts_to_plot$condition = row.names(dPSI20_counts_to_plot)
colnames(dPSI20_counts_to_plot) = c('counts','condition')
ggplot(dPSI20_counts_to_plot,aes(condition,counts)) + geom_col() + theme(axis.text.x = element_text(angle = 90)) + ylab('LSV Junction Count') + geom_text(aes(label=counts),vjust=-0.25,size=4)

ggsave('Y:/DUX4_multiomics/Analysis/splicing_plots/dPSI20_junction_counts.pdf',device='pdf',width=8,height=8)


IR_dPSI20_counts = lapply(MAJIQ_dpsi_contrasts,function(x) c(sum(x$is_IR & x$P..dPSI...0.20..per.LSV.junction<=0.95), sum(x$is_IR & x$P..dPSI...0.20..per.LSV.junction>0.95 & x$E.dPSI..per.LSV.junction>0),sum(x$is_IR & x$P..dPSI...0.20..per.LSV.junction>0.95 & x$E.dPSI..per.LSV.junction<0)))

IR_dPSI20_counts_table = as.data.frame(unlist(IR_dPSI20_counts)[c(1:length(MAJIQ_contrasts))*3-2])
rownames(IR_dPSI20_counts_table) = names(IR_dPSI20_counts)
IR_dPSI20_counts_table$increased = unlist(IR_dPSI20_counts)[c(1:length(MAJIQ_contrasts))*3-1]
IR_dPSI20_counts_table$decreased = unlist(IR_dPSI20_counts)[c(1:length(MAJIQ_contrasts))*3]
colnames(IR_dPSI20_counts_table) = c('unchanged','increased','decreased')
IR_dPSI20_counts_table$condition = row.names(IR_dPSI20_counts_table)
# select the "comparisons of interest" only
IR_dPSI20_counts_to_plot = IR_dPSI20_counts_table[c(1:3,5),c(2:4)]
ggplot(melt(IR_dPSI20_counts_to_plot),aes(condition,value,fill=variable)) + geom_col() + theme(axis.text.x = element_text(angle = 90)) + ylab('LSV Junction Count')
## Using condition as id variables

ggsave('Y:/DUX4_multiomics/Analysis/splicing_plots/intron_retention.pdf',device='pdf',width=8,height=8)

ES_dPSI20_counts = lapply(MAJIQ_dpsi_contrasts,function(x) c(sum(x$exons_skipped>0 & x$P..dPSI...0.20..per.LSV.junction<=0.95), sum(x$exons_skipped>0 & x$P..dPSI...0.20..per.LSV.junction>0.95 & x$E.dPSI..per.LSV.junction>0),sum(x$exons_skipped>0 & x$P..dPSI...0.20..per.LSV.junction>0.95 & x$E.dPSI..per.LSV.junction<0)))
ES_dPSI20_counts_table = as.data.frame(unlist(ES_dPSI20_counts)[c(1:length(MAJIQ_contrasts))*3-2])
rownames(ES_dPSI20_counts_table) = names(ES_dPSI20_counts)
ES_dPSI20_counts_table$increased = unlist(ES_dPSI20_counts)[c(1:length(MAJIQ_contrasts))*3-1]
ES_dPSI20_counts_table$decreased = unlist(ES_dPSI20_counts)[c(1:length(MAJIQ_contrasts))*3]
colnames(ES_dPSI20_counts_table) = c('unchanged','increased','decreased')
ES_dPSI20_counts_table$condition = row.names(ES_dPSI20_counts_table)
# select the "comparisons of interest" only
ES_dPSI20_counts_to_plot = ES_dPSI20_counts_table[c(1:3,5),c(2:4)]
ggplot(melt(ES_dPSI20_counts_to_plot),aes(condition,value,fill=variable)) + geom_col() + theme(axis.text.x = element_text(angle = 90)) + ylab('LSV Junction Count')
## Using condition as id variables

ggsave('Y:/DUX4_multiomics/Analysis/splicing_plots/exon_skipping.pdf',device='pdf',width=8,height=8)


dPSI20_gene_counts = as.data.frame(unlist(lapply(MAJIQ_dpsi_contrasts,function(x) length(unique(x[x$P..dPSI...0.20..per.LSV.junction>0.95,]$Gene.ID)))))
dPSI20_gene_counts$condition = row.names(dPSI20_gene_counts)
colnames(dPSI20_gene_counts) = c('gene_count','condition')
ggplot(dPSI20_gene_counts[c(1:3,5),],aes(condition,gene_count)) + geom_col() + geom_text(aes(label=gene_count),vjust=-0.25,size=4) + ylab('Number of Genes with Significant LSV')

ggsave('Y:/DUX4_multiomics/Analysis/splicing_plots/gene_count_significant_events.pdf',device='pdf',width=8,height=8)

Cross-’omics comparisons

Protein abundance and splicing

Is there overlap in differential protein abundance and splicing changes?

intersect(unique(MAJIQ_dpsi_contrasts$iDUX4t00_iDUX4t14$external_gene_name[MAJIQ_dpsi_contrasts$iDUX4t00_iDUX4t14$P..dPSI...0.20..per.LSV.junction>0.95]), ms_total_protein_conditions_contrasts$iDUX4t14dox_iDUX4dmso$Gene[ms_total_protein_conditions_contrasts$iDUX4t14dox_iDUX4dmso$adj_pvalue<0.1])
## [1] "ZNF638" "TGFB2"  "DBR1"   "ZNF217" "SPG7"

RNA and protein

head(total_protein_comparisons$iDUX4t14dox_iDUX4dmso)
##   Protein   Gene                             Description ProteinGroup
## 1  P40222  TXLNA                           Alpha-taxilin       P40222
## 2  Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5       Q8NBS9
## 3  O14530 TXNDC9 Thioredoxin domain-containing protein 9       O14530
## 4  O43396  TXNL1              Thioredoxin-like protein 1       O43396
## 5  Q16563  SYPL1            Synaptophysin-like protein 1       Q16563
## 6  P47897   QARS                  Glutamine--tRNA ligase       P47897
##        log2FC adj_pvalue    pvalue
## 1 -0.08021061  0.9048223 0.2716738
## 2 -0.01051217  0.9906133 0.9036854
## 3 -0.18985874  0.8334083 0.1551630
## 4  0.11339369  0.7120630 0.0616433
## 5  0.08881894  0.9450211 0.6169264
## 6  0.07102547  0.9259508 0.3539390
head(limma_res_lengthScaled_conditions_contrasts$iDUX4t14dox_iDUX4dmso)
##         Row.names      log2FC  AveExpr          t      P.Value   adj_pvalue
## 1 caDUX4_sequence  8.62217451 1.941414 33.4410293 1.593238e-21 6.212249e-20
## 2 ENSG00000000003  0.02890418 4.758355  0.2320725 8.184649e-01 8.545630e-01
## 3 ENSG00000000419  0.95686464 5.054309 10.6442090 1.569432e-10 7.052899e-10
## 4 ENSG00000000457  1.56161647 3.203081 17.9053584 2.571499e-15 2.541836e-14
## 5 ENSG00000000460 -0.05151938 3.879153 -0.5840386 5.646874e-01 6.311114e-01
## 6 ENSG00000000971  0.86550969 7.175606  9.1097144 3.159315e-09 1.167237e-08
##           B numerator_mean reference_mean ensembl_gene_id_version
## 1 39.406187      224.54924      0.5522552         caDUX4_sequence
## 2 -3.150934       30.05726     29.8187635      ENSG00000000003.15
## 3 18.365104       56.53990     29.3180561      ENSG00000000419.12
## 4 29.746293       21.99483      7.4650823      ENSG00000000457.14
## 5 -2.790102       14.87838     15.5626079      ENSG00000000460.17
## 6 14.994784      225.81310    123.9663307      ENSG00000000971.15
##   external_gene_name             gene_biotype strand chromosome_name
## 1             caDUX4 inducible_protein_coding     NA              NA
## 2             TSPAN6           protein_coding     -1               X
## 3               DPM1           protein_coding     -1              20
## 4              SCYL3           protein_coding     -1               1
## 5           C1orf112           protein_coding      1               1
## 6                CFH           protein_coding      1               1
##   start_position end_position   band
## 1             NA           NA     NA
## 2      100627108    100639991  q22.1
## 3       50934867     50958555 q13.13
## 4      169849631    169894267  q24.2
## 5      169662007    169854080  q24.2
## 6      196651878    196747504  q31.3
##                                                                                      description
## 1                                                                   inducible codon altered DUX4
## 2                                              tetraspanin 6 [Source:HGNC Symbol;Acc:HGNC:11858]
## 3 dolichyl-phosphate mannosyltransferase subunit 1, catalytic [Source:HGNC Symbol;Acc:HGNC:3005]
## 4                                   SCY1 like pseudokinase 3 [Source:HGNC Symbol;Acc:HGNC:19285]
## 5                        chromosome 1 open reading frame 112 [Source:HGNC Symbol;Acc:HGNC:25565]
## 6                                         complement factor H [Source:HGNC Symbol;Acc:HGNC:4883]
merged_RNA_protein=list()
for(contrast_idx in 1:length(rownames(model_contrasts_of_interest))){
  merged_RNA_protein[[contrast_idx]] = merge(limma_res_lengthScaled_conditions_contrasts[[contrast_idx]],total_protein_comparisons[[contrast_idx]],by.x='external_gene_name',by.y='Gene',all=FALSE,suffixes=c('_RNA','_protein'))
  merged_RNA_protein[[contrast_idx]]$significant_analytes = 'neither'
  merged_RNA_protein[[contrast_idx]]$significant_analytes[merged_RNA_protein[[contrast_idx]]$adj_pvalue_RNA<0.05] = 'RNA only'
  merged_RNA_protein[[contrast_idx]]$significant_analytes[merged_RNA_protein[[contrast_idx]]$adj_pvalue_protein<0.05] = 'protein only'
  merged_RNA_protein[[contrast_idx]]$significant_analytes[merged_RNA_protein[[contrast_idx]]$adj_pvalue_RNA<0.05 & merged_RNA_protein[[contrast_idx]]$adj_pvalue_protein<0.05] = 'RNA and protein'
}
names(merged_RNA_protein) = rownames(model_contrasts_of_interest)
RNA_log2FC_lim = 1.01*max(abs(unlist(lapply(merged_RNA_protein,function(x) range(x$log2FC_RNA,na.rm=TRUE,finite=TRUE)))))
protein_log2FC_lim = 1.01*max(abs(unlist(lapply(merged_RNA_protein,function(x) range(x$log2FC_protein,na.rm=TRUE,finite=TRUE)))))

contrast_idx = 2
ggplotly(ggplot(merged_RNA_protein[[contrast_idx]],aes(x=log2FC_RNA,y=log2FC_protein,color=significant_analytes,label=external_gene_name)) + geom_point(alpha=0.5) + ggtitle(paste(rownames(model_contrasts_of_interest)[contrast_idx])) + xlim(RNA_log2FC_lim*c(-1,1)) + ylim(protein_log2FC_lim*c(-1,1)))
ggplot(merged_RNA_protein[[contrast_idx]],aes(x=log2FC_RNA,y=log2FC_protein,color=significant_analytes,label=external_gene_name)) + geom_point(alpha=0.5) + ggtitle(paste(rownames(model_contrasts_of_interest)[contrast_idx])) + xlim(RNA_log2FC_lim*c(-1,1)) + ylim(protein_log2FC_lim*c(-1,1)) + geom_text_repel(max.overlaps=8)
## Warning: ggrepel: 4446 unlabeled data points (too many overlaps). Consider
## increasing max.overlaps

table(merged_RNA_protein[[contrast_idx]]$significant_analytes)
## 
##         neither    protein only RNA and protein        RNA only 
##             621               3              12            3811
contrast_idx = 5
ggplotly(ggplot(merged_RNA_protein[[contrast_idx]],aes(x=log2FC_RNA,y=log2FC_protein,color=significant_analytes,label=external_gene_name)) + geom_point(alpha=0.5) + ggtitle(paste(rownames(model_contrasts_of_interest)[contrast_idx])) + xlim(RNA_log2FC_lim*c(-1,1)) + ylim(protein_log2FC_lim*c(-1,1)))
ggplot(merged_RNA_protein[[contrast_idx]],aes(x=log2FC_RNA,y=log2FC_protein,color=significant_analytes,label=external_gene_name)) + geom_point(alpha=0.5) + ggtitle(paste(rownames(model_contrasts_of_interest)[contrast_idx])) + xlim(RNA_log2FC_lim*c(-1,1)) + ylim(protein_log2FC_lim*c(-1,1)) + geom_text_repel(max.overlaps=8)
## Warning: Removed 3 rows containing missing values (geom_point).
## Warning: Removed 3 rows containing missing values (geom_text_repel).
## Warning: ggrepel: 4443 unlabeled data points (too many overlaps). Consider
## increasing max.overlaps

table(merged_RNA_protein[[contrast_idx]]$significant_analytes)
## 
##         neither    protein only RNA and protein        RNA only 
##             627              10             137            3673

RNA, protein, and splicing

contrast_idx = 5
ggplotly(ggplot(merged_RNA_protein[[contrast_idx]],aes(x=log2FC_RNA,y=log2FC_protein,color=external_gene_name %in% unique(MAJIQ_dpsi_contrasts$iDUX4t00_iDUX4t14$external_gene_name[MAJIQ_dpsi_contrasts$iDUX4t00_iDUX4t14$P..dPSI...0.20..per.LSV.junction>0.95]),label=external_gene_name)) + geom_point(alpha=0.5) + ggtitle(paste(rownames(model_contrasts_of_interest)[contrast_idx])) + xlim(RNA_log2FC_lim*c(-1,1)) + ylim(protein_log2FC_lim*c(-1,1)) + labs(color='P(dPSI>20%)>95%'))

Save results

RNAseq_comparisons_res = list(RNA_genes = limma_res_lengthScaled_conditions_contrasts,RNA_transcripts=transcript_limma_res_lengthScaled_conditions_contrasts)
saveRDS(RNAseq_comparisons_res,'Y:/DUX4_multiomics/Analysis/DUX4_multiomics_viewer/data/comparisons_res.rds')

MS_comparisons_res = list(total_protein = total_protein_comparisons, total_protein_peptides = total_protein_peptide_comparisons, phospho_protein_peptides = phospho_peptide_comparisons)
saveRDS(MS_comparisons_res,'Y:/DUX4_multiomics/Analysis/DUX4_multiomics_viewer/data/MS_comparisons_res.rds')

MS_quants_res = list(total_protein = total_protein_quantwide, total_protein_peptides = total_protein_quantwide_peptides,phospho_protein_peptides = phospho_quantwide_peptides)
saveRDS(MS_quants_res,'Y:/DUX4_multiomics/Analysis/DUX4_multiomics_viewer/data/MS_quants_res.rds')

Session Info

sessionInfo()
## R version 4.2.0 (2022-04-22 ucrt)
## Platform: x86_64-w64-mingw32/x64 (64-bit)
## Running under: Windows 10 x64 (build 19044)
## 
## Matrix products: default
## 
## locale:
## [1] LC_COLLATE=English_United States.utf8 
## [2] LC_CTYPE=English_United States.utf8   
## [3] LC_MONETARY=English_United States.utf8
## [4] LC_NUMERIC=C                          
## [5] LC_TIME=English_United States.utf8    
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] ggrepel_0.9.1               reshape2_1.4.4             
##  [3] pheatmap_1.0.12             NMF_0.24.0                 
##  [5] cluster_2.1.3               rngtools_1.5.2             
##  [7] pkgmaker_0.32.2             registry_0.5-1             
##  [9] scales_1.2.0                plotly_4.10.0              
## [11] httr_1.4.3                  RColorBrewer_1.1-3         
## [13] fgsea_1.22.0                apeglm_1.18.0              
## [15] rtracklayer_1.56.0          biomaRt_2.52.0             
## [17] devtools_2.4.3              usethis_2.1.6              
## [19] gridExtra_2.3               sva_3.44.0                 
## [21] BiocParallel_1.30.2         genefilter_1.78.0          
## [23] mgcv_1.8-40                 nlme_3.1-157               
## [25] swamp_1.5.1                 MASS_7.3-57                
## [27] gplots_3.1.3                amap_0.8-18                
## [29] impute_1.70.0               edgeR_3.38.1               
## [31] limma_3.52.1                DESeq2_1.36.0              
## [33] SummarizedExperiment_1.26.1 Biobase_2.56.0             
## [35] MatrixGenerics_1.8.0        matrixStats_0.62.0         
## [37] GenomicRanges_1.48.0        GenomeInfoDb_1.32.2        
## [39] IRanges_2.30.0              S4Vectors_0.34.0           
## [41] BiocGenerics_0.42.0         tximport_1.24.0            
## [43] forcats_0.5.1               stringr_1.4.0              
## [45] dplyr_1.0.9                 purrr_0.3.4                
## [47] readr_2.1.2                 tidyr_1.2.0                
## [49] tibble_3.1.7                ggplot2_3.3.6              
## [51] tidyverse_1.3.1            
## 
## loaded via a namespace (and not attached):
##   [1] utf8_1.2.2               tidyselect_1.1.2         RSQLite_2.2.14          
##   [4] AnnotationDbi_1.58.0     htmlwidgets_1.5.4        grid_4.2.0              
##   [7] munsell_0.5.0            codetools_0.2-18         withr_2.5.0             
##  [10] colorspace_2.0-3         filelock_1.0.2           highr_0.9               
##  [13] knitr_1.39               rstudioapi_0.13          labeling_0.4.2          
##  [16] bbmle_1.0.25             GenomeInfoDbData_1.2.8   farver_2.1.0            
##  [19] bit64_4.0.5              rprojroot_2.0.3          coda_0.19-4             
##  [22] vctrs_0.4.1              generics_0.1.2           xfun_0.31               
##  [25] BiocFileCache_2.4.0      R6_2.5.1                 doParallel_1.0.17       
##  [28] locfit_1.5-9.5           bitops_1.0-7             cachem_1.0.6            
##  [31] DelayedArray_0.22.0      assertthat_0.2.1         vroom_1.5.7             
##  [34] BiocIO_1.6.0             gtable_0.3.0             processx_3.5.3          
##  [37] rlang_1.0.2              splines_4.2.0            lazyeval_0.2.2          
##  [40] broom_0.8.0              yaml_2.3.5               modelr_0.1.8            
##  [43] crosstalk_1.2.0          backports_1.4.1          tools_4.2.0             
##  [46] gridBase_0.4-7           ellipsis_0.3.2           jquerylib_0.1.4         
##  [49] sessioninfo_1.2.2        Rcpp_1.0.8.3             plyr_1.8.7              
##  [52] progress_1.2.2           zlibbioc_1.42.0          RCurl_1.98-1.6          
##  [55] ps_1.7.0                 prettyunits_1.1.1        haven_2.5.0             
##  [58] fs_1.5.2                 magrittr_2.0.3           data.table_1.14.2       
##  [61] reprex_2.0.1             mvtnorm_1.1-3            pkgload_1.2.4           
##  [64] hms_1.1.1                evaluate_0.15            xtable_1.8-4            
##  [67] XML_3.99-0.9             emdbook_1.3.12           readxl_1.4.0            
##  [70] testthat_3.1.4           compiler_4.2.0           bdsmatrix_1.3-4         
##  [73] KernSmooth_2.23-20       crayon_1.5.1             htmltools_0.5.2         
##  [76] tzdb_0.3.0               geneplotter_1.74.0       lubridate_1.8.0         
##  [79] DBI_1.1.3                dbplyr_2.2.0             rappdirs_0.3.3          
##  [82] Matrix_1.4-1             brio_1.1.3               cli_3.3.0               
##  [85] pkgconfig_2.0.3          GenomicAlignments_1.32.0 numDeriv_2016.8-1.1     
##  [88] xml2_1.3.3               foreach_1.5.2            annotate_1.74.0         
##  [91] bslib_0.3.1              XVector_0.36.0           rvest_1.0.2             
##  [94] callr_3.7.0              digest_0.6.29            Biostrings_2.64.0       
##  [97] rmarkdown_2.14           cellranger_1.1.0         fastmatch_1.1-3         
## [100] restfulr_0.0.13          curl_4.3.2               Rsamtools_2.12.0        
## [103] gtools_3.9.2.1           rjson_0.2.21             lifecycle_1.0.1         
## [106] jsonlite_1.8.0           desc_1.4.1               viridisLite_0.4.0       
## [109] fansi_1.0.3              pillar_1.7.0             lattice_0.20-45         
## [112] KEGGREST_1.36.2          fastmap_1.1.0            pkgbuild_1.3.1          
## [115] survival_3.3-1           glue_1.6.2               remotes_2.4.2           
## [118] png_0.1-7                iterators_1.0.14         bit_4.0.4               
## [121] stringi_1.7.6            sass_0.4.1               blob_1.2.3              
## [124] caTools_1.18.2           memoise_2.0.1